R. Townsend

发表

Identification of biomarkers of response to abatacept in patients with SLE using deconvolution of whole blood transcriptomic data from a phase IIb clinical trial

Somnath Bandyopadhyay, J. Merrill, R. Westhovens, 2017, Lupus Science & Medicine.

Functional T Cells Phosphodiesterase 7 A-Deficient Mice Have

Nadler, K. McIntyre, W. Pitts, 2003 .

Phosphodiesterase 7A-Deficient Mice Have Functional T Cells

K. McIntyre, S. Nadler, W. Pitts, 2003, The Journal of Immunology.

A HIGHLY SELECTIVE INHIBITOR OF IκB KINASE, BMS-345541, AUGMENTS GRAFT SURVIVAL MEDIATED BY SUBOPTIMAL IMMUNOSUPPRESSION IN A MURINE MODEL OF CARDIAC GRAFT REJECTION

K. McIntyre, D. Shuster, Y. Qiu, 2004, Transplantation.

Prophylactic administration of abatacept prevents disease and bone destruction in a rat model of collagen-induced arthritis.

L. Killar, B. Krishnan, D. Kukral, 2005, Journal of autoimmunity.

CD57+ CD4 T Cells Underlie Belatacept‐Resistant Allograft Rejection

A. Kirk, G. Tharp, S. Bosinger, 2016, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

barrier disease across a major histocompatibility complex-haploidentical Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host

R. Korngold, G. Murphy, J. Marini, 2011 .

Inhibitory effect of a CD4-CDR3 peptide analog on graft-versus-host disease across a major histocompatibility complex-haploidentical barrier.

R. Korngold, G. Murphy, J. Marini, 1996, Blood.

Development of a Chimeric Anti-CD40 Monoclonal Antibody That Synergizes with LEA29Y to Prolong Islet Allograft Survival1

N. Kenyon, C. Larsen, R. Hendrix, 2005, The Journal of Immunology.

Combination therapy with a CD4-CDR3 peptide analog and cyclosporin A to prevent graft-vs-host disease in a MHC-haploidentical bone marrow transplantation model.

R. Korngold, R. Townsend, M. Gilbert, 1998, Clinical immunology and immunopathology.

The Effect of Costimulatory and Interleukin 2 Receptor Blockade on Regulatory T Cells in Renal Transplantation

J. Bluestone, A. Putnam, F. Vincenti, 2008, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Selective Itk inhibitors block T-cell activation and murine lung inflammation.

A. Doweyko, S. Spergel, R. Moquin, 2004, Biochemistry.

Five-year safety and efficacy of belatacept in renal transplantation.

P. Friend, P. Halloran, J. Klempnauer, 2010, Journal of the American Society of Nephrology : JASN.

Assessment of Belatacept-Mediated Costimulation Blockade Through Evaluation of CD80/86-Receptor Saturation

P. M. Davis, E. Kulbokas, R. Latek, 2009, Transplantation.

Novel inhibitors of IMPDH: a highly potent and selective quinolone-based series.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Inhibitors of inosine monophosphate dehydrogenase: SARs about the N-[3-Methoxy-4-(5-oxazolyl)phenyl moiety.

D. Cheney, Ping Chen, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

Inhibition of T cell activation by an autoantibody induced by murine retrovirus infection.

F. Coffman, K. Blank, R. Townsend, 1997, Clinical immunology and immunopathology.

Prophylactic administration of abatacept (CTLA4-Ig; BMS-188667) prevents disease induction and bone destruction in a rat model of collagen-induced arthritis

L. Killar, B. Krishnan, D. Kukral, 2005, Arthritis Research & Therapy.

Brequinar sodium: inhibition of dihydroorotic acid dehydrogenase, depletion of pyrimidine pools, and consequent inhibition of immune functions in vitro.

B. Jaffee, R. Harris, R. Townsend, 1993, Transplantation proceedings.

A CCR2/CCR5-dual antagonist, BMS-A, offers a potential novel oral therapy for the treatment of autoimmune disease (92.6)

K. McIntyre, J. Barrish, S. Mandlekar, 2009, Journal of Immunology.

Acridone-based inhibitors of inosine 5'-monophosphate dehydrogenase: discovery and SAR leading to the identification of N-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-yl)propan-2-yl)-2- fluoro-9-oxo-9,10-dihydroacridine-3-carboxamide (BMS-566419).

Ping Chen, Henry H. Gu, E. Iwanowicz, 2007, Journal of medicinal chemistry.

Identification of novel and potent isoquinoline aminooxazole-based IMPDH inhibitors.

D. Cheney, Ping Chen, Derek J. Norris, 2003, Bioorganic & medicinal chemistry letters.

Novel indole-based inhibitors of IMPDH: introduction of hydrogen bond acceptors at indole C-3.

D. Cheney, E. Iwanowicz, J. Barrish, 2003, Bioorganic & medicinal chemistry letters.

Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists.

A. Doweyko, D. Shuster, J. Barrish, 2010, Journal of medicinal chemistry.

Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation.

A. Jankowska, G. Schieven, J. Maciejewski, 2008, Blood.

Alloreactive CD154-expressing T-cell subsets with differential sensitivity to the immunosuppressant, belatacept: potential targets of novel belatacept-based regimens

G. Mazariegos, R. Sindhi, B. Ganguly, 2015, Scientific Reports.

Hepatitis B "e" antigen: an apparent association with lactate dehydrogenase isozyme-5.

G. Vyas, L. Magnius, R. Townsend, 1977, Science.

Rational Development of LEA29Y (belatacept), a High‐Affinity Variant of CTLA4‐Ig with Potent Immunosuppressive Properties

P. Linsley, J. Bajorath, R. Peach, 2005, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

The preferential expansion of functional CD4+ lymphocyte populations in vitro.

R. Townsend, P. Simon, 1992, Journal of immunotherapy : official journal of the Society for Biological Therapy.

Experimental Animal Models in the Study of GVL Reactions

R. Truitt, R. Korngold, B. Blazar, 2000 .

Development of a Molecular Signature to Monitor Pharmacodynamic Responses Mediated by In Vivo Administration of Glucocorticoids

M. Weinblatt, N. Shadick, Somnath Bandyopadhyay, 2018, Arthritis & rheumatology.

Comparison of de novo IgM and IgG anti‐HLA DSAs between belatacept‐ and calcineurin‐treated patients: An analysis of the BENEFIT and BENEFIT‐EXT trial cohorts

R. Bray, H. Gebel, R. Townsend, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Posttransplant reduction in preexisting donor‐specific antibody levels after belatacept‐ versus cyclosporine‐based immunosuppression: Post hoc analyses of BENEFIT and BENEFIT‐EXT

H. Meier‐Kriesche, C. Larsen, R. Bray, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

De novo donor‐specific antibodies in belatacept‐treated vs cyclosporine‐treated kidney‐transplant recipients: Post hoc analyses of the randomized phase III BENEFIT and BENEFIT‐EXT studies

H. Meier‐Kriesche, C. Larsen, R. Bray, 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Belatacept‐Resistant Rejection Is Associated With CD28+ Memory CD8 T Cells

C. Larsen, M. Ford, A. Adams, 2017, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Transcriptional Profiling of Belatacept and Calcineurin Inhibitor Therapy in Renal Allograft Recipients

E. Kulbokas, M. Sarwal, R. Latek, 2014, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl]-3-thiophenecarboxylic acid (BMS-587101)--a small molecule antagonist of leukocyte function associated antigen-1.

P. M. Davis, V. Goldfarb, D. Cheney, 2006, Journal of medicinal chemistry.

Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Belatacept in Adult Kidney Transplant Recipients

Dianna Y. Wu, Jinshan Shen, E. Masson, 2013, Clinical Drug Investigation.

3-cyanoindole-based inhibitors of inosine monophosphate dehydrogenase: synthesis and initial structure-activity relationships.

Ping Chen, Derek J. Norris, Henry H. Gu, 2003, Bioorganic & medicinal chemistry letters.

De-Convolution of Whole Blood Transcriptomic Data from a Phase IIb, Randomized, Double-Blind, Placebo-Controlled Trial of Abatacept in Systemic Lupus Erythematosus

Somnath Bandyopadhyay, J. Merrill, R. Westhovens, 2015 .

Modular Analysis of Peripheral Blood Gene Expression in Rheumatoid Arthritis Captures Reproducible Gene Expression Changes in Tumor Necrosis Factor Responders

Michaela Oswald, Peter K Gregersen, Annette Lee, 2015, Arthritis & rheumatology.

Evaluation of Donor-Specific Antibodies Through 5 Years With Belatacept in BENEFIT and BENEFIT-EXT.: Abstract# 2163

C. Larsen, R. Bray, H. Gebel, 2014 .

A cyclic heptapeptide mimics CD4 domain 1 CC’ loop and inhibits CD4 biological function

J. Aramini, Jimin Gao, T. Satoh, 2002 .

Procede de generation de lymphocytes cd4 proliferatifs

R. Townsend, K. H. Leung, 1990 .

Immune Cell Involvement in Anti-c-myc DNA Prevention of Tumor Formation in a Mouse Model of Burkitt'S Lymphoma

E. Wickstrom, R. Korngold, R. Townsend, 1997 .