J. Sircar

发表

Styrylpyrazoles, styrylisoxazoles, and styrylisothiazoles. Novel 5-lipoxygenase and cyclooxygenase inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991, Journal of medicinal chemistry.

Comparative in vitro and in vivo activities of two 9-deazaguanine analog inhibitors of purine nucleoside phosphorylase, CI-972 and PD 141955.

R. Gilbertsen, M. C. Conroy, J. Sircar, 1992, Biochemical pharmacology.

Pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase (PNP) inhibitors as potential T-cell selective immunosuppressive agents.

R. Gilbertsen, C. Kostlan, J. Sircar, 1991, Advances in experimental medicine and biology.

Substituted 2-phenyl-benzimidazole derivatives: novel compounds that suppress key markers of allergy.

S. Lio, M. Major, A. Sinha, 2006, European journal of medicinal chemistry.

Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a possible mode of action in ulcerative colitis.

J. Sircar, C. F. Schwender, M. Carethers, 1983, Biochemical pharmacology.

Soybean lipoxygenase inhibition by nonsteroidal antiinflammatory drugs.

J. Sircar, E. A. Johnson, C. F. Schwender, 1983, Prostaglandins.

Synthesis and biological evaluation of 5-[[3,5-bis(1,1-dimethylethyl)- 4-hydroxyphenyl]methylene]oxazoles, -thiazoles, and -imidazoles: novel dual 5-lipoxygenase and cyclooxygenase inhibitors with antiinflammatory activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994, Journal of medicinal chemistry.

The chemistry of cyclic enaminoketones. III. Synthesis of bi- and tricyclic enaminoketones from enamine esters and nitriles†

A. Meyers, J. Sircar, A. Reine, 1968 .

Pyrazolo[5,1-b]quinazolin-9-ones: a new series of antiallergic agents.

J. Sircar, T. Capiris, D. J. Herzig, 1981, Journal of medicinal chemistry.

Novel 2-(substituted phenyl)benzimidazole derivatives with potent activity against IgE, cytokines, and CD23 for the treatment of allergy and asthma.

S. Lio, A. Sinha, J. Sircar, 2004, Journal of medicinal chemistry.

Composes de benzimidazole modulateurs de l'ige et inhibiteurs de la proliferation cellulaire

M. Major, J. Sircar, M. Richards, 2002 .

Reactions of 2H‐3,1‐benzoxazine‐2,4‐(1H)dione (isatoic anhydride) with anions of 1,4‐dihydro‐5H‐pyrazol‐5‐ones: Synthesis of pyrazolo[5,1‐b]quinazolin‐9‐ones

J. Sircar, T. Capiris, S. Kesten, 1981 .

Synthesis and Biological Evaluation of 5-((3,5-Bis(1,1-dimethylethyl)- 4-hydroxyphenyl)methylene)oxazoles, -thiazoles, and -imidazoles: Novel Dual 5-Lipoxygenase and Cyclooxygenase Inhibitors with Antiinflammatory Activity.

R. D. Dyer, R. Sorenson, R. Dyer, 1994 .

Oxazole, thiazole, and imidazole derivatives of 2,6-di-tert-butylphenol as dual 5-lipoxygenase and cyclooxygenase inhibitors

R. D. Dyer, R. Sorenson, R. Dyer, 1993 .

2-phenylimidazopyridines, a new series of Golgi compounds with potent antiviral activity.

A. Sinha, Homayon Banie, Richard J Thomas, 2007, Journal of medicinal chemistry.

Discovery of potent cyclic GMP phosphodiesterase inhibitors. 2-Pyridyl- and 2-imidazolylquinazolines possessing cyclic GMP phosphodiesterase and thromboxane synthesis inhibitory activities.

M. Frierson, O. Macina, K. Kondo, 1995, Journal of medicinal chemistry.

Discovery of Potent Cyclic GMP Phosphodiesterase Inhibitors. 2‐Pyridyl‐ and 2‐Imidazolylquinazolines Possessing Cyclic GMP Phoshodiesterase and Thromboxane Synthesis Inhibitory Activities.

M. Frierson, O. Macina, K. Kondo, 1995 .

Reduction of nitroalkenes to nitroalkanes with aqueous sodium borohydride

A. Meyers, J. Sircar, 1967 .

N. Lindo, J. Sircar, J. Shavel, 1982, Journal of medicinal chemistry.

Azasteroids. V. The Direct Conversion of 1-(Carboethoxymethyl)-1,2,3,4-tetrahydroisoquinolines and Cyclic Ketones into Benzo[a]cycloalkano[f]quinolizinones. An Example of Enamine Acylation by an Ester Function1,2

W. Sobotka, A. Meyers, J. Sircar, 1965 .

Styrylpyrazoles, Styrylisoxazoles, and Styrylisothiazoles. Novel 5‐ Lipoxygenase and Cyclooxygenase Inhibitors.

D. Ortwine, D. Flynn, D. T. Connor, 1991 .

Azasteroids—VI : A facile total synthesis of dl-8-azaestrone methyl ether and related systems

A. Meyers, J. Sircar, 1967 .

Inhibitors of human purine nucleoside phosphorylase. Synthesis and biological activities of 8-amino-3-benzylhypoxanthine and related analogues.

P. W. Woo, R. Gilbertsen, C. Kostlan, 1992, Journal of medicinal chemistry.

Antipsoriatic drugs as inhibitors of soybean lipoxygenase. A possible mode of action.

J. Sircar, C. F. Schwender, 1983, Prostaglandins, leukotrienes, and medicine.

Disruption of Golgi processing by 2-phenyl benzimidazole analogs blocks cell proliferation and slows tumor growth

S. Lio, J. Ludwig, A. Sinha, 2008, Cancer Chemotherapy and Pharmacology.

Selective in vitro inhibition of human MOLT-4 T lymphoblasts by the novel purine nucleoside phosphorylase inhibitor, CI-972.

R. Gilbertsen, M. C. Conroy, C. Kostlan, 1991, Biochemical and biophysical research communications.

Photochemical reactions of resin acids. Photochemically initiated addition of methanol to abietic acid

J. Sircar, G. S. Fisher, 1969 .

Activities of Two 9‐Deazaguanine Analogue Inhibitors of Purine Nucleoside Phosphorylase, CI‐972 and PD 141955, in Vitro and in Vivo

R. Gilbertsen, M. C. Conroy, J. Sircar, 1993, Annals of the New York Academy of Sciences.

Preliminary report on 8-amino-9-(2-thienylmethyl)guanine (PD 119,229), a novel and potent purine nucleoside phosphorylase inhibitor

R. Gilbertsen, M. Bennett, D. Schrier, 1987, Agents and Actions.

Nonsteroidal antiinflammatory drug hydroxamic acids. Dual inhibitors of both cyclooxygenase and 5-lipoxygenase.

R. D. Dyer, R. Dyer, D. Flynn, 1990, Journal of medicinal chemistry.

Synthesis of 4-hydroxy-N-[5-(hydroxymethyl)-3-isoxazolyl]-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide and [(5-methyl-3-isoxazolyl)amino]oxoacetic acid. Major metabolites of isoxicam

J. Sircar, T. Capiris, C. F. Schwender, 1985 .

Biochemical and pharmacological properties of CI-972, a novel 9-deazaguanine analog purine nucleoside phosphorylase (PNP) inhibitor.

R. Gilbertsen, M. C. Conroy, C. Kostlan, 1991, Advances in Experimental Medicine and Biology.

Synthesis of 4-Hydroxy-N-[5-(hydroxymethyl)-3-isoxazolyl]-2-methyl-2H-1,2-benzothiazine-3-carboxamide 1,1-Dioxide and [(5-Methyl-3-isoxazolyl)amino]oxoacetic Acid. Major Metabolites of Isoxicam.

J. Sircar, T. Capiris, C. F. Schwender, 1986 .

Inhibitors of human purine nucleoside phosphorylase. Synthesis of pyrrolo[3,2-d]pyrimidines, a new class of purine nucleoside phosphorylase inhibitors as potentially T-cell selective immunosuppressive agents. Description of 2,6-diamino-3,5-dihydro-7-(3-thienylmethyl)-4H-pyrrolo[3,2-d] pyrimidin-4-on

R. Gilbertsen, M. Bennett, C. Kostlan, 1992, Journal of medicinal chemistry.

Hydroxylamine analogs of 2,6-di-t-butylphenols: dual inhibitors of cyclooxygenase and 5-lipoxygenase or selective 5-lipoxygenase inhibitors.

R. D. Dyer, R. Dyer, D. Bornemeier, 1995, Bioorganic & medicinal chemistry.