Bastian Frehland

发表

Hydroxyalkylation with Cyclic Sulfates: Synthesis of Carbazole Derived CB2 Ligands with Increased Polarity

P. Brust, C. Daniliuc, B. Wünsch, 2014, Archiv der Pharmazie.

Synthesis and pharmacological evaluation of like- and unlike-configured tetrahydro-2-benzazepines with the α-substituted benzyl moiety in the 5-position.

R. Fröhlich, B. Wünsch, D. Schepmann, 2014, Organic & biomolecular chemistry.

Characterization of ligand binding to the σ(1) receptor in a human tumor cell line (RPMI 8226) and establishment of a competitive receptor binding assay.

B. Wünsch, D. Schepmann, Bastian Frehland, 2012, Assay and drug development technologies.

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

M. Hollmann, T. Budde, G. Seebohm, 2019, Communications Biology.

Optimization of the metabolic stability of a fluorinated cannabinoid receptor subtype 2 (CB2) ligand designed for PET studies.

H. de Vries, L. Heitman, B. Wünsch, 2018, European journal of medicinal chemistry.

Synthesis and pharmacological evaluation of enantiomerically pure endo-configured KOR agonists with 2-azabicyclo[3.2.1]octane scaffold.

P. Diana, B. Wünsch, Jens Köhler, 2021, Organic & biomolecular chemistry.

Phenol‐benzoxazolone bioisosteres of GluN2B‐NMDA receptor antagonists: Unexpected rearrangement during reductive alkylation with phenylcyclohexanone

R. Fröhlich, G. Seebohm, C. Daniliuc, 2022, Archiv der Pharmazie.

Phenol—Benzoxazolone bioisosteres: Synthesis and biological evaluation of tricyclic GluN2B‐selective N‐methyl‐ d‐aspartate receptor antagonists

G. Seebohm, B. Wünsch, D. Schepmann, 2022, Archiv der Pharmazie.

Negative allosteric modulators of NMDA receptors with GluN2B subunit: Alanine‐derived benzoxazolone bioisosteres of 2‐methyl‐3‐benzazepine‐1,7‐diols

B. Wünsch, D. Schepmann, Bastian Frehland, 2022, Archiv der Pharmazie.

Comparative Pharmacological Study of Common NMDA Receptor Open Channel Blockers Regarding Their Affinity and Functional Activity toward GluN2A and GluN2B NMDA Receptors

B. Wünsch, D. Schepmann, Bastian Frehland, 2018, ChemMedChem.

Development of a selective competitive receptor binding assay for the determination of the affinity to NR2B containing NMDA receptors.

B. Wünsch, D. Schepmann, Bastian Frehland, 2010, Journal of pharmaceutical and biomedical analysis.

Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.

G. Seebohm, N. Strutz‐Seebohm, B. Wünsch, 2017, European journal of medicinal chemistry.

Conformationally constrained NR2B selective NMDA receptor antagonists derived from ifenprodil: Synthesis and biological evaluation of tetrahydro-3-benzazepine-1,7-diols.

T. Winckler, B. Wünsch, Kai‐Uwe Schmidtke, 2010, Bioorganic & medicinal chemistry.

Synthesis, binding affinity and structure-activity relationships of novel, selective and dual targeting CCR2 and CCR5 receptor antagonists.

L. Heitman, M. Schäfers, K. Kopka, 2015, Organic & biomolecular chemistry.

Bioisosteric replacement of central 1,2,4-oxadiazole ring of high affinity CB2 ligands by regioisomeric 1,3,4-oxadiazole ring.

H. de Vries, L. Heitman, B. Wünsch, 2017, MedChemComm.

Design, Synthesis, and Biological Evaluation of 3‐Benzazepin‐1‐ols as NR2B‐Selective NMDA Receptor Antagonists

T. Winckler, B. Wünsch, Kai‐Uwe Schmidtke, 2010, ChemMedChem.

Design and Synthesis of Enantiomerically Pure Decahydroquinoxalines as Potent and Selective κ-Opioid Receptor Agonists with Anti-Inflammatory Activity in Vivo.

R. Autar, S. Ständer, D. Metze, 2017, Journal of medicinal chemistry.

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5‐Phenylsulfanyl‐ and 5‐Benzyl‐Substituted Tetrahydro‐2‐benzazepines

B. Wünsch, D. Schepmann, Bastian Frehland, 2014, ChemMedChem.

Synthesis, σ Receptor Affinity, and Pharmacological Evaluation of 5‐Phenylsulfanyl‐ and 5‐Benzyl‐Substituted Tetrahydro‐2‐benzazepines.

D. Schepmann, Bastian Frehland, Peer Hasebein, 2015 .

Optimization of pharmacokinetic properties by modification of a carbazole-based cannabinoid receptor subtype 2 (CB2) ligand.

H. de Vries, L. Heitman, B. Wünsch, 2018, European journal of medicinal chemistry.

Enantiomerically Pure 2-Methyltetrahydro-3-benzazepin-1-ols Selectively Blocking GluN2B Subunit Containing N-Methyl-D-aspartate Receptors.

W. Sippl, Tanaporn Uengwetwanit, Friedemann Gaube, 2015, Journal of medicinal chemistry.

A common mechanism allows selective targeting of GluN2B subunit-containing N-methyl-D-aspartate receptors

M. Hollmann, T. Budde, G. Seebohm, 2019, Communications Biology.

Novel GluN2B selective NMDA receptor antagonists: relative configuration of 7-methoxy-2-methyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ols

R. Fröhlich, B. Wünsch, Bastian Frehland, 2016, Acta crystallographica. Section E, Crystallographic communications.

Crystal structure of (1S*,2R*)-7-benzyloxy-2-methyl-3-tosyl-2,3,4,5-tetrahydro-1H-3-benzazepin-1-ol: elucidation of the relative configuration of potent allosteric GluN2B selective NMDA receptor antagonists

R. Fröhlich, B. Wünsch, Bastian Frehland, 2016, Acta crystallographica. Section E, Crystallographic communications.

Stereoselective synthesis and pharmacological evaluation of [4.3.3]propellan-8-amines as analogs of adamantanamines.

C. Ehrhardt, C. Daniliuc, B. Wünsch, 2015, Bioorganic & medicinal chemistry.

Indazole as a Phenol Bioisostere: Structure-Affinity Relationships of GluN2B-Selective NMDA Receptor Antagonists.

G. Seebohm, B. Wünsch, J. Schmidt, 2023, Journal of medicinal chemistry.

Ifenprodil Stereoisomers: Synthesis, Absolute Configuration, and Correlation with Biological Activity.

G. Seebohm, C. Daniliuc, B. Wünsch, 2021, Journal of medicinal chemistry.

Hydroxymethyl bioisosteres of phenolic GluN2B-selective NMDA receptor antagonists: Design, synthesis and pharmacological evaluation.

W. Sippl, B. Wünsch, D. Robaa, 2018, European journal of medicinal chemistry.