Toshinori Higashi

发表

Chemoenzymatic synthesis of (2R,3R,4R)-dehydroxymethylepoxyquinomicin (DHMEQ), a new activator of antioxidant transcription factor Nrf2.

K. Umezawa, T. Sugai, M. Shoji, 2011, Organic & biomolecular chemistry.

Lipase-catalyzed enantio- and regioselective transformation of 3-epi-shikimic acid derivatives as the key step for the entry of polyoxygenated carbacycles

K. Umezawa, T. Sugai, M. Hamada, 2010 .

Enzyme-catalyzed resolution of 3,8-dioxatricyclo[3.2.1.02,4]octane-6-carboxylic esters and the application to the synthesis of 3-epishikimic acid

K. Umezawa, T. Sugai, Yasuhito Nagai, 2009 .

A short-step chemo-enzymatic synthesis of a precursor for l-nucleosides from d-lyxose

T. Sugai, J. Calveras, Yasuhito Nagai, 2009 .

Chemo-enzymatic route for (R)-terbutaline hydrochloride based on microbial asymmetric reduction of a substituted α-chloroacetophenone derivative

T. Sugai, M. Shoji, Toshinori Higashi, 2012 .

The scope and limitation of the regio- and enantioselective hydrolysis of aliphatic epoxides using Bacillus subtilis epoxide hydrolase, and exploration toward chirally differentiated tris(hydroxymethyl)methanol

T. Sugai, K. Shimizu, M. Hamada, 2010 .

Examination of spacer effects on stereochemical recognition of a remote sterically hindered chiral center in lipase-catalyzed acylation

T. Sugai, M. Hamada, M. Shoji, 2012 .

Reduction of acetophenones with methyl fluorines and a bulky group on the aromatic ring using microorganisms and related enzymes

Chen Cao, Kengo Hanaya, T. Sugai, 2012 .

Chemoenzymatic Synthesis of Both Enantiomers of 2‐tert‐Butyl‐2‐methyl‐1,3‐benzodioxole‐4‐carboxylic (TBMB) Acid

T. Sugai, K. Ninomiya, C. Abe, 2010 .

Unique behavior of 2,6-bis(bromomethyl)naphthalene as a highly active organic DNA crosslinking molecule.

M. Mochizuki, Toshinori Higashi, K. Inami, 2009, Bioorganic & medicinal chemistry.

Elaboration on the access to (S)-4-(4-methylbenzyl)oxy-3-hydroxybutanenitrile, a key intermediate for statins, by combining the kinetic resolution of racemate and the recycle of undesired enantiomer

T. Sugai, M. Hamada, M. Shoji, 2010 .

New chemo-enzymatic route toward N-acetylneuraminic acid derivatives with alkyl groups at C-7 hydroxyl group

T. Sugai, J. Calveras, Yasuhito Nagai, 2010 .

Synthesis and DNA‐binding properties of 1,10‐phenanthroline analogues as intercalating‐crosslinkers

M. Mochizuki, Toshinori Higashi, K. Inami, 2008 .

The mutagenic mechanism of oxygenated alkylhydrazones occurs through alkyl radicals and alkyldiazonium ions.

M. Mochizuki, M. Takada, Toshinori Higashi, 2017, Toxicology research.

A randomized, placebo-controlled study to evaluate safety and pharmacokinetics of ART-001 with a novel oral pediatric formulation in healthy subjects.

Toshinori Higashi, N. Uemura, H. Nagabukuro, 2023, Clinical and translational science.