J. Yalowich

T. Elton, J. Yalowich, Victor A. Hernandez, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

A. Kinghorn, C. Yuan, J. Yu, 2015, Phytochemistry.

Expressions of resistance and cross-resistance in teniposide-resistant L1210 cells

R. Ashmun, E. Parganas, J. Yalowich, 2004, Cancer Chemotherapy and Pharmacology.

Caveolar endocytosis in lung injury 1 TRIM 72 modulates Caveolar endocytosis in repair of lung cells 1

K. Shilo, J. Christman, M. Nishi, 2015 .

P-glycoprotein mediates profound resistance to bisantrene.

R. Arceci, M. Slovak, L. Greenberger, 1994, Oncology research.

The histone deacetylase inhibitor sodium butyrate induces DNA topoisomerase II alpha expression and confers hypersensitivity to etoposide in human leukemic cell lines.

W. Allan, D. Kroll, B. Sampey, 2001, Molecular cancer therapeutics.

Structure-activity study of the interaction of bioreductive benzoquinone alkylating agents with DNA topoisomerase II

Frank S. Guziec, A. Begleiter, B. Hasinoff, 2005, Cancer Chemotherapy and Pharmacology.

The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G2-M Checkpoint

Shun-qian Jin, B. Rajasekaran, K. Brown, 2010, Molecular Cancer Therapeutics.

Molecular Cancer Therapeutics The Mismatch Repair System Modulates Curcumin Sensitivity through Induction of DNA Strand Breaks and Activation of G 2M Checkpoint

Shun-qian Jin, B. Rajasekaran, K. Brown, 2010 .

Synthesis and biological activity of a photoaffinity etoposide probe.

B. Day, B. Hasinoff, J. Yalowich, 2001, Bioorganic & medicinal chemistry.

Structure-based design, synthesis and biological testing of piperazine-linked bis-epipodophyllotoxin etoposide analogs.

B. Hasinoff, J. Yalowich, Daywin Patel, 2015, Bioorganic & medicinal chemistry.

Structure-based design, synthesis and biological testing of etoposide analog epipodophyllotoxin-N-mustard hybrid compounds designed to covalently bind to topoisomerase II and DNA.

B. Hasinoff, J. Yalowich, Daywin Patel, 2014, Bioorganic & medicinal chemistry.

The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.

B. Hasinoff, J. Yalowich, R. Zhang, 2012, Biochemical pharmacology.

Synthesis and antiproliferative activity of derivatives of the phyllanthusmin class of arylnaphthalene lignan lactones.

A. Kinghorn, J. Woodard, J. Burdette, 2018, Bioorganic & medicinal chemistry.

Analysis of the inhibitory effects of VP-16-213 (etoposide) and podophyllotoxin on thymidine transport and metabolism in Ehrlich ascites tumor cells in vitro.

I. Goldman, J. Yalowich, Jack C. Yalowich, 1984, Cancer research.

Mechanism of the cytotoxicity of the diazoparaquinone antitumor antibiotic kinamycin F.

Hong Liang, O. Adedayo, B. Hasinoff, 2007, Free radical biology & medicine.

Cellular mechanisms of the cytotoxicity of the anticancer drug elesclomol and its complex with Cu(II).

Zhe-Sheng Chen, Deshen Wang, B. Hasinoff, 2015, Biochemical pharmacology.

Nitric Oxide Prevents Oxidative Damage Produced bytert-Butyl Hydroperoxide in Erythroleukemia Cells via Nitrosylation of Heme and Non-heme Iron

N. Gorbunov, V. Kagan, E. Kisin, 1997, The Journal of Biological Chemistry.

Role of topoisomerase II in mediating epipodophyllotoxin-induced DNA cleavage.

L. Liu, W. Ross, W Ross, 1984, Cancer research.

Atypical multiple drug resistance in a human leukemic cell line selected for resistance to teniposide (VM-26).

W. T. Beck, M. Danks, J. Yalowich, 1987, Cancer research.

Verapamil-induced augmentation of etoposide accumulation in L1210 cells in vitro.

W. Ross, J. Yalowich, 1985, Cancer research.

Rapid determination of thymidylate synthase activity and its inhibition in intact L1210 leukemia cells in vitro.

J. Yalowich, T. Kalman, Thomas I. Kalman, 1985, Biochemical pharmacology.

A diazirine-based photoaffinity etoposide probe for labeling topoisomerase II.

B. Hasinoff, J. Yalowich, Xing Wu, 2010, Bioorganic & medicinal chemistry.

Teniposide (VM-26)- and etoposide (VP-16-213)-induced augmentation of methotrexate transport and polyglutamylation in Ehrlich ascites tumor cells in vitro.

D. W. Fry, I. Goldman, J. Yalowich, 1982, Cancer research.

Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with In Vivo Efficacy against MRSA.

Mark J. Mitton-Fry, S. Lindert, C. McElroy, 2021, Journal of medicinal chemistry.

Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus.

S. Lindert, D. Wozniak, Justin T. Seffernick, 2020, ACS medicinal chemistry letters.

A Structure-Based 3D-QSAR Study of Anthrapyrazole Analogues of the Anticancer Agents Losoxantrone and Piroxantrone

Frank S. Guziec, Hong Liang, Jennifer Lang, 2006, J. Chem. Inf. Model..

Mitindomide is a catalytic inhibitor of DNA topoisomerase II that acts at the bisdioxopiperazine binding site.

W. Allan, B. Hasinoff, A. Creighton, 1997, Molecular pharmacology.

Capsicodendrin from Cinnamosma fragrans Exhibits Antiproliferative and Cytotoxic Activity in Human Leukemia Cells: Modulation by Glutathione.

L. Rakotondraibe, J. Yalowich, Shruthi Shetty, 2018, Journal of natural products.

Alternative RNA Processing of Topoisomerase IIα in Etoposide-Resistant Human Leukemia K562 Cells: Intron Retention Results in a Novel C-Terminal Truncated 90-kDa Isoform

T. Elton, J. Yalowich, Lucas D Serdar, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Myeloperoxidase-Dependent Oxidation of Etoposide in Human Myeloid Progenitor CD34 (cid:1) Cells

S. Gollin, V. Kagan, I. I. Vlasova, 2011 .

Pro-oxidant and antioxidant mechanisms of etoposide in HL-60 cells: role of myeloperoxidase.

Y. Tyurina, V. Kagan, A. Shvedova, 2001, Cancer research.

Direct evidence for recycling of myeloperoxidase-catalyzed phenoxyl radicals of a vitamin E homologue, 2,2,5,7,8-pentamethyl-6-hydroxy chromane, by ascorbate/dihydrolipoate in living HL-60 cells.

P. Quinn, Y. Tyurina, V. Tyurin, 2003, Biochimica et biophysica acta.

Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells.

D. Gewirtz, J. Randolph, F. Fornari, 1994, Molecular pharmacology.

Discovery and Characterization of Novel Small Molecule Inhibitors of Human Cdc25B Dual Specificity Phosphatase

Ivet Bahar, Peter Wipf, Dror Tobi, 2004, Molecular Pharmacology.

Myeloperoxidase-catalyzed metabolism of etoposide to its quinone and glutathione adduct forms in HL60 cells.

B. Day, Yun Fan, J. Yalowich, 2006, Chemical research in toxicology.

Regulation of DNA-dependent Protein Kinase Activity by Ionizing Radiation-activated Abl Kinase Is an ATM-dependent Process*

T. Pandita, K. Brown, S. Shangary, 2000, The Journal of Biological Chemistry.

Mechanism-based chemopreventive strategies against etoposide-induced acute myeloid leukemia: free radical/antioxidant approach.

Y. Tyurina, V. Tyurin, V. Kagan, 1999, Molecular pharmacology.

Mechanisms of Action and Reduced Cardiotoxicity of Pixantrone; a Topoisomerase II Targeting Agent with Cellular Selectivity for the Topoisomerase IIα Isoform

B. Hasinoff, J. Yalowich, Daywin Patel, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Toxicity issues in cancer drug development.

David A Gewirtz, D. Gewirtz, Molly L Bristol, 2010, Current opinion in investigational drugs.

Design, synthesis, and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents.

B. Hasinoff, J. Yalowich, R. Zhang, 2011, Bioorganic & medicinal chemistry.

Design, synthesis and biological evaluation of a novel series of anthrapyrazoles linked with netropsin-like oligopyrrole carboxamides as anticancer agents.

Frank S. Guziec, B. Hasinoff, J. Yalowich, 2010, Bioorganic & medicinal chemistry.

The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds.

Frank S. Guziec, Hong Liang, B. Hasinoff, 2008, Bioorganic & medicinal chemistry.

Rapid formation of poly-gamma-glutamyl derivatives of methotrexate and their association with dihydrofolate reductase as assessed by high pressure liquid chromatography in the Ehrlich ascites tumor cell in vitro.

D. W. Fry, D. Goldman, I. Goldman, 1982, The Journal of biological chemistry.

Dissociation between bulk damage to DNA and the antiproliferative activity of teniposide (VM-26) in the MCF-7 breast tumor cell line: evidence for induction of gene-specific damage and alterations in gene expression.

M. S. Orr, L. Povirk, D. Gewirtz, 1993, Cancer research.

CRISPR/Cas9 Genome Editing of the Human Topoisomerase IIα Intron 19 5′ Splice Site Circumvents Etoposide Resistance in Human Leukemia K562 Cells

T. Elton, H. Ozer, Junan Li, 2021, Molecular Pharmacology.

hsa-miR-9-3p and hsa-miR-9-5p as Post-Transcriptional Modulators of DNA Topoisomerase IIα in Human Leukemia K562 Cells with Acquired Resistance to Etoposide

T. Elton, H. Ozer, J. Yalowich, 2019, Molecular Pharmacology.

Ascorbate is the primary reductant of the phenoxyl radical of etoposide in the presence of thiols both in cell homogenates and in model systems.

B. Day, V. Kagan, T. Gantchev, 1994, Biochemistry.

A Three-Dimensional Quantitative Structure-Activity Analysis of a New Class of Bisphenol Topoisomerase IIα Inhibitors

Hong Liang, B. Hasinoff, J. Yalowich, 2008, Molecular Pharmacology.

The effect of dexrazoxane (ICRF-187) on doxorubicin- and daunorubicin-mediated growth inhibition of Chinese hamster ovary cells.

Y. Ling, B. Hasinoff, J. Yalowich, 1996, Anti-cancer drugs.

Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.

V. Kagan, T. Gantchev, J. Yalowich, 1993, Free radical research communications.

Mutational inactivation of the p53 gene in the human erythroid leukemic K562 cell line.

R. Ferrell, J. C. Law, G. Leder, 1993, Leukemia research.

Potentiation of Etoposide-induced DMA Damage by Calcium Antagonists in L 1210 Cells in Wtro 1

W. Ross, J. Yalowich, 2006 .

Potentiation of etoposide-induced DNA damage by calcium antagonists in L1210 cells in vitro.

W. Ross, J. Yalowich, 1984, Cancer research.

Effects of microtubule inhibitors on etoposide accumulation and DNA damage in human K562 cells in vitro.

J. Yalowich, 1987, Cancer research.

The anticancer multi-kinase inhibitor dovitinib also targets topoisomerase I and topoisomerase II.

B. Hasinoff, J. Yalowich, J. Nitiss, 2012, Biochemical pharmacology.

Roleof Topoisomerase II in MediatingEpipodophyllotoxin-induced DMA Cleavage1

W. Ross, Leroy F. Liu, B. Glisson, 1984 .

Augmentation of the intracellular levels of polyglutamyl derivatives of methotrexate by vincristine and probenecid in Ehrlich ascites tumor cells.

D. W. Fry, I. Goldman, J. Yalowich, 1982, Cancer research.

Novel bacterial topoisomerase inhibitors derived from isomannide.

Mark J. Mitton-Fry, J. Gallucci, A. Okumu, 2020, European journal of medicinal chemistry.

Antioxidant mechanisms of nitric oxide against iron-catalyzed oxidative stress in cells.

Y. Tyurina, V. Kagan, A. Shvedova, 2001, Antioxidants & redox signaling.

Hypophosphorylation of topoisomerase II in etoposide (VP-16)-resistant human leukemia K562 cells associated with reduced levels of beta II protein kinase C.

W. Allan, N. Murray, J. Yalowich, 1995, Molecular pharmacology.

Genesis of discrete higher order DNA fragments in apoptotic human prostatic carcinoma cells.

J. Lazo, T. Calmels, J. Yalowich, 1996, Molecular pharmacology.

Mechanisms of nitric oxide protection against tert-butyl hydroperoxide-induced cytotoxicity in iNOS-transduced human erythroleukemia cells.

W. Allan, N. Gorbunov, V. Kagan, 1999, Biochemistry.

1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.

S. Lindert, L. Koeth, A. Okumu, 2019, ACS infectious diseases.

1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.

Mark J. Mitton-Fry, N. Osheroff, M. Hazbón, 2022, ACS medicinal chemistry letters.

Synthesis and anti-staphylococcal activity of novel bacterial topoisomerase inhibitors with a 5-amino-1,3-dioxane linker moiety.

Mark J. Mitton-Fry, A. Okumu, D. Wozniak, 2018, Bioorganic & medicinal chemistry letters.

Effects of verapamil on etoposide, vincristine, and adriamycin activity in normal human bone marrow granulocyte-macrophage progenitors and in human K562 leukemia cells in vitro.

W. Ross, J. Yalowich, J. Zucali, 1985, Cancer research.

Characteristics of the accumulation of methotrexate polyglutamate derivatives in Ehrlich ascites tumor cells and isolated rat hepatocytes.

D. W. Fry, D. Gewirtz, I. Goldman, 1983, Advances in experimental medicine and biology.

The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis.

W. Allan, B. Hasinoff, J. Yalowich, 1999, Anti-cancer drugs.

A phase II study of combined methotrexate and teniposide infusions prior to reinduction therapy in relapsed childhood acute lymphoblastic leukemia: a Pediatric Oncology Group study.

J. Rodman, G. Rivera, J. Ochs, 1991, Journal of Clinical Oncology.

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks

Mark J. Mitton-Fry, N. Osheroff, Jessica A Collins, 2023, International journal of molecular sciences.

Discovery of Anticancer Agents of Diverse Natural Origin.

Xiaoli Zhang, Nicholas H Oberlies, Brent R Stockwell, 2016, Anticancer research.

Damage and Alterations in Gene Expression Breast Tumor Cell Line : Evidence for Induction of Gene-specific Antiproliferative Activity of Teniposide ( VM-26 ) in the MCF-7 Dissociation between Bulk Damage to DNA and the Updated Version

M. S. Orr, L. Povirk, D. Gewirtz, 2006 .

Expression of protein-associated DNA damage in the alkaline elution assay in the absence of enzymatic deproteinization.

L. Povirk, D. Gewirtz, J. Randolph, 1989, Cancer Communications.

Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive Staphylococcus aureus.

Mark J. Mitton-Fry, S. Lindert, D. Wozniak, 2020, ACS medicinal chemistry letters.

Novel bacterial topoisomerase inhibitors: unique targeting activities of amide enzyme-binding motifs for tricyclic analogs

Mark J. Mitton-Fry, J. Yalowich, M. Mitton-Fry, 2023, Antimicrobial agents and chemotherapy.

1,3-Dioxane-Linked Bacterial Topoisomerase Inhibitors with Enhanced Antibacterial Activity and Reduced hERG Inhibition.

Mark J. Mitton-Fry, S. Lindert, L. Koeth, 2019, ACS infectious diseases.

Effects of hsa-miR-9-3p and hsa-miR-9-5p on Topoisomerase IIβ Expression in Human Leukemia K562 Cells with Acquired Resistance to Etoposide

J. Yalowich, Victor A. Hernandez, Xinyi Wang, 2022, The Journal of Pharmacology and Experimental Therapeutics.

Cytotoxic and natural killer cell stimulatory constituents of Phyllanthus songboiensis.

A. Kinghorn, C. Yuan, J. Fuchs, 2015, Phytochemistry.