H. M. Garraffo

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The enantioselective synthesis of poison-frog alkaloids (−)-203A, (−)-209B, (−)-231C, (−)-233D, and (−)-235B″

J. Daly, T. Spande, N. Toyooka, 2006 .

Chapter One - Alkaloids from Amphibian Skins

J. Daly, T. Spande, H. M. Garraffo, 1999 .

Cyclic biospecific affinity chromatographic method for the purification of the sex steroid binding protein (SBP): application to the purification of SBP from toad.

H. M. Garraffo, T. Santa-Coloma, E. Charreau, 1987, Journal of chromatography.

Regulation of Human Adipose Tissue Activation, Gallbladder Size, and Bile Acid Metabolism by a β3-Adrenergic Receptor Agonist

P. Herscovitch, Kong Y. Chen, V. Tolstikov, 2018, Diabetes.

Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics.

J. Sullivan, J. Daly, M. Decker, 2000, Natural product reports.

Epibatidine: a novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an ecuadoran poison frog

L. Pannell, J. Daly, H. Yeh, 1992 .

A new subclass of alkaloids from a dendrobatid poison frog: a structure for deoxypumiliotoxin 251H.

J. Daly, H. Yeh, P. Jain, 1995, Journal of Natural Products.

THE ISOLATION AND STRUCTURE OF PUMILIOTOXIN 341A : A NOVEL CYCLIC ETHER FROM THE FROG EPIPEDOBA TES TRICOLOR

J. Daly, P. Jain, T. Spande, 1999 .

Metreleptin-mediated improvements in insulin sensitivity are independent of food intake in humans with lipodystrophy

Kong Y. Chen, A. Gharib, R. Ouwerkerk, 2018, The Journal of clinical investigation.

Efficient enantio- and diastereodivergent synthesis of poison-frog alkaloids 251O and trans-223B.

J. Daly, S. Kadota, Y. Tezuka, 2009, The Journal of organic chemistry.

Alkaloids in Madagascan frogs (Mantella): pumiliotoxins, indolizidines, quinolizidines, and pyrrolizidines.

J. Daly, T. Spande, M. Andriantsiferana, 1993, Journal of natural products.

Alkaloids from amphibian skin: a tabulation of over eight-hundred compounds.

J. Daly, T. Spande, H. M. Garraffo, 2005, Journal of natural products.

Alkaloids from bufonid toads (Melanophryniscus): decahydroquinolines, pumiliotoxins and homopumiliotoxins, indolizidines, pyrrolizidines, and quinolizidines.

J. Daly, T. Spande, H. M. Garraffo, 1993, Journal of natural products.

Individual and Geographic Variation of Skin Alkaloids in Three Swamp-Forest Species of Madagascan Poison Frogs (Mantella)

M. Vences, D. Vieites, L. Giddings, 2015, Journal of Chemical Ecology.

Individual and Geographic Variation of Skin Alkaloids in Three Species of Madagascan Poison Frogs (Mantella)

M. Vences, J. Daly, D. Vieites, 2008, Journal of Chemical Ecology.

Ammonia chemical ionization tandem mass spectrometry in structure determination of alkaloids. I. Pyrrolidines, piperidines, decahydroquinolines, pyrrolizidines, indolizidines, quinolizidines and an azabicyclo[5.3.0]decane.

J. Daly, T. Spande, T. Jones, 1999, Rapid communications in mass spectrometry : RCM.

Pharmacokinetics of Sucralose and Acesulfame-Potassium in Breast Milk Following Ingestion of Diet Soda

D. Fields, K. Rother, P. Walter, 2017, Journal of pediatric gastroenterology and nutrition.

Vitamin E treatment in NAFLD patients demonstrates that oxidative stress drives steatosis through upregulation of de-novo lipogenesis

D. Kleiner, S. Lingala, R. Shamburek, 2020, Redox biology.

Biosynthesis of bufadienolides in toads. V. the origin of the cholesterol used by toad parotoid glands for biosynthesis of bufadienolides

O. Pignataro, H. M. Garraffo, E. Charreau, 1984, Steroids.

Epibatidine: A Novel (Chloropyridyl)azabicycloheptane with Potent Analgesic Activity from an Ecuadoran Poison Frog.

L. Pannell, J. Daly, H. Yeh, 1992 .

A review of chemical ecology in poison frogs

M. A. Donnelly, R. Saporito, T. Spande, 2012, Chemoecology.

Roughing it: a mantellid poison frog shows greater alkaloid diversity in some disturbed habitats.

J. Daly, R. Saporito, T. Spande, 2010, Journal of natural products.

Homobatrachotoxin in the genus Pitohui: chemical defense in birds?

J. Daly, J. Dumbacher, B. Beehler, 1992, Science.

Identification of histrionicotoxins by GC-MS and GC-FTIR: Photo- and chemical-artefacts and revised 13C NMR assignments

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Alkaloids from dendrobatid poison frogs: Further cis-decahydroquinolines and 8-methylindolizidines

J. Daly, T. Spande, H. M. Garraffo, 1991 .

The Essential Oil of the Leaves of Psidium guajava L.

L. Pannell, Q. Pu, H. M. Garraffo, 1991 .

Specificity of Ascorbate Analogs for Ascorbate Transport

M. Levine, K. Kirk, H. M. Garraffo, 1999, The Journal of Biological Chemistry.

Further Alkaloids Common to Ants and Frogs: Decahydroquinolines and a Quinolizidine

M. Blum, J. Daly, J. Delabie, 1999, Journal of Chemical Ecology.

Arthropod–Frog Connection: Decahydroquinoline and Pyrrolizidine Alkaloids Common to Microsympatric Myrmicine Ants and Dendrobatid Frogs

J. Daly, A. Rand, R. Snelling, 2004, Journal of Chemical Ecology.

Synthesis and nicotinic activity of epiboxidine: an isoxazole analogue of epibatidine.

J. Daly, H. M. Garraffo, W. Padgett, 1997, European journal of pharmacology.

Widespread sucralose exposure in a randomized clinical trial in healthy young adults.

K. Robien, K. Rother, P. Walter, 2017, The American journal of clinical nutrition.

Dioicine: A Novel Prenylated Purine Alkaloid from Gymnocladus dioicus

J. Daly, N. F. Whittaker, T. Spande, 2009 .

Histrionicotoxin alkaloids finally detected in an ant.

T. Schultz, T. Jones, T. Spande, 2012, Journal of natural products.

Identification of Histrionicotoxins by GC-MS and GC-FTIR: Photo- and Chemical-Artefacts and Revised 13C NMR Assignments.

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Facile synthesis of two diastereomeric indolizidines corresponding to the postulated structure of alkaloid 5,9E-259B from a Bufonid toad (Melanophryniscus)

J. Daly, T. Spande, P. Stevenson, 2008, Beilstein journal of organic chemistry.

Individual and Geographic Variation of Skin Alkaloids in Three Swamp-Forest Species of Madagascan Poison Frogs (Mantella)

M. Vences, D. Vieites, L. Giddings, 2015, Journal of Chemical Ecology.

ARTHROPOD ALKALOIDS IN POISON FROGS : A REVIEW OF THE 'DIETARY HYPOTHESIS'

M. A. Donnelly, R. Saporito, T. Spande, 2009 .

Indolizidine 239Q and quinolizidine 275I. Major alkaloids in two Argentinian bufonid toads (Melanophryniscus).

J. Daly, H. Yeh, J. Faivovich, 2008, Toxicon : official journal of the International Society on Toxinology.

Synthesis and spectroscopic comparison of the eight methyl-2,3'-bipyridyls and identification of a hoplonemertine alkaloid as 3-methyl-2,3'-bipyridyl

J. Rocca, W. Kem, H. M. Garraffo, 2009 .

Alkaloids in the Mite Scheloribates laevigatus: Further Alkaloids Common to Oribatid Mites and Poison Frogs

R. Saporito, T. Spande, R. A. Norton, 2011, Journal of Chemical Ecology.

An uptake system for dietary alkaloids in poison frogs (Dendrobatidae).

J. Daly, T. Spande, H. M. Garraffo, 1994, Toxicon : official journal of the International Society on Toxinology.

Evidence for an enantioselective pumiliotoxin 7-hydroxylase in dendrobatid poison frogs of the genus Dendrobates

J. Daly, T. Spande, H. M. Garraffo, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of the Costa Rican poison frog Dendrobates granuliferus in sympatry with Dendrobates pumilio, and comments on taxonomic use of skin alkaloids. American Museum novitates ; no. 3144

J. Daly, H. M. Garraffo, C. W. Myers, 1995 .

Chapter 3 Amphibian Alkaloids

J. Daly, T. Spande, H. M. Garraffo, 1993 .

Variability in alkaloid profiles in neotropical poison frogs (Dendrobatidae): genetic versus environmental determinants.

J. Daly, T. Spande, H. M. Garraffo, 1992, Toxicon : official journal of the International Society on Toxinology.

Venom chemistry of the ant Myrmicaria melanogaster from Brunei.

J. Daly, D. Davidson, R. Snelling, 2007, Journal of Natural Products.

Bioassay-guided isolation of epiquinamide, a novel quinolizidine alkaloid and nicotinic agonist from an Ecuadoran poison frog, Epipedobates tricolor.

J. Daly, H. Yeh, T. Spande, 2003, Journal of natural products.

Synthesis of poison-frog alkaloids 233A, 235U, and 251AA and their inhibitory effects on neuronal nicotinic acetylcholine receptors.

J. Daly, T. Sasaoka, T. Wada, 2007, Bioorganic & medicinal chemistry letters.

Flexible synthetic routes to poison-frog alkaloids of the 5,8-disubstituted indolizidine-class I: synthesis of common lactam chiral building blocks and application to the synthesis of (-)-203A, (-)-205A, and (-)-219F

J. Daly, T. Spande, N. Toyooka, 2007, Beilstein journal of organic chemistry.

Enantioselective syntheses of poison-frog alkaloids : 219F and 221I and an epimer of 193E

J. Daly, T. Spande, N. Toyooka, 2006 .

Enantioselective Synthesis of Poison-Frog Alkaloid 237D and Determination of Absolute Stereochemistry

J. Daly, T. Spande, N. Toyooka, 2005 .

Synthesis of alkaloid 223A and a structural revision.

J. Daly, T. Spande, A. Fukutome, 2002, Organic letters.

Highly stereoselective construction of trans(2,3)-cis(2,6)-trisubstituted piperidines: An application to the chiral synthesis of Dendrobates alkaloids

J. Daly, N. Toyooka, H. M. Garraffo, 1997 .

Facile Synthesis of 4-Piperidones by Condensation of an α,β-Unsaturated Ketone, an Aldehyde and Ammonia: Synthesis of the Dendrobatid Frog Alkaloid 241D

J. Daly, H. M. Garraffo, M. Edwards, 1994 .

Enantioselective syntheses of two 5, 9E diastereomers of 223V, an alkaloid from the poison frog Dendrobates pumilio

J. Daly, T. Spande, N. Toyooka, 2005 .

Epiquinamide: a poison that wasn't from a frog that was.

Shaun R. Patel, J. Daly, T. Spande, 2009, Journal of natural products.

A revised structure for alkaloid 235C isolated from skin extracts of mantellid (Mantella) frogs of Madagascar.

J. Daly, H. Yeh, P. Stevenson, 2005, Journal of natural products.

Alkaloid 223A: the first trisubstituted indolizidine from dendrobatid frogs.

J. Daly, P. Jain, T. Spande, 1997, Journal of natural products.

Alkaloids from single skins of the Argentinian toad Melanophryniscus rubriventris (ANURA, BUFONIDAE): An unexpected variability in alkaloid profiles and a profusion of new structures

M. F. Quiroga, M. Vaira, T. Spande, 2012, SpringerPlus.

Production of the macrocyclic bis-bibenzyls in axenically farmed and wild liverwort Marchantia polymorpha L. subsp. ruderalis Bischl. et Boisselier

C. Bewley, M. Sabovljević, A. Sabovljevic, 2017 .

Identification of a Cryptococcus neoformans Cytochrome P450 Lanosterol 14α-Demethylase (Erg11) Residue Critical for Differential Susceptibility between Fluconazole/Voriconazole and Itraconazole/Posaconazole

M. Ghannoum, E. Sionov, K. Kwon-Chung, 2011, Antimicrobial Agents and Chemotherapy.

Heteroresistance to Fluconazole in Cryptococcus neoformans Is Intrinsic and Associated with Virulence

E. Sionov, K. Kwon-Chung, Yun C Chang, 2009, Antimicrobial Agents and Chemotherapy.

Essential Oils of the Leaf, Bark and Branch of Cinnamomum buramannii Blume

L. Pannell, Q. Pu, H. M. Garraffo, 1991 .

Epibatidine: from frog alkaloid to analgesic clinical candidates: a testimonial to "true grit"!

T. Spande, H. M. Garraffo, Michael Williams, 2009 .

Chemistry of venom alkaloids in someSolenopsis (Diplorhoptrum) species from Puerto Rico

M. Blum, R. Snelling, T. Jones, 1996, Journal of Chemical Ecology.

Biosynthesis of bufadienolides in toads. VI. experiments with [1,2-3H]cholesterol, [21-14C]coprostanol, and 5β-[21-14C]pregnanolone in the toad Bufo arenarum

H. M. Garraffo, E. G. Gros, 1986, Steroids.

Synthesis of |21-14C|-3β-hydroxy-5β-pregnan-20-one and |21-14C|-5β-cholestan-3β-ol

H. M. Garraffo, A. Seldes, M. E. Deluca, 1985 .

Preparation of 3β-Acetoxy-5β-pregnan-20-one from 3α-Acetoxy-5β-cholan-24-oic Acid Aimed at the Isotopic Labelling of the Pregnane Side Chain

H. M. Garraffo, A. Seldes, M. E. Deluca, 1984 .

Molecular Mechanisms of Hypoxic Responses via Unique Roles of Ras1, Cdc24 and Ptp3 in a Human Fungal Pathogen Cryptococcus neoformans

P. Walter, K. Kwon-Chung, H. M. Garraffo, 2014, PLoS genetics.

Oribatid mites as a major dietary source for alkaloids in poison frogs

J. Daly, M. A. Donnelly, R. Saporito, 2007, Proceedings of the National Academy of Sciences.

Bioactive alkaloids of frog skin: Combinatorial bioprospecting reveals that pumiliotoxins have an arthropod source

J. Daly, M. A. Donnelly, T. Spande, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Formicine ants: An arthropod source for the pumiliotoxin alkaloids of dendrobatid poison frogs.

A. L. Edwards, J. Daly, J. Longino, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Geographic and Seasonal Variation in Alkaloid-Based Chemical Defenses of Dendrobates pumilio from Bocas del Toro, Panama

J. Daly, M. A. Donnelly, R. Saporito, 2006, Journal of Chemical Ecology.

Biologically active substances from amphibians: preliminary studies on anurans from twenty-one genera of Thailand.

J. Daly, T. Spande, H. M. Garraffo, 2004, Toxicon : official journal of the International Society on Toxinology.

Pkd1 mutation has no apparent effects on peroxisome structure or lipid metabolism

G. Germino, L. Menezes, P. Walter, 2021, bioRxiv.

A role for muscarinic receptors in neutrophil extracellular trap formation and levamisole-induced autoimmunity.

K. Preston, K. Phillips, J. Graf, 2017, JCI insight.

A Siphonotid Millipede (Rhinotus) as the Source of Spiropyrrolizidine Oximes of Dendrobatid Frogs

J. Daly, R. Hoffman, M. A. Donnelly, 2003, Journal of Chemical Ecology.

Pseudophrynaminol: a potent noncompetitive blocker of nicotinic receptor-channels.

J. Daly, H. M. Garraffo, W. Padgett, 1997, Biochemical pharmacology.

Pyrrolizidine oximes: a novel new class of dendrobatid alkaloids

J. Daly, T. Spande, H. M. Garraffo, 1992 .

Phantasmidine: an epibatidine congener from the ecuadorian poison frog Epipedobates anthonyi.

J. Daly, H. Yeh, T. Spande, 2010, Journal of natural products.

A. A. Madden, M. A. Donnelly, R. Saporito, 2010, Journal of Natural Products.

Evidence for biosynthesis of pseudophrynamine alkaloids by an Australian myobatrachid frog (pseudophryne) and for sequestration of dietary pumiliotoxins.

J. Daly, T. Spande, H. M. Garraffo, 2002, Journal of natural products.

Absence of skin alkaloids in captive-raised Madagascan mantelline frogs (Mantella) and sequestration of dietary alkaloids.

J. Daly, G. Hall, H. M. Garraffo, 1997, Toxicon : official journal of the International Society on Toxinology.

A. A. Madden, M. A. Donnelly, R. Saporito, 2011 .

Elucidation of Dimethylalkylpyrazines from the Ant Streblognathus aethiopicus by GC-FTIR

M. Blum, T. Jones, H. Hastings, 2004, Journal of Chemical Ecology.

Plasma concentrations of sucralose in children and adults

K. Rother, P. Walter, A. Sylvetsky, 2017, Toxicological and environmental chemistry.

Gluconeogenesis and risk for fasting hyperglycemia in Black and White women.

A. Gharib, M. Haymond, A. Courville, 2018, JCI insight.

Nonnutritive Sweeteners in Breast Milk

K. Rother, P. Walter, A. Sylvetsky, 2015, Journal of toxicology and environmental health. Part A.

Flexible synthesis of poison-frog alkaloids of the 5,8-disubstituted indolizidine-class. II: Synthesis of (-)-209B, (-)-231C, (-)-233D, (-)-235B", (-)-221I, and an epimer of 193E and pharmacological effects at neuronal nicotinic acetylcholine receptors.

J. Daly, T. Sasaoka, T. Wada, 2007 .

The chemical defense of the Texas cave harvestman Chinquipellobunus madlae: first report on the family Stygnopsidae and on a North American troglobiont harvestman (Opilones: Gonyleptoidea)

T. Jones, W. Shear, H. M. Garraffo, 2010 .

A 1,4-disubstituted quinolizidine from a Madagascan mantelline frog (Mantella).

J. Daly, H. Yeh, P. Jain, 1996, Journal of natural products.

A Novel Role of Fungal Type I Myosin in Regulating Membrane Properties and Its Association with d-Amino Acid Utilization in Cryptococcus gattii

P. Walter, K. Kwon-Chung, H. M. Garraffo, 2019, mBio.

Structure of alkaloid 275A, a novel 1-azabicyclo[5.3.0]decane from a dendrobatid frog, Dendrobates lehmanni: synthesis of the tetrahydrodiastereomers.

J. Daly, T. Jones, P. Jain, 2001, Journal of natural products.

Alkaloids from dendrobatid poison frogs: Further pumiliotoxins and allopumiliotoxins and a reassignment of the keto function in pumiliotoxin 307F

J. Daly, T. Spande, H. M. Garraffo, 1991 .

Caste-specific tyramides from Myrmicine ants.

J. Daly, R. Snelling, T. Jones, 2010, Journal of natural products.

Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans

K. Kwon-Chung, Hyeseung Lee, H. M. Garraffo, 2012, Molecular microbiology.

Alkaloids in Bufonid Toads (Melanophryniscus): Temporal and Geographic Determinants for Two Argentinian Species

R. Gil, J. Daly, M. Vaira, 2007, Journal of Chemical Ecology.

Alkaloids of Anuran Skin: Antimicrobial Function?

J. Daly, T. Jones, T. Spande, 2005, Zeitschrift fur Naturforschung. C, Journal of biosciences.

3-methyl-4-phenylpyrrole from the ants Anochetus kempfi and Anochetus mayri.

R. Snelling, T. Jones, T. Spande, 1999, Journal of natural products.

A review of chemical ecology in poison frogs

M. A. Donnelly, R. Saporito, T. Spande, 2012, Chemoecology.

DISCOVERY OF BATRACHOTOXIN : THE LAUNCH OF THE FROG ALKALOID PROGRAM AT NIH

T. Spande, H. M. Garraffo, 2009 .

Response : Pitohui : How Toxic and to Whom?

J. Daly, B. Beehler, T. Spande, 1993, Science.