Hervé Broly

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Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

Alex Eon-Duval, Hervé Broly, Ralf Gleixner, 2012, Biotechnology progress.

Robust factor selection in early cell culture process development for the production of a biosimilar monoclonal antibody

Massimo Morbidelli, Jean-Marc Bielser, Dominik Rothenhäusler, 2017, Biotechnology progress.

Application of Quality by Design to the characterization of the cell culture process of an Fc-Fusion protein.

Alex Eon-Duval, Hervé Broly, Ralf Gleixner, 2012, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

Cell culture medium improvement by rigorous shuffling of components using media blending

Hervé Broly, Damien Voisard, Gianni Baer, 2012, Cytotechnology.

Implementation of Plate Imaging for Demonstration of Monoclonality in Biologics Manufacturing Development

Yuan Zhu, Hervé Broly, Andrew J Racher, 2018, PDA Journal of Pharmaceutical Science and Technology.

Cell culture process metabolomics together with multivariate data analysis tools opens new routes for bioprocess development and glycosylation prediction

Massimo Morbidelli, Hervé Broly, Michael Sokolov, 2020, Biotechnology progress.

Semi‐continuous scale‐down models for clone and operating parameter screening in perfusion bioreactors

Massimo Morbidelli, Jean-Marc Bielser, Hervé Broly, 2019, Biotechnology progress.

Shaping the quality of biopharmaceuticals – a multiscale perspective on the utilization of big data for efficient bioprocess development

Massimo Morbidelli, Hervé Broly, Jonathan Ritscher, 2016 .

Sequential Multivariate Cell Culture Modeling at Multiple Scales Supports Systematic Shaping of a Monoclonal Antibody Toward a Quality Target.

Massimo Morbidelli, Hervé Broly, Michael Sokolov, 2018, Biotechnology journal.

Quality by Design Applied to a Fc‐Fusion Protein: A Case Study

Massimo Morbidelli, Alex Eon-Duval, Hervé Broly, 2013 .

Process intensification: Enabling technologies and methodologies

Hervé Broly, Jonathan Souquet, Xavier LeSaout, 2017 .

Perfusion mammalian cell culture for recombinant protein manufacturing - A critical review.

Massimo Morbidelli, Jean-Marc Bielser, Hervé Broly, 2018, Biotechnology advances.

Parallel experimental design and multivariate analysis provides efficient screening of cell culture media supplements to improve biosimilar product quality

Hervé Broly, Michael Sokolov, David Brühlmann, 2017, Biotechnology and bioengineering.

Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies

Massimo Morbidelli, Hervé Broly, Jonathan Souquet, 2020, Biotechnology and bioengineering.

A new flow cell and chemometric protocol for implementing in‐line Raman spectroscopy in chromatography

Massimo Morbidelli, Hervé Broly, Michael Sokolov, 2019, Biotechnology progress.

Screening and assessment of performance and molecule quality attributes of industrial cell lines across different fed‐batch systems

Jean-Marc Bielser, Hervé Broly, David Brühlmann, 2016, Biotechnology progress.

Degradation of an Fc‐fusion recombinant protein by host cell proteases: Identification of a CHO cathepsin D protease

Hervé Broly, Horst Bierau, Thomas Soranzo, 2009, Biotechnology and bioengineering.

Mechanistic reconstruction of glycoprotein secretion through monitoring of intracellular N-glycan processing

Hervé Broly, David Brühlmann, Jonathan Souquet, 2019, Science Advances.

Experimental Evaluation of the Impact of Intrinsic Process Parameters on the Performance of a Continuous Chromatographic Polishing Unit (MCSGP).

Massimo Morbidelli, Hervé Broly, Jonathan Souquet, 2019, Biotechnology journal.

Process design and development of a mammalian cell perfusion culture in shake‐tube and benchtop bioreactors

Massimo Morbidelli, Hervé Broly, Jonathan Souquet, 2019, Biotechnology and bioengineering.

Experimental and CFD physical characterization of animal cell bioreactors: From micro- to production scale

Massimo Morbidelli, Hervé Broly, Benjamin Neunstoecklin, 2017 .

Proteomic analysis of micro-scale bioreactors as scale-down model for a mAb producing CHO industrial fed-batch platform.

Massimo Morbidelli, Hervé Broly, Miroslav Soos, 2018, Journal of biotechnology.

Minimizing hydrodynamic stress in mammalian cell culture through the lobed Taylor-Couette bioreactor.

Massimo Morbidelli, Hervé Broly, Miroslav Soos, 2011, Biotechnology journal.

Determination of the maximum operating range of hydrodynamic stress in mammalian cell culture.

Massimo Morbidelli, Hervé Broly, Benjamin Neunstoecklin, 2015, Journal of biotechnology.

Tailoring recombinant protein quality by rational media design

Hervé Broly, David Brühlmann, Markus Sauer, 2015, Biotechnology progress.

Modulation of mAb quality attributes using microliter scale fed‐batch cultures

Hervé Broly, Matthieu Stettler, Yolande Rouiller, 2014, Biotechnology progress.

Effect of hydrocortisone on the production and glycosylation of an Fc‐fusion protein in CHO cell cultures

Hervé Broly, Matthieu Stettler, Yolande Rouiller, 2012, Biotechnology progress.

Development of a shake tube‐based scale‐down model for perfusion cultures

Massimo Morbidelli, Hervé Broly, Jonathan Souquet, 2018, Biotechnology and bioengineering.

Evaluation of several protein a resins for application to multicolumn chromatography for the rapid purification of fed‐batch bioreactors

Eric Valery, Hervé Broly, Jonathan Souquet, 2017, Biotechnology progress.

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation.

Massimo Morbidelli, Martin Pabst, Hervé Broly, 2016, Journal of biotechnology.

Modulation and modeling of monoclonal antibody N‐linked glycosylation in mammalian cell perfusion reactors

Massimo Morbidelli, Jean-Marc Bielser, Hervé Broly, 2017, Biotechnology and bioengineering.

Application of the quality by design approach to the drug substance manufacturing process of an Fc fusion protein: towards a global multi-step design space.

Hervé Broly, Ralf Gleixner, Thomas Solacroup, 2012, Journal of pharmaceutical sciences.

Lactate metabolism shift in CHO cell culture: the role of mitochondrial oxidative activity.

Hervé Broly, Matthieu Stettler, Martin Jordan, 2013, New biotechnology.