Lei Han

发表

Identification of miRNA-Mediated Core Gene Module for Glioma Patient Prediction by Integrating High-Throughput miRNA, mRNA Expression and Pathway Structure

Lei Han, Wei Yan, Qianlan Yao, 2014, PloS one.

Smart multifunctional core-shell nanospheres with drug and gene co-loaded for enhancing the therapeutic effect in a rat intracranial tumor model.

Xiaomin Wang, C. Kang, P. Pu, 2012, Nanoscale.

ICAT inhibits glioblastoma cell proliferation by suppressing Wnt/β-catenin activity.

T. Jiang, C. Kang, P. Pu, 2015, Cancer letters.

Silencing of IKKε using siRNA inhibits proliferation and invasion of glioma cells in vitro and in vivo.

C. Kang, P. Pu, Hui-bing Li, 2012, International journal of oncology.

LncRNA proﬁle of glioblastoma reveals the potential role of lncRNAs in contributing to glioblastoma pathogenesis.

C. Kang, P. Pu, Shizhu Yu, 2012, International journal of oncology.

MicroRNA‐21 Expression is regulated by β‐catenin/STAT3 Pathway and Promotes Glioma Cell Invasion by Direct Targeting RECK

Lei Han, Wei Zhang, Xuan Zhou, 2012, CNS neuroscience & therapeutics.

Effects of miR-200a and FH535 combined with taxol on proliferation and invasion of gastric cancer.

Lei Han, Xi Liu, Qingyu Zhang, 2017, Pathology, research and practice.

Combination treatment with doxorubicin and microRNA-21 inhibitor synergistically augments anticancer activity through upregulation of tumor suppressing genes.

C. Kang, Xubo Yuan, P. Pu, 2015, International journal of oncology.

AJAP1 is Dysregulated at an Early Stage of Gliomagenesis and Suppresses Invasion Through Cytoskeleton Reorganization

T. Jiang, C. Kang, Junxia Zhang, 2014, CNS neuroscience & therapeutics.

Suppresses Tumor Growth and Progression Mesenchymal Transition and − miR-21 , Reverses Epithelial AC 1 MMYR 2 , an Inhibitor of Dicer-Mediated Biogenesis of Oncomir

C. Kang, P. Pu, Junxia Zhang, 2013 .

AKT2 expression is associated with glioma malignant progression and required for cell survival and invasion.

C. Kang, P. Pu, Yingyi Wang, 2010, Oncology reports.

Interruption of β-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells

T. Jiang, C. Kang, P. Pu, 2010, Brain Research.

HOXA13 is a potential GBM diagnostic marker and promotes glioma invasion by activating the Wnt and TGF-β pathways

C. Kang, Lei Han, Qi-xue Wang, 2015, Oncotarget.

AC 1 MMYR 2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21 / CDK 5 axis

C. Kang, Lun Zhang, Xuan Zhou, 2015 .

AC1MMYR2 impairs high dose paclitaxel-induced tumor metastasis by targeting miR-21/CDK5 axis.

C. Kang, Lun Zhang, Xuan Zhou, 2015, Cancer letters.

Recent advances in unraveling the molecular mechanisms and functions of HOXA11-AS in human cancers and other diseases

Lei Han, Cheng Wei, Y. Zhen, 2020, Oncology reports.

miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells.

C. Kang, P. Pu, Lei Han, 2012, Oncology reports.

Identification of a Core miRNA-Pathway Regulatory Network in Glioma by Therapeutically Targeting miR-181d, miR-21, miR-23b, β-Catenin, CBP, and STAT3

Ronghong Li, Jingrun Ye, Xia Li, 2014, PloS one.

Nuclear Translocation of β-catenin is Essential for Glioma Cell Survival

Tao Jiang, T. Jiang, C. Kang, 2012, Journal of Neuroimmune Pharmacology.

Novel insight into the functions of N6-methyladenosine modified lncRNAs in cancers (Review)

Xuezhi Du, Jinjin Sun, Lei Han, 2022, International journal of oncology.

Unique genome-wide map of TCF4 and STAT3 targets using ChIP-seq reveals their association with new molecular subtypes of glioblastoma.

Jing Zhang, Lei Han, Wei Yan, 2013, Neuro-oncology.

miR-19a and miR-19b Overexpression in Gliomas

C. Kang, P. Pu, Lei Han, 2013, Pathology & Oncology Research.

miR-137 is frequently down-regulated in glioblastoma and is a negative regulator of Cox-2.

T. Jiang, Chuanlu Jiang, C. Kang, 2012, European journal of cancer.

Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo.

Xin-guo Jiang, C. Kang, P. Pu, 2010, Human gene therapy.

MicroRNA‑566 modulates vascular endothelial growth factor by targeting Von Hippel‑Landau in human glioblastoma in vitro and in vivo.

C. Kang, Miao-jing Wu, Xuan Zhou, 2016, Molecular medicine reports.

Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy

Xiaoyang Zhang, Lei Han, Cheng Wei, 2021, Frontiers in Oncology.

The Different Role of Notch1 and Notch2 in Astrocytic Gliomas

J. Cheng, C. Kang, P. Pu, 2013, PloS one.

Molecular classification of gliomas based on whole genome gene expression: a systematic report of 225 samples from the Chinese Glioma Cooperative Group.

Lei Han, Wei Yan, Junxia Zhang, 2012, Neuro-oncology.

Upregulation of miR-20a and miR-106b is involved in the acquisition of malignancy of pediatric brainstem gliomas.

Shao-Hua Yang, Ran Liu, C. Kang, 2012, Oncology reports.

β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma.

Kai Huang, Chuanlu Jiang, C. Kang, 2011, International journal of oncology.

MiR-221 and miR-222 target PUMA to induce cell survival in glioblastoma

J. Cheng, T. Jiang, C. Kang, 2010, Molecular Cancer.

CGCG clinical practice guidelines for the management of adult diffuse gliomas.

Yu Wang, Lei Han, Pei Yang, 2016, Cancer letters.

Wnt/beta-Catenin Signaling in Glioma

C. Kang, P. Pu, Junxia Zhang, 2012, Journal of Neuroimmune Pharmacology.

JAK2/STAT3 targeted therapy suppresses tumor invasion via disruption of the EGFRvIII/JAK2/STAT3 axis and associated focal adhesion in EGFRvIII-expressing glioblastoma.

Xia Li, H. Ren, T. Jiang, 2014, Neuro-oncology.

HOTAIR is a therapeutic target in glioblastoma

Tao Jiang, C. Kang, Xuan Zhou, 2015, Oncotarget.

MicroRNA-566 activates EGFR signaling and its inhibition sensitizes glioblastoma cells to nimotuzumab

E. Wagner, T. Jiang, T. Frank, 2014, Molecular Cancer.

PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth.

Shao-Hua Yang, C. Kang, P. Pu, 2013, Cancer letters.

Genome-wide identification of TCF7L2/TCF4 target miRNAs reveals a role for miR-21 in Wnt-driven epithelial cancer.

C. Kang, P. Pu, Z. Yao, 2011, International journal of oncology.

Expression and function of miR-27b in human glioma.

T. Jiang, Chuanlu Jiang, C. Kang, 2011, Oncology reports.

Inhibition of STAT3 reverses alkylator resistance through modulation of the AKT and β-catenin signaling pathways.

T. Jiang, Peiqian Yang, C. Kang, 2011, Oncology reports.

Antitumor effect of aspirin in glioblastoma cells by modulation of β-catenin/T-cell factor-mediated transcriptional activity.

Kai Huang, T. Jiang, C. Kang, 2011, Journal of neurosurgery.

High β-catenin/Tcf-4 activity confers glioma progression via direct regulation of AKT2 gene expression.

Kai Huang, T. Jiang, C. Kang, 2011, Neuro-oncology.

Inactivation of PI3K/AKT signaling inhibits glioma cell growth through modulation of β-catenin-mediated transcription

Tao Jiang, Kai Huang, Hao Jiang, 2010, Brain Research.

SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma

C. Kang, P. Pu, Xuan Zhou, 2015, Scientific Reports.

MicroRNA roles in beta-catenin pathway

Lei Han, Tao Jiang, Kai Huang, 2010, Molecular Cancer.

HOTAIR, a cell cycle-associated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma.

T. Jiang, C. Kang, P. Pu, 2013, Neuro-oncology.

VHL regulates the effects of miR-23b on glioma survival and invasion via suppression of HIF-1α/VEGF and β-catenin/Tcf-4 signaling.

T. Jiang, Chuanlu Jiang, C. Kang, 2012, Neuro-oncology.

Down-regulation of miR-106b suppresses the growth of human glioma cells

C. Kang, P. Pu, Qiang Huang, 2013, Journal of Neuro-Oncology.

Downregulation of miR-21 Enhances Chemotherapeutic Effect of Taxol in Breast Carcinoma Cells

C. Kang, Xubo Yuan, P. Pu, 2010, Technology in cancer research & treatment.

LY 294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI 3 K / Akt pathway

T. Jiang, Chuanlu Jiang, C. Kang, 2011 .

EZH2 is a negative prognostic factor and exhibits pro-oncogenic activity in glioblastoma.

C. Kang, P. Pu, Junxia Zhang, 2015, Cancer letters.

Clinical practice guidelines for the management of adult diffuse gliomas.

Shuai Liu, D. Nam, Z. Ram, 2020, Cancer letters.

LY294002 enhances cytotoxicity of temozolomide in glioma by down-regulation of the PI3K/Akt pathway.

T. Jiang, Chuanlu Jiang, C. Kang, 2011, Molecular medicine reports.

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

J. Sheng, C. Kang, Xubo Yuan, 2010, Journal of biomaterials science. Polymer edition.

Downregulation of Dicer enhances tumor cell proliferation and invasion.

C. Kang, P. Pu, Xuan Zhou, 2010, International journal of oncology.

Adenovirus-mediated shRNAs for co-repression of miR-221 and miR-222 expression and function in glioblastoma cells.

C. Kang, P. Pu, Chang-hong Shen, 2010, Oncology reports.

MiR-24 regulates the proliferation and invasion of glioma by ST7L via β-catenin/Tcf-4 signaling.

T. Jiang, Chuanlu Jiang, C. Kang, 2013, Cancer letters.

Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status.

T. Jiang, Chuanlu Jiang, C. Kang, 2011, Oncology reports.

High level of miR-221/222 confers increased cell invasion and poor prognosis in glioma

Lei Han, Zhendong Shi, Junxia Zhang, 2012, Journal of Translational Medicine.

Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo.

Hao Jiang, C. Kang, P. Pu, 2009, International journal of oncology.

AURKA induces EMT by regulating histone modification through Wnt/β-catenin and PI3K/Akt signaling pathway in gastric cancer

Lei Han, Yue Song, Zhaoxia Li, 2016, Oncotarget.

HOTAIR upregulates an 18-gene cell cycle-related mRNA network in glioma.

Kai Huang, Chao Yang, C. Kang, 2017, International journal of oncology.

AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression.

Lei Han, Zhendong Shi, Junxia Zhang, 2013, Cancer research.

STAT3 inhibitor WP1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo.

C. Kang, P. Li, Lun Zhang, 2014, Oncology reports.

MicroRNA miR-451 downregulates the PI3K/AKT pathway through CAB39 in human glioma

C. Kang, P. Pu, Yuan Tian, 2011, International journal of oncology.

STAT 3 inhibitor WP 1066 attenuates miRNA-21 to suppress human oral squamous cell carcinoma growth in vitro and in vivo

C. Kang, Lun Zhang, Xudong Wang, 2022 .

MiRNA-451 plays a role as tumor suppressor in human glioma cells

C. Kang, P. Pu, Lei Han, 2010, Brain Research.

miR-221/222 promote malignant progression of glioma through activation of the Akt pathway.

C. Kang, P. Pu, Y. You, 2010, International journal of oncology.

A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo.

C. Kang, P. Pu, Kailiang Zhang, 2014, Oncology reports.

DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression.

C. Kang, Lei Han, Xi Liu, 2015, Cancer letters.

Systemic Delivery of Monoclonal Antibodies to the Central Nervous System for Brain Tumor Therapy

Lei Han, Yang Liu, Yunfeng Lu, 2019, Advanced materials.

Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.

Ming-Yu Yang, C. Kang, P. Pu, 2014, Cancer letters.

A study of the relationship between the Wnt/β-catenin signaling pathway and the gastrointestinal development of rat embryonic and perinatal periods

C. Kang, Lei Han, Qingyu Zhang, 2013, Experimental and therapeutic medicine.

Data Mining Pubmed Using Natural Language Processing to Generate the β-Catenin Biological Association Network

Lei Han, Fengming Lan, Xiao Yue, 2011 .

Combination gene therapy with PTEN and EGFR siRNA suppresses U251 malignant glioma cell growth in vitro and in vivo

C. Kang, P. Pu, Lei Han, 2010, Medical oncology.

Reprogramming carcinoma associated fibroblasts by AC1MMYR2 impedes tumor metastasis and improves chemotherapy efficacy.

Xiulan Zhao, C. Kang, Lun Zhang, 2016, Cancer letters.

Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner

Lei Han, Zhendong Shi, Xuan Zhou, 2014, Oncotarget.

Role of the AKT pathway in microRNA expression of human U251 glioblastoma cells.

C. Kang, P. Pu, Xuan Zhou, 2010, International journal of oncology.

Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

C. Kang, Yu Ren, Yunfei Wang, 2019, Clinical Epigenetics.

Multidimensional analysis of gene expression reveals TGFB1I1-induced EMT contributes to malignant progression of astrocytomas

Lei Han, Pei Yang, Tao Jiang, 2014, Oncotarget.

The putative tumor suppressor miR-524-5p directly targets Jagged-1 and Hes-1 in glioma.

Lei Han, Wei Yan, Zhendong Shi, 2012, Carcinogenesis.

MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol

Lei Han, Mei Mei, Xuan Zhou, 2010, BMC Cancer.

A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma.

C. Kang, P. Pu, Yan-wei Liu, 2016, Cancer letters.

PLK4 is a determinant of temozolomide sensitivity through phosphorylation of IKBKE in glioblastoma.

Kai Huang, Yan-wei Liu, Wei Zhang, 2019, Cancer letters.

Aspirin‐/TMZ‐coloaded Microspheres Exert Synergistic Antiglioma Efficacy via Inhibition of β‐catenin Transactivation

C. Kang, Xubo Yuan, P. Pu, 2013, CNS neuroscience & therapeutics.

[Preliminary study on aberrant expression of miRNAs related to the formation of the distinction between pediatric and adult types of brainstem gliomas].

Hong-wei Zhang, C. Kang, P. Pu, 2012, Zhonghua wai ke za zhi [Chinese journal of surgery].

PUMA is a novel target of miR-221/222 in human epithelial cancers.

C. Kang, P. Pu, Yingyi Wang, 2010, International journal of oncology.

MicroRNA-221 and -222 regulate radiation sensitivity by targeting the PTEN pathway.

ping wang, Bo Xu, C. Kang, 2011, International journal of radiation oncology, biology, physics.

Expression and function of miR-27 b in human glioma

T. Jiang, Chuanlu Jiang, C. Kang, 2022 .

EGFRvIII/integrin β3 interaction in hypoxic and vitronectinenriching microenvironment promote GBM progression and metastasis

Xia Li, Yongsheng Li, H. Ren, 2015, Oncotarget.

Aberrant lncRNA Expression in Multiple Myeloma.

Hui Meng, Lei Han, Jinya Ding, 2018, Oncology research.

The Different Role of Notch1 and Notch2 in Astrocytic Gliomas

C. Kang, P. Pu, Xing Fan, 2013, PloS one.

Nuclear Translocation of β-catenin is Essential for Glioma Cell Survival

T. Jiang, C. Kang, P. Pu, 2012, Journal of Neuroimmune Pharmacology.

Downregulation of lncRNA-HOXA11-AS modulates proliferation and stemness in Glioma cells

P. Pu, Junxia Zhang, Lei Han, 2017, Chinese Neurosurgical Journal.

Inhibition of C6 glioma in vivo by combination chemotherapy of implantation of polymer wafer and intracarotid perfusion of transferrin-decorated nanoparticles.

Lei Han, Lixia Long, Peiyu Pu, 2011, Oncology reports.

Combination therapy with Gamma Knife radiosurgery and antisense EGFR for malignant glioma in vitro and orthotopic xenografts.

Lei Han, Junxia Zhang, Qiang Jia, 2010, Oncology reports.

Targeted design and identification of AC1NOD4Q to block activity of HOTAIR by abrogating the scaffold interaction with EZH2

C. Kang, Yu Ren, Yunfei Wang, 2019, Clinical Epigenetics.

Global changes of mRNA expression reveals an increased activity of the interferon-induced signal transducer and activator of transcription (STAT) pathway by repression of miR-221/222 in glioblastoma U251 cells.

C. Kang, P. Pu, Huazong Zeng, 2010, International journal of oncology.

AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression.

C. Kang, P. Pu, Junxia Zhang, 2013, Cancer research.

Co-delivery of as-miR-21 and 5-FU by Poly(amidoamine) Dendrimer Attenuates Human Glioma Cell Growth in Vitro

J. Sheng, C. Kang, Xubo Yuan, 2010, Journal of biomaterials science. Polymer edition.

BASI, A Potent Small Molecular Inhibitor, Inhibits Glioblastoma Progression by Targeting microRNA‐mediated β‐Catenin Signaling

C. Kang, Xuan Zhou, Kailiang Zhang, 2014, CNS neuroscience & therapeutics.

PRDM1 is directly targeted by miR-30a-5p and modulates the Wnt/β-catenin pathway in a Dkk1-dependent manner during glioma growth.

Shao-Hua Yang, C. Kang, P. Pu, 2013, Cancer letters.

MicroRNA‐21 Expression is regulated by β‐catenin/STAT3 Pathway and Promotes Glioma Cell Invasion by Direct Targeting RECK

J. Cheng, T. Jiang, C. Kang, 2012, CNS neuroscience & therapeutics.

EZH2 is a negative prognostic factor and exhibits pro-oncogenic activity in glioblastoma.

C. Kang, P. Pu, Junxia Zhang, 2015, Cancer letters.

β-catenin/Tcf-4 complex transcriptionally regulates AKT1 in glioma.

Kai Huang, Chuanlu Jiang, C. Kang, 2011, International journal of oncology.

HOTAIR is a therapeutic target in glioblastoma

Tao Jiang, C. Kang, Chuanbao Zhang, 2015, Oncotarget.

miR-221/222 is the regulator of Cx43 expression in human glioblastoma cells.

C. Kang, P. Pu, Lei Han, 2012, Oncology reports.

Downregulation of miR-221/222 sensitizes glioma cells to temozolomide by regulating apoptosis independently of p53 status.

T. Jiang, Chuanlu Jiang, C. Kang, 2011, Oncology reports.

AKT1 and AKT2 promote malignant transformation in human brain glioma LN229 cells

C. Kang, P. Pu, Lei Han, 2011 .

AKT 1 and AKT 2 Promote Malignant Transformation in Human Brain Glioma LN 229 Cells

C. Kang, Lei Han, Zhen-dong Shi, 2011 .

A lentivirus-mediated miR-23b sponge diminishes the malignant phenotype of glioma cells in vitro and in vivo.

C. Kang, P. Pu, Kailiang Zhang, 2014, Oncology reports.

Blockage of a miR-21/EGFR regulatory feedback loop augments anti-EGFR therapy in glioblastomas.

Ming-Yu Yang, C. Kang, P. Pu, 2014, Cancer letters.

A novel cell cycle-associated lncRNA, HOXA11-AS, is transcribed from the 5-prime end of the HOXA transcript and is a biomarker of progression in glioma.

C. Kang, P. Pu, Yan-wei Liu, 2016, Cancer Letters.

Abstract 235: SNORD76, a box C/D snoRNA, acts as a tumor suppressor in glioblastoma

C. Kang, P. Pu, Jian-ning Zhang, 2015 .

Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo.

Hao Jiang, C. Kang, P. Pu, 2009, International journal of oncology.