Naomi X. Y. Ling

发表

Phosphoproteomics reveals conserved exercise‐stimulated signaling and AMPK regulation of store‐operated calcium entry

Nolan J. Hoffman, D. James, J. Burchfield, 2019, The EMBO journal.

The myokine meteorin‐like (metrnl) improves glucose tolerance in both skeletal muscle cells and mice by targeting AMPKα2

B. Kemp, Min-Jeong Shin, K. Song, 2020, The FEBS journal.

Meteorin-like (Metrnl) adipomyokine improves glucose tolerance in type 2 diabetes via AMPK pathway

B. Kemp, Min-Jeong Shin, K. Song, 2018, bioRxiv.

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

S. Lie, Adrian Kaczmarek, J. Petersen, 2019, Nature metabolism.

Inhibition of AMP-Activated Protein Kinase at the Allosteric Drug-Binding Site Promotes Islet Insulin Release.

N. Birnberg, B. Kemp, H. Thomas, 2015, Chemistry & biology.

Genetic loss of AMPK-glycogen binding destabilises AMPK and disrupts metabolism

Nolan J. Hoffman, B. Kemp, J. Hawley, 2020, Molecular metabolism.

Mitochondrial ﬁ ssion protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

B. Kemp, A. Pébay, Guei-Sheung Liu, 2018 .

An AMPKα2-specific phospho-switch controls lysosomal targeting for activation.

B. Kemp, J. Petersen, W. Smiles, 2022, Cell reports.

Structure-function analysis of the AMPK activator SC4 and identification of a potent pan AMPK activator

Nolan J. Hoffman, J. Baell, B. Kemp, 2022, The Biochemical journal.

Impact of Genetic Variation on Human CaMKK2 Regulation by Ca2+-Calmodulin and Multisite Phosphorylation

A. Means, B. Kemp, C. Langendorf, 2017, Scientific Reports.

CaMKK2 is inactivated by cAMP-PKA signaling and 14-3-3 adaptor proteins

B. Kemp, M. Parker, C. Langendorf, 2020, The Journal of Biological Chemistry.

ATP synthase inhibitory factor 1 (IF1), a novel myokine, regulates glucose metabolism by AMPK and Akt dual pathways

R. Krauss, C. Mantzoros, B. Kemp, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Mitochondrial fission protein Drp1 inhibition promotes cardiac mesodermal differentiation of human pluripotent stem cells

B. Kemp, A. Pébay, Guei-Sheung Liu, 2018, Cell Death Discovery.

β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK)

B. Kemp, Zhi-ping Chen, Naomi X. Y. Ling, 2010, Proceedings of the National Academy of Sciences.

Structural Determinants for Small-Molecule Activation of Skeletal Muscle AMPK α2β2γ1 by the Glucose Importagog SC4.

J. Baell, B. Kemp, M. Parker, 2018, Cell chemical biology.

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

B. Kemp, Zhi-ping Chen, Naomi X. Y. Ling, 2011, Science.

AMP-activated protein kinase selectively inhibited by the type II inhibitor SBI-0206965

B. Kemp, L. Furic, C. Langendorf, 2018, The Journal of Biological Chemistry.

Long-chain fatty acyl-CoA esters regulate metabolism via allosteric control of AMPK β1-isoforms

B. Kemp, T. Nero, M. Parker, 2020, Nature Metabolism.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

B. Viollet, B. Kemp, K. Sakamoto, 2017, Nature Communications.

mTORC1 directly inhibits AMPK to promote cell proliferation under nutrient stress

S. Lie, Adrian Kaczmarek, J. Petersen, 2020, Nature Metabolism.

β-subunit myristoylation functions as an energy sensor by modulating the dynamics of AMP-activated Protein Kinase

B. Kemp, G. Anand, D. Stapleton, 2016, Scientific Reports.

Personalized phosphoproteomics identifies functional signaling

Sean J. Humphrey, D. James, K. Højlund, 2021, Nature Biotechnology.

Small molecule drug A-769662 and AMP synergistically activate naive AMPK independent of upstream kinase signaling.

B. Kemp, G. Steinberg, C. Langendorf, 2014, Chemistry & biology.

The autophagy initiator ULK1 sensitizes AMPK to allosteric drugs

B. Viollet, B. Kemp, K. Sakamoto, 2017, Nature Communications.

Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding

B. Kemp, M. Parker, K. Sakamoto, 2016, Nature Communications.

Hydralazine protects the heart against acute ischaemia/reperfusion injury by inhibiting Drp1-mediated mitochondrial fission

J. Holien, D. Yellon, R. Ketteler, 2021, Cardiovascular research.

Blocking AMPK β1 myristoylation enhances AMPK activity and protects mice from high-fat diet-induced obesity and hepatic steatosis.

B. Kemp, R. Brink, G. Steinberg, 2022, Cell reports.

Novel torin1-sensitive phosphorylation sites on the metabolic regulator AMPK revealed by label-free mass spectrometry

B. Kemp, W. Smiles, C. Langendorf, 2021, bioRxiv.

CaMKK2 is not involved in contraction-stimulated AMPK activation and glucose uptake in skeletal muscle

D. Drewry, A. Deshmukh, A. Addinsall, 2023, Molecular metabolism.

A novel small molecule inhibitor of human Drp1

J. Holien, Guei-Sheung Liu, W. Smiles, 2022, Scientific reports.

ATP sensitive bi-quinoline activator of the AMP-activated protein kinase.

B. Kemp, O. Issinger, C. Langendorf, 2014, Biochemical and biophysical research communications.

AMPK Is a Direct Adenylate Charge-Regulated Protein Kinase

B. Kemp, Zhi-ping Chen, Naomi X. Y. Ling, 2011, Science.

An AMPK a 2-speciﬁc phospho-switch controls lysosomal targeting for activation

W. Smiles, S. Galic, Gabrielle Shea, 2022 .

Functional analysis of an R311C variant of Ca 2+ -calmodulin dependent protein kinase kinase-2 (CaMKK2) found as a de novo mutation in a patient with bipolar disorder

C. Langendorf, S. Galic, Naomi X. Y. Ling, 2020 .