J. Wicha

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A synthetic approach to the functionalized hydroazulene core of guanacastepenes and heptemerenes

M. Michalak, K. Michalak, J. Wicha, 2008 .

The lead structure in cardiac glycosides is 5 β,14 β-androstane-3 β,14-diol

M. Masnyk, C. Lindig, K. Repke, 1985, Naunyn-Schmiedeberg's Archives of Pharmacology.

Studies towards dynamic kinetic resolution of 4-hydroxy-2-methylcyclopent-2-en-1-one and its E-O-trityloxime

J. Wójcik, K. Michalak, J. Wicha, 2016 .

The smiles rearrangement and the julia-kocienski olefination reaction.

J. Wicha, Krzysztof Pleśniak, A. Zarecki, 2007, Topics in current chemistry.

The reaction of trimethylsilyl ethylene oxide with α-sulfonyl anions and α,α-sulfonyl dianions. A method for stereocontrolled synthesis of (E)- and (Z)-allylic alcohols

M. Masnyk, P. Jankowski, J. Wicha, 1991 .

Synthesis and evaluation of Na+/K+-ATP-ase inhibiting and cytotoxic in vitro activities of oleandrigenin and its selected 17β-(butenolidyl)- and 17β-(3-furyl)- analogues.

M. Strnad, M. Kubala, K. Michalak, 2020, European journal of medicinal chemistry.

Synthesis and evaluation of cytotoxic and Na+/K+-ATP-ase inhibitory activity of selected 5α-oleandrigenin derivatives.

M. Strnad, M. Kubala, K. Michalak, 2019, European journal of medicinal chemistry.

Synthetic Approach to the Core Structure of Oleandrin and Related Cardiac Glycosides with Highly Functionalized Ring D.

Maja Morawiak, K. Michalak, J. Wicha, 2016, Organic letters.

Enantioselective synthesis of 24,25-dihydroxy vitamin D3 northern portion from (S)-3-hydroxy-2,2-dimethylcyclohexane-1-one. Remote asymmetric induction in an acid-catalysed conjugate addition

J. Wicha, W. Stepanenko, 1998 .

Structural analysis of 25-hydroxycholesterol stereoisomers differing in configuration in position 17 and 20, by three-dimensional NMR spectra

Maria Misiak, W. Koźmiński, J. Wójcik, 2019, Steroids.

The synthesis of cardenolide and bufadienolide aglycones, and related steroids bearing a heterocyclic subunit.

M. Michalak, K. Michalak, J. Wicha, 2017, Natural product reports.

1,3-Chirality Transfer by Fragmentation of Allylsulfinic Acids: A Diastereoselective Approach to Vinyl Bromides Related to trans-Hydrindane or trans-Decalin

J. Wicha, Paweł Chochrek, 2007 .

The first synthesis and biological testing of the enantiomer of 1α,25-dihydroxyvitamin D 3

A. Steinmeyer, U. Zügel, J. Wicha, 2001 .

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

A. Steinmeyer, U. Zügel, J. Wicha, 2001, Bioorganic & medicinal chemistry letters.

Synthetic studies on dicyclopenta[a,d]cyclooctane terpenoids: construction of the core structure of fusicoccins and ophiobolins on the route involving a Wagner-Meerwein rearrangement.

M. Michalak, Z. Urbańczyk-Lipkowska, K. Michalak, 2011, The Journal of organic chemistry.

Enantioselective syntheses of a 1α-hydroxyvitamin D ring A precursor from 3-(triphenylsilyl)glycidol and from malic acid

P. Jankowski, J. Wicha, B. Achmatowicz, 1996 .

Application of a metathesis reaction in the synthesis of sterically congested medium-sized rings. A direct ring closing versus a double bond migration-ring closing process.

M. Michalak, J. Wicha, 2011, Organic & biomolecular chemistry.

Tandem Transformations Initiated by the Migration of a Silyl Group. Some New Synthetic Applications of Silyloxiranes

P. Jankowski, P. Raubo, J. Wicha, 1995 .

Methods for the construction of trans-hydrindane rings and their origins in steroid chemistry. Vitamin D total synthesis

P. Jankowski, J. Wicha, S. Marczak, 1998 .

Total synthesis of a CD-ring: side-chain building block for preparing 17-epi-calcitriol derivatives from the Hajos-Parrish dione.

K. Michalak, J. Wicha, 2011, The Journal of organic chemistry.

Synthesis of 21-hydroxycholesterol and 25-hydroxycholesterol from 3β-hydroxyandrost-5-en-17-one. A method for the stereospecific construction of sterol side-chains

J. Wicha, K. Bal, 1979 .

Various approaches to the construction of aliphatic side chains of steroids and related compounds

J. Wicha, D. Piatak, 1978 .

A new approach to a vitamin D ring C/D building block from the Hajos dione, involving epoxide opening at the more substituted carbon atom

K. Michalak, J. Wicha, Paweł Chochrek, 2006 .

An expedited approach to the vitamin D trans-hydrindane building block from the Hajos dione.

J. Wicha, Paweł Chochrek, 2006, Organic letters.

Catalytic enantioselective annulation using phenylsulfanylmethyl vinyl ketone. An approach to trans-hydrindane building blocks for ent-vitamin D3 synthesis

J. Wicha, W. Stepanenko, A. Przeździecka, 1999 .

TOTAL SYNTHESIS OF 25-HYDROXY VITAMIN D3 NORTHERN PORTION, INVOLVING TANDEM CONJUGATE ADDITIONS

Z. Urbańczyk-Lipkowska, K. Michalak, J. Wicha, 1998 .

Synthesis of a Vitamin D3 Hydrindan Ring−Side-Chain Building Block, Involving Tandem Conjugate Addition and Alkylation Reactions

J. Wicha, P. Grzywacz, A. Marczak, 1997 .

New diastereoselective approach to trans-hydrindane derivatives. Synthesis of a 8-phenylsulphonyl-A,B-descholestane derivative, a precursor to 25-hydroxyvitamin D3

K. Michalak, J. Wicha, W. Stepanenko, 1996 .

Short total synthesis of the CD rings — side chain fragment of 25-hydroxyvitamin D3 and De-AB-Cholestane derivatives, involving two tandem Mukaiyama-Michael conjugate additions

K. Michalak, J. Wicha, S. Marczak, 1995 .

BF3-mediated reaction of a sulphone with aldehydes

J. Wicha, B. Achmatowicz, A. Daniewski, 1988 .

Oxidation of secondary alcohols to ketones by means of iodobenzene dichloride and pyridine

J. Wicha, A. Zarecki, M. Kocór, 1973 .

Lewis Acid-Mediated Addition of Lithiated Alkyl Phenyl Sulphones and Oxiranes. A Method for Synthesis of α, β-Unsaturated Ketones

J. Wicha, S. Marczak, 1990 .

An efficient synthesis of vinylsilanes from acylsilanes and alkyl 1-phenyl-1H-tetrazol-5-yl sulfones. Brook vs Smiles rearrangement.

P. Jankowski, J. Wicha, Krzysztof Pleśniak, 2003, Organic letters.

A facile construction of the tricyclic 5-7-6 scaffold of fungi-derived diterpenoids. The first total synthesis of (±)-heptemerone G and a new approach to Danishefsky’s intermediate for a guanacastepene A synthesis

M. Michalak, K. Michalak, J. Wicha, 2010 .

A convenient preparation of (S)-(−)-4-hydroxy-2-methylcyclopent-2-en-1-one and its application as a chiral synthetic equivalent of 2-methylcyclopent-2-en-1-one in the terpenoid synthesis

K. Michalak, J. Wicha, 2014 .

Enantioselective synthesis of the methylenecyclopropane derivative related to hypoglycine, from malic acid

J. Wicha, M. Kabat, B. Achmatowicz, 1991 .

Synthesis of the glycidol (1R,2R)-1-iodo-2-(triphenylsilyloxy)cyclopropane: new rearrangements of 2,3-epoxy-3-(trialkyl/arylsilyl)-propan-1-ols

P. Raubo, J. Wicha, B. Achmatowicz, 1995 .

Oxidation of an αβ-(epoxyalkyl)trimethylsilane with pyridine oxides in the presence of silylating agents. A facile enantioselective synthesis of glyceraldehyde derivatives

P. Raubo, J. Wicha, 1994 .

The reaction of β-(trimethylsilyl)alkyl phenyl sulfones with oxiranes. A method for stereocontrolled synthesis of homoallylic alcohols

J. Wicha, M. Kabat, 1991 .

An iterative synthesis of optically-active 1,2-diols using α,β-epoxysilanes as key intermediates

P. Raubo, J. Wicha, 1996 .

Iterative syn-1,3,5-triol synthesis utilizing the reaction of β-(trimethylsily)dalkyl phenyl sulphones with oxiranes☆

J. Wicha, B. Achmatowicz, 1993 .

A Facile Approach to 20-Isocholesterol From An Androstane Derivative

A. Jarzebski, J. Wicha, 1989 .

Steroids containing ring A aromatic. XIV. Ruthenium tetroxide oxidation of aromatic steroids

E. Caspi, J. Wicha, D. Piatak, 1969 .

Optically active acylsilanes. Synthesis of selected 2,3-O-isopropylidene-1-(trialkyl/arylsilyl)glyceraldehyde derivatives

P. Raubo, J. Wicha, 1995 .

Methylation and hydroxymethylation involving free radicals. An application to stereoselective construction of 20(S) sterol side-chain

J. Wicha, G. Snatzke, A. Kurek-Tyrlik, 1988 .

Methylation and hydroxymethylation of allylic alcohols via radical cyclization. Methodology for stereoselective construction of an aliphatic chain in application to sterol synthesis

J. Wicha, A. Zarecki, A. Kurek-Tyrlik, 1990 .

Facile synthesis of enantiomerically pure tert-butyl(methyl)phenylsilanes

E. Schaumann, P. Jankowski, G. Adiwidjaja, 1999 .

Directive and shielding effects of the trimethylsilyl group. Unprecedented β-selectivity in the reaction of α,β-epoxyalkylsilanes with hindered α-sulphonyl anions

M. Masnyk, P. Jankowski, J. Wicha, 1991 .

A method for facile syntheses of the enantiomers of endo- and exo-brevicomins from tartaric acid

J. Wicha, B. Achmatowicz, 1988 .

Synthesis of (23R)‐ and (23S)‐23H‐Isocalysterols, Marine Sterols with a Cyclopropene Moiety in the Side Chain

J. Wicha, Kazimierz Minksztym, A. Kurek-Tyrlik, 2000 .

Reaction of arylsulfonylhydrazones of aldehydes with alpha-magnesio sulfones. A novel olefin synthesis.

K. Michalak, J. Wicha, S. Marczak, 2001, The Journal of organic chemistry.

Synthesis of a cardenolide, 3-O-methyl uzarigenin, with 14β-hydroxyandrost-16-ene as the key intermediate

J. Wicha, G. Groszek, A. Kurek-Tyrlik, 1989 .

Regioselective β-addition of sulfonyl anions to an α,β-epoxysilane. Use of triphenylsilyloxirane for synthesis of stable cyclopropene derivatives

P. Jankowski, J. Wicha, 1992 .

Total synthesis of rac-9,11-dehydrodigitoxigenin 3-tetrahydropyranyl ether

H. Duddeck, M. Masnyk, J. Wicha, 1988 .

SYNTHESIS OF PREGN‐17 20 ‐EN‐21‐OIC ACID DERIVATIVES. THE WITTIG‐HORNER REACTION ON STEROIDAL 17‐KETONES

J. Wicha, K. Bal, S. Piekut, 1977 .

Regioselective β-Addition of Sulfonyl Anions to an α,β- Epoxysilane. Use of Triphenylsilyloxirane for Synthesis of Stable Cyclopropene Derivatives.

P. Jankowski, J. Wicha, 1992 .

The reaction of α,β-epoxysilanes with metallated alkylaryl sulphones. A novel approach to allylic alcohols

M. Masnyk, J. Wicha, 1988 .

Chemoenzymatic approach to optically active 4-hydroxy-5-alkylcyclopent-2-en-1-one derivatives: an application of a combined circular dichroism spectroscopy and DFT calculations to assignment of absolute configuration.

J. Frelek, K. Michalak, J. Wicha, 2014, Chirality.

Migration of aryl groups from silicon to carbon in α,β-epoxysilanes. A new model for hypervalent silicon study

P. Jankowski, J. Wicha, B. Achmatowicz, 1998 .

Synthesis of pregnenoic acid derivatives possessing structural elements of prostaglandins [1]

J. Wicha, K. Bal, 1977, Steroids.

Synthesis of (+)‐disparlure using the reaction of 6‐methylheptyl phenyl sulfone with trimethylsilyloxirane and asymmetric epoxidation

M. Masnyk, J. Wicha, S. Marczak, 1990 .

Synthesis of (+)-disparlure using the reaction of 6-methylheptyl phenyl sulphone with trimethylsilyl ethylene oxide and asymmetric epoxidation

M. Masnyk, J. Wicha, S. Marczak, 1989 .

Oxidation with chlorine complexes. Specific oxidation of secondary hydroxyl groups in the presence of primary hydroxyl groups in polyhydric alcohols.

J. Wicha, A. Zarecki, 1974 .

Reaction of (α,β-Epoxyalkyl)silanes with α-Sulfonyl Anions and α-Sulfonyl Anions in the Presence of a Lewis Acid. A Method for the Synthesis of (Z)-sec-Allylic Alcohols and β,γ-Unsaturated Alkyl Phenyl Sulfones

M. Masnyk, J. Wicha, 1994 .

Enantioselective Silicon-Mediated Synthesis of Glyceraldehyde Derivatives from Propargyl Alcohol

P. Raubo, J. Wicha, 1993 .

Expedited approach to the vitamin D trans-hydrindane building block from the Hajos dione. Comparative study on various methods for the selective deoxygenation of one of the hydroxy groups in a diol.

J. Wicha, Paweł Chochrek, 2007, The Journal of organic chemistry.

Oxidation of 1-(Triphenylsilyl)cyclopropenes with Dimethyldioxirane

Xiaotai Wang, P. Jankowski, L. Paquette, 1994 .

Oxidation of 1‐(Triphenylsilyl)cyclopropenes with Dimethyldioxirane.

Xiaotai Wang, P. Jankowski, L. Paquette, 1995 .

Pd-catalyzed cross-coupling reaction of sterically hindered vinyl iodides and organozinc reagents. Synthesis of vitamin D analogues with an aromatic ring attached at C-17

J. Wicha, A. Przeździecka, A. Kurek-Tyrlik, 2002 .

Transformations of steroidal neopentyl systems. II. Migration of acetate from the 3β- to the 19-hydroxyl in Δ5 and A/B-trans steroids

E. Caspi, J. Wicha, 1967 .

Synthesis of Optically Active 2,3-O-Isopropylidene-1-(trimethylsilyl)glyceraldehyde and Other Derivatives of (.alpha.-Hydroxyacyl)silane

P. Raubo, J. Wicha, 1994 .

Transformations of steroidal neopentyl systems. VII. Mechanism of the transformation of (19R)-hydroxy-19a-methyl-(5 )-3-ones to 19-keto-19a-methyl-(5 )-3 -hydroxy analogs.

E. Caspi, J. Wicha, 1973, The Journal of organic chemistry.

Synthesis of 17b-Pyridyl- and 17b-Pyridonyl-androstane Derivatives

M. Masnyk, J. Wicha, 1981 .

Estrogen biosynthesis: concerning the obligatory intermediacy of 2.beta.-hydroxy-10.beta.-formyl androst-4-ene-3,17-dione

G. Spiteller, T. Arunachalam, E. Caspi, 1984 .

α-Methylene-γ-lactone fused to steroidal ring d as potential antitumor agent

W. Peczyńska-Czoch, J. Wicha, M. Kabat, 1983, Steroids.

Cardiotonic steroids 5. a synthesis of bufadienolides and cardenolides from 3 beta acetoxy 5 androsten 17 one via common intermediates

J. Wicha, M. Kabat, A. Kurek, 1983 .

Construction of the tricyclic 5-7-6 scaffold of fungi-derived diterpenoids. Total synthesis of (±)-heptemerone G and an approach to Danishefsky's intermediate for guanacastepene A synthesis.

M. Michalak, K. Michalak, J. Wicha, 2010, The Journal of organic chemistry.

Cardiotonic Steroids. Part 7. Synthesis of 17β‐Pyridylandrostane Derivatives.

H. Duddeck, M. Masnyk, J. Wicha, 1984 .

Synthesis of 21-(3-Methylbutyl)cholest-5-ene-3β,3′,25-triol and 21-(2-Methylpropoxy)cholest-5-ene-2′,3β,25-triol, the First “Double Side Chain” Cholesterol Analogues

J. Wicha, M. Calverley, A. Kurek-Tyrlik, 1997 .

Magnesium in Methanol Selective Reduction of a Conjugate Double Bond in an α,β-Unsaturated Ester Related to Pregnadiene

J. Wicha, A. Zarecki, 1996 .

The lead structure in cardiac glycosides is 5 beta, 14 beta-androstane-3 beta 14-diol.

M. Masnyk, C. Lindig, K. Repke, 1985, Naunyn-Schmiedeberg's archives of pharmacology.

Transformations of tartaric acid: A facile synthesis of derivatives of optically active α-hydrohyaldehydes

J. Wicha, B. Achmatowicz, 1987 .

A synthesis of 17-epi-calcidiol

Z. Urbańczyk-Lipkowska, K. Michalak, J. Wicha, 2004 .

Synthesis and biological activity of the 1alpha,25-dihydroxyvitamin D3 diastereomer with unnatural configuration at the rings C/D side-chain moiety.

A. Steinmeyer, U. Zügel, J. Wicha, 2001, Bioorganic & medicinal chemistry letters.

Transformations of Tartaric Acid: A Facile Synthesis of Derivatives of Optically Active α-Hydroxyaldehydes.

J. Wicha, B. Achmatowicz, 1987 .

A novel approach to prostaglandins from the corey lactone involving BF3-mediated reactions of a sulphone and aldehydes

J. Wicha, B. Achmatowicz, A. Daniewski, 1985 .

Synthesis of four stereoisomeric tetrose derivatives from propargyl alcohol. One-carbon homologation of vinylsilanes via .alpha.,.beta.-epoxy silanes

P. Raubo, J. Wicha, B. Achmatowicz, 1992 .

Cardiotonic steroids. Part 10. Synthesis of digitoxigenin from 3β-acetoxyandrost-5-en-17-one involving palladium-induced rearrangement of an allylic epoxide

J. Wicha, M. Kabat, 1985 .

Studies Towards the Total Synthesis of Di- and Sesterterpenes with Dicyclopenta[a,d]cyclooctane Skeletons. Three-component Approach to the A/B Rings Building Block

M. Michalak, K. Michalak, J. Wicha, 2005, Molecules.

Studies toward the total synthesis of di- and sesterterpenes with a dicyclopenta[a,d]cyclooctane skeleton. Construction of a versatile A/B ring building block via a ring-closing metathesis reaction and carbocationic rearrangement

M. Michalak, K. Michalak, J. Wicha, 2005 .

Synthesis of 25-hydroxycholesterol from 3β-hydroxyandrost-5-en-17-one. A method for stereospecific construction of a sterol side-chain

J. Wicha, K. Bal, 1975 .