Nina F. Gnädig

发表

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model

Min Zhang, Juliana M. Sá, Thomas E. Wellems, 2018, Proceedings of the National Academy of Sciences.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Erika L. Flannery, Victoria C. Corey, Yingyao Zhou, 2018, Science.

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

D. Fidock, John Okombo, S. Sidik, 2020, Nature Communications.

Genetic screens reveal a central role for heme biosynthesis in artemisinin susceptibility

D. Fidock, John Okombo, S. Sidik, 2019, bioRxiv.

Plasmodium falciparum K13 Mutations Differentially Impact Ozonide Susceptibility and Parasite Fitness In Vitro

D. Fidock, Nina F. Gnädig, J. Straimer, 2017, mBio.

TARGETING THE CELL STRESS RESPONSE OF PLASMODIUM FALCIPARUM TO OVERCOME ARTEMISININ RESISTANCE

Zbynek Bozdech, L. Tilley, D. Fidock, 2015 .

MutagenesisSensitivity to Lethal Mutational Robustness of an RNA Virus

M. Vignuzzi, C. Cameron, Jason D Graci, 2013 .

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

M. Llinás, T. Egan, Jill M Combrinck, 2016, PLoS pathogens.

Pan-active imidazolopiperazine antimalarials target the falciparum intracellular secretory pathway.

Gregory M. Goldgof, Andrea L. Cheung, E. Winzeler, 2020 .

Artemisinin Action and Resistance in Plasmodium falciparum.

Leann Tilley, S. Ralph, L. Tilley, 2016, Trends in parasitology.

Anti-PfGARP activates programmed cell death of parasites and reduces severe malaria

D. Weissman, Choukri Ben Mamoun, A. Oleinikov, 2020, Nature.

Coxsackievirus B3 mutator strains are attenuated in vivo

M. Vignuzzi, Grace Campagnola, O. Peersen, 2012, Proceedings of the National Academy of Sciences.

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Adele M. Lehane, Rowena E. Martin, D. Fidock, 2016, Nature Communications.

Artemisinin-resistant K13 mutations rewire Plasmodium falciparum’s intra-erythrocytic metabolic program to enhance survival

Zbynek Bozdech, M. Llinás, D. Fidock, 2021, Nature Communications.

A broad analysis of resistance development in the malaria parasite

Gregory M. Goldgof, Victoria C. Corey, Yingyao Zhou, 2016, Nature Communications.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13

D. Fidock, Rachel L. Edwards, Marcus C. S. Lee, 2020, PLoS pathogens.

The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance

E. Winzeler, K. Chibale, E. Istvan, 2021, Cell Chemical Biology.

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

D. Fidock, Lei Zhang, P. Gregory, 2015, Science.

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells.

M. Prevost, O. Schwartz, A. Mallet, 2012, Blood.

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

R. Price, P. Rosenthal, D. Fidock, 2021, Science Translational Medicine.

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Victoria C. Corey, Yingyao Zhou, E. Winzeler, 2017, Science.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

Gregory M. Goldgof, Andrea L. Cheung, E. Winzeler, 2019, Nature Communications.

Fidelity Variants of RNA Dependent RNA Polymerases Uncover an Indirect, Mutagenic Activity of Amiloride Compounds

M. Vignuzzi, J. Arnold, B. Baron, 2010, PLoS pathogens.

The antimalarial natural product salinipostin A identifies essential α/β serine hydrolases involved in lipid metabolism in P. falciparum parasites

Roger G. Linington, Kenji L. Kurita, M. Bogyo, 2019, bioRxiv.

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

DsRed-mediated oligomerization stabilizes HMGB1 on chromatin in vivo and on DNA in vitro.

M. Lecerf, V. Maréchal, Nina F. Gnädig, 2013, Biochimie.

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

R. Price, D. Fidock, R. Sinden, 2016, PLoS medicine.

Group Selection and Contribution of Minority Variants during Virus Adaptation Determines Virus Fitness and Phenotype

M. Vignuzzi, N. Shomron, A. Alcover, 2015, PLoS pathogens.

Isolation of Fidelity Variants of RNA Viruses and Characterization of Virus Mutation Frequency

M. Vignuzzi, L. Coffey, A. V. Bordería, 2011, Journal of visualized experiments : JoVE.

Mutation in the Plasmodium falciparum BTB/POZ Domain of K13 Protein Confers Artemisinin Resistance

D. Fidock, J. Augereau, J. Clain, 2021, Antimicrobial agents and chemotherapy.

Mutational Robustness of an RNA Virus Influences Sensitivity to Lethal Mutagenesis

M. Vignuzzi, C. Cameron, Jason D Graci, 2011, Journal of Virology.

Discovering unknown response patterns in progress test data to improve the estimation of student performance

Zbynek Bozdech, D. Fidock, S. Foote, 2023, BMC Medical Education.

Transcytosis of HTLV-1 across a tight human epithelial barrier and infection of subepithelial dendritic cells.

M. Prevost, O. Schwartz, A. Mallet, 2012, Blood.