A. T. Parsons

发表

Formal [4 + 2] cycloaddition of donor-acceptor cyclobutanes and aldehydes: stereoselective access to substituted tetrahydropyrans.

Jeffrey S Johnson, A. T. Parsons, Jeffrey S. Johnson, 2009, Journal of the American Chemical Society.

Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

E. Lobenhofer, Kristin L. Andrews, B. Herberich, 2015, ACS medicinal chemistry letters.

An Improved Process for the Preparation of a Covalent Kinase Inhibitor through a C–N Bond-Forming SNAr Reaction

A. T. Parsons, O. Thiel, Matthew S. Potter-Racine, 2018, Organic Process Research & Development.

Iron(II)-catalyzed trifluoromethylation of potassium vinyltrifluoroborates.

S. Buchwald, A. T. Parsons, T. Senecal, 2012, Angewandte Chemie.

Organic chemistry: A radical approach to diversity

S. Buchwald, A. T. Parsons, S. Buchwald, 2011, Nature.

Copper-catalyzed trifluoromethylation of unactivated olefins.

S. Buchwald, A. T. Parsons, S. Buchwald, 2011, Angewandte Chemie.

Dynamic kinetic asymmetric synthesis of substituted pyrrolidines from racemic cyclopropanes and aldimines: reaction development and mechanistic insights.

Andrew J. Neel, Andrew J Neel, A. T. Parsons, 2010, Journal of the American Chemical Society.

Synthesis of Substituted Pyridines via Formal (3+3) Cycloaddition of Enamines with Unsaturated Aldehydes and Ketones.

James I. Murray, A. T. Parsons, Carolyn S. Wei, 2022, The Journal of organic chemistry.

Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.

S. Buchwald, A. T. Parsons, T. Senecal, 2011, The Journal of organic chemistry.

Complexity-building annulations of strained cycloalkanes and C═O π bonds.

P. Pohlhaus, A. T. Parsons, S. D. Sanders, 2010, The Journal of organic chemistry.

Axial Chirality in the Sotorasib Drug Substance, Part 2: Leveraging a High-Temperature Thermal Racemization to Recycle the Classical Resolution Waste Stream

Kevin D. Nagy, Matthew G. Beaver, Derek B. Brown, 2022, Organic Process Research & Development.

Catalytic enantioselective synthesis of tetrahydrofurans: a dynamic kinetic asymmetric [3 + 2] cycloaddition of racemic cyclopropanes and aldehydes.

A. T. Parsons, Jeffrey S. Johnson, 2009, Journal of the American Chemical Society.

Catalytic Enantioselective Synthesis of Tetrahydrofurans: A Dynamic Kinetic Asymmetric [3 + 2] Cycloaddition of Racemic Cyclopropanes and Aldehydes.

A. T. Parsons, Jeffrey S. Johnson, 2009 .

Scope and mechanism for lewis acid-catalyzed cycloadditions of aldehydes and donor-acceptor cyclopropanes: evidence for a stereospecific intimate ion pair pathway.

P. Pohlhaus, A. T. Parsons, Wei Li, 2008, Journal of the American Chemical Society.

Diastereoselective synthesis of tetrahydrofurans via Palladium(0)-catalyzed [3 + 2] cycloaddition of vinylcyclopropanes and aldehydes.

A. T. Parsons, M. Campbell, Jeffrey S. Johnson, 2008, Organic letters.

Enantioselective Synthesis of a γ-Secretase Modulator via Vinylogous Dynamic Kinetic Resolution.

Jun Yu Li, Thomas E. La Cruz, Antonio Ramirez, 2018, The Journal of organic chemistry.

Dynamic Kinetic Asymmetric Transformations Involving Carbon–Carbon Bond Cleavage

A. T. Parsons, Jeffrey S. Johnson, 2013 .

Addressing Atropisomerism in the Development of Sotorasib, a Covalent Inhibitor of KRAS G12C: Structural, Analytical, and Synthetic Considerations

A. T. Parsons, S. Zech, B. Lanman, 2022, Accounts of chemical research.

Axial Chirality in the Sotorasib Drug Substance, Part 1: Development of a Classical Resolution to Prepare an Atropisomerically Pure Sotorasib Intermediate

Michael A. Lovette, W. Powazinik, M. Caporini, 2022, Organic Process Research & Development.

Kinetic and Mechanistic Investigations to Enable a Key Suzuki Coupling for Sotorasib Manufacture─What a Difference a Base Makes

A. T. Parsons, Carolyn S. Wei, Seb Caille, 2022, Organic Process Research & Development.

CMC development of [14C]-labeled sotorasib for the conduct of microtracer human ADME study

Prashant Agarwal, J. Huckle, A. T. Parsons, 2023, AAPS Open.

A Virtual Plant for Integrated Continuous Manufacturing of a Carfilzomib Drug Substance Intermediate, Part 2: Enone Synthesis via a Barbier-Type Grignard Process

Richard D. Braatz, Elçin Içten, Andrew J. Maloney, 2020 .

Characterization of false positive, contaminant-driven mutagenicity in impurities associated with the sotorasib drug substance.

Sheroy Minocherhomji, T. Monticello, Yong Xie, 2022, Regulatory toxicology and pharmacology : RTP.

Process development and manufacture of potassium 2-fluoro-6-hydroxyphenyltrifluoroborate

J. Tedrow, Lokesh Pawar, A. T. Parsons, 2019, Tetrahedron.

Room Temperature Aryl Trifluoromethylation via Copper-Mediated

A. T. Parsons, D. Sénécal, 2012 .

Continuous Process Improvement in the Manufacture of Carfilzomib, Part 2: An Improved Process for Synthesis of the Epoxyketone Warhead

Elçin Içten, Ning Yang, Sheng Cui, 2020 .

Development of a Commercial Manufacturing Process for Sotorasib, a First-in-Class KRASG12C Inhibitor

Alan H. Cherney, Matthew G. Beaver, Michael A. Lovette, 2022, Organic Process Research & Development.

Oxopyrido[2,3-d]pyrimidines as Covalent L858R/T790M Mutant Selective Epidermal Growth Factor Receptor (EGFR) Inhibitors.

E. Lobenhofer, B. Herberich, A. Tasker, 2015, ACS Medicinal Chemistry Letters.

Iron(II)-catalyzed trifluoromethylation of potassium vinyltrifluoroborates.

A. T. Parsons, T. Senecal, S. Buchwald, 2012, Angewandte Chemie.

Scope and mechanism for lewis acid-catalyzed cycloadditions of aldehydes and donor-acceptor cyclopropanes: evidence for a stereospecific intimate ion pair pathway.

P. Pohlhaus, A. T. Parsons, Wei Li, 2008, Journal of the American Chemical Society.