Ranae M. Ranade

发表

High-Throughput Orthogonal Screening Methionyl-tRNA Synthetase via Trypanosoma brucei Identification of Potent Inhibitors of the

Peter Hodder, Louis Scampavia, Franck Madoux, 2014 .

From Cells to Mice to Target: Characterization of NEU-1053 (SB-443342) and Its Analogues for Treatment of Human African Trypanosomiasis.

F. Buckner, W. Hol, William G. Devine, 2017, ACS infectious diseases.

Urea-based inhibitors of Trypanosoma brucei methionyl-tRNA synthetase: selectivity and in vivo characterization.

F. Buckner, C. Verlinde, W. Hol, 2012, Journal of medicinal chemistry.

Leishmania donovani tyrosyl-tRNA synthetase structure in complex with a tyrosyl adenylate analog and comparisons with human and protozoan counterparts.

F. Buckner, C. Verlinde, W. Hol, 2017, Biochimie.

5-Fluoroimidazo[4,5-b]pyridine Is a Privileged Fragment That Conveys Bioavailability to Potent Trypanosomal Methionyl-tRNA Synthetase Inhibitors

M. Gelb, F. Buckner, C. Verlinde, 2016, ACS infectious diseases.

1-Benzyl-3-aryl-2-thiohydantoin Derivatives as New Anti-Trypanosoma brucei Agents: SAR and in Vivo Efficacy

M. Gelb, F. Buckner, J. R. Gillespie, 2017, ACS medicinal chemistry letters.

Structure-guided design of novel Trypanosoma brucei Methionyl-tRNA synthetase inhibitors.

F. Buckner, C. Verlinde, W. Hol, 2016, European journal of medicinal chemistry.

Identification of Potent Inhibitors of the Trypanosoma brucei Methionyl-tRNA Synthetase via High-Throughput Orthogonal Screening

Steven J Brown, F. Buckner, C. Verlinde, 2015, Journal of biomolecular screening.

Substituted 2-phenylimidazopyridines: a new class of drug leads for human African trypanosomiasis.

F. Supek, M. Gelb, F. Buckner, 2014, Journal of medicinal chemistry.

Optimization of a binding fragment targeting the "enlarged methionine pocket" leads to potent Trypanosoma brucei methionyl-tRNA synthetase inhibitors.

F. Buckner, C. Verlinde, W. Hol, 2017, Bioorganic & medicinal chemistry letters.

Structures of Trypanosoma brucei Methionyl-tRNA Synthetase with Urea-Based Inhibitors Provide Guidance for Drug Design against Sleeping Sickness

F. Buckner, C. Verlinde, W. Hol, 2014, PLoS neglected tropical diseases.

Distinct states of methionyl-tRNA synthetase indicate inhibitor binding by conformational selection.

F. Buckner, C. Verlinde, W. Hol, 2012, Structure.

Urea Derivatives of 2-Aryl-benzothiazol-5-amines: A New Class of Potential Drugs for Human African Trypanosomiasis.

M. Gelb, F. Buckner, R. Tidwell, 2017, Journal of medicinal chemistry.

Methionyl-tRNA synthetase inhibitor has potent in vivo activity in a novel Giardia lamblia luciferase murine infection model

F. Buckner, E. Merritt, A. Paredez, 2019, bioRxiv.

Inhibitors of Methionyl-tRNA Synthetase Have Potent Activity against Giardia intestinalis Trophozoites

F. Buckner, C. Verlinde, W. Hol, 2015, Antimicrobial Agents and Chemotherapy.

Spontaneous Selection of Cryptosporidium Drug Resistance in a Calf Model of Infection

D. Griggs, F. Buckner, C. Verlinde, 2021, Antimicrobial Agents and Chemotherapy.

Optimization of Methionyl tRNA-Synthetase Inhibitors for Treatment of Cryptosporidium Infection

F. Buckner, C. Verlinde, W. Hol, 2019, Antimicrobial Agents and Chemotherapy.

Induced Resistance to Methionyl-tRNA Synthetase Inhibitors in Trypanosoma brucei Is Due to Overexpression of the Target

F. Buckner, C. Verlinde, W. Hol, 2013, Antimicrobial Agents and Chemotherapy.

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

F. Buckner, Ranae M. Ranade, R. Don, 2014, PLoS neglected tropical diseases.

New Class of Antitrypanosomal Agents Based on Imidazopyridines.

M. Gelb, F. Buckner, C. Montanari, 2017, ACS medicinal chemistry letters.

Development of Methionyl-tRNA Synthetase Inhibitors as Antibiotics for Gram-Positive Bacterial Infections

F. Buckner, C. Verlinde, W. Hol, 2017, Antimicrobial Agents and Chemotherapy.

Brucella melitensis Methionyl-tRNA-Synthetase (MetRS), a Potential Drug Target for Brucellosis

F. Buckner, S. Boyle, W. V. Van Voorhis, 2016, PloS one.

Induced Resistance to Methionyl-tRNA Synthetase 1 Inhibitors in Trypanosoma brucei is Due to Overexpression 2 of the Target 3 4 Running title : Induced resistance in Trypanosoma brucei 5 6 7

F. Buckner, C. Verlinde, W. Hol, 2013 .

Structure-guided discovery of selective methionyl-tRNA synthetase inhibitors with potent activity against Trypanosoma brucei.

F. Buckner, C. Verlinde, W. Hol, 2020, RSC medicinal chemistry.

The crystal structure of the drug target Mycobacterium tuberculosis methionyl-tRNA synthetase in complex with a catalytic intermediate.

F. Buckner, C. Verlinde, W. Hol, 2018, Acta crystallographica. Section F, Structural biology communications.

Triazolopyrimidines and Imidazopyridines: Structure-Activity Relationships and in Vivo Efficacy for Trypanosomiasis.

M. Gelb, F. Buckner, J. R. Gillespie, 2018, ACS medicinal chemistry letters.

Discovery of N-(2-aminoethyl)-N-benzyloxyphenyl benzamides: New potent Trypanosoma brucei inhibitors.

M. Gelb, F. Buckner, J. R. Gillespie, 2017, Bioorganic & medicinal chemistry.

A binding hotspot in Trypanosoma cruzi histidyl-tRNA synthetase revealed by fragment-based crystallographic cocktail screens.

Wim G J Hol, F. Buckner, C. Verlinde, 2015, Acta crystallographica. Section D, Biological crystallography.