John C Widen

发表

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

M. Walters, D. Harki, François Grillet, 2020, Journal of medicinal chemistry.

Synthesis and antileukemic activities of C1-C10-modified parthenolide analogues.

D. Largaespada, D. Harki, Z. Sachs, 2015, Bioorganic & medicinal chemistry.

SN-38 Conjugated Gold Nanoparticles Activated by Ewing Sarcoma Specific mRNAs Exhibit In Vitro and In Vivo Efficacy.

D. Harki, David J. Gordon, Jian Tang, 2018, Bioconjugate chemistry.

A synthetic covalent ligand of the C/EBPβ transactivation domain inhibits acute myeloid leukemia cells.

K. Klempnauer, D. Harki, M. Yusenko, 2022, Cancer letters.

Alkyne Ligation Handles: Propargylation of Hydroxyl, Sulfhydryl, Amino, and Carboxyl Groups via the Nicholas Reaction.

D. Harki, K. Brummond, Daniel A. Harki, 2016, Organic letters.

The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection

Ryan A. Flynn, M. Bogyo, J. Carette, 2022, Science.

Challenges for Targeting SARS-CoV-2 Proteases as a Therapeutic Strategy for COVID-19

M. Bogyo, C. Peters, R. Bartenschlager, 2020, bioRxiv.

Covalent Modifiers: A Chemical Perspective on the Reactivity of α,β-Unsaturated Carbonyls with Thiols via Hetero-Michael Addition Reactions.

D. Harki, K. Brummond, Daniel A. Harki, 2017, Journal of medicinal chemistry.

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

M. Walters, D. Harki, François Grillet, 2020, Journal of medicinal chemistry.

Helenalin Analogues Targeting NF‐κB p65: Thiol Reactivity and Cellular Potency Studies of Varied Electrophiles

D. Harki, Jacob T. Edwards, Jacob T Edwards, 2018, ChemMedChem.

Targeting NF-κB p65 with a Helenalin Inspired Bis-electrophile.

P. Villalta, D. Harki, Daniel A. Harki, 2017, ACS chemical biology.

A redox economical synthesis of bioactive 6,12-guaianolides.

D. Harki, K. Brummond, Daniel A. Harki, 2013, Organic letters.

Tetrapyridyl tetraphenylethylenes: supramolecular building blocks with aggregation-induced emission properties

John C Widen, D. Swenson, F. Pigge, 2011 .

AND-gate contrast agents for enhanced fluorescence-guided surgery

M. Bogyo, Joshua J. Yim, Alexander L. Antaris, 2020, Nature Biomedical Engineering.

Molecular Basis for the N-Terminal Bromodomain-and-Extra-Terminal-Family Selectivity of a Dual Kinase-Bromodomain Inhibitor.

N. Mishra, N. Berndt, D. Harki, 2018, Journal of medicinal chemistry.