Laura M. Sanz

发表

P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action

Jeremy N. Burrows, Benigno Crespo, Francisco-Javier Gamo, 2012, PloS one.

Cyclopropyl Carboxamides, a Chemically Novel Class of Antimalarial Agents Identified in a Phenotypic Screen

Jeremy N. Burrows, Benigno Crespo, Francisco-Javier Gamo, 2011, Antimicrobial Agents and Chemotherapy.

Benzoxaborole antimalarial agents. Part 2: Discovery of fluoro-substituted 7-(2-carboxyethyl)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles.

F. Gamo, Laura M Sanz, Huchen Zhou, 2012, Bioorganic & medicinal chemistry letters.

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Juan A. Bueren-Calabuig, Andrei V. Pisliakov, David W. Gray, 2019, Proceedings of the National Academy of Sciences.

Identification and Activity of a Series of Azole-based Compounds with Lactate Dehydrogenase-directed Anti-malarial Activity*

Araceli, V. J. Winter, S. Croft, 2004, Journal of Biological Chemistry.

Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing N-Methyl Amino Acids as Antiplasmodial Agents.

E. Winzeler, V. Yardley, F. Gamo, 2018, ACS medicinal chemistry letters.

Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials

E. Winzeler, S. Meister, S. Norval, 2016, Journal of medicinal chemistry.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance

David M. Shackleford, R. Price, D. Fidock, 2017, Nature Communications.

Lumefantrine attenuates Plasmodium falciparum artemisinin resistance during the early ring stage

P. Wilairat, F. Gamo, Laura M Sanz, 2021, International journal for parasitology. Drugs and drug resistance.

Thousands of chemical starting points for antimalarial lead identification

James R. Brown, L. Cardon, C. E. Peishoff, 2010, Nature.

Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.

Danny W. Wilson, G. McFadden, A. Cowman, 2021, Bioorganic chemistry.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance

M. Foley, P. Rosenthal, P. Bhanot, 2018, Proceedings of the National Academy of Sciences.

A novel multiple-stage antimalarial agent that inhibits protein synthesis

David W. Gray, E. Winzeler, S. Meister, 2015, Nature.

Quinolone-3-Diarylethers: A New Class of Antimalarial Drug

Yuexin Li, David M. Shackleford, Susan A Charman, 2013, Science Translational Medicine.

Quinolone-3-Diarylethers : A new class of drugs for a new era of malaria eradication

David M. Shackleford, R. Price, M. Mather, 2014 .

High-throughput microsphiltration to assess red blood cell deformability and screen for malaria transmission–blocking drugs

F. Gamo, Laura M Sanz, P. Buffet, 2018, Nature Protocols.

Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase

David M. Shackleford, G. Drewes, M. Bantscheff, 2017, Science Translational Medicine.

Triaminopyrimidine is a fast-killing and long-acting antimalarial clinical candidate

D. Wirth, D. Fidock, Pavithra Viswanath, 2015, Nature Communications.

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

R. Price, P. Rosenthal, D. Fidock, 2021, Science Translational Medicine.

A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue

Patrick G. Schupp, J. Derisi, J. Gut, 2017, Nature Communications.

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine

P. Wilairat, F. Gamo, N. White, 2018, International journal for parasitology. Drugs and drug resistance.

N-aryl-2-aminobenzimidazoles: novel, efficacious, antimalarial lead compounds.

D. Fidock, F. Gamo, A. Srivastava, 2014, Journal of medicinal chemistry.

Aminoazabenzimidazoles, a novel class of orally active antimalarial agents.

D. Wirth, F. Gamo, Pavithra Viswanath, 2014, Journal of medicinal chemistry.

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

S. Croft, T. Bousema, F. Gamo, 2017, Nature Communications.

Development of a Novel High-Density [3H]Hypoxanthine Scintillation Proximity Assay To Assess Plasmodium falciparum Growth

F. Gamo, Gonzalo Colmenarejo, E. Álvarez-Ruíz, 2016, Antimicrobial Agents and Chemotherapy.

Magnetic isolation of Plasmodium falciparum schizonts iRBCs to generate a high parasitaemia and synchronized in vitro culture

Laura M. Sanz, M. Lafuente, Lydia Mata-Cantero, 2014, Malaria Journal.

Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate.

V. Ciaravino, P. Rosenthal, F. Gamo, 2017, Journal of medicinal chemistry.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

Laura M Sanz, L. Ballell-Pages, M. Blackman, 2015, Journal of medicinal chemistry.

Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6-(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles

P. Rosenthal, F. Gamo, J. Plattner, 2015, Journal of Medicinal Chemistry.