Xiaojuan Chen

发表

Structural basis of binding of homodimers of the nuclear receptor NR4A2 to selective Nur-responsive DNA elements

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, The Journal of Biological Chemistry.

Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, Chemical communications.

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2018, Chemical communications.

Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors

Yongheng Chen, Zhuchu Chen, S. Dai, 2022, Communications Chemistry.

Development of a Potent and Specific FGFR4 Inhibitor for the Treatment of Hepatocellular Carcinoma.

J. Carpten, Yongheng Chen, P. Cao, 2020, Journal of medicinal chemistry.

Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter.

Yongheng Chen, Zhuchu Chen, S. Dai, 2019, Biochemical and biophysical research communications.

Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site.

Jared M. Sagendorf, A. C. Dantas Machado, R. Rohs, 2017, Biochemistry.

Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, PloS one.

Structural study of ponatinib in inhibiting SRC kinase.

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2022, Biochemical and biophysical research communications.

Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor.

Yongheng Chen, S. Dai, L. Qu, 2022, Biochemical and biophysical research communications.

Structural basis of tropifexor as a potent and selective agonist of farnesoid X receptor.

Yongheng Chen, D. Xiao, S. Dai, 2020, Biochemical and biophysical research communications.

Characterization of the cholangiocarcinoma drug pemigatinib against FGFR gatekeeper mutants

S. Dai, L. Qu, Xiaojuan Chen, 2022, Communications Chemistry.

Characterization of ibrutinib as a non-covalent inhibitor of SRC-family kinases.

Yongheng Chen, Zhuchu Chen, Yankun Duan, 2020, Bioorganic & medicinal chemistry letters.

Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.

J. Smaill, Yongheng Chen, Xiaoyun Lu, 2021, ACS medicinal chemistry letters.

Discovery of D6808, a Highly Selective and Potent Macrocyclic c-Met Inhibitor for Gastric Cancer Harboring MET Gene Alteration Treatment.

Zheng-chao Tu, Zhang Zhang, L. Qu, 2022, Journal of medicinal chemistry.

FGFR-TKI resistance in cancer: current status and perspectives

Yongheng Chen, Xiaojuan Chen, Yu-kun Li, 2021, Journal of Hematology & Oncology.

Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates.

Yongheng Chen, Zhuchu Chen, S. Dai, 2022, Biochemical and biophysical research communications.

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nature communications.

Mechanism of forkhead transcription factors binding to a novel palindromic DNA site

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nucleic acids research.

Structure-based design of a dual-warhead covalent inhibitor of FGFR4

Yongheng Chen, S. Dai, Jun Li, 2022, Communications Chemistry.

Design, Synthesis, and Biological Evaluation of 5-Formyl-pyrrolo[3,2-b]pyridine-3-carboxamides as New Selective, Potent, and Reversible-Covalent FGFR4 Inhibitors.

J. Smaill, Zheng-chao Tu, A. Patterson, 2022, Journal of medicinal chemistry.

Structural basis for DNA recognition by FOXG1 and the characterization of disease-causing FOXG1 mutations.

Yongheng Chen, Zhuchu Chen, S. Dai, 2020, Journal of molecular biology.

Structural basis for DNA recognition by FOXC2.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019 .

Structural basis for DNA recognition by FOXC2

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019, Nucleic acids research.

DNA-binding properties of FOXP3 transcription factor

Yongheng Chen, Zhuchu Chen, Lin Chen, 2017, Acta biochimica et biophysica Sinica.

Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor

Yongheng Chen, Jun Li, S. Dai, 2022, Nature Communications.

Characterization of an aromatic trifluoromethyl ketone as a new warhead for covalently reversible kinase inhibitor design.

Yongheng Chen, Zheng-chao Tu, Ke Ding, 2021, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of Aminoindazole Derivatives as Highly Selective Covalent Inhibitors of Wild-Type and Gatekeeper Mutant FGFR4.

J. Smaill, Yongheng Chen, Xiaoyun Lu, 2022, Journal of medicinal chemistry.

Expression and purification of the kinase domain of PINK1 in Pichia pastoris.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, Protein expression and purification.

Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity

Zhuchu Chen, S. Dai, L. Qu, 2023, Nature communications.

Structural insight into the molecular mechanism of p53-mediated mitochondrial apoptosis

Yongheng Chen, Zhuchu Chen, Lin Chen, 2021, Nature Communications.

Crystal Structural of FOXC2 DNA binding domain bound to PC promoter

Yongheng Chen, Zhuchu Chen, Lin Chen, 2019 .

Structural basis of NR4A1 bound to the human pituitary proopiomelanocortin gene promoter

Yongheng Chen, Zhuchu Chen, L. Jiang, 2019 .

Expression and purification of the kinase domain of PINK1 in Pichia pastoris.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2016, Protein expression and purification.

Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity.

J. Smaill, A. Patterson, Xiaojuan Chen, 2024, Journal of medicinal chemistry.

LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance.

Yongheng Chen, Zhuchu Chen, Lin Chen, 2018, Chemical communications.

Structural basis and selectivity of sulfatinib binding to FGFR and CSF-1R

S. Dai, L. Qu, Xiaojuan Chen, 2024, Communications chemistry.