Robert M. Oliver

发表

Chemically-enabled synthesis of 1,2,3,4-tetrahydroisoquinolin-1-ones

Edward L. Conn, Yu Hui, Paul S. Humphries, 2009 .

In vitro and in vivo characterization of 3-[2-[6-(2-tert-butoxyethoxy)pyridin-3-yl]-1H-imidazol-4-yl]benzonitrile hydrochloride salt, a potent and selective NPY5 receptor antagonist.

T. Maurer, D. Hargrove, C. Mack, 2003, Journal of medicinal chemistry.

Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.

Daniel P. Walker, A. Kalgutkar, Joel Morris, 2009, Bioorganic & medicinal chemistry letters.

Structure-activity relationship studies on 2-heteroaryl-4-arylimidazoles NPY5 receptor antagonists.

T. Maurer, C. Mack, Robert M. Oliver, 2003, Bioorganic & medicinal chemistry letters.

Strain-Release Heteroatom Functionalization: Development, Scope, and Stereospecificity

N. Sach, W. Farrell, J. Mousseau, 2017, Journal of the American Chemical Society.

One-pot (1-ethoxycarbonylcyclopropyl)triphenylphosphonium tetrafluoroborate ring-opening and Wittig reaction.

Laura A McAllister, Robert M. Oliver, Seungwon Chung, 2011, Organic letters.

Pyridone methylsulfone hydroxamate LpxC inhibitors for the treatment of serious gram-negative infections.

V. Shanmugasundaram, K. Leach, M. Huband, 2012, Journal of medicinal chemistry.

Potent inhibitors of LpxC for the treatment of Gram-negative infections.

V. Shanmugasundaram, J. Warmus, K. Leach, 2012, Journal of medicinal chemistry.

Delineating the role of cooperativity in the design of potent PROTACs for BTK

Graham M. West, James Smith, V. Shanmugasundaram, 2018, Proceedings of the National Academy of Sciences.

The discovery of novel calcium sensing receptor negative allosteric modulators.

J. Bauman, David A. Price, A. Kalgutkar, 2009, Bioorganic & medicinal chemistry letters.

Trifluoromethylpyrimidine-based inhibitors of proline-rich tyrosine kinase 2 (PYK2): structure-activity relationships and strategies for the elimination of reactive metabolite formation.

Leonard Buckbinder, Jacquelyn Klug-McLeod, Angel Guzman-Perez, 2008, Bioorganic & medicinal chemistry letters.

Facile synthesis of 4,5-disubstituted-3(2H)-pyridazinones

Paul S. Humphries, Robert M. Oliver, 2009 .

Structure-activity relationships in a series of NPY Y5 antagonists: 3-amido-9-ethylcarbazoles, core-modified analogues and amide isosteres.

C. Mack, Robert M. Oliver, R. Hank, 2003, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of 1,2,3,4-tetrahydroisoquinolin-1-ones as novel G-protein-coupled receptor 40 (GPR40) antagonists.

W. Soeller, Edward L. Conn, Paul S. Humphries, 2009, Bioorganic & medicinal chemistry letters.

Heterocyclic methylsulfone hydroxamic acid LpxC inhibitors as Gram-negative antibacterial agents.

Mark J. Mitton-Fry, V. Shanmugasundaram, Ye Che, 2012, Bioorganic & medicinal chemistry letters.

Discovery of N-benzyl-2-[(4S)-4-(1H-indol-3-ylmethyl)-5-oxo-1-phenyl-4,5-dihydro-6H-[1,2,4]triazolo[4,3-a][1,5]benzodiazepin-6-yl]-N-isopropylacetamide, an orally active, gut-selective CCK1 receptor agonist for the potential treatment of obesity.

A. Kalgutkar, T. Maurer, D. Scott, 2010, Bioorganic & medicinal chemistry letters.

Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.

Daniel P. Walker, J. Bauman, A. Kalgutkar, 2010, Chemical research in toxicology.

Metabolism-guided design of short-acting calcium-sensing receptor antagonists.

J. Bauman, David A. Price, A. Kalgutkar, 2010, ACS medicinal chemistry letters.

Discovery of a Selective Covalent Inhibitor of Lysophospholipase-like 1 (LYPLAL1) as a Tool to Evaluate the Role of this Serine Hydrolase in Metabolism.

K. Fennell, J. Pandit, K. Parris, 2016, ACS chemical biology.

The discovery of novel calcium sensing receptor negative allosteric modulators.

J. Bauman, A. Kalgutkar, V. Paralkar, 2009, Bioorganic & medicinal chemistry letters.