D Kostrewa

Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening.

D. Kostrewa, H. Gmuender, D. Bur, 2000, Journal of medicinal chemistry.

Crystal structure of Aspergillus niger pH 2.5 acid phosphatase at 2. 4 A resolution.

M. Wyss, A. D'arcy, D. Kostrewa, 1999, Journal of molecular biology.

From DNA sequence to improved functionality: using protein sequence comparisons to rapidly design a thermostable consensus phytase.

M. Lehmann, M. Wyss, A. D'arcy, 2000, Protein engineering.

Mg2+ binding to the active site of EcoRV endonuclease: a crystallographic study of complexes with substrate and product DNA at 2 A resolution.

F. Winkler, D. Kostrewa, F K Winkler, 1995, Biochemistry.

Active site residue 297 of Aspergillus niger phytase critically affects the catalytic properties

M. Wyss, K. Vogel, D. Kostrewa, 2000, FEBS letters.

Structure and function of the dihydropteroate synthase from Staphylococcus aureus.

M. Page, A. D'arcy, I. Hampele, 1997, Journal of molecular biology.