W. Sligl

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Prosthetic Valve and Other Cardiovascular Device-Related Endocarditis

K. Doucette, W. Sligl, 2006 .

Anticonvulsant overdose : Can we shorten the coma ? *

S. Majumdar, W. Sligl, 2009 .

Macrolides and Mortality in Critically Ill Patients With Community-Acquired Pneumonia: A Systematic Review and Meta-Analysis*

T. Marrie, S. Majumdar, L. Tjosvold, 2014, Critical care medicine.

Macrolide-based regimens and mortality in hospitalized patients with community-acquired pneumonia: a systematic review and meta-analysis.

T. Marrie, S. Majumdar, L. Tjosvold, 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

A controlled study of postpartum depression among Nepalese women: validation of the Edinburgh Postpartum Depression Scale in Kathmandu

M. Seear, W. Sligl, Shishir K. Regmi, 2002, Tropical medicine & international health : TM & IH.

Lopinavir-ritonavir and hydroxychloroquine for critically ill patients with COVID-19: REMAP-CAP randomized controlled trial

Matthew A. Wiles, Manisha, Christopher M. Horvat, 2021, Intensive Care Medicine.

Neurologic Infections

S. Shafran, W. Sligl, 2017 .

Impact of cytomegalovirus reactivation on clinical outcomes in immunocompetent critically ill patients: protocol for a systematic review and meta-analysis

R. Featherstone, P. Lachance, W. Sligl, 2016, Systematic Reviews.

High rates of influenza-associated invasive pulmonary aspergillosis may not be universal: a retrospective cohort study from Alberta, Canada.

T. Dingle, N. Zelyas, N. Lee, 2020, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Pseudomonas aeruginosa infection in intensive care: Epidemiology, outcomes, and antimicrobial susceptibilities.

W. Sligl, D. Hudson, B. Kula, 2020, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada.

Community-acquired pneumonia

W. Sligl, L. Remington, 2014, Current opinion in pulmonary medicine.

Triaging severe pneumonia: what is the "score" on prediction rules?

T. Marrie, S. Majumdar, W. Sligl, 2009, Critical Care Medicine.

Cluster of cases of hantavirus pulmonary syndrome in Alberta, Canada.

H. Feldmann, A. Joffe, D. Safronetz, 2007, The American journal of tropical medicine and hygiene.

Five years of nosocomial Gram-negative bacteremia in a general intensive care unit: epidemiology, antimicrobial susceptibility patterns, and outcomes.

G. Taylor, P. Brindley, W. Sligl, 2006, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Severe flu management: a point of view

A. Torres, N. Lee, W. Sligl, 2020, Intensive Care Medicine.

The Value of Macrolide-Based Regimens for Community-Acquired Pneumonia

Alexandra Mcfarlane, W. Sligl, 2015, Current Infectious Disease Reports.

Macrolide use in the treatment of critically ill patients with pneumonia: Incidence, correlates, timing and outcomes.

A. Malhotra, T. Marrie, S. Majumdar, 2013, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial

Y. Keynan, J. Conly, R. Zarychanski, 2022, CMAJ open.

Procalcitonin measurement in West Nile virus neuroinvasive disease: A first case series.

S. Bagshaw, J. Conly, Christopher J Doig, 2021, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada.

Moving Past the Routine Use of Macrolides—Reviewing the Role of Combination Therapy in Community-Acquired Pneumonia

W. Sligl, G. Shumilak, 2018, Current Infectious Disease Reports.

Sepsis in Traumatic Brain Injury: Epidemiology and Outcomes

Dustin Anderson, D. Kutsogiannis, W. Sligl, 2020, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

LIBERATE: a study protocol for midodrine for the early liberation from vasopressor support in the intensive care unit (LIBERATE): protocol for a randomized controlled trial

S. Bagshaw, K. Fiest, O. Rewa, 2022, Trials.

MENINGITIS Key Points

S. Shafran, W. Sligl, Stephen D. Shafran, 2008 .

Differential effects of age, sex and dexamethasone therapy on ACE2/TMPRSS2 expression and susceptibility to SARS-CoV-2 infection

S. Elahi, W. Sligl, M. Osman, 2022, Frontiers in Immunology.

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 - Preliminary report

Christopher M. Horvat, H. Goossens, C. Seymour, 2021, medRxiv.

Detection of SARS-CoV-2 antibodies formed in response to the BNT162b2 and mRNA-1237 mRNA vaccine by commercial antibody tests

S. Plitt, J. Kanji, G. Tipples, 2021, Vaccine.

Variation in communication and family visiting policies in intensive care within and between countries during the Covid-19 pandemic: The COVISIT international survey

P. Póvoa, K. Laupland, M. Jeitziner, 2022, Journal of Critical Care.

Midodrine therapy for vasopressor dependent shock in the intensive care unit: a protocol for a systematic review and meta-analysis

S. Bagshaw, B. Rochwerg, K. Fiest, 2022, BMJ Open.

COVID-19 epidemiology in Canada from January to December 2020: the pre-vaccine era

L. Saxinger, D. Webster, W. Sligl, 2021 .

Best evidence in critical care medicine Early antibiotics and survival from septic shock: it’s about time

P. Brindley, W. Sligl, N. Zhu, 2006, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Long-term (180-Day) Outcomes in Critically Ill Patients With COVID-19 in the REMAP-CAP Randomized Clinical Trial.

Matthew A. Wiles, Nerissa C. Brown, Christopher M. Horvat, 2022, JAMA.

Convalescent plasma for hospitalized patients with COVID-19: an open-label, randomized controlled trial

Kelly A. Fusco, Maria Cristina Lopes, D. Devine, 2021, Nature Medicine.

Erythroid precursors and progenitors suppress adaptive immunity and get invaded by SARS-CoV-2

Lai Xu, Justin Shields, S. Elahi, 2020, bioRxiv.

Defining COVID-19–associated pulmonary aspergillosis: systematic review and meta-analysis

B. Vandermeer, T. Dingle, I. Schwartz, 2022, Clinical Microbiology and Infection.

COVID-19 Associated Pulmonary Aspergillosis: Systematic Review and Patient-Level Meta-Analysis

T. Dingle, I. Schwartz, W. Sligl, 2021, medRxiv.

Galectin-9, a Player in Cytokine Release Syndrome and a Surrogate Diagnostic Biomarker in SARS-CoV-2 Infection

Lai Xu, S. Elahi, C. O’Neil, 2021, mBio.

Non-steroidal anti-inflammatories for analgesia in critically ill patients: a systematic review and meta-analysis of randomized control trials

S. Bagshaw, B. Rochwerg, O. Rewa, 2023, medRxiv.

Association between Mycoplasma and Ureaplasma airway positivity, ammonia levels, and outcomes post–lung transplantation: A prospective surveillance study

J. Preiksaitis, N. Zelyas, J. Nagendran, 2020, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

Christopher M. Horvat, H. Goossens, C. Seymour, 2021, medRxiv.

Do COVID-19 Infections Result in a Different Form of Secondary Hemophagocytic Lymphohistiocytosis

Sneha Suresh, J. C. Cohen Tervaert, W. Sligl, 2021, International journal of molecular sciences.

Impaired natural killer cell counts and cytolytic activity in patients with severe COVID-19

J. C. Cohen Tervaert, J. Storek, A. Kalra, 2020, Blood Advances.

Could treatment with immunomodulatory agents targeting IL-1, IL-6, or JAK signalling improve outcomes in patients with severe influenza pneumonia? A systematic and narrative review

M. Shankar-Hari, D. Annane, T. Uyeki, 2022, HRB Open Research.

Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial.

Paul W. Dul, John Man-shun Ma, M. Surette, 2021, JAMA.

Dysregulation of ACE (Angiotensin-Converting Enzyme)-2 and Renin-Angiotensin Peptides in SARS-CoV-2 Mediated Mortality and End-Organ Injuries

G. Oudit, A. Nikhanj, Kaiming Wang, 2021, Hypertension.

Hyperammonemia syndrome post‐lung transplantation: Case series and systematic review of literature

J. Preiksaitis, N. Zelyas, J. Nagendran, 2022, Transplant infectious disease : an official journal of the Transplantation Society.

Adult-onset presentation of a urea cycle disorder necessitating intensive care unit admission

Dustin Anderson, W. Sligl, Shailly Jain‐Ghai, 2020, Canadian Journal of Anesthesia/Journal canadien d'anesthésie.

Safety and efficacy of corticosteroids for the treatment of septic shock: A systematic review and meta-analysis.

W. Mphatswe, S. Majumdar, D. Milner, 2009, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Clostridioides difficile infection in mechanically ventilated critically ill patients: A nested cohort study.

N. Adhikari, B. Rochwerg, D. Niven, 2023, Journal of critical care.

Severe Community-Acquired Pneumonia

T. Marrie, W. Sligl, 2013, Critical Care Clinics.

Usefulness of spironolactone in a specialized heart failure clinic.

Paul W Armstrong, P. Armstrong, F. McAlister, 2004, The American journal of cardiology.

Epidemiology and Outcomes in Critically Ill Patients with Human Immunodeficiency Virus Infection in the Era of Combination Antiretroviral Therapy

S. Bagshaw, D. Eurich, S. Turvey, 2017, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Gonococcal septic shock, acute respiratory distress syndrome, and multisystem organ failure: a case report.

W. Sligl, D. Djogovic, J. Landy, 2010, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

How important is age in defining the prognosis of patients with community-acquired pneumonia?

S. Majumdar, W. Sligl, 2011, Current opinion in infectious diseases.

Only severely limited, premorbid functional status is associated with short- and long-term mortality in patients with pneumonia who are critically ill: a prospective observational study.

T. Marrie, S. Majumdar, D. Eurich, 2011, Chest.

Age still matters: Prognosticating short- and long-term mortality for critically ill patients with pneumonia

T. Marrie, S. Majumdar, D. Eurich, 2010, Critical care medicine.

Prevention of Critical Care Complications in the Coronary Intensive Care Unit: Protocols, Bundles, and Insights From Intensive Care Studies.

R. Arora, S. van Diepen, J. Katz, 2017, The Canadian journal of cardiology.

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

S. Murthy, Kevin Schwartz, F. Lamontagne, 2022, Canadian Medical Association Journal.

Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study

S. Murthy, H. Stelfox, K. Menon, 2021, CMAJ open.

Association Between Cytomegalovirus Reactivation and Clinical Outcomes in Immunocompetent Critically Ill Patients: A Systematic Review and Meta-Analysis

R. Featherstone, P. Lachance, W. Sligl, 2017, Open forum infectious diseases.

Predicting in-hospital mortality in pneumonia-associated septic shock patients using a classification and regression tree: a nested cohort study

Aseem Kumar, Y. Mirzanejad, J. Speiser, 2018, Journal of Intensive Care.

Nosocomial Gram-negative bacteremia in intensive care: epidemiology, antimicrobial susceptibilities, and outcomes.

W. Sligl, Tatiana Dragan, Stephanie W. Smith, 2015, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis

S. Elahi, D. Tyrrell, W. Sligl, 2022, Microbiology spectrum.

Outcomes among critically ill adults with influenza infection.

N. Lee, W. Sligl, Stephanie M Smith, 2021, Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada.

Epidemiology and outcomes of hospital-acquired bloodstream infections in intensive care unit patients: the EUROBACT-2 international cohort study

B. Souweine, A. Nica, P. Póvoa, 2023, Intensive Care Medicine.

Systemic Nonsteroidal Anti-Inflammatories for Analgesia in Postoperative Critical Care Patients: A Systematic Review and Meta-Analysis of Randomized Control Trials

S. Bagshaw, B. Rochwerg, O. Rewa, 2023, Critical care explorations.

The Quality of SARS-CoV-2–Specific T Cell Functions Differs in Patients with Mild/Moderate versus Severe Disease, and T Cells Expressing Coinhibitory Receptors Are Highly Activated

Lai Xu, S. Elahi, W. Sligl, 2021, The Journal of Immunology.

Longitudinal studies of community-acquired bacteremia (and other such longitudinal studies) requiring admission to intensive care a need for more comprehensive data collection.

T. Marrie, W. Sligl, 2013, Critical care medicine.

Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study.

N. Adhikari, H. Stelfox, B. Rochwerg, 2023, Journal of critical care.

7 versus 14 days of antibiotic treatment for critically ill patients with bloodstream infection: a pilot randomized clinical trial

D. Cook, J. Marshall, S. Bagshaw, 2018, Trials.

Antimicrobial stewardship, procalcitonin testing, and rapid blood-culture identification to optimize sepsis care in critically ill adult patients: A quality improvement initiative

S. Bagshaw, D. Zygun, T. Dingle, 2023, Antimicrobial Stewardship & Healthcare Epidemiology.

Methicillin-resistant Staphylococcus aureus in a Canadian intensive care unit: Delays in initiating effective therapy due to the low prevalence of infection.

G. Taylor, L. Chui, R. Rennie, 2007, The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale.

Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19

H. Goossens, C. Seymour, M. Shankar-Hari, 2021, The New England Journal of Medicine.

Severe Non-influenza Viral Pneumonia in the Critical Care Unit

T. Marrie, W. Sligl, D. Waldner, 2020 .

What determines do-not-resuscitate status in critically ill HIV-infected patients admitted to ICU?

S. Bagshaw, S. Turvey, W. Sligl, 2019, Journal of critical care.

Age still matters: Prognosticating short- and long-term mortality for critically ill patients with pneumonia

T. Marrie, S. Majumdar, D. Eurich, 2010, Critical care medicine.

Modelling the potential increase in eligible participants in clinical trials with inclusion of community intensive care units patients in Alberta, Canada: a decision tree analysis

O. Rewa, D. Opgenorth, W. Sligl, 2023, Canadian Journal of Anaesthesia-journal Canadien D Anesthesie.

Needs Assessment Survey Identifying Research Processes Which may be Improved by Automation or Artificial Intelligence: ICU Community Modeling and Artificial Intelligence to Improve Efficiency (ICU-Comma)

S. Bagshaw, D. Zuege, E. McDonald, 2021, Journal of intensive care medicine.