J. Katz

发表

Diastereoselective alkylations of oxazolidinone glycolates: a useful extension of the Evans asymmetric alkylation.

K. A. Emmitte, M. Crimmins, J. Katz, 2000, Organic letters.

Asymmetric total synthesis of spongistatins 1 and 2.

M. Crimmins, S. Allwein, J. Katz, 2002, Journal of the American Chemical Society.

Aminopurine based JNK inhibitors for the prevention of ischemia reperfusion injury.

Y. Satoh, B. Bennett, D. Giegel, 2012, Bioorganic & medicinal chemistry letters.

The cGAS–STING pathway as a therapeutic target in inflammatory diseases

S. Venkatraman, A. Ablasser, J. Katz, 2021, Nature Reviews Immunology.

Characterizing Pharmacokinetic–Pharmacodynamic Relationships and Efficacy of PI3Kδ Inhibitors in Respiratory Models of TH2 and TH1 Inflammation

H. Houshyar, Hongshi Yu, S. Alves, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Divergent and Regioselective Synthesis of Pyrazolo[1,5-a]pyridines and Imidazo[1,5-a]pyridines.

J. Katz, J. Saurí, Kaila A. Margrey, 2021, Organic letters.

Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.

H. Su, Sangita Patel, H. Gunaydin, 2016, Bioorganic & medicinal chemistry letters.

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.

M. Altman, X. Fradera, Hongshi Yu, 2021, Journal of medicinal chemistry.

Optimization of Versatile Oxindoles as Selective PI3Kδ Inhibitors.

M. Augustin, X. Fradera, Karin M. Otte, 2020, ACS medicinal chemistry letters.

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

T. Fischmann, M. Altman, X. Fradera, 2019, Journal of medicinal chemistry.

Pomalidomide Shows Significant Therapeutic Activity against CNS Lymphoma with a Major Impact on the Tumor Microenvironment in Murine Models

J. Copland, H. Tun, P. Huang, 2013, PloS one.

Studies towards the total synthesis of palau'amine. Formation of 4,5-dihydropyrrole-2-carboxylate intermediates by alkene–enamide ring-closing metathesis

L. Overman, J. Katz, 2004 .

An aldol approach to the synthesis of the EF fragment of spongistatin 1.

M. Crimmins, S. Kirincich, J. Katz, 2001, Organic letters.

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

K. Kunii, M. Altman, A. Szewczak, 2011, Journal of medicinal chemistry.

Preparation of a stable trifluoroborate salt for the synthesis of 1-aryl-2,2-difluoro-enolethers and/or 2,2-difluoro-1-aryl-ketones via palladium-mediated cross-coupling.

C. Dinsmore, J. Katz, Blair T. Lapointe, 2009, The Journal of organic chemistry.

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor.

Philip Chamberlain, Y. Satoh, B. Bennett, 2012, Bioorganic & medicinal chemistry letters.

Discovery and optimization of heteroaryl piperazines as potent and selective PI3Kδ inhibitors.

M. Augustin, X. Fradera, A. Bass, 2019, Bioorganic & medicinal chemistry letters.

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.

Synthesis of the C16-C28 spiroketal subunit of spongistatin 1 (altohyrtin A): the pyrone approach.

M. Crimmins, J. Katz, 2000, Organic letters.

Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.

M. Augustin, M. Altman, X. Fradera, 2019, Bioorganic & medicinal chemistry letters.

The Discovery of a Dual TTK Protein Kinase/CDC2-Like Kinase (CLK2) Inhibitor for the Treatment of Triple Negative Breast Cancer Initiated from a Phenotypic Screen.

L. LeBrun, Dan Zhu, B. Pagarigan, 2017, Journal of medicinal chemistry.

Structure Overhaul Affords a Potent Purine PI3K delta Inhibitor with Improved Tolerability.

T. Fischmann, X. Fradera, T. Guzi, 2019 .

Process Development and Large-Scale Synthesis of a c-Met Kinase Inhibitor

Simon E. Hamilton, Jeremy P. Scott, D. J. Wallace, 2010 .

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.

M. Augustin, M. Altman, X. Fradera, 2021, Bioorganic & medicinal chemistry letters.

523 Antitumor activity of mTOR kinase and DNA-PK inhibitor CC-115 in a mouse model of glioblastoma

D. Mortensen, C. Phan, M. Moghaddam, 2014 .

Discovery and optimization of thieno[2,3-d]pyrimidines as B-Raf inhibitors.

B. Cathers, S. Sakata, J. Leisten, 2012, Bioorganic & medicinal chemistry letters.

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.

Andrew M Haidle, H. Su, S. Munshi, 2017, Bioorganic & medicinal chemistry letters.

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.

Andrew M Haidle, M. Altman, A. Szewczak, 2017, Bioorganic & medicinal chemistry letters.

MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.

C. Paweletz, K. Kunii, I. Kariv, 2010, Cancer research.