A. Klapars

发表

A general and efficient copper catalyst for the amidation of aryl halides.

S. Buchwald, A. Klapars, Xiaohua Huang, 2002, Journal of the American Chemical Society.

Preparation of enamides via palladium-catalyzed amidation of enol tosylates.

R. Volante, Cheng-yi Chen, A. Klapars, 2005, Organic letters.

A general and efficient copper catalyst for the amidation of aryl halides.

S. Buchwald, A. Klapars, Xiaohua Huang, 2002, Journal of the American Chemical Society.

Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions.

S. Buchwald, A. Klapars, Xiaohua Huang, 2003 .

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

M. Wismer, A. Klapars, Dan Lehnherr, 2021, ACS central science.

Copper-catalyzed coupling of alkylamines and aryl iodides: an efficient system even in an air atmosphere.

S. Buchwald, A. Klapars, F. Kwong, 2002, Organic letters.

Asymmetric Synthesis of N-Boc-(R)-Silaproline via Rh-Catalyzed Intramolecular Hydrosilylation of Dehydroalanine and Continuous Flow N-Alkylation.

John Y. L. Chung, A. Klapars, M. Shevlin, 2016, Organic letters.

Copper-catalyzed domino halide exchange-cyanation of aryl bromides.

S. Buchwald, J. Zanon, A. Klapars, 2003, Journal of the American Chemical Society.

Enantioselective Synthesis of a Highly Substituted Tetrahydrofluorene Derivative as a Potent and Selective Estrogen Receptor Beta Agonist

Jeremy P. Scott, Matthew L. Maddess, J. Lynch, 2014 .

Electrochemical Activation of Galactose Oxidase: Mechanistic Studies and Synthetic Applications

A. Fryszkowska, A. Klapars, N. Strotman, 2021 .

Engineered Ribosyl-1-Kinase Enables Concise Synthesis of Molnupiravir, an Antiviral for COVID-19

T. Itoh, G. Murphy, K. Maloney, 2021, ACS central science.

Efficient synthesis of antiviral agent uprifosbuvir enabled by new synthetic methods†

Timothy J. Wright, Rebecca T. Ruck, Tyler A. Davis, 2021, Chemical science.

Biocatalytic oxidation of alcohols using galactose oxidase and a manganese(III) activator for the synthesis of islatravir.

A. Fryszkowska, A. Klapars, M. Huffman, 2021, Organic & biomolecular chemistry.

Enantioselective, palladium-catalyzed alpha-arylation of N-Boc-pyrrolidine.

Cheng-yi Chen, A. Klapars, P. Dormer, 2006, Journal of the American Chemical Society.

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine

Cheng-yi Chen, A. Klapars, P. Dormer, 2006 .

Expanding Pd-catalyzed C-N bond-forming processes: the first amidation of aryl sulfonates, aqueous amination, and complementarity with Cu-catalyzed reactions.

S. Buchwald, A. Klapars, Xiaohua Huang, 2003, Journal of the American Chemical Society.

A general and efficient copper catalyst for the amidation of aryl halides and the N-arylation of nitrogen heterocycles.

S. Buchwald, J. Antilla, A. Klapars, 2001, Journal of the American Chemical Society.

Synthesis of the GPR40 Partial Agonist MK-8666 through a Kinetically Controlled Dynamic Enzymatic Ketone Reduction.

Nicholas J Agard, L. Tan, Eric Ashley, 2016, Organic letters.

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.

S. Buchwald, A. Klapars, Artis Klapars, 2002, Journal of the American Chemical Society.

Enantioselective Pd-catalyzed alpha-arylation of N-Boc-pyrrolidine: the key to an efficient and practical synthesis of a glucokinase activator.

D. Zewge, Cheng-yi Chen, A. Klapars, 2008, The Journal of organic chemistry.

Identification and structural elucidation of process impurities generated in the end-game synthesis of taranabant (MK-0364) via cyanuric chloride.

Yadan W. Chen, Cheng-yi Chen, L. Frey, 2009, Journal of pharmaceutical and biomedical analysis.

Copper-catalyzed coupling of amides and carbamates with vinyl halides.

S. Buchwald, A. Klapars, Lei Jiang, 2003, Organic letters.

The copper-catalyzed N-arylation of indoles.

S. Buchwald, J. Antilla, A. Klapars, 2002, Journal of the American Chemical Society.

Mild and Practical Method for the α-Arylation of Nitriles with Heteroaryl Halides

M. McLaughlin, Cheng-yi Chen, John Y. L. Chung, 2005 .

Synthesis of N-aryl hydrazides by copper-catalyzed coupling of hydrazides with aryl iodides.

S. Buchwald, M. Wolter, A. Klapars, 2001, Organic letters.

New Efficient Asymmetric Synthesis of Taranabant, a CB1R Inverse Agonist for the Treatment of Obesity

D. Zewge, Yong-kui Sun, Cheng-yi Chen, 2009 .

Enantioselective, palladium-catalyzed α-arylation of N-Boc pyrrolidine: in situ react IR spectroscopic monitoring, scope, and synthetic applications.

P. O’Brien, G. Barker, A. Klapars, 2011, The Journal of organic chemistry.

Enantioselective synthesis of an HCV NS5a antagonist.

Melodie Christensen, Ryan Cohen, Yonggang Chen, 2014, Organic letters.

Synthesis of medium ring nitrogen heterocycles via a tandem copper-catalyzed C-N bond formation-ring-expansion process.

Artis Klapars, S. Buchwald, Stephen L Buchwald, 2004, Journal of the American Chemical Society.

Selective 1,4-Addition of Organolithiums to Maleate Monoesters with Application for a Short Efficient Route to Azaindanones

John Y. L. Chung, A. Klapars, Alan M. Hyde, 2020, Synlett.

Enantiocontrolled Synthesis of (1S,2S)-6-Desmethyl-(methylaziridino)mitosene

E. Vedejs, A. Klapars, F. Tucci, 2000 .

N-silyl protecting groups for labile aziridines: application toward the synthesis of N-H aziridinomitosenes.

E. Vedejs, D. Warner, A. Klapars, 2007, The Journal of organic chemistry.

A multifunctional catalyst that stereoselectively assembles prodrugs

Yining Ji, Louis-Charles Campeau, Rebecca T. Ruck, 2017, Science.

8. Glucokinase Activator

A. Klapars, 2010 .

Mechanistic Understanding of a Robust and Scalable Synthesis of Per(6-deoxy-6-halo)cyclodextrins, Versatile Intermediates for Cyclodextrin Modification

Jon A. Jurica, M. Reibarkh, D. Gauthier, 2020 .

Enantioselective, Palladium-Catalyzed α-Arylation of N-Boc-pyrrolidine.

Cheng-yi Chen, A. Klapars, P. Dormer, 2006 .

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

Michael K. Wismer, Dan Lehnherr, Jonas Rein, 2021, ACS central science.

Synthetic enantiopure aziridinomitosenes: preparation, reactivity, and DNA alkylation studies.

Don L. Warner, H. Kohn, Y. Na, 2003, Journal of the American Chemical Society.

Investigating the Underappreciated Hydrolytic Instability of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Related Unsaturated Nitrogenous Bases

Rebecca A. Arvary, A. Klapars, Alan M. Hyde, 2019, Organic Process Research & Development.

Supercritical fluid chromatography-photodiode array detection-electrospray ionization mass spectrometry as a framework for impurity fate mapping in the development and manufacture of drug substances.

Robert Hartman, Artis Klapars, E. Regalado, 2018, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Manufacturing Process Development for Uprifosbuvir (MK-3682): A Green and Sustainable Process for Preparing Penultimate 2′-Deoxy-α-2′-Chloro-β-2′-Methyluridine

Michael A. Zompa, Rebecca T. Ruck, George Zhou, 2022, Organic Process Research & Development.

Development and Implementation of an Aluminum-Promoted Phosphorylation in the Uprifosbuvir Manufacturing Route

M. Weisel, A. Klapars, S. Silverman, 2020 .

Mechanism-Based Solution to the ProTide Synthesis Problem: Selective Access to Sofosbuvir, Acelarin, and INX-08189.

A. Klapars, S. Silverman, A. Bellomo, 2017, Organic letters.

New Mechanism for Cinchona Alkaloid-Catalysis Allows for an Efficient Thiophosphorylation Reaction.

B. Sherry, A. Klapars, J. Qi, 2020, Journal of the American Chemical Society.

Metal‐Free Electrochemical Synthesis of Sulfonamides Directly from (Hetero)arenes, SO2, and Amines

D. Schollmeyer, S. Waldvogel, A. Klapars, 2020, Angewandte Chemie.

Impact of Lead Impurities in Zinc Dust on the Selective Reduction of a Dibromoimidazole Derivative

A. Brunskill, A. Klapars, N. Yasuda, 2017 .

Evaluation and Control of Mutagenic Impurities in a Development Compound: Purge Factor Estimates vs Measured Amounts

Artis Klapars, Renee K. Dermenjian, M. McLaughlin, 2015 .

A highly efficient asymmetric synthesis of vernakalant.

M. Truppo, Eric Ashley, G. Beutner, 2014, Organic letters.