S. Gleason

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The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

P. Davis, W. Guo, F. Porreca, 2019, Pharmacology Biochemistry and Behavior.

Meta-chlorophenylpiperazine induced changes in locomotor activity are mediated by 5-HT1 as well as 5-HT2C receptors in mice.

H. Shannon, S. Gleason, 1998, European journal of pharmacology.

Chronic pain impairs cognitive flexibility and engages novel learning strategies in rats

Stephen L. Cowen, D. McKinzie, E. Navratilova, 2018, Pain.

The selective norepinephrine reuptake inhibitor, LY368975, reduces food consumption in animal models of feeding.

D. Wong, R. Fuller, S. Hemrick-Luecke, 1998, The Journal of pharmacology and experimental therapeutics.

Microsoft Word-67692688-file00

B. Giros, K. Perry, E. Tzavara, 2012 .

mGlu2/3 agonist-induced hyperthermia: an in vivo assay for detection of mGlu2/3 receptor antagonism and its relation to antidepressant-like efficacy in mice.

J. Witkin, B. Heinz, M. Baez, 2013, CNS & neurological disorders drug targets.

An antidepressant-related pharmacological signature for positive allosteric modulators of α2/3-containing GABAA receptors

J. Witkin, J. Fisher, J. Cook, 2018, Pharmacology Biochemistry and Behavior.

Pharmacological characterization of the neurotrophic sesquiterpene jiadifenolide reveals a non‐convulsant signature and potential for progression in neurodegenerative disease studies

Timothy S. Carpenter, F. Lightstone, Xia Li, 2018, Biochemical pharmacology.

Effects of dopamine D1 receptor agonists in rats trained to discriminate dihydrexidine

J. Witkin, S. Gleason, 2006, Psychopharmacology.

Effects of dopamine D1 receptor full agonists in rats trained to discriminate SKF 38393

J. Witkin, S. Gleason, J. M. Witkin, 2004, Behavioural pharmacology.

Forebrain-selective AMPA-receptor antagonism guided by TARP γ-8 as an antiepileptic mechanism

J. Isaac, D. Bredt, E. Nisenbaum, 2016, Nature Medicine.

Hedonic and motivational responses to food reward are unchanged in rats with neuropathic pain

Stephen L. Cowen, D. McKinzie, E. Navratilova, 2016, Pain.

Perampanel, an Antagonist of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptors, for the Treatment of Epilepsy: Studies in Human Epileptic Brain and Nonepileptic Brain and in Rodent Models

E. Sher, J. Witkin, A. Chappell, 2014, The Journal of Pharmacology and Experimental Therapeutics.

Evaluation of 5-HT7 receptor antagonism for the treatment of anxiety, depression, and schizophrenia through the use of receptor-deficient mice

M. Seager, G. Nomikos, Xia Li, 2019, Behavioural Brain Research.

Blockade of phencyclidine-induced hyperlocomotion by olanzapine, clozapine and serotonin receptor subtype selective antagonists in mice

H. Shannon, S. Gleason, 1997, Psychopharmacology.

Effects of 5-HT7 receptor antagonists on behaviors of mice that detect drugs used in the treatment of anxiety, depression, or schizophrenia

Xia Li, J. Witkin, K. Svensson, 2019, Behavioural Brain Research.

In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders

Xia Li, J. Witkin, D. Bleakman, 2006, Psychopharmacology.

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

D. Bredt, G. Stephenson, P. Ornstein, 2016, Journal of medicinal chemistry.

Bioisosteres of ethyl 8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo [1,5-a][1,4]diazepine-3-carboxylate (HZ-166) as novel alpha 2,3 selective potentiators of GABAA receptors: Improved bioavailability enhances anticonvulsant efficacy

D. Airey, J. Witkin, J. Fisher, 2018, Neuropharmacology.

Further evaluation of the potential anxiolytic activity of imidazo[1,5-a][1,4]diazepin agents selective for α2/3-containing GABAA receptors

L. Arnold, J. Cook, J. Schkeryantz, 2017, Pharmacology Biochemistry and Behavior.

Preclinical findings predicting efficacy and side‐effect profile of LY2940094, an antagonist of nociceptin receptors

Janice W. Smith, D. McKinzie, J. Pintar, 2016, Pharmacology research & perspectives.

Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors

S. Mitchell, G. Gilmour, J. Witkin, 2017, Neuropharmacology.

Negative allosteric modulation of alpha 5-containing GABAA receptors engenders antidepressant-like effects and selectively prevents age-associated hyperactivity in tau-depositing mice

Xia Li, Denise Morrow, J. Witkin, 2018, Psychopharmacology.

Inquiries into the Biological Significance of Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8 Through Investigations of TARP γ-8 Null Mice§.

Xia Li, J. Witkin, L. Thompson, 2015, CNS & neurological disorders drug targets.

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT2C receptors but not 5-HT2A or 5-HT2B receptors

D. Nelson, H. Shannon, V. Lucaites, 2001, Behavioural pharmacology.

Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611).

Jodi L. Smith, J. Witkin, D. Gehlert, 2017, CNS & neurological disorders drug targets.

A parametric analysis of punishment frequency as a determinant of the response to chlordiazepoxide in the Vogel conflict test in rats

J. Witkin, S. Gleason, Scott D. Gleason, 2007, Pharmacology Biochemistry and Behavior.

Anxiolytic-like effects through a GLUK5 kainate receptor mechanism

P. Ornstein, J. Witkin, D. Bleakman, 2007, Neuropharmacology.

A medium throughput rodent model of relapse from addiction with behavioral and pharmacological specificity

Jodi L. Smith, J. Witkin, William J. A. Eiler, 2019, Pharmacology Biochemistry and Behavior.

Behavioral pharmacology of olanzapine: a novel antipsychotic drug.

H. Shannon, N. Moore, M. Benvenga, 1997, The Journal of clinical psychiatry.

Multiple dopamine receptors mediate the discriminative stimulus effects of dihydrexidine in rats

J. Witkin, S. Little, N. Delapp, 2011, Behavioural pharmacology.

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8.

D. Bredt, P. Ornstein, J. Witkin, 2016, Journal of medicinal chemistry.

m-CPP hypolocomotion is selectively antagonized by compounds with high affinity for 5-HT receptors but not

D. Nelson, H. Shannon, V. Lucaites, 2001 .

In Vivo Occupancy of Dopamine D3 Receptors by Antagonists Produces Neurochemical and Behavioral Effects of Potential Relevance to Attention-Deficit–Hyperactivity Disorder

B. Giros, K. Perry, E. Tzavara, 2013, The Journal of Pharmacology and Experimental Therapeutics.

The α2,3-selective potentiator of GABAA receptors, KRM-II-81, reduces nociceptive-associated behaviors induced by formalin and spinal nerve ligation in rats

P. Davis, J. Witkin, K. Freeman, 2019, Pharmacology Biochemistry and Behavior.