Gloria Rubiales

发表

Antileishmanial effect of new indeno-1,5-naphthyridines, selective inhibitors of Leishmania infantum type IB DNA topoisomerase.

Y. Pérez-Pertejo, R. Balaña-Fouce, F. Palacios, 2016, European journal of medicinal chemistry.

Hetero-Diels-Alder reaction of phosphinyl and phosphonyl nitroso alkenes with conjugated dienes: an aza-Cope rearrangement.

F. Palacios, Gloria Rubiales, Jesús M. de los Santos, 2011, The Journal of organic chemistry.

Synthetic Strategies, Reactivity and Applications of 1,5-Naphthyridines

C. Masdeu, F. Palacios, C. Alonso, 2020, Molecules.

Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes.

F. Palacios, C. Alonso, Gloria Rubiales, 2015, Chemical reviews.

Synthesis of novel antiproliferative hybrid bis-(3-indolyl)methane phosphonate derivatives.

F. Palacios, J. Vicario, C. Alonso, 2018, European journal of medicinal chemistry.

Regioselective synthesis of pyridines and dihydropyridines derived from β-amino acids and aminophosphonates by reaction of N-vinylic phosphazenes with α,β-unsaturated ketones

F. Palacios, C. Alonso, Gloria Rubiales, 2007 .

Synthesis of fluorinated β-aminophosphonates and γ-lactams.

F. Palacios, C. Alonso, Maria Fuertes, 2013, The Journal of organic chemistry.

Fluoroalkylated α,β-unsaturated imines as synthons for the preparation of fluorinated triazinane-2,4-diones and dihydropyrimidin-2(1H)-ones.

F. Palacios, A. M. Ochoa de Retana, Gloria Rubiales, 2014, The Journal of organic chemistry.

Carbon Trifluoromethylation Reactions of Hydrocarbon Derivatives and Heteroarenes

F. Palacios, C. Alonso, Gloria Rubiales, 2015 .

Regioselective synthesis of dihydropyridines and pyridines derived from β-aminoacids from N-vinylic phosphazenes

F. Palacios, C. Alonso, Gloria Rubiales, 2007 .

Cycloaddition Reactions of Neutral 2‐Azadienes with Enamines − Regiospecific Synthesis of Highly Substituted Dihydropyridines and Pyridines

F. Palacios, C. Alonso, Gloria Rubiales, 2001 .

Reaction of acetylenic esters and N-functionalized phosphazenes. 1,2-versus 1,4-addition of N-vinylic phosphazenes.

F. Palacios, A. M. Ochoa de Retana, C. Alonso, 2003, Organic & biomolecular chemistry.

Fused 1,5-Naphthyridines: Synthetic Tools and Applications

C. Masdeu, F. Palacios, C. Alonso, 2020, Molecules.

Preparation of 3-(Fluoroalkyl)-2-azadienes and Its Application in the Synthesis of (Fluoroalkyl)isoquinoline and -pyridine Derivatives

F. Palacios, C. Alonso, Gloria Rubiales, 2005 .

The aza-Wittig reaction: an efficient tool for the construction of carbon–nitrogen double bonds

F. Palacios, C. Alonso, Gloria Rubiales, 2007 .

Preparation of 3‐(Fluoroalkyl)‐2‐azadienes and Its Application in the Synthesis of (Fluoroalkyl)isoquinoline and ‐pyridine Derivatives.

F. Palacios, C. Alonso, Gloria Rubiales, 2005 .

Regioselective synthesis of fluoroalkyl pyridine derivatives from 3-fluoroalkyl substituted 2-aza-1,3-butadienes

F. Palacios, C. Alonso, Gloria Rubiales, 2004 .

Cycloaddition reaction of 2-azadienes derived from beta-amino acids with electron-rich and electron-deficient alkenes and carbonyl compounds. Synthesis of pyridine and 1,3-oxazine derivatives.

F. Palacios, Gloria Rubiales, J. M. Ezpeleta, 2002, Journal of Organic Chemistry.

Synthesis of aza polycyclic compounds derived from pyrrolidine, indolizidine, and indole via intramolecular Diels-Alder cycloadditions of neutral 2-azadienes.

F. Palacios, C. Alonso, Gloria Rubiales, 2002, The Journal of organic chemistry.

Reactivity of Conjugated Phosphazenes Derived from Dehydroaspartic Esters with Acyl Halides. Synthesis of 5(4H)-Oxazolone

F. Palacios, Gloria Rubiales, M. Legido, 2000 .

Reaction of N-Vinylic Phosphazenes Derived from β-Amino Acids with Aldehydes. Azadiene-Mediated Synthesis of Dihydropyridines, Pyridines, and Polycyclic Nitrogen Derivatives

F. Palacios, Gloria Rubiales, E. Herrán, 1999 .

Aza-Wittig Reaction of N-Vinylic Phosphazenes with Carbonyl Compounds. Azadiene-Mediated Synthesis of Isoquinolines and 5,6-Dihydro-2H-1,3-oxazines

F. Palacios, Gloria Rubiales, A. C. Alonso, 1997 .

Aza-Wittig reaction of fluoroalkylated N-vinylic phosphazenes with carbonyl compounds. Usefulness of 2-azadienes for the preparation of fluoroalkyl pyridine derivatives

F. Palacios, C. Alonso, Gloria Rubiales, 2005 .

Synthesis and subsequent reactivity of 1-amino-2-aza-1,3-butadienes derived from β-amino esters

F. Palacios, C. Alonso, Gloria Rubiales, 2006 .

Synthesis and Reactivity of Electron-Poor 2-Azadienes. [4 + 2] Cycloaddition Reactions with Alkenes and Enamines

F. Palacios, Gloria Rubiales, I. P. D. Heredia, 1995 .

The aza‐Wittig Reaction: An Efficient Tool for the Construction of Carbon—Nitrogen Double Bonds

F. Palacios, C. Alonso, Gloria Rubiales, 2007 .

Mechanism and stereoselectivity of the aza-Wittig reaction between phosphazenes and aldehydes.

F. Cossío, F. Palacios, C. Alonso, 2006, The Journal of organic chemistry.

Synthesis of N-Functionalized Carbodiimides, Hydantoins, 1,3-Diazetidines, and Imidazolidine Derivatives from N-Vinylic Phosphazenes Derived from b-Amino Acids

F. Palacios, Gloria Rubiales, J. M. Ezpeleta, 2001 .

Aza-Wittig reaction of N-vinylic phosphazenes with carbonyl compounds. Azadiene-mediated synthesis of dihydropyridines and pyridines

F. Palacios, Gloria Rubiales, 1996 .

A new and efficient synthesis of imidazo[1,5-a] pyridine derivatives by a tandem aza-Wittig / electrocyclic ring closure of N-vinylic phosphazenes

F. Palacios, C. Alonso, Gloria Rubiales, 1995 .

Regioselective cycloaddition of 3-azatrienes with enamines. Synthesis of pyridines derived from β-aminoacids

F. Palacios, C. Alonso, Gloria Rubiales, 2006 .

Preparation and reactivity of electron-poor 2-azadienes. Diels-Alder reaction with trans-cyclooctene.

F. Palacios, Gloria Rubiales, I. P. D. Heredia, 1993 .

Regioselective synthesis of pyrrolin-3-ones and 2,3,4,5-tetrahydro[1,3]-oxazines from N-vinylic amidines

F. Palacios, C. Alonso, Gloria Rubiales, 2009 .

Glyoxalate‐Derived Aldimines in Cycloaddition Reactions with Olefins

F. Palacios, C. Alonso, Maria Fuertes, 2011 .

Reactions of N-vinylic phosphazenes with azodicarboxylic and acetylenic esters

F. Palacios, C. Alonso, Gloria Rubiales, 2004 .

“ONE POT” SYNTHESIS OF β-FUNCTIONALIZED VINYL AZIDES THROUGH ADDITION OF TETRAMETYLGUANIDINIUM AZIDE TO ACETYLENIC AND ALLENIC COMPOUNDS

Gloria Rubiales, Francisco Palacios, F. Palacios, 1995 .

Reaction of N-Vinylic Phosphazenes Derived from β-Amino Acids with Aldehydes. Azadiene-Mediated Synthesis of Dihydropyridines, Pyridines, and Polycyclic Nitrogen Derivatives.

F. Palacios, Gloria Rubiales, E. Herrán, 2000 .

Regioselective Synthesis of Fluoroalkyl Pyridine Derivatives from 3-Fluoroalkyl Substituted 2-Aza-1,3-butadienes.

F. Palacios, C. Alonso, Gloria Rubiales, 2004 .

Aza-Wittig Reaction of N-Vinylic Phosphazenes with Carbonyl Compounds. Azadiene-Mediated Synthesis of Isoquinolines and 5,6-Dihydro-2H-1,3- oxazines.

F. Palacios, C. Alonso, Gloria Rubiales, 2010 .

Reactivity of Conjugated Phosphazenes Derived from Dehydroaspartic Esters with Acyl Halides. Synthesis of 5(4H)‐Oxazolone.

F. Palacios, Gloria Rubiales, M. Legido, 2000 .

Reliable Synthesis of Phosphino‐ and Phosphine Sulfide‐1,2,3,4‐Tetrahydroquinolines and Phosphine Sulfide Quinolines

F. Palacios, C. Alonso, Gloria Rubiales, 2017 .

Lewis Acid Activated Aza-Diels–Alder Reaction of N-(3-Pyridyl)aldimines: An Experimental and Computational Study

A. Arrieta, F. Cossío, F. Palacios, 2010 .

Synthesis of Aza Polycyclic Compounds Derived from Pyrrolidine, Indolizidine, and Indole via Intramolecular Diels—Alder Cycloadditions of Neutral 2-Azadienes.

F. Palacios, C. Alonso, Gloria Rubiales, 2002 .

Cycloaddition Reaction of 2‐Azadienes Derived from β‐Amino Acids with Electron‐Rich and Electron‐Deficient Alkenes and Carbonyl Compounds. Synthesis of Pyridine and 1,3‐Oxazine Derivatives.

F. Palacios, Gloria Rubiales, J. M. Ezpeleta, 2002 .

Synthetic Applications of Intramolecular Aza-Wittig Reaction for the Preparation of Heterocyclic Compounds

F. Palacios, C. Alonso, Gloria Rubiales, 2009 .

Synthetic Applications of Intramolecular Aza‐Wittig Reaction for the Preparation of Heterocyclic Compounds

F. Palacios, C. Alonso, Gloria Rubiales, 2010 .

Study of the Hetero-[4+2]-Cycloaddition Reaction of Aldimines and Alkynes. Synthesis of 1,5-Naphthyridine and Isoindolone Derivatives.

F. Palacios, C. Alonso, María Gonzalez, 2017, The Journal of organic chemistry.

Novel phosphine sulphide gold(i) complexes: topoisomerase I inhibitors and antiproliferative agents.

B. Knudsen, J. M. Martínez-Ilarduya, F. Palacios, 2020, Dalton transactions.

A β-lactam approach to ψ-amino-β-keto acid derivatives.

F. Cossío, C. Palomo, Gloria Rubiales, 1991 .

Straightforward synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents of hybrid Chromeno[4,3-b][1,5]Naphthyridines and Chromeno[4,3-b][1,5]Naphthyridin-6-ones.

F. Palacios, C. Alonso, Gloria Rubiales, 2019, European journal of medicinal chemistry.

Reaction of phosphinyl nitrosoalkenes with electron-rich heterocycles

F. Palacios, A. M. Ochoa de Retana, Gloria Rubiales, 2019, Phosphorus, Sulfur, and Silicon and the Related Elements.

Reaction of phosphinylated nitrosoalkenes with electron-rich heterocycles. Electrophilic aromatic substitution vs. cycloaddition.

F. Palacios, A. M. Ochoa de Retana, Gloria Rubiales, 2017, Organic & biomolecular chemistry.

Reaction of N-Vinylic Phosphazenes with α,β-Unsaturated Aldehydes. Azatriene-Mediated Synthesis of Dihydropyridines and Pyridines Derived from β-Amino Acids

F. Cossío, F. Palacios, C. Alonso, 2006 .

Dienediolates from unsaturated carboxylic acids. Reaction with para-substituted benzaldehydes. Electronic effects on regioselectivity

N. Durana, M. Parra, Gloria Rubiales, 1989 .

Substituted 1,5-naphthyridine derivatives as novel antileishmanial agents. Synthesis and biological evaluation.

Y. Pérez-Pertejo, R. Balaña-Fouce, F. Palacios, 2018, European journal of medicinal chemistry.

Fused chromeno and quinolino[1,8]naphthyridines: Synthesis and biological evaluation as topoisomerase I inhibitors and antiproliferative agents.

B. Knudsen, F. Palacios, C. Alonso, 2021, Bioorganic & medicinal chemistry.

Synthesis of novel hybrid quinolino[4,3-b][1,5]naphthyridines and quinolino[4,3-b][1,5]naphthyridin-6(5H)-one derivatives and biological evaluation as topoisomerase I inhibitors and antiproliferatives.

B. Knudsen, F. Palacios, C. Tesauro, 2020, European journal of medicinal chemistry.

Synthesis and biological evaluation of indeno[1,5]naphthyridines as topoisomerase I (TopI) inhibitors with antiproliferative activity.

B. Knudsen, F. Palacios, C. Tesauro, 2016, European journal of medicinal chemistry.

Synthetic utility of azetidine-2,3-diones: a new approach to 3-hydroxyethylβ-lactams and α-aminoacid derivatives

F. Cossío, C. López, C. Palomo, 1988 .

Advantages of an optical nanosensor system for the mechanistic analysis of a novel topoisomerase I targeting drug: a case study.

Y. Ho, A. Coletta, B. Knudsen, 2017, Nanoscale.

A patent review of topoisomerase I inhibitors (2016–present)

C. Masdeu, F. Palacios, C. Alonso, 2021, Expert opinion on therapeutic patents.

Antileishmanial activity of new hybrid tetrahydroquinoline and quinoline derivatives with phosphorus substituents.

Y. Pérez-Pertejo, R. Balaña-Fouce, F. Palacios, 2019, European journal of medicinal chemistry.

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity.

F. Palacios, C. Tesauro, C. Alonso, 2018, European journal of medicinal chemistry.

Nucleophilic trifluoromethylation of carbonyl compounds and derivatives

F. Palacios, C. Alonso, Gloria Rubiales, 2014 .

Novel topoisomerase I inhibitors. Syntheses and biological evaluation of phosphorus substituted quinoline derivates with antiproliferative activity.

F. Palacios, C. Tesauro, C. Alonso, 2018, European journal of medicinal chemistry.