Yun-long Li

发表

Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties.

Chong-Hwan Chang, P. Lam, D. Cheney, 2008, Bioorganic & medicinal chemistry letters.

Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy

H. Koblish, M. Stubbs, Q. Wang, 2020, The Journal of Pharmacology and Experimental Therapeutics.

Differential expression of glycoprotein non-metastatic melanoma protein B (GPNMB) involved in trichostatin A-induced apoptosis in gastric cancer.

G. Nie, X. Zou, Yun-long Li, 2014, International journal of clinical and experimental medicine.

Preclinical characterization of INCB053914, a novel pan-PIM kinase inhibitor, alone and in combination with anticancer agents, in models of hematologic malignancies

R. Wynn, A. Margulis, H. Koblish, 2018, PloS one.

Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.

R. Wynn, P. Scherle, K. Vaddi, 2022, Bioorganic & medicinal chemistry letters.

Ternary nanoparticles composed of cationic solid lipid nanoparticles, protamine, and DNA for gene delivery

Wei Zhang, Hong Yuan, F. Hu, 2013, International journal of nanomedicine.

Preparation and characteristics of lipid nanoemulsion formulations loaded with doxorubicin

Hong Yuan, F. Hu, Yongzhong Du, 2013, International journal of nanomedicine.

A Potent and Selective Dual Inhibitor of AXL and MERTK Possesses Both Immunomodulatory and Tumor-Targeted Activity

R. Wynn, H. Koblish, X. Wen, 2020, Frontiers in Oncology.

Abstract 3759: Characterization of INCB081776, a potent and selective dual AXL/MER kinase inhibitor

R. Wynn, X. Liu, H. Koblish, 2018, Immunology.

Chinese medicine single-walled carbon nanotube targeting compound for antitumor therapy: A feasible way?

Yun-long Li, Ze-feng Lai, Jie-jia Li, 2012, Chinese Journal of Integrative Medicine.

INCB050465 (Parsaclisib), a Novel Next-Generation Inhibitor of Phosphoinositide 3-Kinase Delta (PI3Kδ).

H. Koblish, P. Scherle, T. Maduskuie, 2019, ACS medicinal chemistry letters.

Discovery of a novel 2-spiro-proline steroid mimetic scaffold for the potent inhibition of 11β-HSD1.

R. Wynn, P. Scherle, Yanlong Li, 2022, Bioorganic & medicinal chemistry letters.

A Facile Stereoselective Synthesis of Sphingosine and Ceramide

Yu-lin Wu, Yun-long Li, Yu‐lin Wu, 1996 .

Downregulation of growth differentiation factor-15 in trichostatin A-induced apoptosis could play a role in progression of gastric cancer.

F. Gao, Xiao-lin Li, Zhi Cao, 2015, International journal of clinical and experimental pathology.

Preparation of 1-(3-aminobenzo[d]isoxazol-5-yl)-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones as potent, selective, and efficacious inhibitors of coagulation factor Xa.

P. Lam, R. Knabb, R. Wexler, 2006, Bioorganic & medicinal chemistry letters.

Diastereoselective propargylation of α-alkoxy ldehydes with propargyl bromide and zinc. A versatile and efficient method for the synthesis of chiral oxygenated acyclic natural

Z. Yao, Yi Xia, Yu-lin Wu, 1995 .

Application of Ferrocenylalkyl Chiral Auxiliaries to Syntheses of Indolenine Alkaloids: Enantioselective Syntheses of Vincadifformine, ψ- and 20-epi-ψ-Vincadifformines, Tabersonine, Ibophyllidine, and Mossambine

Tiansheng Wang, U. Bandarage, Yun-long Li, 1998 .

Synthesis and glycosylation of thio-D-fructofuranoside donors

Yu-lin Wu, Yun-long Li, Yu‐lin Wu, 1996 .

Syntheses of Chiral Acyclic Natural Products from Sugar

Z. Yao, Wang Yifei, Zhihua Peng, 1995 .

Asymmetric Synthesis of Conformationally Constrained trans-2,3-Piperidinedicarboxylic Acid Derivatives

B. Metcalf, W. Yao, Meizhong Xu, 2007 .

Chinese Medicine Amygdalin and β-Glucosidase Combined with Antibody Enzymatic Prodrug System As A Feasible Antitumor Therapy

Xiang‐qian Shen, Yun-long Li, Ruijiang Liu, 2018, Chinese Journal of Integrative Medicine.

Pyrones. X: Lateropyrone, a new antibiotic from the fungus Fusarium lateritium nees

Yun-long Li, G. W. Bushnell, G. Poulton, 1984 .

Solid-liquid synthesis of Ti3SiC2 particulate by fluctuation procedure

Y. Y. Li, Y. Zhang, Y. Zhou, 2003 .

Deracemization of aryl secondary alcohols via enantioselective oxidation and stereoselective reduction with tandem whole-cell biocatalysts

Jian‐He Xu, Yun-long Li, Y. Xu, 2010 .

Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.

P. Scherle, Yanlong Li, M. Covington, 2009, Bioorganic & medicinal chemistry letters.

INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies

Jun Yu Li, Qianqian Wang, B. Rumberger, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Effect of trichostatin a on SGC-7901 gastric cancer cells.

Tong-Shu Yang, X. Zou, Yun-long Li, 2014, International journal of clinical and experimental medicine.

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

R. Wynn, J. Fridman, P. Scherle, 2009, Bioorganic & Medicinal Chemistry Letters.

Vanillic acid alleviates palmitic acid-induced oxidative stress in human umbilical vein endothelial cells via Adenosine Monophosphate-Activated Protein Kinase signaling pathway.

Yun-long Li, Xue Meng, Min Wang, 2019, Journal of food biochemistry.

Electrical Sensitivity and Mechanical Properties of Fast Responsive PAMPS–PAA‐PVA T–IPN Hydrogels

Yun-long Li, Song-bai Lin, C. Yuan, 2013 .

Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.

J. Fridman, P. Scherle, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.

M. Bower, R. Wynn, J. Fridman, 2007, Journal of medicinal chemistry.

Gastric cancer cell lines induced by trichostatin A.

Songbin Fu, Hao Wang, Xiao-lin Li, 2008, World journal of gastroenterology.

R. Wynn, P. Scherle, K. Vaddi, 2022, Bioorganic & medicinal chemistry letters.

INCB040093 Is a Novel PI3Kδ Inhibitor for the Treatment of B Cell Lymphoid Malignancies

Jun Yu Li, Qianqian Wang, B. Rumberger, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Abstract C103: The combination of PI3kδ-selective inhibition and immunomodulation shows efficacy in solid tumor models

H. Koblish, Yue Zhang, P. Scherle, 2015 .

Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.

P. Scherle, Yanlong Li, M. Covington, 2009, Bioorganic & medicinal chemistry letters.