S. Iimura

发表

Enantioselective total synthesis of guanacastepene N using an uncommon 7-endo Heck cyclization as a pivotal step.

L. Overman, A. Zakarian, Ralph Paulini, 2006, Journal of the American Chemical Society.

Enantioselective Total Synthesis of Guanacastepene N Using an Uncommon 7-Endo Heck Cyclization as a Pivotal Step.

L. Overman, A. Zakarian, Ralph Paulini, 2007 .

A novel inhibitor of I-kappaB kinase beta ameliorates experimental arthritis through downregulation of proinflammatory cytokines in arthritic joints.

Shinji Tanaka, M. Yokoyama, K. Morishita, 2014, Biological & pharmaceutical bulletin.

Hydrophobic, low-loading and alkylated polystyrene-supported sulfonic acid for several organic reactions in water: remarkable effects of both the polymer structures and loading levels of sulfonic acids.

Shuj Kobayashi, K. Manabe, S. Iimura, 2003, Organic & biomolecular chemistry.

Mannich-type reactions in water using a hydrophobic polymer-supported sulfonic acid catalyst

Shuj Kobayashi, K. Manabe, S. Iimura, 2003 .

Dehydration reactions in water. Brønsted Acid-surfactant-combined catalyst for ester, ether, thioether, and dithioacetal formation in water.

Shuj Kobayashi, K. Manabe, S. Iimura, 2002, Journal of the American Chemical Society.

Studies on Steric and Electronic Control of 2'-3' Phosphoryl Migration in 2'-Phosphorylated Uridine Derivatives and Its Application to the Synthesis of 2'-Phosphorylated Oligouridylates.

M. Sekine, T. Wada, S. Iimura, 1996, The Journal of organic chemistry.

Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

S. Iimura, Haiming Zhang, Ngiap-Kie Lim, 2020 .

A novel, potent, and orally active VLA-4 antagonist with good aqueous solubility: trans-4-[1-[[2-(5-Fluoro-2-methylphenylamino)-7-fluoro-6-benzoxazolyl]acetyl]-(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2013, Bioorganic & medicinal chemistry.

Identification of trans-4-[1-[[7-fluoro-2-(1-methyl-3-indolyl)-6-benzoxazolyl]acetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2012, Bioorganic & medicinal chemistry.

A novel and potent VLA-4 antagonist based on trans-4-substituted cyclohexanecarboxylic acid.

J. Chiba, M. Yokoyama, S. Iimura, 2009, Bioorganic & medicinal chemistry.

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist.

J. Chiba, M. Yokoyama, S. Iimura, 2008, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of benzoic acid derivatives as potent, orally active VLA-4 antagonists.

J. Chiba, M. Yokoyama, A. Satoh, 2007, Bioorganic & medicinal chemistry.

4-(Pyrrolidinyl)methoxybenzoic acid derivatives as a potent, orally active VLA-4 antagonist.

T. Horiuchi, J. Chiba, M. Yokoyama, 2006, Chemical & pharmaceutical bulletin.

Synthesis of a new class of 2'-phosphorylated oligoribonucleotides capable of conversion to oligoribonucleotides

M. Sekine, S. Iimura, K. Furusawa, 1993 .

Discovery of trans-4-[1-[[2,5-Dichloro-4-(1-methyl-3-indolylcarboxamido)phenyl]acetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylic acid: an orally active, selective very late antigen-4 antagonist.

J. Chiba, M. Yokoyama, A. Satoh, 2009, Journal of medicinal chemistry.

Simultaneous Removal of two 2-cyano-1,1-dimethylethyl Groups from Bis(2-cyano-1,1-dimethylethyl) Thymidine 3′-phosphate Derivatives by the Use of DBU/BSA

M. Sekine, T. Wada, S. Iimura, 1994 .

Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel.

K. Uoto, T. Soga, S. Iimura, 1997, Chemical & pharmaceutical bulletin.

Hydrophobic polymer-supported scandium catalyst for carbon–carbon bond-forming reactions in water

K. Manabe, S. Iimura, S. Kobayashi, 2004 .

Discovery of Novel Pyrido-pyridazinone Derivatives as FER Tyrosine Kinase Inhibitors with Antitumor Activity.

Y. Shibata, T. Taniguchi, T. Imaoka, 2019, ACS medicinal chemistry letters.

Aza-pinacol rearrangement: acid-catalyzed rearrangement of aziridines to imines.

J. Nakayama, S. Iimura, Y. Sugihara, 2002, Chemical communications.

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.

A. Matsuda, B. Schwartz, Steffi Koerner, 2016, Journal of medicinal chemistry.

Discovery of imidazo[1,2-b]pyridazine derivatives as IKKbeta inhibitors. Part 1: Hit-to-lead study and structure-activity relationship.

Shinji Tanaka, K. Morishita, S. Iimura, 2010, Bioorganic & medicinal chemistry letters.

K. Manabe, S. Iimura, S. Kobayashi, 2003, Organic & biomolecular chemistry.

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 3: exploration of effective compounds in arthritis models.

Shinji Tanaka, M. Yokoyama, K. Morishita, 2011, Bioorganic & medicinal chemistry letters.

Catalytic deprotection of protected alcohols in water using low-loading and alkylated polystyrene-supported sulfonic acid.

K. Manabe, S. Iimura, S. Kobayashi, 2003, The Journal of organic chemistry.

Hydrophobic polymer-supported catalyst for organic reactions in water: acid-catalyzed hydrolysis of thioesters and transprotection of thiols.

K. Manabe, S. Iimura, S. Kobayashi, 2003, Organic letters.

Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes

S. Iimura, Youchu Wang, Xiaodong Gu, 2020 .

Synthesis and cytotoxic activity of novel 10-alkylated docetaxel analogs.

K. Uoto, T. Soga, K. Nakayama, 1998, Bioorganic & medicinal chemistry letters.

Aza‐Pinacol Rearrangement: Acid‐Catalyzed Rearrangement of Aziridines to Imines.

J. Nakayama, S. Iimura, Y. Sugihara, 2002 .

New highly active taxoids from 9β-dihydrobaccatin-9,10-acetals. Part 2

K. Uoto, J. Chiba, T. Soga, 2002 .

Palladium-catalyzed borylation of l-tyrosine triflate derivative with pinacolborane: practical route to 4-borono-l-phenylalanine (l-BPA) derivatives

S. Iimura, Wenxue Wu, 2010 .

Dehydration Reactions in Water. Surfactant-type Brønsted Acid-catalyzed Dehydrative Etherification, Thioetherification, and Dithioacetalization in Water

K. Manabe, S. Iimura, S. Kobayashi, 2002 .

A convenient method for removal of the t-butyl group from nucleoside bis(t-butyl) phosphates under non-acidic conditions

M. Sekine, S. Iimura, Nakanishi Takeshi, 1991 .

Orally active docetaxel analogue: synthesis of 10-deoxy-10-C-morpholinoethyl docetaxel analogues.

K. Uoto, J. Chiba, T. Soga, 2001, Bioorganic & medicinal chemistry letters.

A novel inhibitor stabilizes the inactive conformation of MAPK-interacting kinase 1.

Yutaka Ikeno, O. Ubukata, H. Hanzawa, 2018, Acta crystallographica. Section F, Structural biology communications.

Synthesis and Antitumor Activity of Non-Prodrug Water-soluble Taxoid: 10-C-Aminoalkylated Docetaxel Analogs

K. Uoto, J. Chiba, T. Soga, 2000 .

Discovery of imidazo[1,2-b]pyridazines as IKKβ inhibitors. Part 2: improvement of potency in vitro and in vivo.

Shinji Tanaka, M. Yokoyama, K. Morishita, 2011, Bioorganic & medicinal chemistry letters.

A Convenient Method for the Synthesis of C-10 Alkylated Docetaxel Analogs Using Tris-(trimethylsilyl)silane as a Radical Mediator

K. Uoto, T. Soga, K. Nakayama, 2000 .

Direct thioesterification from carboxylic acids and thiols catalyzed by a Brønsted acid.

K. Manabe, S. Iimura, S. Kobayashi, 2002, Chemical communications.

Dehydration Reactions in Water. Broensted Acid—Surfactant‐Combined Catalyst for Ester, Ether, Thioether, and Dithioacetal Formation in Water.

K. Manabe, S. Iimura, Xiang Sun, 2003 .

Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.

A. Matsuda, B. Schwartz, R. Savage, 2016, Journal of medicinal chemistry.

Hydrophobic Polymer‐Supported Scandium Catalyst for Carbon—Carbon Bond‐Forming Reactions in Water.

K. Manabe, S. Iimura, S. Kobayashi, 2004 .