Xiaoan Wen

发表

Electronic and steric effects on the intramolecular Schmidt reaction of alkyl azides with secondary benzyl alcohols

Hongbin Sun, Xiaowei Sun, Chengzhe Gao, 2014 .

Design, Synthesis, and Biological Evaluation of Triazolone Derivatives as Potent PPARα/δ Dual Agonists for the Treatment of Nonalcoholic Steatohepatitis.

Jun Liu, Hongbin Sun, Gan Sun, 2022, Journal of medicinal chemistry.

Synthesis and cytotoxicity evaluation of oleanolic acid derivatives.

Jun O. Liu, Hongbin Sun, Xiaoan Wen, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Novel Nucleotide Prodrugs with Improved Potency Against HCV Variants Carrying NS5B S282T Mutation.

Guangji Wang, Hongbin Sun, Haoliang Yuan, 2017, Journal of medicinal chemistry.

Direct Intermolecular C-H Functionalization Triggered by 1,5-Hydride Shift: Access to N-Arylprolinamides via Ugi-Type Reaction.

Guangji Wang, Hongbin Sun, Xiaoan Wen, 2017, Organic letters.

Discovery of Novel Potent Muscarinic M3 Receptor Antagonists with Proper Plasma Stability by Structural Recombination of Marketed M3 Antagonists

Jun O. Liu, Hongbin Sun, Xiaoan Wen, 2017, ChemMedChem.

Structural insights into ligand binding features of dual FABP4/5 inhibitors by molecular dynamics simulations

Hongbin Sun, Haoliang Yuan, Chaoxin Wang, 2019, Journal of biomolecular structure & dynamics.

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design.

Hongbin Sun, Liu Yang, Xiaoan Wen, 2018, Bioorganic & medicinal chemistry letters.

Stereoselective Synthesis of Arylglycine Derivatives via Palladium-Catalyzed α-Arylation of a Chiral Nickel(II) Glycinate.

Hongbin Sun, Fan Zhang, Zhuang Song, 2015, The Journal of organic chemistry.

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid.

Hongbin Sun, Haoliang Yuan, Xiaoan Wen, 2020, European journal of medicinal chemistry.

Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline.

Juzheng Zhang, Xiaoan Wen, Keguang Cheng, 2022, Bioorganic chemistry.

Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors.

W. Gu, Chang Xu, Hongbin Sun, 2017, Bioorganic & medicinal chemistry letters.

Synthesis of Functionalized Thiazolidin-2-imine and Oxazolidin-2-one Derivatives from p-Quinamines via [3 + 2] Annulation of Isothiocyanates and CO2.

Haoliang Yuan, Xiaoan Wen, Qinglong Xu, 2022, The Journal of organic chemistry.

Current developments in pharmacological therapeutics for chronic constipation

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015, Acta pharmaceutica Sinica. B.

Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression

Hongbin Sun, Xiaoan Wen, Zhi-Qi Feng, 2019, Acta pharmaceutica Sinica. B.

Synthesis and biological evaluation of Complex I inhibitor R419 and its derivatives as anticancer agents in HepG2 cells.

Hongbin Sun, Xiaoan Wen, Pengfei Wang, 2018, Bioorganic & medicinal chemistry letters.

Concise Access to 1,2-Pyrrole-Annulated Benzazepines through a Brønsted Acid Catalyzed Redox-Neutral Domino Reaction

Hongbin Sun, H. Yaping, Xiaoan Wen, 2015 .

Synthesis and Evaluation of Novel Oleanolic Acid Derivatives as Potential Antidiabetic Agents

Luyong Zhang, Jun O. Liu, X. Jia, 2014, Chemical biology & drug design.

USP7: Target Validation and Drug Discovery for Cancer Therapy.

Hongbin Sun, Haoliang Yuan, Xiaoan Wen, 2018, Medicinal chemistry (Shariqah (United Arab Emirates)).

Discovery of highly potent renin inhibitors potentially interacting with the S3' subsite of renin.

Yong Wu, Hongbin Sun, Xiuhong Yang, 2015, European journal of medicinal chemistry.

Pentacyclic triterpenes. Part 5: synthesis and SAR study of corosolic acid derivatives as inhibitors of glycogen phosphorylases.

Luyong Zhang, Jun O. Liu, Hongbin Sun, 2007, Bioorganic & medicinal chemistry letters.

Pentacyclic triterpenes. Part 1: the first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases.

Luyong Zhang, Jun O. Liu, Guan-zhong Wu, 2005, Bioorganic & medicinal chemistry letters.

Formal [4 + 1] cycloaddition of o-quinone methides: facile synthesis of dihydrobenzofurans

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015 .

Synthesis and anti-cancer activity of ND-646 and its derivatives as acetyl-CoA carboxylase 1 inhibitors.

Wei Zhao, Xiaoan Wen, Zhi-Qi Feng, 2019, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, synthesis, and biological evaluation of (2E)-(2-oxo-1, 2-dihydro-3H-indol-3-ylidene)acetate derivatives as anti-proliferative agents through ROS-induced cell apoptosis.

Jun O. Liu, Hongbin Sun, Haoliang Yuan, 2016, European journal of medicinal chemistry.

Efficient propylphosphonic anhydride (®T3P) mediated synthesis of benzothiazoles, benzoxazoles and benzimidazoles

B. Déprez, R. Deprez-Poulain, Xiaoan Wen, 2012 .

Construction of Oxadiazepines via Lewis Acid-Catalyzed Tandem 1,5-Hydride Shift/Cyclization.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015, The Journal of organic chemistry.

Approach to N-aryl pyrroles via diphenyl phosphate-catalyzed [1,5]-Hydride shift/isomerization reaction with indoles

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015 .

Quinone methides as [1, 5]-hydride acceptors: approach to N-aryl pyrroles

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015 .

Intramolecular redox reaction for the synthesis of N-aryl pyrroles catalyzed by Lewis acids.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2014, Organic & biomolecular chemistry.

Lewis acid-catalyzed redox-neutral amination of 2-(3-pyrroline-1-yl)benzaldehydes via intramolecular [1,5]-hydride shift/isomerization reaction

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2014, Beilstein journal of organic chemistry.

Discovery of highly potent DPP-4 inhibitors by hybrid compound design based on linagliptin and alogliptin.

Jun O. Liu, Hongbin Sun, L. Kong, 2014, European journal of medicinal chemistry.

Visible-light induced isoindoles formation to trigger intermolecular Diels-Alder reactions in the presence of air.

H Zhao, Yong Cheng, Hongbin Sun, 2015, Organic letters.

Proton-exchanged montmorillonite-mediated reactions of methoxybenzyl esters and ethers

Hongbin Sun, Chang Xu, Lingyi Kong, 2014 .

Synthesis of indole-fused scaffolds via [3+3] cyclization reaction of 2-indolylmethanols with quinone imines

Xiaoan Wen, Qinglong Xu, Le Zhen, 2021 .

Asymmetric Synthesis of 3,4‐Disubstituted Proline Derivatives: Application in Synthesis of Hepatitis C Virus Protease Inhibitor Telaprevir

Hongbin Sun, Fan Zhang, Xiaoan Wen, 2014 .

Concise Synthesis of Spiro[indoline‐3,2′‐pyrrolidine] and 1‐Azacarbazole Derivatives via Copper‐Catalyzed Cyclization of Indoles

Hongbin Sun, Xiaoan Wen, Pengfei Wang, 2017 .

Dearomatization of Indole Derivatives via Palladium‐Catalyzed CH Bond Functionalization of Pyrroles: Convenient Construction of Spiroindolenines

Hongbin Sun, Chang Xu, Xiaoan Wen, 2016 .

C–H bond functionalization via [1,5]-hydride shift/cyclization sequence: approach to spiroindolenines.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2015, The Journal of organic chemistry.

The Rh(ii)-catalyzed formal N-S bond insertion reaction of aryldiazoacetates into N-phenyl-sulfenyl phthalimide.

Hongbin Sun, T. Xin, Zhuang Song, 2016, Chemical communications.

Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.

Luyong Zhang, Jun O. Liu, Xiao-ming Wu, 2006, Bioorganic & medicinal chemistry letters.

Copper-catalyzed intramolecular redox reaction: Asymmetric synthesis of chiral 2-(1H-pyrrol-1-yl)-mandelic acid esters

Xiaoan Wen, Qinglong Xu, Chao Lin, 2018, Tetrahedron.

Synthesis and Preliminary Evaluation of 1‐[18F]Fluoro‐1‐deoxy‐2,5‐anhydro‐D‐mannitol as a PET Radiotracer for Breast Cancer Imaging

Ben Niu, Xiao-ming Wu, Hongbin Sun, 2013 .

Structure-activity relationships of imidazole-derived 2-[N-carbamoylmethyl-alkylamino]acetic acids, dual binders of human insulin-degrading enzyme.

Wei-Jen Tang, B. Staels, F. Leroux, 2015, European journal of medicinal chemistry.

N-Substituted 3(10H)-Acridones as Visible-Light, Water-Soluble Photocatalysts: Aerobic Oxidative Hydroxylation of Arylboronic Acids.

Yong Cheng, Hongbin Sun, Xiaoan Wen, 2017, The Journal of organic chemistry.

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I.

Haoliang Yuan, M. Qian, Xiaoan Wen, 2020, European journal of medicinal chemistry.

Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies.

S. Zographos, N. Oikonomakos, D. Leonidas, 2008, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4-Epi-hederagonic Acid as Glycogen Phosphorylase Inhibitors

Luyong Zhang, Jun O. Liu, Hongbin Sun, 2010 .

Efficient access to 2-isobetulinic acid, 2-isooleanolic acid, and 2-isoursolic acid.

Hongbin Sun, Xiaoan Wen, Jia Hao, 2008, The Journal of organic chemistry.

Practical Synthesis of α‐Amyrin, β‐Amyrin, and Lupeol: The Potential Natural Inhibitors of Human Oxidosqualene Cyclase

Jun O. Liu, Hongbin Sun, Xiaoan Wen, 2017, Archiv der Pharmazie.

(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7.

Xiaoan Wen, Keguang Cheng, Jingjing Liu, 2022, Chemico-biological interactions.

Hypolipidemic effect of oleanolic acid is mediated by the miR‐98‐5p/PGC‐1β axis in high‐fat diet‐induced hyperlipidemic mice

Siyu Chen, Jun O. Liu, Wenxiang Zhang, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A formal intermolecular [4 + 2] cycloaddition reaction of 1,3-disubstituted indoles and alkylquinones.

H Zhao, Hongbin Sun, Xiaoan Wen, 2017, Organic & biomolecular chemistry.

Oleanolic acid derivatives for pharmaceutical use: a patent review

Hongbin Sun, Xiaoan Wen, Chao Lin, 2016, Expert opinion on therapeutic patents.

N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure-activity relationships and X-ray crystallographic studies.

Jun O. Liu, Hongbin Sun, Hui Chen, 2020, European journal of medicinal chemistry.

Discovery of Orally Bioavailable N-Benzylpiperidinol Derivatives as Potent and Selective USP7 Inhibitors with In Vivo Antitumor Immunity Activity against Colon Cancer.

Yuchen Gao, Hongbin Sun, Xiaoan Wen, 2022, Journal of medicinal chemistry.

Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors.

Xiaoan Wen, Dongyin Chen, Fei Li, 2019, Bioorganic & medicinal chemistry letters.

Discovery of novel estrogen-related receptor α inverse agonists by virtual screening and biological evaluation

H Zhao, Xiaoan Wen, Kaiwen Hu, 2019, Journal of Biomolecular Structure and Dynamics.

Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation

Keguang Cheng, Xiaoan Wen, Liang Dai, 2020, J. Chem. Inf. Model..

Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction

Liang Dai, Keguang Cheng, Hongbin Sun, 2021, J. Chem. Inf. Model..

Discovery of the First Subnanomolar PPARα/δ Dual Agonist for the Treatment of Cholestatic Liver Diseases.

Hongbin Sun, Gan Sun, Xin Liu, 2023, Journal of medicinal chemistry.

Efficient Propylphosphonic Anhydride (®T3P) Mediated Synthesis of Benzothiazoles, Benzoxazoles and Benzimidazoles.

B. Déprez, R. Deprez-Poulain, Xiaoan Wen, 2012 .

The STING antagonist H‐151 ameliorates psoriasis via suppression of STING/NF‐κB‐mediated inflammation

Jun O. Liu, Hongbin Sun, Xiaoan Wen, 2021, British journal of pharmacology.

Identification of indole-based activators of insulin degrading enzyme.

B. Staels, F. Leroux, B. Déprez, 2021, European journal of medicinal chemistry.

Organocatalytic Para-Selective Amination of Phenols with Iminoquinone Monoacetals.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2017, Organic letters.

Chiral Phosphoric Acid Catalyzed Asymmetric Desymmetrization of para-Quinamines with Isocyanates: Access to Functionalized Imidazolidin-2-one Derivatives.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2021, Organic letters.

N-substituted-3(10H)-acridones as visible-light photosensitizers for organic photoredox catalysis

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2018 .

Protonated montmorillonite-mediated highly specific isomerization of oleanolic acid esters: application to the synthesis of Δ13(18)-CDDO-Me.

Hongbin Sun, L. Kong, Xiaoan Wen, 2016, Organic & biomolecular chemistry.

Organophosphorus-Catalyzed "Dual-Substrate Deoxygenation" Strategy for C-S Bond Formation from Sulfonyl Chlorides and Alcohols/Acids.

Xin Liu, Hongbin Sun, Gan Sun, 2023, Journal of Organic Chemistry.

Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.

Hualiang Jiang, Honglin Li, Hong Liu, 2011, European journal of medicinal chemistry.

Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Hongbin Sun, Wenfeng Zhao, Xiaoan Wen, 2020, J. Chem. Inf. Model..

A Selectivity Study of FFAR4/FFAR1 Agonists by Molecular Modeling

Hongbin Sun, Xiangying Zhang, Xiaoan Wen, 2019, J. Chem. Inf. Model..

Fragment-based discovery of novel pentacyclic triterpenoid derivatives as cholesteryl ester transfer protein inhibitors.

Hongbin Sun, Xiaoan Wen, Wenfeng Zhao, 2017, European journal of medicinal chemistry.

Cu-Catalyzed Dimerization of Indole Derived Oxime Acetate for Synthesis of Biimidazo[1,2-a]indoles.

Hongbin Sun, Xiaoan Wen, Qinglong Xu, 2021, Journal of Organic Chemistry.

Discovery of pentacyclic triterpene 3β-ester derivatives as a new class of cholesterol ester transfer protein inhibitors.

Jun O. Liu, Hongbin Sun, Xinyi He, 2017, European journal of medicinal chemistry.

Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with l-phenylalanine or l-proline.

Juzheng Zhang, Xiaoan Wen, Keguang Cheng, 2022, Bioorganic chemistry.

Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4- Epi -hederagonic Acid as Glycogen Phosphorylase Inhibitors: Synthesis and Biological Evaluation of Arjunolic Acid, Bayogenin, Hederagonic Acid and 4- Epi -hederagonic Acid as Glycogen Phosphorylase Inhibitors

Luyong Zhang, Jun O. Liu, Hongbin Sun, 2011 .

N-Substituted 3(10H)-Acridones as Visible-Light, Water-Soluble Photocatalysts: Aerobic Oxidative Hydroxylation of Arylboronic Acids.

Yong Cheng, Hongbin Sun, Xiaoan Wen, 2017, The Journal of organic chemistry.

Discovery of a Novel Macrocyclic ATP Citrate Lyase Inhibitor

Hongbin Sun, Xiaoan Wen, Liang Dai, 2022, J. Chem. Inf. Model..