L. G. Grunnet

发表

Lysine deacetylases are produced in pancreatic beta cells and are differentially regulated by proinflammatory cytokines

C. Dinarello, N. Billestrup, T. Mandrup-Poulsen, 2010, Diabetologia.

Zwitterionically modified alginates mitigate cellular overgrowth for cell encapsulation

P. de Vos, Wei Song, Wendy F. Liu, 2019, Nature Communications.

Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stress- but not nitric oxide-mediated apoptosis in INS-1E cells.

N. Billestrup, T. Mandrup-Poulsen, A. K. Cardozo, 2009, Endocrinology.

Macrophage Contact Dependent and Independent TLR4 Mechanisms Induce β-Cell Dysfunction and Apoptosis in a Mouse Model of Type 2 Diabetes

A. Rosendahl, L. G. Grunnet, M. Tonnesen, 2014, PloS one.

Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and β-cell protection

C. Workman, S. Mandrup, C. Mathieu, 2014, Proceedings of the National Academy of Sciences.

Transporter function and cyclic AMP turnover in normal colonic mucosa from patients with and without colorectal neoplasia

S. Poulsen, Karen Kleberg, M. Hansen, 2012, BMC Gastroenterology.

Accumulation of M1‐like macrophages in type 2 diabetic islets is followed by a systemic shift in macrophage polarization

A. Rosendahl, L. G. Grunnet, Helena Cucak, 2014, Journal of leukocyte biology.

Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines.

N. Andrews, F. Pociot, M. Aalund, 2012, Cell metabolism.

Cytokines and Type 1 Diabetes: A Numbers Game

T. Mandrup-Poulsen, L. G. Grunnet, 2011, Diabetes.

Histone deacetylases 1 and 3 but not 2 mediate cytokine-induced beta cell apoptosis in INS-1 cells and dispersed primary islets from rats and are differentially regulated in the islets of type 1 diabetic children

N. Morgan, S. Richardson, J. Berthelsen, 2012, Diabetologia.

The lysine deacetylase inhibitor givinostat inhibits β-cell IL-1β induced IL-1β transcription and processing

C. Dinarello, T. Mandrup-Poulsen, D. P. Christensen, 2012, Islets.

Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus

N. Billestrup, T. Mandrup-Poulsen, Thomas Mandrup-Poulsen, 2011, Molecular medicine.

Proinflammatory Cytokines Activate the Intrinsic Apoptotic Pathway in β-Cells

S. Paraskevas, D. Maysinger, L. Rosenberg, 2009, Diabetes.

Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes

Jintu Fan, Meredith Silberstein, Alan Chiu, 2017, Proceedings of the National Academy of Sciences.

Altering β-cell number through stable alteration of miR-21 and miR-34a expression

T. Mandrup-Poulsen, D. P. Christensen, L. G. Grunnet, 2014, Islets.

High Glucose Suppresses Human Islet Insulin Biosynthesis by Inducing miR-133a Leading to Decreased Polypyrimidine Tract Binding Protein-Expression

N. Welsh, T. Mandrup-Poulsen, C. Bang-Berthelsen, 2010, PloS one.

NKX6.1 induced pluripotent stem cell reporter lines for isolation and analysis of functionally relevant neuronal and pancreas populations.

M. McCarthy, A. Gloyn, N. Beer, 2018, Stem cell research.

A Safe, Fibrosis-Mitigating, and Scalable Encapsulation Device Supports Long-Term Function of Insulin-Producing Cells.

C. Rescan, Minglin Ma, Alan Chiu, 2021, Small.

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

J. Ahnfelt-Rønne, J. Hald, O. Madsen, 2017, Molecular metabolism.

Histone Deacetylase (HDAC) Inhibition as a Novel Treatment for Diabetes Mellitus

N. Billestrup, T. Mandrup-Poulsen, D. P. Christensen, 2011, Molecular Medicine.