M. Moriya

发表

Enantiodivergent Preparation of Chiral 2,5-Cyclohexadienone Synthons

Y. Higashi, S. Takano, T. Kamikubo, 1993 .

Discovery of imidazo[1,2-a]pyridines as potent MCH1R antagonists.

H. Iwaasa, S. Sakuraba, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Characterization of MCH-mediated obesity in mice.

H. Iwaasa, H. Matsushita, A. Kanatani, 2003, American journal of physiology. Endocrinology and metabolism.

Chronic intracerebroventricular infusion of MCH causes obesity in mice. Melanin-concentrating hormone.

H. Iwaasa, H. Matsushita, A. Kanatani, 2003, American journal of physiology. Endocrinology and metabolism.

Discovery of novel phenylpyridone derivatives as potent and selective MCH1R antagonists.

H. Iwaasa, A. Kanatani, Masahiko Ito, 2011, Bioorganic & medicinal chemistry.

Neuropeptide Y receptors as targets of obesity treatment

D. Macneil, A. Kanatani, T. Fukami, 2006 .

Identification of positron emission tomography ligands for NPY Y5 receptors in the brain.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Design, syntheses, and structure-activity relationships of novel NPY Y5 receptor antagonists: 2-{3-Oxospiro[isobenzofuran-1(3H),4'-piperidin]-1'-yl}benzimidazole derivatives.

H. Iwaasa, K. Matsuda, M. Ishikawa, 2008, Bioorganic & medicinal chemistry letters.

Identification of 1-Methyl-N-(propan-2-yl)-N-({2-[4-(trifluoromethoxy)phenyl]pyridin-4-yl}methyl)-1H-imidazole-4-carboxamide as a Potent and Orally Available Glycine Transporter 1 Inhibitor.

M. Moriya, H. Ohta, Y. Kawakita, 2016, Chemical & pharmaceutical bulletin.

(9S)-9-(2-hydroxy-4,4-dimethyl-6-oxo-1-cyclohexen-1-yl)-3,3-dimethyl-2,3,4,9-tetrahydro-1H-xanthen-1-one, a selective and orally active neuropeptide Y Y5 receptor antagonist.

H. Iwaasa, M. Ando, T. Ohe, 2008, Journal of medicinal chemistry.

Enantiocontrolled syntheses of the cuparene sesquiterpenes, (−)-herbertene, (+)-β-cuparenone, (−)-debromoaplysin, and (−)-aplysin

S. Takano, M. Moriya, K. Ogasawara, 1992 .

Enantiocontrolled Synthesis of Two Amino Acids; (S)-Glutamic Acid and (S)-2-Aminoadipic Acid

S. Takano, T. Kamikubo, M. Moriya, 1994 .

Novel dithiocarbamate carbapenems with anti-MRSA activity.

H. Satō, N. Ohtake, M. Moriya, 1997, Bioorganic & medicinal chemistry.

Chiral synthesis of both enantiomers of 1,4-dideoxy-1,4-immolyxitol and 1,4-dideoxy-1,4-iminoribitol

S. Takano, M. Moriya, K. Ogasawara, 1992 .

Discovery of novel spiro-piperidine derivatives as highly potent and selective melanin-concentrating hormone 1 receptor antagonists.

H. Iwaasa, M. Ishikawa, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Concise synthesis of C2-symmetric trans-2,5-dioxymethylpyrrolidine derivatives by novel cyclization

Y. Iwabuchi, S. Takano, M. Moriya, 1989 .

Enantiocontrolled synthesis of optically pure 5-trimethylsilyl- and 5-tributylstannyl-cyclohex-2-enones

Y. Higashi, S. Takano, T. Kamikubo, 1993 .

Enantio-and Stereo-controlled Construction of Tertiary and Quaternary Carbon Centers Using Chiral O-Benzylglycidol as Template

S. Takano, M. Moriya, K. Ogasawara, 1990 .

Non-hazardous preparation of 3-acetoxy- and 3-oxodicyclopentadienes

S. Takano, M. Moriya, K. Ogasawara, 1994 .

Enantiodivergent route to conduritol C via lipase-mediated asymmetrization

Y. Higashi, S. Takano, M. Moriya, 1993 .

A concise stereocontrolled total synthesis of (+)-estrone

S. Takano, M. Moriya, K. Ogasawara, 1992 .

Discovery of novel phenethylpyridone derivatives as potent melanin-concentrating hormone 1 receptor antagonists.

H. Iwaasa, M. Ando, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Discovery of novel diarylketoxime derivatives as selective and orally active melanin-concentrating hormone 1 receptor antagonists.

Kouta Masutani, M. Kameda, H. Matsushita, 2009, Bioorganic & medicinal chemistry letters.

Identification of 2-aminobenzimidazoles as potent melanin-concentrating hormone 1-receptor (MCH1R) antagonists.

H. Iwaasa, S. Sakuraba, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Identification and characterization of a selective radioligand for melanin-concentrating hormone 1-receptor (MCH1R).

H. Iwaasa, H. Matsushita, D. Dean, 2009, Bioorganic & medicinal chemistry letters.

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.

Identification of novel and orally active spiroindoline NPY Y5 receptor antagonists.

D. Macneil, H. Iwaasa, A. Kanatani, 2009, Bioorganic & Medicinal Chemistry Letters.

Novel orally active NPY Y5 receptor antagonists: Synthesis and structure-activity relationship of spiroindoline class compounds.

H. Iwaasa, A. Kanatani, T. Fukami, 2009, Bioorganic & medicinal chemistry.

Syntheses and structure-activity relationships of novel, potent, and selective trans-2-[3-oxospiro[isobenzofuran-1(3H),1'-cyclohexan]-4'-yl]benzimidazole NPY Y5 receptor antagonists.

H. Iwaasa, K. Matsuda, M. Ishikawa, 2008, Bioorganic & medicinal chemistry letters.

Enantiocontrolled total syntheses of (-)-physovenine and (-)-physostigmine

S. Takano, M. Moriya, K. Ogasawara, 1991 .

A Chiral Route to Both Enantiomers of Physostigmine and the First Synthesis of (−)-Norphysostigmine

Y. Iwabuchi, S. Takano, M. Moriya, 1990 .

Enantiodivergent Preparation of Chiral 2,5-Cyclohexadienone Synthons.

Y. Higashi, S. Takano, T. Kamikubo, 1994 .

Melanin-concentrating hormone 1-receptor antagonist suppresses body weight gain correlated with high receptor occupancy levels in diet-induced obesity mice.

D. Macneil, H. Iwaasa, H. Matsushita, 2009, European journal of pharmacology.

Aryl urea derivatives of spiropiperidines as NPY Y5 receptor antagonists.

H. Iwaasa, T. Ohe, A. Kanatani, 2009, Bioorganic & medicinal chemistry letters.