M. Neu

发表

Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode.

Brian Evans, Michael Kranz, J. Gross, 2009, Bioorganic & medicinal chemistry.

New direct inhibitors of InhA with antimycobacterial activity based on a tetrahydropyran scaffold.

David Barros, L. Ballell-Pages, C. Chung, 2016, European journal of medicinal chemistry.

The crystal and molecular structures of diferric porcine and rabbit serum transferrins at resolutions of 2.15 and 2.60 A, respectively.

D. Hall, G. Leonard, M. Winn, 2002, Acta crystallographica. Section D, Biological crystallography.

Metal-induced conformational changes in transferrins.

J. G. Grossmann, R. W. Evans, S. Hasnain, 1993, Journal of molecular biology.

X-ray scattering using synchrotron radiation shows nitrite reductase from Achromobacter xylosoxidans to be a trimer in solution.

J. G. Grossmann, S. Hasnain, E. Adman, 1993, Biochemistry.

X-ray Crystal Structure of Human Dopamine Sulfotransferase, SULT1A3

A. Hersey, R. Cooke, H. Jhoti, 1999, The Journal of Biological Chemistry.

Influence of protein dynamics on the metal-sites of ovotransferrin

M. Neu, H. Appel, W. Thies, 2004, European Biophysics Journal.

Targeting the regulatory site of ER aminopeptidase 1 leads to the discovery of a natural product modulator of antigen presentation.

Jonathan M. Lea, J. Liddle, P. Rowland, 2020, Journal of medicinal chemistry.

High-Resolution Crystal Structure of Endoplasmic Reticulum Aminopeptidase 1 with Bound Phosphinic Transition-State Analogue Inhibitor

P. Rowland, E. Stratikos, M. Neu, 2019, ACS medicinal chemistry letters.

Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism.

Birgit Dümpelfeld, James M. Woolven, S. Teague, 2021, Journal of medicinal chemistry.

The development of highly potent and selective small molecule correctors of Z α1-antitrypsin misfolding.

J. Irving, Zhengrong Zhu, D. Lomas, 2021, Bioorganic & medicinal chemistry letters.

Quinolines as a novel structural class of potent and selective PDE4 inhibitors: optimisation for oral administration.

M. Lindvall, D. Somers, T. Shipley, 2009, Bioorganic & medicinal chemistry letters.

Asp ligand provides the trigger for closure of transferrin molecules. Direct evidence from X-ray scattering studies of site-specific mutants of the N-terminal half-molecule of human transferrin.

A. Mason, R. Woodworth, S. Hasnain, 1993, Journal of molecular biology.

Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors.

M. Lindvall, P. Jones, D. Somers, 2008, Bioorganic & medicinal chemistry letters.

X-ray solution scattering reveals conformational changes upon iron uptake in lactoferrin, serum and ovo-transferrins.

R. W. Evans, S. Hasnain, P. Lindley, 1992, Journal of molecular biology.

Exploring the SAR of the β-Ketoacyl-ACP Synthase Inhibitor GSK3011724A and Optimization around a Genotoxic Metabolite.

Robert H Bates, Fraser Cunningham, C. Chung, 2020, ACS infectious diseases.

N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.

R. Angell, P. Rowland, M. Cichy-Knight, 2007, Bioorganic & medicinal chemistry letters.

Structure-guided design of antibacterials that allosterically inhibit DNA gyrase.

Shruti Jain, R. Stavenger, K. Raha, 2019, Bioorganic & medicinal chemistry letters.

5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors.

P. Bamborough, A. Bridges, S. Belyanskaya, 2012, Bioorganic & medicinal chemistry letters.

Characterization and structural analysis of a functional human serum transferrin variant and implications for receptor recognition.

A. Aitken, R. Garratt, R. W. Evans, 1994, Biochemistry.

Mechanism for antigenic peptide selection by endoplasmic reticulum aminopeptidase 1

J. Liddle, P. Rowland, D. Georgiadis, 2019, Proceedings of the National Academy of Sciences.

Optimisation of a novel series of potent and orally bioavailable azanaphthyridine SYK inhibitors.

David M. Wilson, J. Liddle, D. Lugo, 2016, Bioorganic & medicinal chemistry letters.

Novel Interaction Mechanism of a Domain Antibody-based Inhibitor of Human Vascular Endothelial Growth Factor with Greater Potency than Ranibizumab and Bevacizumab and Improved Capacity over Aflibercept*

C. Chung, Gavin Jones, M. Mullin, 2016, The Journal of Biological Chemistry.

Identification of KasA as the cellular target of an anti-tubercular scaffold

Robert H Bates, N. Loman, G. Drewes, 2016, Nature Communications.

Rab7: NMR and kinetics analysis of intact and C‐terminal truncated constructs

M. Zerial, H. Oschkinat, P. Metcalf, 1997, Proteins.

Encoded library technology as a source of hits for the discovery and lead optimization of a potent and selective class of bactericidal direct inhibitors of Mycobacterium tuberculosis InhA.

Hongfang Yang, William McDowell, Paolo A Centrella, 2014, Journal of medicinal chemistry.

Rab7: Crystallization of intact and C‐terminal truncated constructs complexed with GDP and GppNHp

P. Metcalf, M. Neu, V. Brachvogel, 1997, Proteins.

Quick Fluorescence XAFS: A Technique for Recording Fluorescence X-ray Absorption Spectra during Chemical/Biochemical Reactions

B. Dobson, S. Hasnain, M. Neu, 1993 .

The mechanism of iron uptake by transferrins: the X-ray structures of the 18 kDa NII domain fragment of duck ovotransferrin and its nitrilotriacetate complex.

D. Hall, R. W. Evans, P. Lindley, 2002, Acta crystallographica. Section D, Biological crystallography.

The nature of ligand-induced conformational change in transferrin in solution. An investigation using X-ray scattering, XAFS and site-directed mutants.

R. Strange, R. W. Evans, S. Hasnain, 1998, Journal of molecular biology.

Discovery of potent and selective Spleen Tyrosine Kinase inhibitors for the topical treatment of inflammatory skin disease.

David M. Wilson, J. Liddle, D. Somers, 2018, Bioorganic & medicinal chemistry letters.

Evidence of internal protein dynamics in transferrins from TDPAC experiments

M. Neu, H. Appel, W. Thies, 1993 .

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration.

Tony W Dean, Michael D. Woodrow, D. Somers, 2009, Bioorganic & medicinal chemistry letters.

Quick Fluorescence-EXAFS: an Improved Method for Collection of Conventional XAFS Data, an Improved Method for Collection of Conventional XAFS Data and for Studying Reaction Intermediates in Dilute Systems.

B. Dobson, R. Strange, S. Hasnain, 1995, Journal of synchrotron radiation.

Perturbed angular correlation studies of the metal-binding sites in ovotransferrin and its C- and N-terminal halves

A. Mason, M. Neu, H. Appel, 1993, Biometals.

The mechanism of iron uptake by transferrins: the structure of an 18 kDa NII-domain fragment from duck ovotransferrin at 2.3 A resolution.

R. Strange, H. Jhoti, R. Garratt, 1993, Acta crystallographica. Section D, Biological crystallography.

Development of a small molecule that corrects misfolding and increases secretion of Z α1-antitrypsin

J. Irving, Zhengrong Zhu, D. Lomas, 2020, bioRxiv.

Catalytic Domain of Human Phosphodiesterase 4B2B in Complex with a Quinoline Inhibitor

D. Somers, M. Neu, 2010 .