Yi-Shuan J. Li

发表

Coordinated histone modifications and chromatin reorganization in a single cell revealed by FRET biosensors

Bing Ren, Shu Chien, Shaoying Lu, 2018, Proceedings of the National Academy of Sciences.

Piezo1, a mechanically activated ion channel, is required for vascular development in mice

Shu Chien, Sung Sik Hur, A. Patapoutian, 2014, Proceedings of the National Academy of Sciences.

Induction of apoptosis in vascular smooth muscle cells by mechanical stretch.

A. Ratcliffe, S. Usami, S. Chien, 2002, American journal of physiology. Heart and circulatory physiology.

Deterministically patterned biomimetic human iPSC-derived hepatic model via rapid 3D bioprinting

Y. Li, S. Chien, Wei Zhu, 2016, Proceedings of the National Academy of Sciences.

Shear stress, SIRT1, and vascular homeostasis

Y. Li, S. Chien, J. Shyy, 2010, Proceedings of the National Academy of Sciences.

Flow-dependent YAP/TAZ activities regulate endothelial phenotypes and atherosclerosis

S. Chien, K. Guan, Yi-Ting Yeh, 2016, Proceedings of the National Academy of Sciences.

Mechanotransduction in Response to Shear Stress

Shu Chien, Yi-Shuan Li, S. Chien, 1999, The Journal of Biological Chemistry.

Fluid Shear Stress Activation of IκB Kinase Is Integrin-dependent*

E. Zandi, S. Chien, J. Shyy, 1998, The Journal of Biological Chemistry.

Matrix Stiffness Regulates Endothelial Cell Proliferation through Septin 9

S. Chien, J. Chiu, Yi-Ting Yeh, 2012, PloS one.

Directional shear flow and Rho activation prevent the endothelial cell apoptosis induced by micropatterned anisotropic geometry

Fong-Chin Su, Shu Chien, Yi-Shuan Li, 2007, Proceedings of the National Academy of Sciences.

IFN-γ Induction of the Human Monocyte Chemoattractant Protein (hMCP)-1 Gene in Astrocytoma Cells: Functional Interaction Between an IFN-γ-Activated Site and a GC-Rich Element

R. Ransohoff, P. Chaturvedi, P. Kolattukudy, 1998, The Journal of Immunology.

Control of matrix stiffness promotes endodermal lineage specification by regulating SMAD2/3 via lncRNA LINC00458

O. Lee, Chih-Hung Chou, Hsien-Da Huang, 2020, Science Advances.

Regulation of Vascular Smooth Muscle Cell Turnover by Endothelial Cell–Secreted MicroRNA-126: Role of Shear Stress

Shu Chien, Yi-Shuan Li, Y. Li, 2013, Circulation research.

Flow-Dependent Regulation of Kruppel-Like Factor 2 Is Mediated by MicroRNA-92a.

Hsien-Da Huang, Yuzhi Zhang, G. Garcı́a-Cardeña, 2011, Circulation.

Role of microRNA-23b in flow-regulation of Rb phosphorylation and endothelial cell growth

S. Subramaniam, S. Chien, J. Shyy, 2010, Proceedings of the National Academy of Sciences.

Genomic analysis of smooth muscle cells in three‐dimensional collagen matrix

K. Peck, Y. Li, S. Chien, 2003, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Human Mesenchymal Stem Cells Suppress the Stretch–Induced Inflammatory miR-155 and Cytokines in Bronchial Epithelial Cells

O. Lee, Y. Li, S. Chien, 2013, PloS one.

Shear stress activation of nuclear receptor PXR in endothelial detoxification

Y. Li, S. Chien, Xiaohong Wang, 2013, Proceedings of the National Academy of Sciences.

Biomechanical regulation of matrix metalloproteinase‐9 in cultured chondrocytes

S. Chien, M. Lotz, R. Sah, 2000, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

Corrigendum: Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention

F. Su, Ya-ju Chang, Hui-Chun Huang, 2016, Scientific Reports.

Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention

Ya-ju Chang, Hui-Chun Huang, Yuan-Yu Hsueh, 2016, Scientific Reports.

Oscillatory Flow-induced Proliferation of Osteoblast-like Cells Is Mediated by αvβ3 and β1 Integrins through Synergistic Interactions of Focal Adhesion Kinase and Shc with Phosphatidylinositol 3-Kinase and the Akt/mTOR/p70S6K Pathway*

S. Chien, Shun-Fu Chang, J. Chiu, 2009, The Journal of Biological Chemistry.

Shear Stress Regulates the Flk-1/Cbl/PI3K/NF-κB Pathway Via Actin and Tyrosine Kinases

S. Chien, Yingxiao Wang, Shaoying Lu, 2009, Cellular and molecular bioengineering.

Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis

J. Lasheras, Y. Li, S. Chien, 2017, Proceedings of the National Academy of Sciences.

Live Cells Exert 3-Dimensional Traction Forces on Their Substrata

Shu Chien, Sung Sik Hur, Yihua Zhao, 2009, Cellular and molecular bioengineering.

Ephrin-A1 Regulates Cell Remodeling and Migration

P. Nguyen, Yi-Shuan J. Li, Ying-li Hu, 2011 .

The expression of monocyte chemotactic protein (MCP-1) in human vascular endotheliumin vitro andin vivo

James G. Wright, A. J. Valente, J. Cornhill, 1993, Molecular and Cellular Biochemistry.

Extracellular MicroRNA-92a Mediates Endothelial Cell-Macrophage Communication.

Ya-ju Chang, Y. Li, S. Chien, 2019, Arteriosclerosis, thrombosis, and vascular biology.

LINC00341 exerts an anti-inflammatory effect on endothelial cells by repressing VCAM1.

S. Subramaniam, S. Chien, J. Shyy, 2017, Physiological genomics.

Maintenance of HDACs and H3K9me3 Prevents Arterial Flow-Induced Venous Endothelial Damage

S. Chien, Chia-Ching Wu, Yi-Shuan J. Li, 2021, Frontiers in Cell and Developmental Biology.

Shear stress-initiated signaling and its regulation of endothelial function.

S. Chien, Jing Zhou, Yi-Shuan J. Li, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

Qingbo Xu, A. Zampetaki, S. Chien, 2009, Proceedings of the National Academy of Sciences.

Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow

S. Usami, J. Haga, F. Su, 2006, Journal of cellular biochemistry.

Stent Implantation Activates Akt in the Vessel Wall: Role of Mechanical Stretch in Vascular Smooth Muscle Cells

Shu Chien, John Y-J Shyy, Yi-Shuan Li, 2003, Arteriosclerosis, thrombosis, and vascular biology.

Molecular basis of mechanical modulation of endothelial cell migration.

Shu Chien, Yi-Shuan Li, S. Chien, 2005, Frontiers in bioscience : a journal and virtual library.

Vitexin inhibits APEX1 to counteract the flow-induced endothelial inflammation

S. Chien, Qinghua Cui, Dong Wang, 2021, Proceedings of the National Academy of Sciences.

Interplay between integrins and FLK-1 in shear stress-induced signaling.

S. Chien, Song Li, J. Shyy, 2002, American journal of physiology. Cell physiology.

Molecular basis of the effects of shear stress on vascular endothelial cells.

J. Haga, Y. Li, S. Chien, 2005, Journal of biomechanics.

Shear stress and VEGF activate IKK via the Flk-1/Cbl/Akt signaling pathway.

S. Chien, J. Shyy, Yingxiao Wang, 2004, American journal of physiology. Heart and circulatory physiology.

Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

S. Chien, Jing Zhou, Yi-Shuan J. Li, 2014, Cellular and Molecular Bioengineering.

Epigenetic Mechanism in Regulation of Endothelial Function by Disturbed Flow: Induction of DNA Hypermethylation by DNMT1

S. Chien, Jing Zhou, Yi-Shuan J. Li, 2014, Cellular and molecular bioengineering.

The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow

Y. Li, S. Chien, Yue-Feng Liu, 2017, Scientific Reports.

Shear stress regulation of miR-93 and miR-484 maturation through nucleolin

Traci L. Marin, Y. Li, S. Chien, 2019, Proceedings of the National Academy of Sciences.

Shear stress regulation of Krüppel-like factor 2 expression is flow pattern-specific.

Shu Chien, Angela Young, Yi-Shuan Li, 2006, Biochemical and biophysical research communications.

Endothelial Trauma From Mechanical Thrombectomy in Acute Stroke: In Vitro Live-Cell Platform With Animal Validation

Y. Li, S. Chien, V. Wong, 2015, Stroke.

Molecular basis of the effects of mechanical stretch on vascular smooth muscle cells.

J. Haga, Y. Li, S. Chien, 2007, Journal of biomechanics.

Synergistic roles of platelet-derived growth factor-BB and interleukin-1beta in phenotypic modulation of human aortic smooth muscle cells.

S. Usami, Y. Li, S. Chien, 2006, Proceedings of the National Academy of Sciences of the United States of America.

MicroRNA-23b Regulates Cyclin-Dependent Kinase–Activating Kinase Complex Through Cyclin H Repression to Modulate Endothelial Transcription and Growth Under Flow

S. Subramaniam, S. Chien, Yi-Ting Yeh, 2014, Arteriosclerosis, thrombosis, and vascular biology.

VAMP3 and SNAP23 mediate the disturbed flow-induced endothelial microRNA secretion and smooth muscle hyperplasia

S. Chien, Yue-Feng Liu, Jing Zhou, 2017, Proceedings of the National Academy of Sciences.

Flow Activation of AMP-Activated Protein Kinase in Vascular Endothelium Leads to Krüppel-Like Factor 2 Expression

G. Garcı́a-Cardeña, Y. Li, S. Chien, 2009, Arteriosclerosis, thrombosis, and vascular biology.

MiR-145 mediates cell morphology-regulated mesenchymal stem cell differentiation to smooth muscle cells

S. Chien, Yi-Ting Yeh, J. C. del Álamo, 2019, Biomaterials.

Roles of cell confluency and fluid shear in 3-dimensional intracellular forces in endothelial cells

Shu Chien, Sung Sik Hur, Yi-Shuan Li, 2012, Proceedings of the National Academy of Sciences.

Interactions of mechanotransduction pathways.

Y. Li, S. Chien, S. Muller, 2003, Biorheology.

Anisotropic rheology and directional mechanotransduction in vascular endothelial cells

Juan C. del Álamo, Shu Chien, Juan C. Lasheras, 2008, Proceedings of the National Academy of Sciences.

Functional role of the cis-acting elements in human monocyte chemotactic protein-1 gene in the regulation of its expression by phorbol ester in human glioblastoma cells

P. Kolattukudy, Yi-Shuan J. Li, 1994, Molecular and Cellular Biochemistry.

endothelial cells in response to 24-h shear stress DNA microarray analysis of gene expression in

B. Chen, S. Chien, Yihua Zhao, 2015 .

The Mammalian Target of Rapamycin and DNA methyltransferase 1 axis mediates vascular endothelial dysfunction in response to disturbed flow

S. Chien, Yue-Feng Liu, Jing Zhou, 2017, Scientific Reports.

miR‐23b regulates CDK‐activating kinase complex through cyclin H repression to modulate endothelial transcription and growth under flow (696.7)

S. Chien, Yi-Shuan J. Li, Kuei‐Chun Wang, 2014 .

Roles of microfilaments and microtubules in paxillin dynamics.

J. Haga, S. Chien, Yingxiao Wang, 2006, Biochemical and biophysical research communications.

Shear stress activates p60src-Ras-MAPK signaling pathways in vascular endothelial cells.

S. Chien, Song Li, S. Li, 1998, Arteriosclerosis, thrombosis, and vascular biology.

Vascular Mechanotransduction.

S. Chien, S. Earley, Yi-Shuan J. Li, 2023, Physiological reviews.

Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands.

S. Chien, M. Schwartz, K. Chen, 2001, Proceedings of the National Academy of Sciences of the United States of America.

DNA microarray study on gene expression profiles in co-cultured endothelial and smooth muscle cells in response to 4- and 24-h shear stress

S. Nelander, J. Haga, Y. Li, 2006, Molecular and Cellular Biochemistry.

Improved significance test for DNA microarray data: temporal effects of shear stress on endothelial genes.

David M. Rocke, Shu Chien, Yi-Shuan Li, 2002, Physiological genomics.

Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation.

A Ratcliffe, A. Ratcliffe, S. Usami, 2001, Biochemical and biophysical research communications.