C. Kostlan

发表

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991, Journal of medicinal chemistry.

Succinic acid amides as P2-P3 replacements for inhibitors of interleukin-1beta converting enzyme (ICE or caspase 1).

E. Lunney, J. Rubin, R. Talanian, 2010, Bioorganic & medicinal chemistry letters.

Inhibition of interleukin-1beta converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones.

E. Lunney, D. Downing, J. Warmus, 2010, Bioorganic & medicinal chemistry letters.

Structure-based design of nonpeptide inhibitors of interleukin-1beta converting enzyme (ICE, caspase-1).

C. Humblet, E. Lunney, H. Albrecht, 2002, Bioorganic & medicinal chemistry.

Chapter 18 – Blocking lnterleukin-1 Action

D. Giegel, C. Kostlan, 1998 .

The design and synthesis of sulfonamides as caspase-1 inhibitors.

J. Dunbar, N. Walker, W. Harter, 2004, Bioorganic & medicinal chemistry letters.

Rational design of a topical androgen receptor antagonist for the suppression of sebum production with properties suitable for follicular delivery.

T. R. Johnson, V. Shanmugasundaram, D. Pocalyko, 2010, Journal of medicinal chemistry.

Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents.

R. Gilbertsen, C. Kostlan, J. Sircar, 1991, Advances in experimental medicine and biology.

Synthesis of reversed hydroxamic acids of indomethacin: dual inhibitors of cyclooxygenase and 5-lipoxygenase

R. D. Dyer, D. Boschelli, R. Dyer, 1992 .

Synthesis of pyrimidine analogs of 2,6‐Di‐tert‐butylphenol antiinflammatory agents

D. T. Connor, P. Unangst, C. Kostlan, 1995 .

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994, Journal of medicinal chemistry.

Design of 5-(3,5-di-tert-butyl-4-hydroxyphenyl)-1,3,4-thiadiazoles, -1,3,4-oxadiazoles, and -1,2,4-triazoles as orally-active, nonulcerogenic antiinflammatory agents.

R. D. Dyer, M. D. Mullican, M. Wilson, 1993, Journal of medicinal chemistry.

Synthesis and Biological Evaluation of 5-((3,5-Bis(1,1-dimethylethyl)- 4-hydroxyphenyl)methylene)oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994 .

Cyclooxygenase and 5-lipoxygenase inhibitory activity of 2,6 di-t-butylphenols linked by a sulfur atom to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles

D. Boschelli, R. Dyer, D. T. Connor, 1993 .

Styrylpyrazoles, Styrylisoxazoles, and Styrylisothiazoles. Novel 5‐ Lipoxygenase and Cyclooxygenase Inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991 .

Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.

P. W. Woo, R. Gilbertsen, C. Kostlan, 1992, Journal of medicinal chemistry.

Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.

R. Gilbertsen, M. C. Conroy, C. Kostlan, 1991, Biochemical and biophysical research communications.

Discovery of a series of 2-(1H-pyrazol-1-yl)pyridines as ALK5 inhibitors with potential utility in the prevention of dermal scarring.

Mostofa A Hena, B. Finzel, R. Gilbertsen, 2012, Bioorganic & medicinal chemistry letters.

Preparation of 4-aryl-2-trifluoromethylbenzonitrile derivatives as androgen receptor antagonists for topical suppression of sebum production.

Danielle E. Dettling, B. Lefker, D. Pocalyko, 2007, Bioorganic & medicinal chemistry letters.

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

R. D. Dyer, R. Dyer, D. Flynn, 1990, Journal of medicinal chemistry.

Diphenyl ethers as androgen receptor antagonists for the topical suppression of sebum production.

Danielle E. Dettling, Y. Smith, B. Lefker, 2009, Bioorganic & medicinal chemistry letters.

4-(Alkylthio)- and 4-(arylthio)-benzonitrile derivatives as androgen receptor antagonists for the topical suppression of sebum production.

Danielle E. Dettling, D. Pocalyko, C. Kostlan, 2009, Bioorganic & medicinal chemistry letters.

(1R,2S)-4-(2-cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, a potent androgen receptor antagonist for stimulating hair growth and reducing sebum production.

Danielle E. Dettling, T. R. Johnson, Mostofa A Hena, 2007, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluation of amino-pyridines as androgen receptor antagonists for stimulating hair growth and reducing sebum production.

Danielle E. Dettling, T. R. Johnson, T. Krieger-Burke, 2007, Bioorganic & Medicinal Chemistry Letters.

Pantolactams as androgen receptor antagonists for the topical suppression of sebum production.

Danielle E. Dettling, V. Shanmugasundaram, S. Barrett, 2011, Bioorganic & medicinal chemistry letters.

Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.

R. Gilbertsen, M. C. Conroy, C. Kostlan, 1991, Advances in Experimental Medicine and Biology.

Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-on

R. Gilbertsen, M. Bennett, C. Kostlan, 1992, Journal of medicinal chemistry.

The design and synthesis of human branched-chain amino acid aminotransferase inhibitors for treatment of neurodegenerative diseases.

R. T. Carroll, Xiaohong Liu, J. Rubin, 2006, Bioorganic & medicinal chemistry letters.