P. Brown

发表

Flexible palladium-catalysed amidation reactions for the synthesis of complex aryl amides

S. Dabbs, D. Davies, R. Markwell, 2010 .

Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity.

A. K. Forrest, R. Sheppard, Murray J. B. Brown, 2003, Bioorganic & medicinal chemistry letters.

The chemistry of Pseudomonic acid. 15. Synthesis and antibacterial activity of a series of 5-alkyl, 5-alkenyl, and 5-heterosubstituted oxazoles.

D. Davies, P. Brown, J. Wilson, 1996, Journal of medicinal chemistry.

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2016, Bioorganic & medicinal chemistry letters.

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, E. Minthorn, 2013, Bioorganic & medicinal chemistry letters.

Novel cyclohexyl-amides as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, Susanne Eyrisch, 2011, Bioorganic & medicinal chemistry letters.

Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases.

S. Dabbs, D. Davies, T. Gallagher, 2011, Bioorganic & medicinal chemistry letters.

Potent synthetic inhibitors of tyrosyl tRNA synthetase derived from C-pyranosyl analogues of SB-219383.

A. Pope, D. Hamprecht, P. Brown, 2001, Bioorganic & medicinal chemistry letters.

Crystal structure of Staphylococcus aureus tyrosyl‐tRNA synthetase in complex with a class of potent and specific inhibitors

Xiayang Qiu, Paul Carter, Judith M. LaLonde, 2001, Protein science : a publication of the Protein Society.

Direct modifications of the cyclic peptide Polymyxin B leading to analogues with enhanced in vitro antibacterial activity.

M. Dawson, S. Stanway, S. Boakes, 2020, Bioorganic & medicinal chemistry letters.

A perspective on the next generation of antibacterial agents derived by manipulation of natural products.

Pamela Brown, Michael J Dawson, M. Dawson, 2015, Progress in medicinal chemistry.

The Chemistry of Pseudomonic Acid.† 18. Heterocyclic Replacement of the α,β-Unsaturated Ester: Synthesis, Molecular Modeling, and Antibacterial Activity1

N. F. Osborne, T. Mitchell, P. Brown, 1997 .

β-Lactamase-stable penicillins. Synthesis and structure–activity relationships of (Z)-alkyloxyimino penicillins; selection of BRL 44154

M. J. Pearson, J. Lowther, A. J. Eglington, 1991 .

Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.

A. Pope, D. Eggleston, R. Haltiwanger, 2001, Bioorganic & medicinal chemistry letters.

Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues.

A. K. Forrest, Murray J. B. Brown, R. Copley, 2004, Bioorganic & medicinal chemistry letters.

Molecular recognition of tyrosinyl adenylate analogues by prokaryotic tyrosyl tRNA synthetases.

N. F. Osborne, A. Pope, C. Richardson, 1999, Bioorganic & medicinal chemistry.

The design of efficient and selective routes to pyridyl analogues of 2,3-dihydro-1,4-benzodioxin-6-carbaldehyde

S. Dabbs, D. Davies, Christopher W. Barfoot, 2010 .

A stereocontrolled route to optically active 1-methyl carbapenems

R. Southgate, P. Brown, 1986 .

Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections

M. Dawson, P. Brown, 2017, The Journal of Antibiotics.

Influence of Lipophilicity on the Antibacterial Activity of Polymyxin Derivatives and on Their Ability to Act as Potentiators of Rifampicin.

M. Dawson, S. Stanway, S. Boakes, 2021, ACS infectious diseases.

Design of Next Generation Polymyxins with Lower Toxicity: The Discovery of SPR206.

M. Dawson, S. Stanway, S. Boakes, 2019, ACS infectious diseases.

Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity.

A. Pope, S. Rittenhouse, P. Brown, 2003, Bioorganic & medicinal chemistry letters.

The chemistry of pseudomonic acid. 18. Heterocyclic replacement of the alpha,beta-unsaturated ester: synthesis, molecular modeling, and antibacterial activity.

N. F. Osborne, T. Mitchell, P. Brown, 1997, Journal of medicinal chemistry.