Alexander V. Statsyuk

发表

A Fragment-Based Method to Discover Irreversible Covalent Inhibitors of Cysteine Proteases

Stefan G. Kathman, Ziyang Xu, Alexander V. Statsyuk, 2014, Journal of medicinal chemistry.

Structural Basis of Substrate Recognition and Covalent Inhibition of Cdu1 from Chlamydia trachomatis

C. Sotriffer, E. Altmann, C. Kisker, 2018, ChemMedChem.

Mapping low-affinity/high-specificity peptide–protein interactions using ligand-footprinting mass spectrometry

Eric L. Weiss, A. Nesvizhskii, E. Weiss, 2019, Proceedings of the National Academy of Sciences.

An inhibitor of ubiquitin conjugation and aggresome formation† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c5sc01351h Click here for additional data file.

Alexander V. Statsyuk, Heeseon An, 2015, Chemical science.

High‐Throughput Screening of HECT E3 Ubiquitin Ligases Using UbFluor

Alexander V. Statsyuk, Peter K. Foote, David T. Krist, 2017, Current protocols in chemical biology.

Facile synthesis of covalent probes to capture enzymatic intermediates during E1 enzyme catalysis.

Alexander V. Statsyuk, Heeseon An, 2016, Chemical communications.

Development of activity-based probes for ubiquitin and ubiquitin-like protein signaling pathways.

Alexander V. Statsyuk, Heeseon An, 2013, Journal of the American Chemical Society.

UbFluor: a mechanism-based probe for HECT E3 ligases

S. Rice, Sungjin Park, Alexander V. Statsyuk, 2016, Chemical science.

Covalent-Fragment Screening of Brd4 Identifies a Ligandable Site Orthogonal to the Acetyl-Lysine Binding Sites

Brian C. Smith, Michael D. Olp, Stefan G. Kathman, 2019 .

Monitoring PARKIN RBR Ubiquitin Ligase Activation States with UbFluor

Alexander V. Statsyuk, Peter K. Foote, 2018, Current protocols in chemical biology.

UbMES and UbFluor: Novel probes for ring-between-ring (RBR) E3 ubiquitin ligase PARKIN

S. Rice, Sungjin Park, Alexander V. Statsyuk, 2017, The Journal of Biological Chemistry.

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

H. Ovaa, J. Kirstein, E. Reits, 2018, Scientific Reports.

Inhibiting protein synthesis to treat malaria

Alexander V. Statsyuk, 2022, Science.

Discovery of covalent enzyme inhibitors using virtual docking of covalent fragments.

Kai Zhu, S. Chowdhury, Rama K. Mishra, 2019, Bioorganic & medicinal chemistry letters.

UbFluor: A Fluorescent Thioester to Monitor HECT E3 Ligase Catalysis

Alexander V. Statsyuk, Peter K. Foote, David T. Krist, 2017, Current protocols in chemical biology.

A Small Molecule That Switches a Ubiquitin Ligase From a Processive to a Distributive Enzymatic Mechanism.

Aaron T. Smith, A. Rosenzweig, Stefan G. Kathman, 2015, Journal of the American Chemical Society.

Methodology for Identification of Cysteine-Reactive Covalent Inhibitors.

Stefan G. Kathman, Alexander V. Statsyuk, 2019, Methods in molecular biology.

The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles.

Alexander V. Statsyuk, Cynthia M Hong, 2013, Organic and biomolecular chemistry.

Crosstalk between kinases and Nedd4 family ubiquitin ligases.

Alexander V. Statsyuk, Heeseon An, David T. Krist, 2014, Molecular bioSystems.

LiF-MS: Mapping unstructured peptide-protein interactions using Ligand-Footprinting Mass Spectrometry

Eric L. Weiss, A. Nesvizhskii, Alexander V. Statsyuk, 2018, bioRxiv.

Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

H. Ovaa, J. Kirstein, E. Reits, 2018, Scientific Reports.

Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc02340d Click here for additional data file. Click here for additional data file.

Sungjin Park, Alexander V. Statsyuk, David T. Krist, 2014, Chemical science.

Covalent Tethering of Fragments For Covalent Probe Discovery.

Stefan G. Kathman, Alexander V. Statsyuk, 2016, MedChemComm.

Dissecting the Specificity of Adenosyl Sulfamate Inhibitors Targeting the Ubiquitin-Activating Enzyme.

C. Sotriffer, H. Schindelin, Alexander V. Statsyuk, 2017, Structure.

Identification of non-peptidic cysteine reactive fragments as inhibitors of cysteine protease rhodesain.

I. V. Ogungbe, Stefan G. Kathman, Alexander V. Statsyuk, 2015, Bioorganic & medicinal chemistry letters.

Crosstalk between kinases and Nedd4 family ubiquitin ligases.

Alexander V. Statsyuk, Heeseon An, David T. Krist, 2014, Molecular bioSystems.

Covalent-fragment screening of BRD4 identifies a ligandable site orthogonal to the acetyl-lysine binding sites.

Michael D. Olp, Ziyang Xu, Stefan G. Kathman, 2020, ACS chemical biology.

AI is a viable alternative to high throughput screening: a 318-target study

Eva M García-Cuesta, Frederick S. Vizeacoumar, Stephen J. Capuzzi, 2024, Scientific reports.