Tomoko Azuma-Kanoh

A novel class of cycloalkano[b]pyridines as potent and orally active opioid receptor-like 1 antagonists with minimal binding affinity to the hERG K+ channel.

Hisashi Ohta, Hiroshi Kawamoto, Satoshi Ozaki, 2008, Journal of medicinal chemistry.

Identification of an orally active opioid receptor-like 1 (ORL1) receptor antagonist 4-{3-[(2R)-2,3-dihydroxypropyl]-2-oxo-2,3-dihydro-1H-benzimidazol-1-yl}-1-[(1S,3S,4R)-spiro[bicyclo[2.2.1]heptane-2,1'-cyclopropan]-3-ylmethyl]piperidine as clinical candidate.

Hisashi Ohta, Hiroshi Kawamoto, Satoshi Ozaki, 2009, Journal of medicinal chemistry.