Helena M. Cochemé

发表

Metformin Retards Aging in C. elegans by Altering Microbial Folate and Methionine Metabolism

David Weinkove, David Gems, Nicholas D.E. Greene, 2013, Cell.

Lipophilic triphenylphosphonium cations as tools in mitochondrial bioenergetics and free radical biology

T. Hurd, H. M. Cochemé, Robin A. J. Smith, 2005, Biochemistry (Moscow).

Redox regulation of the insulin signalling pathway

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2021, Redox biology.

Superoxide Activates Uncoupling Proteins by Generating Carbon-centered Radicals and Initiating Lipid Peroxidation

E. R. Taylor, C. Cooper, H. M. Cochemé, 2003, Journal of Biological Chemistry.

Measurement of H2O2 within Living Drosophila during Aging Using a Ratiometric Mass Spectrometry Probe Targeted to the Mitochondrial Matrix

L. Partridge, M. Singer, D. Gems, 2011, Cell metabolism.

Mitochondrial pharmacology.

H. M. Cochemé, Robin A. J. Smith, R. Hartley, 2012, Trends in pharmacological sciences.

Can antioxidants be effective therapeutics?

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2010, Current opinion in investigational drugs.

Using exomarkers to assess mitochondrial reactive species in vivo.

Edward T Chouchani, H. M. Cochemé, Robin A. J. Smith, 2014, Biochimica et biophysica acta.

Mitochondrial redox signalling at a glance

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2012, Journal of Cell Science.

Redox metabolism: ROS as specific molecular regulators of cell signaling and function.

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2021, Molecular cell.

Using the mitochondria-targeted ratiometric mass spectrometry probe MitoB to measure H2O2 in living Drosophila

L. Partridge, H. M. Cochemé, Robin A. J. Smith, 2012, Nature Protocols.

Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction

J. Hardy, L. Partridge, K. Bhatia, 2015, Brain : a journal of neurology.

Genome-wide dFOXO targets and topology of the transcriptomic response to stress and insulin signalling

J. Thornton, L. Partridge, I. Papatheodorou, 2011, Molecular systems biology.

Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila

T. P. Neufeld, J. Thornton, L. Partridge, 2020, PLoS genetics.

Cardioprotection by S-nitrosation of a cysteine switch on mitochondrial complex I

Linda Partridge, Kathryn S Lilley, Edward T Chouchani, 2013, Nature Medicine.

Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer’s disease

J. Thornton, L. Partridge, D. Ivanov, 2017, PLoS genetics.

Mitochondria-Targeted Antioxidant MitoQ10 Improves Endothelial Function and Attenuates Cardiac Hypertrophy

A. Dominiczak, C. Hamilton, H. M. Cochemé, 2009, Hypertension.

Interactions of Mitochondria-targeted and Untargeted Ubiquinones with the Mitochondrial Respiratory Chain and Reactive Oxygen Species

A. M. James, H. M. Cochemé, Robin A. J. Smith, 2005, Journal of Biological Chemistry.

Consequences of long-term oral administration of the mitochondria-targeted antioxidant MitoQ to wild-type mice.

D. Rubinsztein, H. M. Cochemé, Robin A. J. Smith, 2010, Free radical biology & medicine.

Redox signalling and ageing: insights from Drosophila

H. M. Cochemé, Claudia Lennicke, Helena M. Cochemé, 2020, Biochemical Society transactions.

Using mitochondria-targeted molecules to study mitochondrial radical production and its consequences.

H. M. Cochemé, Robin A. J. Smith, M. Murphy, 2003, Biochemical Society transactions.

Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy

K. Bryson, W. Lieb, C. Kaleta, 2019, Cell.

Mitochondria‐Targeted Antioxidants in the Treatment of Disease

J. Trnka, H. M. Cochemé, Robin A. J. Smith, 2008, Annals of the New York Academy of Sciences.

Myostatin-like proteins regulate synaptic function and neuronal morphology

L. Partridge, J. Steinert, J. Kittler, 2017, Development.

Mitochondrial redox signalling at a glance (vol 125, pg 801, 2012)

Helena M. Cochemé, Yvonne Collins, Katja E. Menger, 2012 .

Sugar-Induced Obesity and Insulin Resistance Are Uncoupled from Shortened Survival in Drosophila

W. Lieb, C. Kaleta, A. Franke, 2020, Cell metabolism.

Fasting, but Not Aging, Dramatically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster

L. Partridge, H. M. Cochemé, M. Murphy, 2015, Cell reports.

mTOR links nutrients, inflammaging and lifespan.

Helena M. Cochemé, Jesús Gil, 2024, Nature aging.

Fasting , but Not Aging , Dra matically Alters the Redox Status of Cysteine Residues on Proteins in Drosophila melanogaster Graphical Abstract Highlights

Edward T Chouchani, L. Partridge, H. M. Cochemé, 2015 .

Complex I Is the Major Site of Mitochondrial Superoxide Production by Paraquat*

H. M. Cochemé, M. Murphy, Michael P Murphy, 2008, Journal of Biological Chemistry.

Chapter 22 The uptake and interactions of the redox cycler paraquat with mitochondria.

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2009, Methods in enzymology.

Selective superoxide generation within mitochondria by the targeted redox cycler MitoParaquat.

H. Senn, D. Aksentijević, Ellen L. Robb, 2015, Free radical biology & medicine.

Mitochondrial targeting of quinones: therapeutic implications.

J. Trnka, H. M. Cochemé, Robin A. J. Smith, 2007, Mitochondrion.

Enhancing autophagy by redox regulation extends lifespan in Drosophila

A. M. James, L. Partridge, H. M. Cochemé, 2019, bioRxiv.

Mitochondria-targeted redox probes as tools in the study of oxidative damage and ageing

H. M. Cochemé, M. Murphy, Helena M. Cochemé, 2005, Mechanisms of Ageing and Development.

Assessing the Mitochondrial Membrane Potential in Cells and In Vivo using Targeted Click Chemistry and Mass Spectrometry

L. Partridge, H. M. Cochemé, Robin A. J. Smith, 2016, Cell metabolism.

Click-PEGylation – A mobility shift approach to assess the redox state of cysteines in candidate proteins

H. M. Cochemé, Ellen L. Robb, M. Murphy, 2017, Free radical biology & medicine.