Frank Bretz

发表

An Exact Confidence Set for a Maximum Point of a Univariate Polynomial Function in a Given Interval

Fang Wan, Wei Liu, Yang Han, 2015, Technometrics.

Bayesian Response-Adaptive MCP-Mod for Efficient Target Dose Estimation

Frank Bretz, 2008 .

Connecting Instrumental Variable methods for causal inference to the Estimand Framework

Frank Bretz, Jack Bowden, Bjoern Bornkamp, 2020, Statistics in medicine.

General Concepts and Basic Multiple Comparison Procedures

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2016 .

Modeling and Simulation in Clinical Drug Development

Frank Bretz, Jing Yu, Anna Georgieva, 2010 .

Bayesian predictive power for interim adaptation in seamless phase II/III trials where the endpoint is survival up to some specified timepoint

Frank Bretz, Heinz Schmidli, Amy Racine-Poon, 2007, Statistics in medicine.

MCP2013 - 8th International Conference on Multiple Comparison Procedures.

Wei Liu, Frank Bretz, Martin Posch, 2015, Biometrical journal. Biometrische Zeitschrift.

Authors' response to comments

Frank Bretz, Gernot Wassmer, Peter Bauer, 2016, Statistics in medicine.

From Adaptive Design to Modern Protocol Design for Drug Development: Part I. Editorial and Summary of Adaptive Designs Session at the Third FDA/DIA Statistics Forum

Frank Bretz, Sue-Jane Wang, Sue-Jane Wang, 2010 .

Adaptive Trial Designs

Frank Bretz, Chyi-Hung Hsu, José Pinheiro, 2011 .

Multiple Testing in Group Sequential Trials Using Graphical Approaches

Frank Bretz, Willi Maurer, F. Bretz, 2013 .

Multiple Comparisons in Parametric Models

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2016 .

Efficient design and analysis of two colour factorial microarray experiments

Edgar Brunner, Frank Bretz, Jobst Landgrebe, 2006, Comput. Stat. Data Anal..

On the efficiency of adaptive designs

Holger Dette, Frank Bretz, Björn Bornkamp, 2010 .

Clinical Trials Impacted by the COVID-19 Pandemic: Adaptive Designs to the Rescue?

Frank Bretz, Christoph Gerlinger, Tim Friede, 2020, Statistics in biopharmaceutical research.

Author's reply

Frank Bretz, Martin Posch, Willi Maurer, 2013, Biometrical journal. Biometrische Zeitschrift.

Practical considerations for optimal designs in clinical dose finding studies

Holger Dette, Frank Bretz, Jose C Pinheiro, 2010, Statistics in medicine.

A simple and flexible graphical approach for adaptive group-sequential clinical trials

Frank Bretz, Willi Maurer, Toshifumi Sugitani, 2016, Journal of biopharmaceutical statistics.

Simultaneous Inference in General Parametric Models [R package multcomp version 1.4-14]

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2020 .

Methods That Approximate the Integral

Frank Bretz, Alan Genz, 2009 .

Approaches for Optimal Dose Selection for Adaptive Design Trials

Frank Bretz, David Lawrence, F. Bretz, 2014 .

Bayesian two‐stage dose finding for cytostatic agents via model adaptation

Frank Bretz, Guosheng Yin, David Ohlssen, 2016 .

Introduction to Multiple Test Problems, with Applications to Adaptive Designs

Frank Bretz, Jeff Maca, Willi Maurer, 2014 .

Multiple Comparisons Procedures in Parametric Models

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2010 .

FORTRAN 90 and SAS-IML Programs for Computation of Critical Values for Multiple Testing and Simultaneous Confidence Intervals

Frank Bretz, Paul N. Somerville, 2001 .

Dose Finding – A Challenge in Statistics

Frank Bretz, José Pinheiro, Yi Liu, 2008, Biometrical journal. Biometrische Zeitschrift.

Test and power considerations for multiple endpoint analyses using sequentially rejective graphical procedures

Frank Bretz, Willi Maurer, Gerhard Hommel, 2011, Statistics in medicine.

Graphical Approaches to Multiple Testing

Frank Bretz, Jeff Maca, Willi Maurer, 2014 .

The MCP-Mod Methodology: Practical Considerations and the DoseFinding R Package

Frank Bretz, Xiaolei Xun, 2017 .

Graphical approaches for multiple comparison procedures using weighted Bonferroni, Simes, or parametric tests

Frank Bretz, Martin Posch, Willi Maurer, 2011, Biometrical journal. Biometrische Zeitschrift.

Adaptivity in drug discovery and development

Frank Bretz, Michael Branson, Christy Chuang-Stein, 2009 .

An extension of the Williams trend test to general unbalanced linear models

Frank Bretz, 2006, Comput. Stat. Data Anal..

Advanced multiplicity adjustment methods in clinical trials

Mohamed Alosh, Frank Bretz, Mohammad Huque, 2014, Statistics in medicine.

Multiple Comparison Procedures

Frank Bretz, Sue-Jane Wang, Chihiro Hirotsu, 1990 .

A Simulation Study to Compare New Adaptive Dose–Ranging Designs

Frank Bretz, Joshua R. Smith, José Pinheiro, 2010 .

MCP2009 – 6th International Conference on Multiple Comparison Procedures

Frank Bretz, Martin Posch, Chihiro Hirotsu, 2008, Biometrical journal. Biometrische Zeitschrift.

Flexible alpha allocation strategies for confirmatory adaptive enrichment clinical trials with a prespecified subgroup

Frank Bretz, Martin Posch, Toshifumi Sugitani, 2018, Statistics in medicine.

Adaptive Dunnett tests for treatment selection

Frank Bretz, Martin Posch, Werner Brannath, 2008, Statistics in medicine.

MCPMod: An R Package for the Design and Analysis of Dose-Finding Studies

Frank Bretz, Björn Bornkamp, José Pinheiro, 2009 .

Confidence Sets for Statistical Classification (II): Exact Confidence Sets

Frank Bretz, Wei Liu, Anthony J. Hayter, 2019 .

TUTORIAL IN BIOSTATISTICS Adaptive designs for conﬁrmatory clinical trials

Frank Bretz, Martin Posch, Werner Brannath, 2022 .

Memory and other properties of multiple test procedures generated by entangled graphs

Frank Bretz, Willi Maurer, F. Bretz, 2013, Statistics in medicine.

Simultaneous confidence bands for all contrasts of three or more simple linear regression models over an interval

Wei Liu, Frank Bretz, Mortaza Jamshidian, 2010, Comput. Stat. Data Anal..

Type I error rate control in adaptive designs for confirmatory clinical trials with treatment selection at interim

Frank Bretz, Martin Posch, Willi Maurer, 2011, Pharmaceutical statistics.

Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: Applications and Practical Considerations

Frank Bretz, Heinz Schmidli, Willi Maurer, 2006, Biometrical journal. Biometrische Zeitschrift.

Recent developments in multiple comparison procedures

Frank Bretz, Yoav Benjamini, Sanat K. Sarkar, 2004 .

Data Monitoring in Adaptive Dose-Ranging Trials

Frank Bretz, Paul Gallo, Michael Krams, 2010 .

Graphical approaches for the control of generalized error rates.

Frank Bretz, David S. Robertson, James M. S. Wason, 2020, Statistics in medicine.

Robustness considerations in selecting efficient two-color microarray designs

Edgar Brunner, Frank Bretz, A. H. M. Mahbub Latif, 2009, Bioinform..

Model‐based dose finding under model uncertainty using general parametric models

Frank Bretz, José Pinheiro, Ekkehard Glimm, 2013, Statistics in medicine.

Simultaneous confidence bands for a percentile line in linear regression

Fang Wan, Wei Liu, Yang Han, 2015, Comput. Stat. Data Anal..

Predictive probability of success in clinical drug development

Frank Bretz, Amy Racine-Poon, Mauro Gasparini, 2013 .

Optimal designs for dose finding studies with an active control

Frank Bretz, Norbert Benda, Christine Kiss, 2011 .

Confirmatory Seamless Phase II/III Clinical Trials with Hypotheses Selection at Interim: General Concepts

Frank Bretz, Heinz Schmidli, Willi Maurer, 2006, Biometrical journal. Biometrische Zeitschrift.

Confidence Sets for Statistical Classification

Frank Bretz, Wei Liu, Anthony J. Hayter, 2019, Stats.

Adaptive Dose-Ranging Studies

Frank Bretz, José Pinheiro, Björn Bornkamp, 2010 .

INHANCE: An Adaptive Confirmatory Study with Dose Selection at Interim

Frank Bretz, David Lawrence, Stuart J. Pocock, 2014 .

Confirmatory adaptive designs with Bayesian decision tools for a targeted therapy in oncology

Frank Bretz, Martin Posch, Michael Branson, 2009, Statistics in medicine.

Twenty‐five years of confirmatory adaptive designs: opportunities and pitfalls

Frank Bretz, Gernot Wassmer, Peter Bauer, 2015, Statistics in medicine.

Efficient two-sample designs for microarray experiments with biological replications

Edgar Brunner, Frank Bretz, Jobst Landgrebe, 2004, Silico Biol..

Adaptive designs: The Swiss Army knife among clinical trial designs?

Frank Bretz, Willi Maurer, Paul Gallo, 2017, Clinical trials.

Exact simultaneous confidence intervals for a finite set of contrasts of three, four or five generally correlated normal means

Frank Bretz, Anthony J. Hayter, Wei Liu, 2013, Comput. Stat. Data Anal..

Interview with Editor of Statistics in Biopharmaceutical Research

Frank Bretz, 2017 .

Analysis of Dose–Response Studies—Modeling Approaches

Frank Bretz, Michael Branson, José Pinheiro, 2006 .

The Need for and the Future of Adaptive Designs in Clinical Development

Frank Bretz, Christy Chuang-Stein, F. Bretz, 2014 .

Simultaneous Confidence Tubes for Comparison of Several Multivariate Linear Regression Models

Wei Liu, Frank Bretz, A J Hayter, 2020, 2005.10059.

Assessment of Optimal Selected Prognostic Factors

Frank Bretz, Torsten Hothorn, Berthold Lausen, 2002 .

Dose response signal detection under model uncertainty

Holger Dette, Frank Bretz, Stanislav Volgushev, 2015, Biometrics.

Statistical Analysis of Monotone or Non-monotone Dose–Response Data from In Vitro Toxicological Assays

Frank Bretz, Ludwig A. Hothorn, L. Hothorn, 2003, Alternatives to laboratory animals : ATLA.

Identifying effective and/or safe doses by stepwise confidence intervals for ratios

Frank Bretz, Ludwig A Hothorn, Jason C Hsu, 2003, Statistics in medicine.

Preface: Biom. J. 1/2007

Frank Bretz, Jason C. Hsu, Jie Chen, 2007 .

Counting by weighing: construction of two-sided confidence intervals

Frank Bretz, Anthony J. Hayter, Wei Liu, 2019 .

On weighted parametric tests

Frank Bretz, Willi Maurer, Ekkehard Glimm, 2016, 1605.06397.

A note on testing families of hypotheses using graphical procedures.

Frank Bretz, Willi Maurer, 2014, Statistics in medicine.

Challenges in Assessing the Impact of the COVID-19 Pandemic on the Integrity and Interpretability of Clinical Trials

Frank Bretz, Janice Branson, Paul Gallo, 2020, Statistics in biopharmaceutical research.

Equivalence of dose response curves

Holger Dette, Frank Bretz, Stanislav Volgushev, 2015, 1505.05266.

Design and Analysis of Dose-Finding Studies Combining Multiple Comparisons and Modeling Procedures

Frank Bretz, José Pinheiro, Björn Bornkamp, 2006, Journal of biopharmaceutical statistics.

A unified framework for weighted parametric multiple test procedures

Frank Bretz, Willi Maurer, Ekkehard Glimm, 2017, Biometrical journal. Biometrische Zeitschrift.

Some new methods for the comparison of two linear regression models

Ying Zhang, Frank Bretz, Wei Liu, 2007 .

Adaptive designs based on the truncated product method

Frank Bretz, Markus Neuhäuser, F. Bretz, 2005, BMC medical research methodology.

Tutorial on statistical considerations on subgroup analysis in confirmatory clinical trials

Mohammad F Huque, Mohamed Alosh, Frank Bretz, 2017, Statistics in medicine.

Hierarchical testing of multiple endpoints in group‐sequential trials

Frank Bretz, Willi Maurer, Ekkehard Glimm, 2010, Statistics in medicine.

Detecting dose–response using contrasts: asymptotic power and sample size determination for binomial data

Frank Bretz, Ludwig A Hothorn, L. Hothorn, 2002, Statistics in medicine.

Some practical considerations for phase III studies with biomarker evaluations.

Frank Bretz, F. Bretz, C. Massacesi, 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Counting by weighing: know your numbers with confidence

Yang Han, Frank Bretz, Wei Liu, 2016 .

Comparison of Methods for the Computation of Multivariate t Probabilities

Frank Bretz, Alan Genz, A. Genz, 2002 .

Symmetric graphs for equally weighted tests, with application to the Hochberg procedure.

Frank Bretz, Dong Xi, F. Bretz, 2019, Statistics in medicine.

Multiple Test Strategies for Comparing Several Doses with a Control in Confirmatory Trials

Frank Bretz, Franz König, Björn Bornkamp, 2017 .

Simultaneous inference for several quantiles of a normal population with applications.

Wei Liu, Frank Bretz, Ekkehard Glimm, 2013, Biometrical journal. Biometrische Zeitschrift.

ON MULTIVARIATE t AND GAUSS PROBABILITIES IN R

Frank Bretz, Torsten Hothorn, Alan Genz, 2016 .

Aesthetics and Power Considerations in Multiple Testing – A Contradiction?

Frank Bretz, Gerhard Hommel, G. Hommel, 2008, Biometrical journal. Biometrische Zeitschrift.

Adaptive and Model-Based Dose-Ranging Trials: Quantitative Evaluation and Recommendations. White Paper of the PhRMA Working Group on Adaptive Dose-Ranging Studies

Frank Bretz, Joshua R. Smith, Chyi-Hung Hsu, 2010 .

Power and sample size computations in simultaneous tests for non‐inferiority based on relative margins

Frank Bretz, Ludwig A Hothorn, L. Hothorn, 2006, Statistics in medicine.

Statistical calibration and exact one-sided simultaneous tolerance intervals for polynomial regression

Yang Han, Frank Bretz, Wei Liu, 2016 .

Trimmed Weighted Simes' Test for Two One‐Sided Hypotheses With Arbitrarily Correlated Test Statistics

Frank Bretz, Willi Maurer, Werner Brannath, 2009, Biometrical journal. Biometrische Zeitschrift.

Optimal Designs for Dose-Finding Studies

Holger Dette, Frank Bretz, José Pinheiro, 2008 .

Compatible confidence intervals for intersection union tests involving two hypotheses

Frank Bretz, Yosef Hochberg, Klaus Strassburger, 2004 .

Joint EMA, ISBS, and DR‐IBS International Symposium on Biopharmaceutical Statistics: Bridging drug development from research to marketing

Frank Bretz, Franz Koenig, F. Bretz, 2013, Statistics in medicine.

Optimal designs for the emax, log-linear and exponential models

Holger Dette, Frank Bretz, Christine Kiss, 2010 .

Beyond Randomized Clinical Trials: Use of External Controls

Frank Bretz, Heinz Schmidli, Sebastian Weber, 2019, Clinical pharmacology and therapeutics.

Simultaneous Inference

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2020, Biostatistics Decoded.

The Evaluation of Multiple Clinical Endpoints, with Application to Asthma

Frank Bretz, Markus Neuhäuser, F. Bretz, 1999 .

Confidence sets for optimal factor levels of a response surface

Wei Liu, Yang Han, Frank Bretz, 2016, Biometrics.

On Multiple Comparisons in R ∗

Frank Bretz, Torsten Hothorn, T. Hothorn, 2004 .

Multiple Hypotheses Testing Based on Ordered p Values—A Historical Survey with Applications to Medical Research

Frank Bretz, Willi Maurer, Gerhard Hommel, 2011, Journal of biopharmaceutical statistics.

Perspectives on the Use of Adaptive Designs in Clinical Trials. Part II. Panel Discussion

Frank Bretz, Tim Friede, Norbert Benda, 2010, Journal of biopharmaceutical statistics.

Discussion of “Some Controversial Multiple Testing Problems in Regulatory Applications” by H. M. J. Hung and S.-J. Wang

Frank Bretz, Willi Maurer, Paul Gallo, 2009 .

Exact Simultaneous Confidence Bands for Quadratic and Cubic Polynomial Regression with Applications in Dose Response Study

Frank Bretz, Sanyu Zhou, Wei Liu, 2013 .

Nonparametric All‐Pairs Multiple Comparisons

Frank Bretz, Markus Neuhäuser, F. Bretz, 2001 .

Power and sample size when multiple endpoints are considered

Frank Bretz, Stephen Senn, S. Senn, 2007, Pharmaceutical statistics.

Evaluation of Animal Carcinogenicity Studies: Cochran‐Armitage Trend Test vs. Multiple Contrast Tests

Frank Bretz, Ludwig A. Hothorn, L. Hothorn, 2000 .

Estimands: discussion points from the PSI estimands and sensitivity expert group

Frank Bretz, David Morgan, Michael O'Kelly, 2017, Pharmaceutical statistics.

Multiple Comparison Procedures in Linear Models

Frank Bretz, Torsten Hothorn, Peter H. Westfall, 2008 .

Multiplicity and replicability: two sides of the same coin

Frank Bretz, P. Westfall, F. Bretz, 2014, Pharmaceutical statistics.

Computation of an exact confidence set for a maximum point of a univariate polynomial function in a given interval

Wei Liu, Frank Bretz, Sanyu Zhou, 2017 .

Multiple and Repeated Testing of Primary, Coprimary, and Secondary Hypotheses

Frank Bretz, Willi Maurer, Ekkehard Glimm, 2011 .