H. Knust

发表

Total synthesis of (-)-reidispongiolide A, an actin-targeting macrolide isolated from the marine sponge Reidispongia coerulea.

I. Paterson, G. J. Florence, R. Britton, 2008, Chemistry, an Asian journal.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

F. Blasco, F. Knoflach, G. Trube, 2009, Bioorganic & medicinal chemistry letters.

Imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepines as potent and highly selective GABAA alpha5 inverse agonists with potential for the treatment of cognitive dysfunction.

F. Knoflach, G. Trube, Maria-Clemencia Hernández, 2009, Bioorganic & medicinal chemistry letters.

Synthesis of antimicrofilament marine macrolides: synthesis and configurational assignment of a C5-C16 degradation fragment of reidispongiolide A.

I. Paterson, R. Britton, K. Ashton, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Toward the synthesis of reidispongiolide a: stereocontrolled synthesis of the C17-C22 and C23-C35 degradation fragments.

I. Paterson, R. Britton, K. Ashton, 2003, Organic letters.

Direct photocatalytic fluorination of benzylic C-H bonds with N-fluorobenzenesulfonimide.

Rainer E. Martin, Matthew B. Nodwell, H. Knust, 2015, Chemical communications.

Preclinical Evaluation of 18F-RO6958948, 11C-RO6931643, and 11C-RO6924963 as Novel PET Radiotracers for Imaging Tau Aggregates in Alzheimer Disease

D. Wong, R. Dannals, M. Honer, 2017, The Journal of Nuclear Medicine.

Preclinical Evaluation of 18 FRO 6958948 , 11 CRO 6931643 and 11 CRO 6924963 as Novel Radiotracers for Imaging Aggregated Tau in Alzheimer ’ s Disease with Positron Emission Tomography

D. Wong, R. Dannals, M. Honer, 2017 .

Synthesis of fluorinated tricyclic scaffolds by intramolecular [2+2] photocycloaddition reactions.

T. Woltering, T. Bach, M. Nettekoven, 2012, Angewandte Chemie.

Biochemical and behavioural characterization of EMPA, a novel high‐affinity, selective antagonist for the OX2 receptor

E. Pinard, P. Malherbe, J. Moreau, 2009, British journal of pharmacology.

Bis(arylvinyl)pyrazines, -pyrimidines, and -pyridazines as imaging agents for tau fibrils and β-amyloid plaques in Alzheimer's disease models.

I. Hilger, J. Herms, B. Schmidt, 2012, Journal of medicinal chemistry.

Conformationally restricted pyrrolidines by intramolecular [2+2] photocycloaddition reactions.

T. Woltering, T. Bach, M. Nettekoven, 2013, Chemical communications.

Synthesis and structural analysis of a new class of azaspiro[3.3]heptanes as building blocks for medicinal chemistry.

E. Carreira, M. Rogers-Evans, Carine M. Guerot, 2010, Organic letters.

Expanding the azaspiro[3.3]heptane family: synthesis of novel highly functionalized building blocks.

E. Carreira, Carine M. Guerot, H. Knust, 2012, Organic letters.

Adventures in drug-like chemistry space: from oxetanes to spiroazetidines and beyond!

E. Carreira, Jean-Marc Plancher, M. Rogers-Evans, 2014, Chimia.

Synthesis of novel angular spirocyclic azetidines.

E. Carreira, Carine M. Guerot, H. Knust, 2011, Organic letters.

Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer's Disease with Positron Emission Tomography.

M. Körner, D. Holt, T. Hartung, 2017, Journal of medicinal chemistry.

Mapping the binding pocket of a novel, high-affinity, slow dissociating tachykinin NK3 receptor antagonist: Biochemical and electrophysiological characterization

W. Spooren, C. Bissantz, P. Malherbe, 2014, Neuropharmacology.

RO4938581, a novel cognitive enhancer acting at GABAA α5 subunit-containing receptors

J. Moreau, F. Knoflach, G. Trube, 2008, Psychopharmacology.

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

James Robert Brašić, C. Lyketsos, S. Resnick, 2018, bioRxiv.

Basmisanil, a highly selective GABAA-α5 negative allosteric modulator: preclinical pharmacology and demonstration of functional target engagement in man

J. Hipp, L. Squassante, M. Honer, 2021, Scientific Reports.

The discovery and unique pharmacological profile of RO4938581 and RO4882224 as potent and selective GABAA alpha5 inverse agonists for the treatment of cognitive dysfunction.

F. Knoflach, G. Trube, H. Fischer, 2009, Bioorganic & medicinal chemistry letters.

A case study in conformation design: learning by doing.

R. W. Hoffmann, H. Knust, 2002, Chemical record.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

F. Blasco, F. Knoflach, G. Trube, 2009, Bioorganic & Medicinal Chemistry Letters.

First in-human PET study of 3 novel tau radiopharmaceuticals: [11C]RO6924963, [11C]RO6931643, and [18F]RO6958948

Dean F. Wong, Hiroto Kuwabara, Robert A. Comley, 2015, Alzheimer's & Dementia.