Isamu Shiina

发表

Reaction modes of oxidative dimerization of epoxycyclohexenols

H. Kakeya, H. Osada, Y. Hayashi, 2003 .

Computational study on the reaction mechanism of the key thermal [4 + 4] cycloaddition reaction in the biosynthesis of epoxytwinol A.

H. Kakeya, H. Osada, T. Uchimaru, 2006, Organic letters.

A novel tamoxifen derivative, ridaifen-F, is a nonpeptidic small-molecule proteasome inhibitor.

T. Kunoh, T. Mizukami, M. Shionyu, 2014, European journal of medicinal chemistry.

Non-enzymatic dynamic kinetic resolution of racemic α-arylalkanoic acids: an advanced asymmetric synthesis of chiral nonsteroidal anti-inflammatory drugs (NSAIDs)

Isamu Shiina, K. Nakata, K. Ono, 2012 .

Novel tamoxifen derivative Ridaifen-B induces Bcl-2 independent autophagy without estrogen receptor involvement.

M. Ikekita, S. Dan, Y. Nagahara, 2013, Biochemical and biophysical research communications.

Ridaifen-SB8, a novel tamoxifen derivative, induces apoptosis via reactive oxygen species-dependent signaling pathway.

S. Dan, T. Yamori, Wenzhi Guo, 2013, Biochemical pharmacology.

Novel Ridaifen-B Structure Analog Induces Apoptosis and Autophagy Depending on Pyrrolidine Side Chain.

Y. Nagahara, T. Shinomiya, Isamu Shiina, 2019, Biological & pharmaceutical bulletin.

M‐COPA, a novel Golgi system disruptor, suppresses apoptosis induced by Shiga toxin

S. Dan, M. Naito, T. Yamori, 2016, Genes to cells : devoted to molecular & cellular mechanisms.

Asymmetric aldol reaction between achiral silyl enol ethers and achiral aldehydes by use of a chiral promoter system

Isamu Shiina, T. Mukaiyama, Yuko Fujishita, 1991 .

A New Method for the Synthesis of Unsymmetrical Bis-Aldols by the Samarium(II) Iodide-Mediated Aldol Reaction of Aldehydes with Aryl or Alkyl Oxiranyl Ketones

Isamu Shiina, T. Mukaiyama, H. Arai, 2000 .

Induction of mitochondria‐involved apoptosis in estrogen receptor‐negative cells by a novel tamoxifen derivative, ridaifen‐B

M. Ikekita, Y. Nagahara, Akane Sasaki, 2008, Cancer science.

Enantioselective synthesis of the α-hydroxy-α-methyl-β-hydroxy units via asymmetric aldol reaction

Isamu Shiina, T. Mukaiyama, J. Izumi, 1993 .

Medium‐Sized Lactones

Isamu Shiina, K. Nakata, Kenya Nakata, 2013 .

The catalytic Friedel–Crafts alkylation reaction of aromatic compounds with benzyl or allyl silyl ethers using Cl2Si(OTf)2 or Hf(OTf)4

Isamu Shiina, Masahiko Suzuki, 2002 .

Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2.

F. Sugawara, Toshifumi Takeuchi, Y. Takakusagi, 2013, Bioorganic & medicinal chemistry.

A New Method for Production of Chiral 2-Aryl-2-fluoropropanoic Acids Using an Effective Kinetic Resolution of Racemic 2-Aryl-2-fluoropropanoic Acids

Isamu Shiina, Atsushi Tengeiji, 2012, Molecules.

Anti-proliferative effect of ridaifen-B on hepatoma cells.

M. Shimonaka, Isamu Shiina, Go Hasegawa, 2018, Biomedical reports.

Enantioselective Alkylation of Aldehydes with Diethylzinc Using a New Catalyst System, ((R)-Thiolan-2-yl)diphenylmethanol and Metal Alkoxides

Isamu Shiina, Katsuhiko Konishi, Y. Kuramoto, 2002 .

Kinetic resolution of racemic α-hydroxyphosphonates by asymmetric esterification using achiral carboxylic acids with pivalic anhydride and a chiral acyl-transfer catalyst.

Isamu Shiina, K. Ono, T. Nakahara, 2013, Chemical communications.

An effective use of benzoic anhydride and its derivatives for the synthesis of carboxylic esters and lactones: a powerful and convenient mixed anhydride method promoted by basic catalysts.

Isamu Shiina, Minako Hashizume, Mari Kubota, 2004, The Journal of organic chemistry.

Kinetic Resolution of Racemic Secondary Benzylic Alcohols by the Enantioselective Esterification Using Pyridine‐3‐carboxylic Anhydride (3‐PCA) with Chiral Acyl‐Transfer Catalysts

Isamu Shiina, T. Mukaiyama, K. Nakata, 2012 .

4-(Dimethylamino)pyridine N-oxide (DMAPO): an effective nucleophilic catalyst in the peptide coupling reaction with 2-methyl-6-nitrobenzoic anhydride.

Isamu Shiina, K. Nakata, H. Ushiyama, 2008, Chemistry, an Asian journal.

The effective use of substituted benzoic anhydrides for the synthesis of carboxamides

Isamu Shiina, Yo-ichi Kawakita, 2004 .

A novel and efficient macrolactonization of ω-hydroxycarboxylic acids using 2-methyl-6-nitrobenzoic anhydride (MNBA)

Isamu Shiina, Mari Kubota, R. Ibuka, 2002 .

A New Condensation Reaction for the Synthesis of Carboxylic Esters from Nearly Equimolar Amounts of Carboxylic Acids and Alcohols Using 2-Methyl-6-nitrobenzoic Anhydride

Isamu Shiina, Mari Kubota, R. Ibuka, 2002 .

A Facile Synthesis of Carboxamides by Dehydration Condensation Between Free Carboxylic Acids and Amines Using O,O'-Di(2-pyridyl) Thiocarbonate as a Coupling Reagent

Masakazu Nakano, Isamu Shiina, T. Mukaiyama, 2000 .

O,O′-Di(2-pyridyl) Thiocarbonate as an Efficient Reagent for the Preparation of Carboxylic Esters from Highly Hindered Alcohols

Isamu Shiina, T. Mukaiyama, K. Saitoh, 1998 .

An Efficient Esterification Reaction between Equimolar Amounts of Free Carboxylic Acids and Alcohols by the Combined Use of Octamethylcyclotetrasiloxane and a Catalytic Amount of Titanium(IV) Chloride Tris(trifluoromethanesulfonate)

Isamu Shiina, T. Mukaiyama, J. Izumi, 1995 .

A Useful Method for the Preparation of Carboxylic Esters from Free Carboxylic Acids and Alcohols

Isamu Shiina, T. Mukaiyama, So Miyoshi, 1994 .

An expeditious synthesis of tamoxifen, a representative SERM (selective estrogen receptor modulator), via the three-component coupling reaction among aromatic aldehyde, cinnamyltrimethylsilane, and beta-chlorophenetole.

M. Ikekita, Y. Nagahara, Akane Sasaki, 2007, Bioorganic & medicinal chemistry.

The Direct, Enantioselective, One-Pot, Three-Component, Cross-Mannich Reaction of Aldehydes: The Reason for the Higher Reactivity of Aldimine versus Aldehyde in Proline-Mediated Mannich and Aldol Reactions

T. Uchimaru, Y. Hayashi, M. Shoji, 2005 .

Asymmetric Total Synthesis of Taxol\R

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1999 .

A Convenient and Versatile Route for the Stereoselective Synthesis of Monosaccharides via Key Chiral Synthons Prepared from Achiral Sources

Susumu Kobayashi, Isamu Shiina, T. Mukaiyama, 1990 .

A New and Efficient Esterification Reaction via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid

Isamu Shiina, T. Mukaiyama, So Miyoshi, 1993 .

An Efficient Method for the Preparation of Carboxylic Esters via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid

Isamu Shiina, T. Mukaiyama, M. Miyashita, 1992 .

Diastereo- and Enantioselective Synthesis of syn- and anti-1,2-Diol Units by Asymmetric Aldol Reactions

Susumu Kobayashi, Isamu Shiina, T. Mukaiyama, 1994 .

An effective method for the synthesis of carboxylic esters and lactones using substituted benzoic anhydrides with Lewis acid catalysts

Isamu Shiina, 2004 .

New and Efficient Method for the Preparation of Medium-sized Lactones from the Correspondingω-Hydroxycarboxylic Acids

Isamu Shiina, T. Mukaiyama, J. Izumi, 1997 .

Facile Synthesis of Lactones from Silyl ω-Siloxycarboxylates Using p-Trifluoromethylbenzoic Anhydride and a Catalytic Amount of Active Lewis Acid

Isamu Shiina, T. Mukaiyama, J. Izumi, 1993 .

Total synthesis of natural 8- and 9-membered lactones: recent advancements in medium-sized ring formation.

Isamu Shiina, 2007, Chemical reviews.

(S)‐1‐Methyl‐2‐(piperidinomethyl)pyrrolidine

Isamu Shiina, T. Mukaiyama, 2003 .

Total synthesis of buergerinin F via effective construction of the asymmetric quaternary carbons using an enantioselective aldol reaction.

Isamu Shiina, K. Yokoyama, Yo-ichi Kawakita, 2005, Chemical communications.

Nonenzymatic, Enantioconvergent Dynamic Kinetic Resolution (DKR) of Racemic 2-(1H-Pyrrol-1-yl)alkanoic Acids as α-Amino Acid Equivalents

Isamu Shiina, Eri Tokumaru, Atsushi Tengeiji, 2015 .

The Esterification Reaction between Silyl Derivatives of Carboxylic Acids and Alcohols by the Promotion of a Catalytic Amount of Lewis Acid

Isamu Shiina, T. Mukaiyama, 1992 .

A Novel Method for the Preparation of Macrolides from ω-Hydroxycarboxylic Acids

Isamu Shiina, T. Mukaiyama, 1994 .

Tin‐promoted Aldol Reactions and their Application to Total Syntheses of Natural Products

Isamu Shiina, 2008 .

Catalytic asymmetric aldol-type reaction using a chiral tin(II) Lewis acid

Isamu Shiina, S. Kobayashi, T. Mukaiyama, 1993 .

(R)-(+)-N-methylbenzoguanidine ((R)-NMBG) catalyzed kinetic resolution of racemic secondary benzylic alcohols with free carboxylic acids by asymmetric esterification.

Isamu Shiina, K. Nakata, 2011, Organic & biomolecular chemistry.

Synthesis of Lasofoxifene, Nafoxidine and Their Positional Isomers via the Novel Three-Component Coupling Reaction

Isamu Shiina, K. Nakata, Y. Sano, 2010, Molecules.

Short-step synthesis of tamoxifen and its derivatives via the three-component coupling reaction and migration of the double bond

Isamu Shiina, K. Yokoyama, Masahiko Suzuki, 2004 .

A convenient method for the synthesis of 4,4-diarylbut-1-enes via the successive allylation of aromatic aldehydes and the Friedel-Crafts alkylation reaction of aromatic nucleophiles with the intermediary benzyl silyl ethers using HfCl4 or Cl2Si(OTf)2

Isamu Shiina, K. Yokoyama, Masahiko Suzuki, 2002 .

MNBA-mediated β-lactone formation: mechanistic studies and application for the asymmetric total synthesis of tetrahydrolipstatin.

T. Katoh, Isamu Shiina, Takashi Iizumi, 2012, The Journal of organic chemistry.

Asymmetric Mukaiyama aldol reactions using chiral diamine-coordinated Sn(II) triflate: development and application to natural product synthesis.

Isamu Shiina, 2014, Chemical record.

Kinetic resolution of racemic 2-hydroxy-γ-butyrolactones by asymmetric esterification using diphenylacetic acid with pivalic anhydride and a chiral acyl-transfer catalyst.

Isamu Shiina, K. Nakata, K. Ono, 2013, Organic letters.

Total Asymmetric Synthesis of Taxol by Dehydration Condensation between 7-TES Baccatin III and Protected N-Benzoylphenylisoserines Prepared by Enantioselective Aldol Reaction

Isamu Shiina, T. Mukaiyama, K. Saitoh, 1998 .

Kinetic resolution of racemic alpha-arylalkanoic acids with achiral alcohols via the asymmetric esterification using carboxylic anhydrides and acyl-transfer catalysts.

Y. Onda, Isamu Shiina, K. Nakata, 2010, Journal of the American Chemical Society.

Kinetic Resolution of Racemic Carboxylic Acids Using Achiral Alcohols by the Promotion of Benzoic Anhydrides and Tetramisole Derivatives: Production of Chiral Nonsteroidal Anti-Inflammatory Drugs and Their Esters

Y. Onda, Isamu Shiina, K. Nakata, 2008 .

Kinetic Resolution of Racemic 2‐Hydroxyarylketones by Asymmetric Esterification: Investigation of the Influence of the Co‐Base on the Selectivity

Isamu Shiina, K. Nakata, K. Ono, 2020 .

Acylative kinetic resolution of racemic aromatic β-hydroxy esters catalyzed by chiral nucleophilic N-(1-arylethyl)benzoguanidines

Isamu Shiina, K. Nakata, A. Yamada, 2017 .

An Adventurous Synthetic Journey with MNBA from Its Reaction Chemistry to the Total Synthesis of Natural Products

Isamu Shiina, 2014 .

Kinetic Resolution of Racemic 1-Heteroarylalkanols by Asymmetric Esterification Using Diphenylacetic Acid with Pivalic Anhydride and a Chiral Acyl-transfer Catalyst

Isamu Shiina, K. Nakata, K. Ono, 2011 .

An effective kinetic resolution of racemic α-arylpropanoic acids, α-arylbutanoic acids, and β-substituted-α-arylpropanoic acids with bis(9-phenanthryl)methanol as a new achiral nucleophile in the asymmetric esterification using carboxylic anhydrides and the acyl-transfer catalyst

Isamu Shiina, K. Nakata, K. Ono, 2010 .

Kinetic resolution of the racemic 2-hydroxyalkanoates using the enantioselective mixed-anhydride method with pivalic anhydride and a chiral acyl-transfer catalyst.

Isamu Shiina, K. Nakata, K. Ono, 2010, Chemistry.

An effective kinetic resolution of racemic secondary benzylic alcohols using 3-pyridinecarboxylic anhydride and a chiral acyl-transfer catalyst in the absence of tertiary amine

Isamu Shiina, K. Nakata, 2010 .

2,2-DISUBSTITUTED PROPIONIC ANHYDRIDES : EFFECTIVE COUPLING REAGENTS FOR THE KINETIC RESOLUTION OF SECONDARY BENZYLIC ALCOHOLS USING BTM

Y. Onda, Isamu Shiina, K. Nakata, 2009 .

The first asymmetric esterification of free carboxylic acids with racemic alcohols using benzoic anhydrides and tetramisole derivatives: an application to the kinetic resolution of secondary benzylic alcohols

Isamu Shiina, K. Nakata, Kenya Nakata, 2007 .

Asymmetric Total Synthesis of (-)-Astakolactin and Confirmation of Its Stereostructure.

Takashi Kato, Isamu Shiina, Takayuki Tonoi, 2017, Journal of natural products.

Kinetic Resolution of Racemic 2-Hydroxyamides Using a Diphenylacetyl Component as an Acyl Source and a Chiral Acyl-Transfer Catalyst

Isamu Shiina, K. Nakata, K. Ono, 2018, Molecules.

A new method for production of chiral 2-aryloxypropanoic acids using effective kinetic resolution of racemic 2-aryloxycarboxylic acids

Isamu Shiina, K. Nakata, K. Ono, 2012 .

Synthesis of lactones using substituted benzoic anhydride as a coupling reagent

Akane Sasaki, Isamu Shiina, H. Fukui, 2007, Nature Protocols.

A Convenient and Versatile Route for the Stereoselective Synthesis of Monosaccharides via Key Chiral Synthons Prepared from Achiral Sources.

Susumu Kobayashi, Isamu Shiina, T. Mukaiyama, 2010 .

Enantioselective Synthesis of β‐Hydroxy‐α‐methyl‐α‐methylthio Esters as Precursors of anti‐vic‐Hydroxymethyl Units.

Isamu Shiina, R. Ibuka, 2001 .

Facile synthesis of optically active anti-.ALPHA.,.BETA.-dihydroxy ester derivatives.

Isamu Shiina, T. Mukaiyama, H. Uchiro, 1990 .

[1,3] Sigmatropic rearrangement of ketene silyl acetals derived from benzyl α-substituted propanoates

Isamu Shiina, Hiroshi Nagasue, 2002 .

An Effective Method for Acylation of Weakly Nucleophilic Anilines with Silyl Carboxylates via Mixed Anhydrides

Isamu Shiina, T. Mukaiyama, M. Miyashita, 1994 .

An Efficient Method for the Preparation of Carboxylic Esters via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid.

Isamu Shiina, T. Mukaiyama, M. Miyashita, 1992 .

Determination of Relative and Absolute Stereochemistry of Cephalosporolide D and Its Enantioselective Total Synthesis

T. Ishii, Isamu Shiina, T. Mukaiyama, 1998 .

A New and Efficient Esterification Reaction via Mixed Anhydrides by the Promotion of a Catalytic Amount of Lewis Acid.

Isamu Shiina, T. Mukaiyama, So Miyoshi, 1993 .

A Convenient Synthesis of Carboxanilides from Silyl Carboxylates and Weakly Nucleophilic Anilines Using p-Trifluoromethylbenzoic Anhydride and a Catalytic Amount of Active Titanium(IV) Salt

Isamu Shiina, T. Mukaiyama, M. Miyashita, 1993 .

Enantioselective aldol reaction of tetrasubstituted ketene silyl acetals with achiral aldehydes for the construction of asymmetric tertiary alcohols: An application for the divergent total syntheses of buergerinins F and G

Isamu Shiina, K. Yokoyama, Takashi Iizumi, 2009 .

Catalytic Asymmetric Aldol Reaction of Silyl Enol Ethers with Aldehydes by the Use of Chiral Diamine Coordinated Tin(II) Triflate

Isamu Shiina, T. Mukaiyama, H. Uchiro, 1990 .

Highly Enantioselective Synthesis of syn-α,β-Dihydroxy Thioesters by the Asymmetric Aldol Reaction Using a Chiral Tin(II) Lewis Acid

Susumu Kobayashi, Isamu Shiina, T. Mukaiyama, 1991 .

An Efficient Method for the Preparation of Chiral Synthons Starting from Racemic Compounds by Way of Asymmetric Synthesis

Isamu Shiina, S. Kobayashi, T. Mukaiyama, 1992 .

Diastereoselective Aldol and Reformatsky Reactions of α-Halo Carbonyl Compounds and Aldehydes Mediated by Titanium(II) Chloride

Isamu Shiina, T. Mukaiyama, Akifumi Kagayama, 2000 .

Facile Synthesis of Optically Active anti-α,β-Dihydroxy Ester Derivatives

Susumu Kobayashi, Isamu Shiina, T. Mukaiyama, 1990 .

Enantio- and diastereoselective total synthesis of EI-1941-1, -2, and -3, inhibitors of interleukin-1beta converting enzyme, and biological properties of their derivatives.

H. Kakeya, H. Osada, R. Onose, 2005, The Journal of organic chemistry.

An Effective Method for the Preparation of Chiral Polyoxy 8-Membered Ring Enone Corresponding to the B Ring of Taxol

J. Shibata, Isamu Shiina, T. Mukaiyama, 2001 .

A direct and selective syntheses of α,α-dichloro-and α-chloro-ethyl ketones by the reaction of alkyl carboxylates with 1,1-dichloroethyllithium

Isamu Shiina, T. Mukaiyama, Y. Imai, 2000 .

Total Synthesis of Botcinolides and Botcinins; Determination of the Structure of Natural Products Isolated from Botrytis cinerea

Isamu Shiina, H. Fukui, 2009 .

Chemistry and structural determination of botcinolides, botcinins, and botcinic acids.

Isamu Shiina, H. Fukui, 2009, Chemical communications.

Diethylaluminum Ethoxide Mediated Stereoselective Diels-Alder Reaction of α,β-unsaturated Ketones and Acetoxy-1,3-butadienes as Diene Components

J. Shibata, Isamu Shiina, T. Mukaiyama, 1999 .

Total synthesis of (3R,16E,20E,23R)-(−)-eushearilide and structural determination of naturally occurring eushearilide

Isamu Shiina, R. Kawahara, K. Fujimori, 2015 .

Total synthesis of 2-hydroxytetracosanolide and 2-hydroxy-24-oxooctacosanolide by using an effective lactonization.

Akane Sasaki, Isamu Shiina, H. Fukui, 2008, Chemistry, an Asian journal.

Stereoselective total synthesis of the proposed structure of 2-epibotcinolide.

Isamu Shiina, H. Fukui, R. Suzuki, 2006, Organic letters.

The first total synthesis of (-) and (+)-2-hydroxy-24-oxooctacosanolide using an effective lactonization.

Akane Sasaki, Isamu Shiina, Takaaki Kikuchi, 2006, Organic letters.

Synthesis of (9E)-isoambrettolide, a macrocyclic musk compound, using the effective lactonization promoted by symmetric benzoic anhydrides with basic catalysts

Isamu Shiina, Minako Hashizume, 2006 .

Total Synthesis and Antimicrobial Activities of All Stereoisomers of (16 Z,20 E)-Eushearilide and (16 E,20 E)-Eushearilide.

Teruyuki Sato, Tomoki Yoshida, Isamu Shiina, 2018, The Journal of organic chemistry.

Enantioselective total synthesis of naturally occurring eushearilide and evaluation of its antifungal activity

Isamu Shiina, R. Kawahara, Takayuki Tonoi, 2016, The Journal of Antibiotics.

Efficient method for pinacol coupling of aromatic and aliphatic ketones by using titanium(II) chloride and zinc in the presence of pivalonitrile

Isamu Shiina, T. Mukaiyama, Akifumi Kagayama, 1998 .

Evaluation of the efficiency of the macrolactonization using MNBA in the synthesis of erythromycin A aglycon.

Takashi Katoh, T. Katoh, Isamu Shiina, 2009, Chemical record.

A NEW METHOD FOR THE SYNTHESIS OF BACCATIN III

Isamu Shiina, T. Mukaiyama, H. Iwadare, 1998 .

An Asymmetric Synthesis of the ABC Ring System of 8-Demethyltaxoids from Optically Active 8-Membered Ring Compound via Intramolecular Aldol and Pinacol Coupling Reactions

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1997 .

An Enantiodivergent Synthesis of (+)‐ and (−)‐Centrolobines by Asymmetric Esterification Catalyzed by (R)‐(+)‐N‐Methylbenzoguanidine ((R)‐NMBG)

Isamu Shiina, H. Iwamoto, K. Nakata, 2013 .

An effective method for formylation of weakly nucleophilic anilines and indole

Isamu Shiina, T. Mukaiyama, M. Nagai, 1995 .

Fine structures in vibrational circular dichroism spectra of chiral molecules with rotatable hydroxyl groups and their application in the analysis of local intermolecular interactions

Hiroharu Yui, Isamu Shiina, Kohzo Konno, 2013 .

A convenient method for the kinetic resolution of racemic 2-hydroxyalkanoates using diphenylacetic anhydride (DPHAA) and a chiral acyl-transfer catalyst

Isamu Shiina, K. Nakata, Akihiro Sekiguchi, 2011 .

Enantioselective total synthesis of octalactin a using asymmetric aldol reactions and a rapid lactonization to form a medium-sized ring.

Isamu Shiina, Minako Hashizume, Yu-ji Takasuna, 2005, Chemistry.

Asymmetric Total Synthesis of Taxol

Isamu Shiina, T. Mukaiyama, H. Iwadare, 1999 .

Total synthesis of the proposed structure of astakolactin.

Isamu Shiina, Takayuki Tonoi, Yutaka Yoshinaga, 2014 .

2‐Methyl‐6‐nitrobenzoic Anhydride (MNBA)

Isamu Shiina, 2009 .

(Z)‐1‐Methoxy‐2‐Methylseleno‐1‐(Trimethylsiloxy)Propene

Isamu Shiina, 2007 .

Enantioselective Total Synthesis of Octalactin A Using Asymmetric Aldol Reactions and a Rapid Lactonization to Form a Medium‐Sized Ring.

Isamu Shiina, Minako Hashizume, Yu-ji Takasuna, 2006 .

An Effective Use of Benzoic Anhydride and Its Derivatives for the Synthesis of Carboxylic Esters and Lactones-Powerful and Convenient Mixed Anhydride Methods Promoted by Lewis Acids or Basic Catalysts

Isamu Shiina, 2005 .

Asymmetric total synthesis of octalactin B using a new and rapid lactonization

Isamu Shiina, Minako Hashizume, Hiromi Oshiumi, 2004 .

Stereoselective total synthesis of cephalosporolide D

T. Ishii, Isamu Shiina, Y. Fukuda, 2000 .

Asymmetric Total Synthesis of TaxolR

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1999 .

Targeting the Golgi apparatus to overcome acquired resistance of non-small cell lung cancer cells to EGFR tyrosine kinase inhibitors

Ryohei Katayama, S. Dan, N. Fujita, 2017, Oncotarget.

Family-wide Analysis of the Inhibition of Arf Guanine Nucleotide Exchange Factors with Small Molecules: Evidence of Unique Inhibitory Profiles.

J. Cherfils, M. Zeghouf, S. Dan, 2017, Biochemistry.

Golgi retention and oncogenic KIT signaling via PLCγ2-PKD2-PI4KIIIβ activation in GIST cells

A. Nakano, T. Nishida, R. Abe, 2022, bioRxiv.

An Asymmetric Synthesis of the BC Ring System of 8-Epitaxoids by Way of Intramolecular Aldol and Successive Stereoselective Methylation Reactions

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1996 .

M-COPA, a Golgi Disruptor, Inhibits Cell Surface Expression of MET Protein and Exhibits Antitumor Activity against MET-Addicted Gastric Cancers.

S. Dan, T. Yamori, K. Yoshimatsu, 2016, Cancer research.

Taxol derivatives are selective inhibitors of DNA polymerase alpha.

K. Sakaguchi, F. Sugawara, Toshifumi Takeuchi, 2004, Bioorganic & medicinal chemistry.

Ridaifen-F conjugated with cell-penetrating peptides inhibits intracellular proteasome activities and induces drug-resistant cell death.

T. Mizukami, M. Shionyu, M. Hasegawa, 2018, European journal of medicinal chemistry.

FLT3-ITD transduces autonomous growth signals during its biosynthetic trafficking in acute myelogenous leukemia cells

T. Nishida, R. Abe, Y. Obata, 2021, Scientific Reports.

An Asymmetric Synthesis of the Fully Functionalized AB Ring System of 12-Demethyltaxol via Successive Stereoselective Allylation and Intramolecular Aldol Reactions

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1995 .

A Novel Approach to the Synthesis of Taxol. A Synthesis of Optically Active 3,7-dibenzyloxy-4,8-di-t-butyl-dimethylsiloxy-5,5-dimethyl-6-p-methoxybenzyloxy-2-octanone by Way of Stereoselective Aldol Reactions.

Isamu Shiina, T. Mukaiyama, M. Saitoh, 1995 .

AN ASYMMETRIC SYNTHESIS OF FULLY FUNCTIONALIZED B RING SYSTEM OF TAXOL

K. Uoto, Isamu Shiina, N. Mori, 1995 .

New and Effective Synthesis of 7-Triethylsilylbaccatin III from 7β ,13α-Bistriethylsiloxy-1β,2α,10β-trihydroxy-9- oxo-4(20),11-taxadiene.

Isamu Shiina, T. Mukaiyama, M. Saitoh, 1996 .

A Novel Approach to the Synthesis of Taxol. A Synthesis of Optically Active 3,7-Dibenzyloxy-4,8-di-t-butyl-dimethylsiloxy-5,5-dimethyl-6-p- methoxybenzyloxy-2-octanone by Way of Stereoselective Aldol Reactions.

Isamu Shiina, T. Mukaiyama, M. Saitoh, 1995 .

An Asymmetric Synthesis of Fully Functionalized B Ring System of Taxol.

K. Uoto, Isamu Shiina, N. Mori, 1995 .

An Asymmetric Synthesis of the Fully Functionalized AB Ring System of 12‐Demethyltaxol via Successive Stereoselective Allylation and Intramolecular Aldol Reactions.

Toshihiro Nishimura, Isamu Shiina, T. Mukaiyama, 1996 .

M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells

R. Abe, Y. Obata, Isamu Shiina, 2017, PloS one.

Search for novel anti-tumor agents from ridaifens using JFCR39, a panel of human cancer cell lines.

S. Dan, T. Yamori, Wenzhi Guo, 2013, Biological & pharmaceutical bulletin.

Synthesis of the new pseudo-symmetrical tamoxifen derivatives and their anti-tumor activity.

M. Ikekita, Akane Sasaki, Isamu Shiina, 2007, Bioorganic & medicinal chemistry letters.

Total synthesis of AMF-26, an antitumor agent for inhibition of the Golgi system, targeting ADP-ribosylation factor 1.

S. Dan, T. Yamori, Isamu Shiina, 2013, Journal of medicinal chemistry.

Synthesis and pharmacological evaluation of the novel pseudo-symmetrical tamoxifen derivatives as anti-tumor agents.

M. Ikekita, Y. Nagahara, T. Yamori, 2008, Biochemical pharmacology.

Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors.

K. Morohashi, F. Sugawara, S. Dan, 2015, Bioorganic & medicinal chemistry.

Total Synthesis of the Antitumor Depsipeptide FE399 and Its S‐Benzyl Derivative: A Macrolactamization Approach

Teruyuki Sato, Isamu Shiina, R. Kawahara, 2020, European Journal of Organic Chemistry.

Oncogenic Kit signalling on the Golgi is suppressed by blocking secretory trafficking with M-COPA in gastrointestinal stromal tumours.

H. Esumi, T. Nishida, R. Abe, 2018, Cancer letters.

BRAP2 inhibits the Ras/Raf/MEK and PI3K/Akt pathways in leukemia cells, thereby inducing apoptosis and inhibiting cell growth.

Y. Nagahara, T. Shinomiya, Isamu Shiina, 2021, Experimental and therapeutic medicine.

N822K- or V560G-mutated KIT activation preferentially occurs in lipid rafts of the Golgi apparatus in leukemia cells

T. Nishida, R. Abe, Tsuyoshi Takahashi, 2019, Cell Communication and Signaling.

Total Synthesis of Natural 8‐ and 9‐Membered Lactones: Recent Advancements in Medium‐Sized Ring Formation

Isamu Shiina, 2007 .

First Total Synthesis of Tanzawaic Acid B

Teruyuki Sato, Isamu Shiina, T. Mori, 2023, ACS Omega.

Asymmetric Total Synthesis of (+)-Coprophilin

Isamu Shiina, Takayuki Tonoi, Yuma Umezaki, 2017, Synthesis.

Chemistry and Structural Determination of Botcinolides, Botcinins, and Botcinic Acids

Isamu Shiina, H. Fukui, 2009 .

Asymmetric total synthesis of botcinins C, D, and F.

Isamu Shiina, H. Fukui, 2008, Organic letters.

Total Synthesis and the Confirmation of the Revised Structures of Botcinins A and B

Keisuke Tsuji, Isamu Shiina, H. Fukui, 2009 .

Asymmetric total synthesis of botcinic acid and its derivatives: synthetic revision of the structure of botcinolides

Keisuke Tsuji, Isamu Shiina, H. Fukui, 2008 .

Total Synthesis and Antimicrobial Evaluation of 23-Demethyleushearilide and Extensive Antimicrobial Evaluation of All Synthetic Stereoisomers of (16Z,20E)-Eushearilide and (16E,20E)-Eushearilide

Teruyuki Sato, K. Kamei, N. Ishiwada, 2019, Molecules.

An Effective Use of Benzoic Anhydride and Its Derivatives for the Synthesis of Carboxylic Esters and Lactones — Poweful and Convenient Mixed Anhydride Methods Promoted by Lewis Acids or Basic Catalysts

Isamu Shiina, 2004 .

A Convenient Method for the Preparations of Carboxamides and Peptides by Using Di(2-pyridyl) Carbonate and O,O′-Di(2-pyridyl) Thiocarbonate as Dehydrating Reagents