Chitra M. Vaidya

Synthesis and in vitro antitumor activity of new deaza analogues of the nonpolyglutamatable antifolate Nα-(4-amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523)

Joel E. Wright, Chitra M. Vaidya, Andre Rosowsky, 2002 .

The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine.

A. Rosowsky, Chitra M. Vaidya, J. Wright, 2000, Pharmacology & therapeutics.

Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues.

A. Rosowsky, Chitra M. Vaidya, J. Wright, 2000, Biochemical pharmacology.

Synthesis and Potent Antifolate Activity and Cytotoxicity of B-Ring Deaza Analogues of the Nonpolyglutamatable Dihydrofolate Reductase Inhibitor Nα-(4-Amino-4-deoxypteroyl)-Nδ-hemiphthaloyl-l-ornithine (PT523)

A. Rosowsky, Joel E. Wright, Ying-Nan P. Chen, 1998 .

Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.

A. Rosowsky, Chitra M. Vaidya, J. Wright, 2000, Journal of medicinal chemistry.

Thromboxane A2/prostaglandin H2 receptor antagonists.

G. L. Le Breton, D. Venton, Chitra M. Vaidya, 1990, Methods in enzymology.

Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.

B. Teicher, A. Rosowsky, Chitra M. Vaidya, 1997, Journal of medicinal chemistry.