D. Tikhonov

发表

Mutational analysis of state-dependent contacts in the pore module of eukaryotic sodium channels.

Y. Nomura, Yuzhe Du, K. Dong, 2018, Archives of biochemistry and biophysics.

Conservation and variability of the pore-lining helices in P-loop channels

B. Zhorov, D. Tikhonov, 2017, Channels.

Intersegment contacts determine geometry of the open and closed states in P-loop channels

B. Zhorov, D. Tikhonov, 2020, Journal of biomolecular structure & dynamics.

Architecture of the Neuronal Nicotinic Acetylcholine Receptor Ion Channel at the Binding Site of bis-Ammonium Blockers

V. Gmiro, B. Zhorov, N. Brovtsyna, 1996, The Journal of Membrane Biology.

Mechanism of sodium channel block by local anesthetics, antiarrhythmics, and anticonvulsants

B. Zhorov, D. Tikhonov, 2017, The Journal of general physiology.

Optical control of L-type Ca2+ channels using a diltiazem photoswitch

D. Trauner, T. Bruegmann, D. Malan, 2018, Nature Chemical Biology.

Computational Structural Pharmacology and Toxicology of Voltage-Gated Sodium Channels.

B. Zhorov, D. Tikhonov, 2016, Current topics in membranes.

Monoamine NMDA receptor channel blockers inhibit and potentiate native and recombinant proton-gated ion channels

T. B. Tikhonova, D. Tikhonov, K. Bolshakov, 2015, Neuropharmacology.

Extremely Potent Block of Bacterial Voltage-Gated Sodium Channels by µ-Conotoxin PIIIA

R. French, J. McArthur, Rocio K. Finol-Urdaneta, 2019, Marine drugs.

Hydrophobic Amines and Their Guanidine Analogues Modulate Activation and Desensitization of ASIC3

D. Tikhonov, V. Gmiro, N. N. Potapieva, 2019, International journal of molecular sciences.

Multiple modes of action of hydrophobic amines and their guanidine analogues on ASIC1a

D. Tikhonov, V. Gmiro, O. I. Barygin, 2019, European journal of pharmacology.

Possible Roles of Exceptionally Conserved Residues around the Selectivity Filters of Sodium and Calcium Channels*

B. Zhorov, D. Tikhonov, 2010, The Journal of Biological Chemistry.

B. Zhorov, D. Tikhonov, V. S. Korkosh, 2014, The Journal of general physiology.

Modeling interactions between blocking and permeant cations in the NavMs channel.

B. Zhorov, D. Tikhonov, Vyacheslav S Korkosh, 2016, European journal of pharmacology.

Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels

R. Gaudet, R. French, J. McArthur, 2018, The Journal of general physiology.

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels

Daniel P. Garden, B. Zhorov, Iva Bruhova, 2015, Pflügers Archiv - European Journal of Physiology.

Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels

B. Zhorov, D. Tikhonov, V. S. Korkosh, 2016, European Biophysics Journal.

Determinants of trapping block of N‐methyl‐d‐aspartate receptor channels

D. Tikhonov, V. Gmiro, K. Bolshakov, 2003, Journal of neurochemistry.

Determinants of action of hydrophobic amines on ASIC1a and ASIC2a.

L. Magazanik, D. Tikhonov, V. Gmiro, 2016, European journal of pharmacology.

Voltage‐dependent and ‐independent block of α‐amino‐3‐hydroxy‐5‐methylisoxazole‐4‐propionate receptor channels

N. V. Luchkina, D. Tikhonov, O. I. Barygin, 2010, Journal of neurochemistry.

Effect of Flumazenil on GABAA Receptors in Isolated Rat Hippocampal Neurons

M. Weiss, D. Tikhonov, S. Buldakova, 2002, Neurochemical Research.

Properties of spontaneous and miniature excitatory postsynaptic currents in neurons of the rat prefrontal cortex

A. Zaitsev, D. Tikhonov, S. L. Malkin, 2014, Journal of Evolutionary Biochemistry and Physiology.

Molecular evolution of ion channels: Amino acid sequences and 3D structures

B. Zhorov, D. Tikhonov, V. S. Korkosh, 2016, Journal of Evolutionary Biochemistry and Physiology.

Ligands of histamine receptors modulate acid-sensing ion channels.

D. Tikhonov, N. N. Potapieva, V. Shteinikov, 2017, Biochemical and biophysical research communications.

Histamine selectively potentiates acid-sensing ion channel 1a

L. Magazanik, D. Tikhonov, E. Nagaeva, 2016, Neuroscience Letters.

Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2003, Molecular pharmacology.

Irreversible Block of Cardiac Mutant Na+ Channels by Batrachotoxin

Jane Mitchell, B. Zhorov, D. Tikhonov, 2007, Channels.

How Batrachotoxin Modifies the Sodium Channel Permeation Pathway: Computer Modeling and Site-Directed Mutagenesis

Jane Mitchell, B. Zhorov, D. Tikhonov, 2006, Molecular Pharmacology.

Structural Model for Dihydropyridine Binding to L-type Calcium Channels*

Boris S Zhorov, Denis B Tikhonov, B. Zhorov, 2009, The Journal of Biological Chemistry.

Intersegment hydrogen bonds as possible structural determinants of the N/Q/R site in glutamate receptors.

B. Zhorov, D. Tikhonov, L. Magazanik, 1999, Biophysical journal.

Design of antagonists for NMDA and AMPA receptors

P. Usherwood, I. Mellor, D. Tikhonov, 2005, Neuropharmacology.

Development of a quaternary ammonium photoswitchable antagonist of NMDA receptors.

Daniil M. Strashkov, M. N. Ryazantsev, D. Tikhonov, 2022, European journal of pharmacology.

Optical Control of N-Methyl-d-aspartate Receptors by Azobenzene Quaternary Ammonium Compounds.

Mikhail N. Ryazantsev, Daniil M. Strashkov, M. N. Ryazantsev, 2021, ACS chemical neuroscience.

The Effects of Conformational Constraints in the Polyamine Moiety of Philanthotoxins on AMPAR Inhibition

J. Jaroszewski, H. Franzyk, I. Mellor, 2014, ChemMedChem.

The Effect of Hydrophobic Monoamines on Acid-Sensing Ion Channels ASIC1B

D. Tikhonov, E. Nagaeva, N. N. Potapieva, 2015, Acta naturae.

Potassium, sodium, calcium and glutamate‐gated channels: pore architecture and ligand action

B. Zhorov, D. Tikhonov, 2004, Journal of neurochemistry.

Access and Binding of Local Anesthetics in the Closed Sodium Channel

B. Zhorov, Iva Bruhova, D. Tikhonov, 2008, Molecular Pharmacology.

3D Structures and Molecular Evolution of Ion Channels

B. Zhorov, D. Tikhonov, 2018 .

Chapter 14 3 D Structures and Molecular Evolution of Ion Channels

B. Zhorov, D. Tikhonov, 2018 .

Predicting Structural Details of the Sodium Channel Pore Basing on Animal Toxin Studies

B. Zhorov, D. Tikhonov, 2018, Front. Pharmacol..

Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations

L. Magazanik, D. Tikhonov, M. Nikolaev, 2012, Neuropharmacology.

Ion channels of glutamate receptors: structural modeling

D. Tikhonov, 2007, Molecular membrane biology.

Inhibition of the NMDA and AMPA receptor channels by antidepressants and antipsychotics

N. Vanchakova, D. Tikhonov, N. Shestakova, 2017, Brain Research.

Ligand action on sodium, potassium, and calcium channels: role of permeant ions.

B. Zhorov, D. Tikhonov, 2013, Trends in pharmacological sciences.

Architecture and Pore Block of Eukaryotic Voltage-Gated Sodium Channels in View of NavAb Bacterial Sodium Channel Structure

B. Zhorov, D. Tikhonov, 2012, Molecular Pharmacology.

Modeling P-loops domain of sodium channel: homology with potassium channels and interaction with ligands.

B. Zhorov, D. Tikhonov, 2005, Biophysical journal.

Glutamate potentiates heterologously expressed homomeric acid‐sensing ion channel 1a

D. Tikhonov, K. Bolshakov, V. Shteinikov, 2022 .

Statistical models suggest presence of two distinct subpopulations of miniature EPSCs in fast-spiking interneurons of rat prefrontal cortex

A. Zaitsev, L. Magazanik, D. Tikhonov, 2015, Neuroscience.

ω-Tbo-IT1–New Inhibitor of Insect Calcium Channels Isolated from Spider Venom

E. Grishin, A. Lipkin, E. Bocharov, 2015, Scientific Reports.

Computational Analysis of the Crystal and Cryo-EM Structures of P-Loop Channels with Drugs

B. Zhorov, D. Tikhonov, 2021, International journal of molecular sciences.

Modulation of Proton-Gated Channels by Antidepressants.

M. S. Komarova, D. Tikhonov, M. Nikolaev, 2018, ACS chemical neuroscience.

Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs

M. S. Komarova, L. Magazanik, D. Tikhonov, 2017, Channels.

Derivatives of 2-aminobenzimidazole potentiate ASIC open state with slow kinetics of activation and desensitization

M. S. Komarova, D. Tikhonov, O. Zhukovskaya, 2023, Frontiers in Physiology.

Mechanisms of acid-sensing ion channels inhibition by nafamostat, sepimostat and diminazene.

D. Tikhonov, O. I. Barygin, A. S. Zhigulin, 2022, European journal of pharmacology.

Ligand Docking to the Acidic Pocket of the Proton-Gated Ion Channel Asic1A

D. Tikhonov, V. S. Korkosh, 2019, Doklady Biochemistry and Biophysics.

Potentiation and Block of ASIC1a by Memantine

D. Tikhonov, Vyacheslav S Korkosh, Tatiana B. Tikhonova, 2018, Cellular and Molecular Neurobiology.

Modulation of Slow Desensitization (Tachyphylaxis) of Acid-Sensing Ion Channel (ASIC)1a

M. S. Komarova, D. Tikhonov, N. N. Potapieva, 2022, Cellular and Molecular Neurobiology.

Reversible Slow Desensitization of the Acid-Sensing Ion Channel (ASIC) 1a

M. S. Komarova, D. Tikhonov, N. N. Potapieva, 2021 .

TRPV1 activation power can switch an action mode for its polypeptide ligands

M. S. Komarova, E. Grishin, Yuliya V. Korolkova, 2017, PloS one.

Non‐classical mechanism of α‐amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid receptor channel block by fluoxetine

M. S. Komarova, D. Tikhonov, O. I. Barygin, 2015, The European journal of neuroscience.

Sodium channel activators: Model of binding inside the pore and a possible mechanism of action

B. Zhorov, D. Tikhonov, 2005, FEBS letters.

P-Loop Channels: Experimental Structures, and Physics-Based and Neural Networks-Based Models

B. Zhorov, D. Tikhonov, 2022, Membranes.

Serine-401 as a batrachotoxin- and local anesthetic-sensing residue in the human cardiac Na+ channel

Jane Mitchell, B. Zhorov, D. Tikhonov, 2007, Pflügers Archiv - European Journal of Physiology.

Common Binding Site for Externally and Internally Applied AMPA Receptor Channel Blockers

L. Magazanik, D. Tikhonov, T. B. Tikhonova, 2009, Journal of Molecular Neuroscience.

Organic blockers escape from trapping in the AMPA receptor channels by leaking into the cytoplasm

D. Tikhonov, V. Gmiro, O. I. Barygin, 2008, Neuropharmacology.

Modeling noncompetitive antagonism of a nicotinic acetylcholine receptor.

P. Usherwood, I. Mellor, D. Tikhonov, 2004, Biophysical journal.

Voltage‐dependent block of native AMPA receptor channels by dicationic compounds

M. Samoilova, D. Tikhonov, S. Buldakova, 2000, British journal of pharmacology.

Argiotoxin in the closed AMPA receptor channel: experimental and modeling study.

E. Grishin, D. Tikhonov, O. I. Barygin, 2011, Biochemistry.

Uncompetitive antagonism of AMPA receptors: Mechanistic insights from studies of polyamine toxin derivatives.

K. Strømgaard, J. Egebjerg, I. Mellor, 2006, Journal of medicinal chemistry.

Effects of the Ionic Composition of the External Medium on Blockade of the Ion Channels of AMPA Receptors

D. Tikhonov, L. Magazanik, T. B. Tikhonova, 2011, Neuroscience and Behavioral Physiology.

Sodium channels: ionic model of slow inactivation and state-dependent drug binding.

Boris S Zhorov, Denis B Tikhonov, B. Zhorov, 2007, Biophysical journal.

Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers.

P. Usherwood, L. Magazanik, D. Tikhonov, 2002, Biophysical journal.

Molecular Modeling of Benzothiazepine Binding in the L-type Calcium Channel*

Boris S Zhorov, Denis B Tikhonov, B. Zhorov, 2008, Journal of Biological Chemistry.

Characterization of acid-sensitive ion channels in freshly isolated rat brain neurons

K. Essin, S. Skatchkov, M. Eaton, 2002, Neuroscience.

The pore domain in glutamate-gated ion channels: Structure, drug binding and similarity with potassium channels.

B. Zhorov, D. Tikhonov, 2020, Biochimica et biophysica acta. Biomembranes.

Blockade of NMDA receptor channels by 9-aminoacridine and its derivatives

L. Magazanik, D. Tikhonov, V. Gmiro, 2009, Neuroscience Letters.

Voltage Dependence of Open Channel Blockade: Onset and Offset Rates

D. Tikhonov, L. Magazanik, 1998, The Journal of Membrane Biology.

State-dependent inter-repeat contacts of exceptionally conserved asparagines in the inner helices of sodium and calcium channels

Daniel P. Garden, B. Zhorov, Iva Bruhova, 2015, Pflügers Archiv - European Journal of Physiology.

Homology modeling of Kv1.5 channel block by cationic and electroneutral ligands.

B. Zhorov, D. Tikhonov, 2014, Biochimica et biophysica acta.

Kinked-helices model of the nicotinic acetylcholine receptor ion channel and its complexes with blockers: simulation by the Monte Carlo minimization method.

B. Zhorov, D. Tikhonov, Denis B. Tikhonov, 1998, Biophysical journal.

Molecular Modeling in Studies of Ion Channels and their Modulation by Ligands

B. Zhorov, D. Tikhonov, 2020, Neuroscience and Behavioral Physiology.

Mechanisms of action of ligands of potential-dependent sodium channels

D. Tikhonov, 2008, Neuroscience and Behavioral Physiology.

Atomic determinants of state‐dependent block of sodium channels by charged local anesthetics and benzocaine

B. Zhorov, Iva Bruhova, D. Tikhonov, 2006, FEBS letters.

In silico activation of KcsA K+ channel by lateral forces applied to the C-termini of inner helices.

Boris S Zhorov, Denis B Tikhonov, B. Zhorov, 2004, Biophysical journal.

Access and Binding of Local Anesthetics in the Closed Sodium Channel

B. Zhorov, Iva Bruhova, D. Tikhonov, 2008, Molecular Pharmacology.

Structural Model for Phenylalkylamine Binding to L-type Calcium Channels*

Boris S Zhorov, Denis B Tikhonov, B. Zhorov, 2009, The Journal of Biological Chemistry.

Molecular mechanisms of action determine inhibition of paroxysmal depolarizing shifts by NMDA receptor antagonists in rat cortical neurons

A. Chizhov, D. Tikhonov, M. Nikolaev, 2020, Neuropharmacology.

Analysis of inter-residue contacts reveals folding stabilizers in P-loops of potassium, sodium, and TRPV channels

B. Zhorov, D. Tikhonov, V. S. Korkosh, 2016, European Biophysics Journal.

Possible Compensatory Role of ASICs in Glutamatergic Synapses

D. Tikhonov, A. S. Zhigulin, Konstantin K Evlanenkov, 2023, International journal of molecular sciences.

Analysis of residue–residue interactions in the structures of ASIC1a suggests possible gating mechanisms

D. Tikhonov, Vyacheslav S Korkosh, 2023, European Biophysics Journal.

Ligands of Acid-Sensing Ion Channel 1a: Mechanisms of Action and Binding Sites

L. Magazanik, D. Tikhonov, E. Nagaeva, 2019, Acta naturae.

Phenylalkylamines in calcium channels: computational analysis of experimental structures

Boris S. Zhorov, Denis B. Tikhonov, Lianyun Lin, 2020, Journal of Computer-Aided Molecular Design.

Structural Model for Dihydropyridine Binding to L-type Calcium Channels*

B. Zhorov, D. Tikhonov, 2009, The Journal of Biological Chemistry.

Optical control of L-type Ca2+ channels using a diltiazem photoswitch

D. Trauner, T. Bruegmann, D. Malan, 2018, Nature Chemical Biology.

Influence of external magnesium ions on the NMDA receptor channel block by different types of organic cations

L. Magazanik, D. Tikhonov, M. Nikolaev, 2012, Neuropharmacology.

Complex action of tyramine, tryptamine and histamine on native and recombinant ASICs

M. S. Komarova, L. Magazanik, D. Tikhonov, 2017, Channels.

Research Online Research Online Extremely potent block of bacterial voltage-gated sodium Extremely potent block of bacterial voltage-gated sodium channels by µ-conotoxin PIIIA channels by µ-conotoxin PIIIA

R. Mcarthur, Rocio K. Finol-Urdaneta, Sun Huang, 2019 .

Mechanisms of dihydropyridine agonists and antagonists in view of cryo-EM structures of calcium and sodium channels

B. Zhorov, D. Tikhonov, 2023, The Journal of general physiology.

Ligand action on sodium, potassium, and calcium channels: role of permeant ions.

B. Zhorov, D. Tikhonov, 2013, Trends in pharmacological sciences.

Lidocaine and carbamazepine inhibit while phenytoin and lamotrigine paradoxically enhance the insect neuromuscular transmission

D. Tikhonov, I. M. Fedorova, 2019, Invertebrate Neuroscience.