D. Schepmann

G. Seebohm, B. Wünsch, Marvin Korff, 2021, Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.

Thiophene bioisosteres of GluN2B selective NMDA receptor antagonists: Synthesis and pharmacological evaluation of [7]annuleno[b]thiophen-6-amines.

B. Wünsch, D. Schepmann, S. Baumeister, 2019, Bioorganic & medicinal chemistry.

Pharmacokinetic properties of enantiomerically pure GluN2B selective NMDA receptor antagonists with 3-benzazepine scaffold.

S. Ametamey, B. Wünsch, D. Schepmann, 2019, Journal of pharmaceutical and biomedical analysis.

Modification of the 4-phenylbutyl side chain of potent 3-benzazepine-based GluN2B receptor antagonists.

S. Ametamey, Marina Wagner, B. Wünsch, 2019, Bioorganic & medicinal chemistry.

Fluorinated GluN2B Receptor Antagonists with a 3‐Benzazepine Scaffold Designed for PET Studies

S. Ametamey, A. Haider, B. Wünsch, 2018, ChemMedChem.

Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors

B. Wünsch, D. Schepmann, Bastian Frehland, 2018, ChemMedChem.

2-Methyltetrahydro-3-benzazepin-1-ols - The missing link in SAR of GluN2B selective NMDA receptor antagonists.

B. Wünsch, D. Schepmann, Sougata Dey, 2018, Bioorganic & medicinal chemistry.

Replacement of benzylic hydroxy group by vinyl or hydroxymethyl moiety at the 3-benzazepine scaffold retaining GluN2B affinity.

S. Rath, B. Wünsch, D. Schepmann, 2017, Bioorganic & medicinal chemistry.

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

B. Wünsch, M. Kitamura, Y. Shuto, 2017, MedChemComm.

Role of the phenolic OH moiety of GluN2B-selective NMDA antagonists with 3-benzazepine scaffold.

B. Wünsch, D. Schepmann, Sougata Dey, 2016, Bioorganic & medicinal chemistry letters.

Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.

B. Wünsch, D. Schepmann, Bastian Frehland, 2010, Journal of pharmaceutical and biomedical analysis.

Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2017, European journal of medicinal chemistry.

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B‐Selective NMDA Receptor Antagonists with a Benzo[7]annulen‐7‐amine Scaffold

W. Sippl, G. Seebohm, Alessandro Bonifazi, 2017, ChemMedChem.

Synthesis, GluN2B affinity and selectivity of benzo[7]annulen-7-amines.

Alessandro Bonifazi, B. Wünsch, D. Schepmann, 2014, Bioorganic & medicinal chemistry.

Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.

T. Winckler, B. Wünsch, Kai‐Uwe Schmidtke, 2010, Bioorganic & medicinal chemistry.

Synthesis and σ receptor affinity of spiro[[2]benzopyran-1,1'-cyclohexanes] with an exocyclic amino moiety in the 3'-position.

B. Wünsch, D. Schepmann, F. Weber, 2021, RSC medicinal chemistry.

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.

L. Heitman, M. Schäfers, K. Kopka, 2015, Organic & biomolecular chemistry.

Structure–Affinity Relationships of Fluorinated Spirocyclic σ2 Receptor Ligands with an Exocyclic Benzylamino Moiety

P. Brust, B. Wünsch, D. Schepmann, 2019, ChemMedChem.

Diastereoselective synthesis of conformationally restricted KOR agonists.

O. Koch, C. Daniliuc, B. Wünsch, 2021, Organic & biomolecular chemistry.

Synthesis and pharmacological evaluation of fluorinated benzo[7]annulen-7-amines as GluN2B-selective NMDA receptor antagonists.

S. Ametamey, B. Wünsch, R. F. Reinoso, 2019, Journal of labelled compounds & radiopharmaceuticals.

Investigation of the Role of Chirality in the Interaction with σ Receptors and Effect on Binge Eating Episode of a Potent σ1 Antagonist Analogue of Spipethiane.

G. Vistoli, Alessandro Bonifazi, C. Cifani, 2019, ACS chemical neuroscience.

Fluorinated 2-Arylcyclopropan-1-amines - A new class of sigma receptor ligands.

C. Daniliuc, B. Wünsch, G. Haufe, 2020, Bioorganic & medicinal chemistry.

Synthesis, Receptor Affinity, and Antiallodynic Activity of Spirocyclic σ Receptor Ligands with Exocyclic Amino Moiety.

P. Brust, C. Daniliuc, B. Wünsch, 2018, Journal of medicinal chemistry.

Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists

S. Ametamey, G. Seebohm, N. Strutz‐Seebohm, 2018, ChemMedChem.

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring.

H. de Vries, L. Heitman, B. Wünsch, 2017, MedChemComm.

Synthesis and biological evaluation of spirocyclic antagonists of CCR2 (chemokine CC receptor subtype 2).

L. Heitman, B. Wünsch, Anna Junker, 2015, Bioorganic & medicinal chemistry.

Synthesis and σ receptor affinity of regioisomeric spirocyclic furopyridines.

B. Wünsch, D. Schepmann, K. Miyata, 2014, European journal of medicinal chemistry.

Pyridine analogues of spirocyclic σ₁ receptor ligands.

B. Wünsch, D. Schepmann, K. Miyata, 2014, Bioorganic & medicinal chemistry.

Combination of cyclohexane and piperazine based κ-opioid receptor agonists: Synthesis and pharmacological evaluation of trans,trans-configured perhydroquinoxalines.

B. Wünsch, D. Schepmann, Christian Bourgeois, 2014, Bioorganic & medicinal chemistry.

Sharpless asymmetric dihydroxylation as the key step in the enantioselective synthesis of spirocyclic σ1 receptor ligands

C. Daniliuc, B. Wünsch, D. Schepmann, 2014 .

New combination of pharmacophoric elements of potent σ₁ ligands: design, synthesis and σ receptor affinity of aminoethyl substituted tetrahydrobenzothiophenes.

B. Wünsch, D. Schepmann, D. Harel, 2013, European journal of medicinal chemistry.

Homologous piperazine-alcanols: chiral pool synthesis and pharmacological evaluation

B. Wünsch, D. Schepmann, Ralph Holl, 2012 .

High‐Affinity, Selective σ Ligands of the 1,2,3,4‐Tetrahydro‐1,4′‐silaspiro[naphthalene‐1,4′‐piperidine] Type: Syntheses, Structures, and Pharmacological Properties

M. Fischer, B. Wünsch, I. Arnason, 2012, ChemMedChem.

Synthesis of 7,9-diazabicyclo[4.2.2]decanes as conformationally restricted κ receptor agonists: fine tuning of the dihedral angle of the ethylenediamine pharmacophore.

B. Wünsch, D. Schepmann, S. K. Sunnam, 2011, European journal of medicinal chemistry.

Synthesis and NMDA receptor affinity of dexoxadrol analogues with modifications in position 4 of the piperidine ring

B. Wünsch, A. Banerjee, D. Schepmann, 2010 .

Synthesis and NMDA receptor affinity of fluorinated dioxadrol analogues.

B. Wünsch, A. Banerjee, D. Schepmann, 2010, Bioorganic & medicinal chemistry.

Synthesis of sigma receptor ligands with unsymmetrical spiro connection of the piperidine moiety.

J. Holenz, H. Buschmann, B. Wünsch, 2009, European journal of medicinal chemistry.

Asymmetric synthesis and σ receptor affinity of enantiomerically pure 1,4-disubstituted tetrahydro-1H-3-benzazepines

B. Wünsch, S. M. Husain, D. Schepmann, 2009 .

Synthesis and structure-affinity relationships of novel spirocyclic sigma receptor ligands with furopyrazole structure.

B. Wünsch, E. Würthwein, D. Schepmann, 2008, Bioorganic & medicinal chemistry.

Chemical, pharmacodynamic and pharmacokinetic characterization of the GluN2B receptor antagonist 3-(4-phenylbutyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-1,7-diol – starting point for PET tracer development

S. Meuth, G. Seebohm, B. Wünsch, 2022, Biological chemistry.

Identification of dual Sigma1 receptor modulators/acetylcholinesterase inhibitors with antioxidant and neurotrophic properties, as neuroprotective agents.

D. Rossi, S. Collina, G. Cavaletti, 2018, European journal of medicinal chemistry.

Role of the NMDA Receptor in the Antitumor Activity of Chiral 1,4-Dioxane Ligands in MCF-7 and SKBR3 Breast Cancer Cells.

G. Santoni, C. Amantini, Alessandro Bonifazi, 2019, ACS medicinal chemistry letters.

In vitro and in vivo Human Metabolism of (S)-[18F]Fluspidine – A Radioligand for Imaging σ1 Receptors With Positron Emission Tomography (PET)

J. Steinbach, P. Brust, M. Patt, 2019, Front. Pharmacol..

Conformationally restricted κ-opioid receptor agonists: Synthesis and pharmacological evaluation of diastereoisomeric and enantiomeric decahydroquinoxalines.

R. Fröhlich, R. Autar, B. Wünsch, 2015, Bioorganic & medicinal chemistry letters.

Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

L. Heitman, K. Kopka, Nuska Tschammer, 2020, ChemMedChem.

Synthesis and Biological Evaluation of Natural-Product-Inspired, Aminoalkyl-Substituted 1-Benzopyrans as Novel Antiplasmodial Agents.

M. Nonato, R. Krauth-Siegel, B. Wünsch, 2021, Journal of medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 3‐Benzazepin‐1‐ols as NR2B‐Selective NMDA Receptor Antagonists

T. Winckler, B. Wünsch, Kai‐Uwe Schmidtke, 2010, ChemMedChem.

Rigidity versus Flexibility: Is This an Issue in σ1 Receptor Ligand Affinity and Activity?

E. Laurini, M. Fermeglia, S. Pricl, 2016, Journal of medicinal chemistry.

Oxetanyl Amino Acids for Peptidomimetics.

E. Carreira, B. Wünsch, Steffen Müller, 2017, Organic letters.

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

T. Che, B. Wünsch, T. Schmidt, 2020, Chemmedchem.

Chemoenzymatic synthesis of 2,6-disubstituted tetrahydropyrans with high σ1 receptor affinity, antitumor and analgesic activity.

E. Laurini, D. Marson, S. Pricl, 2021, European journal of medicinal chemistry.

Design, synthesis and SAR analysis of novel selective sigma1 ligands (Part 2).

C. Laggner, D. Rossi, S. Collina, 2007, Bioorganic & medicinal chemistry.

Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.

G. Seebohm, B. Wünsch, D. Schepmann, 2020, European journal of medicinal chemistry.

Natural product derived antiprotozoal agents: synthesis, biological evaluation, and structure-activity relationships of novel chromene and chromane derivatives.

B. Wünsch, R. Brun, T. Schmidt, 2013, Journal of medicinal chemistry.

Asymmetric synthesis of enantiomerically pure 2-substituted tetrahydro-3-benzazepines and their affinity to sigma1 receptors.

B. Wünsch, S. M. Husain, D. Schepmann, 2009, The Journal of organic chemistry.

Asymmetric synthesis of 1-substituted tetrahydro-3-benzazepines as NMDA receptor antagonists

B. Wünsch, D. Schepmann, Ursula Wirt, 2007 .

Sila‐Haloperidol, a Silicon Analogue of the Dopamine (D2) Receptor Antagonist Haloperidol: Synthesis, Pharmacological Properties, and Metabolic Fate

B. Wünsch, A. Hamacher, M. Kassack, 2008, ChemMedChem.

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.

R. Autar, S. Ständer, D. Metze, 2017, Journal of medicinal chemistry.

Enantioselective synthesis of encecaline-derived potent antimalarial agents.

B. Wünsch, R. Brun, T. Schmidt, 2013, Organic & biomolecular chemistry.

Impact of hydroxy moieties at the benzo[7]annulene ring system of GluN2B ligands: Design, synthesis and biological evaluation.

W. Sippl, C. Daniliuc, B. Wünsch, 2019, Bioorganic & medicinal chemistry.

Heck reaction of ortho-substituted iodobenzenes with α,β-unsaturated nitriles as a key step in the synthesis of tetrahydro-2-benzazepines and hexahydro-3-benzazocines

B. Wünsch, D. Schepmann, Peer Hasebein, 2013 .

New Insights into the Opening of the Occluded Ligand-Binding Pocket of Sigma1 Receptor: Binding of a Novel Bivalent RC-33 Derivative

Giacomo Rossino, Ivana Orellana, Julio Caballero, 2019, J. Chem. Inf. Model..

Synthesis and NMDA-receptor affinity of 4-oxo-dexoxadrol derivatives.

B. Wünsch, B. Wibbeling, M. Sax, 2006, Bioorganic & medicinal chemistry.

Enantiomerically pure 1,3-dioxanes as highly selective NMDA and σ₁ receptor ligands.

B. Wünsch, Jörg Fabian, Jens Köhler, 2012, Journal of medicinal chemistry.

The Action of Reproductive Fluids and Contained Steroids, Prostaglandins, and Zn2+ on CatSper Ca2+ Channels in Human Sperm

B. Wünsch, M. von Wolff, C. Brenker, 2021, Frontiers in Cell and Developmental Biology.

Synthesis and NMDA Receptor Affinity of Ring and Side Chain Homologues of Dexoxadrol

B. Wünsch, M. Sax, D. Schepmann, 2008 .

Thiazole‐Based σ1 Receptor Ligands: Diversity by Late‐Stage C−H Arylation of Thiazoles, Structure–Affinity and Selectivity Relationships, and Molecular Interactions

E. Laurini, M. Fermeglia, S. Pricl, 2017, ChemMedChem.

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5‐Phenylsulfanyl‐ and 5‐Benzyl‐Substituted Tetrahydro‐2‐benzazepines

B. Wünsch, D. Schepmann, Bastian Frehland, 2014, ChemMedChem.

Discovery of a σ1 receptor antagonist by combination of unbiased cell painting and thermal proteome profiling.

H. Waldmann, H. Osada, B. Wünsch, 2021, Cell chemical biology.

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5‐Phenylsulfanyl‐ and 5‐Benzyl‐Substituted Tetrahydro‐2‐benzazepines.

D. Schepmann, Bastian Frehland, Peer Hasebein, 2015 .

Improvement of σ1 receptor affinity by late-stage C-H-bond arylation of spirocyclic lactones.

B. Wünsch, Junichiro Yamaguchi, K. Itami, 2013, Bioorganic & medicinal chemistry.

Asymmetric Synthesis of Potent and Selective σ1 Receptor Ligands with Tetrahydro‐3‐benzazepine Scaffold

B. Wünsch, Jens Köhler, D. Schepmann, 2012 .

Synthesis and SAR studies of chiral non-racemic dexoxadrol analogues as uncompetitive NMDA receptor antagonists.

Dirk Schepmann, Bernhard Wünsch, B. Wünsch, 2010, Bioorganic & medicinal chemistry.

Antinociceptive effects of a new sigma-1 receptor antagonist (N-(2-morpholin-4-yl-ethyl)-2-(1-naphthyloxy)acetamide) in two types of nociception.

F. López-Muñoz, A. Domínguez-Ramírez, O. A. Jaramillo-Morales, 2016, European journal of pharmacology.

Pharmacological and metabolic characterisation of the potent sigma1 receptor ligand 1'-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4'-piperidine].

J. Holenz, H. Buschmann, B. Wünsch, 2009, The Journal of pharmacy and pharmacology.

Thiophene bioisosteres of spirocyclic sigma receptor ligands. 1. N-substituted spiro[piperidine-4,4'-thieno[3,2-c]pyrans].

J. Holenz, J. Díaz, B. Wünsch, 2008, Journal of medicinal chemistry.

Separation and identification of zaleplon metabolites in human urine using capillary electrophoresis with laser-induced fluorescence detection and liquid chromatography-mass spectrometry.

G. Blaschke, D. Schepmann, C. Horstkötter, 2003, Journal of chromatography. A.

Synthesis and biological evaluation of new aryl-alkyl ( alkenyl )-4-benzylpiperidines , novel Sigma Receptor ( SR ) modulators , as potential anticancer-agent

Simona, Sabrina, A. Tesei, 2016 .

Synthesis of tropane-based σ1 receptor antagonists with antiallodynic activity.

G. Seebohm, C. Daniliuc, B. Wünsch, 2022, European journal of medicinal chemistry.

Design, synthesis and pharmacological evaluation of spirocyclic σ(1) receptor ligands with exocyclic amino moiety (increased distance 1).

R. Fröhlich, B. Wünsch, D. Schepmann, 2011, Bioorganic & medicinal chemistry.

Development of fluorinated CB(2) receptor agonists for PET studies.

P. Brust, B. Wünsch, R. Günther, 2013, Bioorganic & medicinal chemistry.

Optimization of pharmacokinetic properties by modification of a carbazole-based cannabinoid receptor subtype 2 (CB2) ligand.

H. de Vries, L. Heitman, B. Wünsch, 2018, European journal of medicinal chemistry.

Microwave-assisted regioselective direct C–H arylation of thiazole derivatives leading to increased σ1 receptor affinity

B. Wünsch, Junichiro Yamaguchi, K. Itami, 2016 .

Bitopic Sigma 1 Receptor Modulators to Shed Light on Molecular Mechanisms Underpinning Ligand Binding and Receptor Oligomerization.

Julio Caballero, D. Rossi, S. Collina, 2021, Journal of medicinal chemistry.

Novel Highly Potent and Selective Sigma1 Receptor Antagonists Effectively Block the Binge Eating Episode in Female Rats

G. Vistoli, Alessandro Bonifazi, C. Cifani, 2020, ACS chemical neuroscience.

Synthesis and Structure-Affinity Relationships of Spirocyclic Benzopyrans with Exocyclic Amino Moiety.

E. Laurini, S. Pricl, B. Wünsch, 2019, Journal of medicinal chemistry.

Synthesis, Characterization, and Metabolism Studies of Fluspidine Enantiomers

P. Brust, H. Humpf, B. Wünsch, 2013, ChemMedChem.

Identification of a potent and selective σ₁ receptor agonist potentiating NGF-induced neurite outgrowth in PC12 cells.

M. Fernández, Julio Caballero, L. Fernández, 2011, Bioorganic & medicinal chemistry.

Synthesis of Aminoethyl‐Substituted Piperidine Derivatives as σ1 Receptor Ligands with Antiproliferative Properties

E. Laurini, D. Marson, S. Pricl, 2022, ChemMedChem.

Propellanes as Rigid Scaffolds for the Stereodefined Attachment of σ-Pharmacophoric Structural Elements to Achieve σ Affinity

E. Laurini, S. Pricl, C. Daniliuc, 2021, International journal of molecular sciences.

Design, Radiosynthesis and Preliminary Biological Evaluation in Mice of a Brain-Penetrant 18F-Labelled σ2 Receptor Ligand

P. Brust, B. Wünsch, Rareş-Petru Moldovan, 2021, International journal of molecular sciences.

Conformationally Restricted σ1 Receptor Antagonists from (-)-Isopulegol.

E. Laurini, S. Pricl, B. Wünsch, 2023, Journal of medicinal chemistry.

Synthesis of Bicyclic σ Receptor Ligands with Cytotoxic Activity

P. Bednarski, B. Wünsch, B. Wibbeling, 2007 .

Negative allosteric modulators of the GluN2B NMDA receptor with phenylethylamine structure embedded in ring-expanded and ring-contracted scaffolds.

W. Sippl, G. Seebohm, B. Wünsch, 2020, European journal of medicinal chemistry.

Effects of polar κ receptor agonists designed for the periphery on ATP-induced Ca2+ release from keratinocytes

S. Ständer, T. Lotts, B. Wünsch, 2016 .

Asymmetric synthesis of enantiomerically pure 1,4-di- and 1,1,4-trisubstituted tetrahydro-1H-3-benzazepines

B. Wünsch, D. Schepmann, Soumya Sarkar, 2011 .

Bicyclic sigma receptor ligands by stereoselective Dieckmann analogous cyclization of piperazinebutyrate.

B. Wünsch, B. Wibbeling, D. Schepmann, 2010, Organic & biomolecular chemistry.

Synthesis of σ Receptor Ligands with a Spirocyclic System Connected with a Tetrahydroisoquinoline Moiety via Different Linkers

B. Wünsch, D. Schepmann, Melanie Bergkemper, 2020, ChemMedChem.

Synthesis of spirocyclic sigma1 receptor ligands as potential PET radiotracers, structure-affinity relationships and in vitro metabolic stability.

M. Scheunemann, P. Brust, B. Wünsch, 2009, Bioorganic & medicinal chemistry.

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.

W. Sippl, Tanaporn Uengwetwanit, Friedemann Gaube, 2015, Journal of medicinal chemistry.

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.

J. Lehmann, J. Heilmann, Friedemann Gaube, 2010, Journal of medicinal chemistry.

Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1'-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4'-piperidine].

P. Brust, S. Grimme, H. Humpf, 2011, Chirality.

Development of Novel Quinoxaline-Based κ-Opioid Receptor Agonists for the Treatment of Neuroinflammation.

T. Che, S. Ständer, B. Wünsch, 2018, Journal of medicinal chemistry.

[2.2]Paracyclophane‐Based TCN‐201 Analogs as GluN2A‐Selective NMDA Receptor Antagonists

G. Seebohm, B. Wünsch, J. Jose, 2021, ChemMedChem.

Synthesis and pharmacological evaluation of conformationally restricted κ-opioid receptor agonists

S. Ständer, C. Daniliuc, B. Wünsch, 2016 .

Conformationally constrained kappa receptor agonists: stereoselective synthesis and pharmacological evaluation of 6,8-diazabicyclo[3.2.2]nonane derivatives.

B. Wünsch, W. Englberger, C. Zelenka, 2010, Journal of medicinal chemistry.

Stereoselective synthesis and structure-affinity relationships of bicyclic kappa receptor agonists.

R. Fröhlich, B. Wünsch, D. Schepmann, 2010, Organic & biomolecular chemistry.

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

M. Hollmann, T. Budde, G. Seebohm, 2019, Communications Biology.

Synthesis and receptor binding of thiophene bioisosteres of potent GluN2B ligands with a benzo[7]annulene-scaffold.

B. Wünsch, D. Schepmann, S. Baumeister, 2019, MedChemComm.

Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.

G. Seebohm, C. Daniliuc, B. Wünsch, 2022, European journal of medicinal chemistry.

Benzimidazolone bioisosteres of potent GluN2B selective NMDA receptor antagonists.

B. Wünsch, D. Schepmann, Ines Lütnant, 2016, European journal of medicinal chemistry.

Systematic variation of the benzoylhydrazine moiety of the GluN2A selective NMDA receptor antagonist TCN-201.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2018, European journal of medicinal chemistry.

Replacement of the Benzylpiperidine Moiety with Fluorinated Phenylalkyl Side Chains for the Development of GluN2B Receptor Ligands

S. Ametamey, B. Wünsch, D. Kalinin, 2018, ChemMedChem.

Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold.

B. Wünsch, D. Schepmann, S. Baumeister, 2018, European journal of medicinal chemistry.

Benzo[7]annulene-based GluN2B selective NMDA receptor antagonists: Surprising effect of a nitro group in 2-position.

W. Sippl, Alessandro Bonifazi, B. Wünsch, 2015, Bioorganic & medicinal chemistry letters.

GluN2B‐Selective N‐Methyl‐d‐aspartate (NMDA) Receptor Antagonists Derived from 3‐Benzazepines: Synthesis and Pharmacological Evaluation of Benzo[7]annulen‐7‐amines

O. Shoji, Alessandro Bonifazi, C. Shirataki, 2014, ChemMedChem.

Diverse Modifications of the 4‐Methylphenyl Moiety of TAK‐779 by Late‐Stage Suzuki—Miyaura Cross‐Coupling.

K. Kopka, Junichiro Yamaguchi, K. Itami, 2014 .

Relationships between the structure of spiro[[2]benzopyran-1,1’-cyclohexan]-4’-amines and their σ1 receptor affinity and selectivity

B. Wünsch, D. Schepmann, Elisabeth Kronenberg, 2023, Results in Chemistry.

Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2017, European journal of medicinal chemistry.

Downstream Allosteric Modulation of NMDA Receptors by 3-Benzazepine Derivatives

S. Ametamey, T. Budde, G. Seebohm, 2023, Molecular Neurobiology.

Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.

C. Ehrhardt, C. Daniliuc, B. Wünsch, 2015, Bioorganic & medicinal chemistry.

Synthesis of morphan derivatives with additional substituents in 8-position

C. Daniliuc, B. Wünsch, S. Saito, 2016 .

Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.

G. Seebohm, B. Wünsch, J. Schmidt, 2023, Journal of Medicinal Chemistry.

Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.

G. Seebohm, C. Daniliuc, B. Wünsch, 2021, Journal of medicinal chemistry.

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.

W. Sippl, B. Wünsch, D. Robaa, 2018, European journal of medicinal chemistry.

Pyridine bioisosteres of potent GluN2B subunit containing NMDA receptor antagonists with benzo[7]annulene scaffold.

B. Wünsch, D. Schepmann, S. Baumeister, 2018, European journal of medicinal chemistry.

Bivalent beta-carbolines as potential multitarget anti-Alzheimer agents.

J. Lehmann, J. Heilmann, Friedemann Gaube, 2010, Journal of medicinal chemistry.

Stereoselective synthesis of conformationally restricted KOR agonists based on the 2,5-diazabicyclo[2.2.2]octane scaffold.

C. Daniliuc, B. Wünsch, D. Schepmann, 2017, Organic & biomolecular chemistry.

Enantiomerically Pure Quinoline‐Based κ‐Opioid Receptor Agonists: Chemoenzymatic Synthesis and Pharmacological Evaluation

T. Che, B. Wünsch, T. Schmidt, 2020, ChemMedChem.

Discovery of RC-752, a Novel Sigma-1 Receptor Antagonist with Antinociceptive Activity: A Promising Tool for Fighting Neuropathic Pain

U. Laforenza, A. Tesei, D. Rossi, 2023, Pharmaceuticals.

Gaining in pan-affinity towards sigma 1 and sigma 2 receptors. SAR studies on arylalkylamines.

D. Rossi, S. Collina, K. Liedl, 2017, Bioorganic & medicinal chemistry.

Frontiers in Medicinal Chemistry 2010: The Highlights

B. Wünsch, D. Schepmann, 2010, ChemMedChem.

Quinolone bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists.

D. Schepmann, Bernhard Wünsch, Friederike Rathing, 2024, Archiv der Pharmazie.