Gregory P. Tochtrop

发表

A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo

Alexander D. MacKerell, Chayan Acharya, Jianxing Song, 2012, PloS one.

Progestin therapy to prevent preterm birth: History and effectiveness of current strategies and development of novel approaches.

G. Peters, S. Mesiano, F. van den Akker, 2019, Placenta.

Structure and Spectroscopy of Alkene-Cleaving Dioxygenases Containing an Atypically Coordinated Non-Heme Iron Center.

K. Palczewski, X. Sui, P. Kiser, 2017, Biochemistry.

Glutathionylated 4-hydroxy-2-(E)-alkenal enantiomers in rat organs and their contributions toward the disposal of 4-hydroxy-2-(E)-nonenal in rat liver.

Guo-Fang Zhang, Gregory P. Tochtrop, Y. Han, 2014, Free radical biology & medicine.

Catabolism of (2E)-4-Hydroxy-2-nonenal via ω- and ω-1-Oxidation Stimulated by Ketogenic Diet*

Guo-Fang Zhang, M. Puchowicz, Zhong-Jing Huang, 2014, The Journal of Biological Chemistry.

Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal

Guo-Fang Zhang, J. Letterio, Gregory P. Tochtrop, 2014, Redox biology.

Potent suppression of both spontaneous and carcinogen-induced colitis-associated colorectal cancer in mice by dietary celastrol supplementation

J. Letterio, Byung-Gyu Kim, Sung-Hee Choi, 2018, Carcinogenesis.

Inter-relations between 3-hydroxypropionate and propionate metabolism in rat liver: relevance to disorders of propionyl-CoA metabolism.

G. Cline, Guo-Fang Zhang, H. Brunengraber, 2017, American journal of physiology. Endocrinology and metabolism.

Bile Acid Recognition by Mouse Ileal Bile Acid Binding Protein.

Gregory P. Tochtrop, M. Badiee, 2017, ACS chemical biology.

Isotopomer enrichment assay for very short chain fatty acids and its metabolic applications.

Guo-Fang Zhang, Gregory P. Tochtrop, R. Ibarra, 2011, Analytical biochemistry.

A new strategy for the synthesis of β-benzylmercaptoethylamine derivatives.

Subrata K. Ghosh, Gregory P. Tochtrop, 2009, Tetrahedron letters.

Metabolism of Levulinate in Perfused Rat Livers and Live Rats

S. R. Harris, Guo-Fang Zhang, H. Brunengraber, 2010, The Journal of Biological Chemistry.

4-Hydroxy-2(E)-nonenal (HNE) catabolism and formation of HNE adducts are modulated by β oxidation of fatty acids in the isolated rat heart.

Guofang Zhang, Gregory P. Tochtrop, L. Nagy, 2013, Free radical biology & medicine.

Nonretinoid chaperones improve rhodopsin homeostasis in a mouse model of retinitis pigmentosa

S. Picaud, K. Lathrop, Gregory P. Tochtrop, 2022, JCI insight.

Bryonolic acid transcriptional control of anti-inflammatory and antioxidant genes in macrophages in vitro and in vivo.

J. Letterio, Gregory P. Tochtrop, Tonibelle Gatbonton-Schwager, 2012, Journal of natural products.

A mass spectrometric analysis of 4-hydroxy-2-(E)-nonenal modification of cytochrome c.

Xiaoxia Tang, L. Sayre, Gregory P. Tochtrop, 2011, Journal of mass spectrometry : JMS.

A novel small molecule chaperone of rod opsin and its potential therapy for retinal degeneration

P. Stewart, K. Palczewski, M. Golczak, 2018, Nature Communications.

The syntheses and applications of β-benzylmercaptoethylamine derivatives

Subrata K. Ghosh, Gregory P. Tochtrop, Sushabhan Sadhukhan, 2009 .

A single hydroxyl group governs ligand site selectivity in human ileal bile acid binding protein.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2004, Journal of the American Chemical Society.

Steroid ring hydroxylation patterns govern cooperativity in human bile acid binding protein.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2003, Biochemistry.

Design, synthesis, and evaluation of an isotopic labeling strategy for studying fatty acid-protein binding by NMR.

Gregory P. Tochtrop, Y. Han, Timothy E Alexander, 2008, Molecular bioSystems.

Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

S. R. Harris, Guo-Fang Zhang, H. Brunengraber, 2013, Chemical research in toxicology.

Retinoid isomerase inhibitors impair but do not block mammalian cone photoreceptor function

K. Palczewski, A. Kolesnikov, Jianye Zhang, 2018, The Journal of general physiology.

Using isotopic tools to dissect and quantitate parallel metabolic pathways.

Guo-Fang Zhang, H. Brunengraber, Gregory P. Tochtrop, 2010, Journal of the American Chemical Society.

Mass spectrometric evidence for the existence of distinct modifications of different proteins by 2(E),4(E)-decadienal.

Jianye Zhang, V. Anderson, Xiaoxia Tang, 2010, Chemical research in toxicology.

Catabolism of 4-Hydroxyacids and 4-Hydroxynonenal via 4-Hydroxy-4-phosphoacyl-CoAs*♦

Guo-Fang Zhang, K. Gibson, R. Kombu, 2009, The Journal of Biological Chemistry.

Rational Tuning of Visual Cycle Modulator Pharmacodynamics

Gregory P Tochtrop, Krzysztof Palczewski, Jianye Zhang, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Approach for expanding triterpenoid complexity via divergent Norrish-Yang photocyclization.

Gregory P. Tochtrop, V. Ignatenko, 2013, The Journal of organic chemistry.

Catalytic synthesis of 9-cis-retinoids: mechanistic insights.

K. Palczewski, A. Kubas, Gregory P. Tochtrop, 2019, Dalton transactions.

Catalytic mechanism of a retinoid isomerase essential for vertebrate vision

K. Palczewski, X. Sui, M. Golczak, 2015, Nature chemical biology.

Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone.

Gregory P. Tochtrop, Y. Han, V. Ignatenko, 2013, The Journal of organic chemistry.

Molecular library synthesis using complex substrates: expanding the framework of triterpenoids.

Gregory P. Tochtrop, Y. Han, V. Ignatenko, 2013, The Journal of organic chemistry.

Energetics by NMR: Site-specific binding in a positively cooperative system

D. Cistola, K. Richter, D. Covey, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Tris(Macrocycles) as Models for Transmembrane, Cation-Conducting Channels

G. Gokel, T. Jin, G. E. Maguire, 1998 .

Bryonolic acid: a large-scale isolation and evaluation of heme oxygenase 1 expression in activated macrophages.

J. Letterio, Emily C. Barker, Gregory P. Tochtrop, 2010, Journal of Natural Products.

Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis.

K. Palczewski, A. Kubas, Gregory P. Tochtrop, 2019, Organic & biomolecular chemistry.

Photocyclic behavior of rhodopsin induced by an atypical isomerization mechanism

P. Stewart, K. Palczewski, S. Filipek, 2017, Proceedings of the National Academy of Sciences.

A simple efficient synthesis of [23,24]-(13)C(2)-labeled bile salts as NMR probes of protein-ligand interactions.

D. Cistola, D. Covey, Gregory P. Tochtrop, 2002, Bioorganic & medicinal chemistry letters.

Synthesis of [3,4-13C2]-Enriched Bile Salts as NMR Probes of Protein−Ligand Interactions

D. Cistola, D. Covey, Gregory P. Tochtrop, 2002 .

Target identification strategies in chemical genetics.

Gregory P Tochtrop, Randall W King, R. King, 2004, Combinatorial chemistry & high throughput screening.

Genetic ablation of the fatty acid-binding protein FABP5 suppresses HER2-induced mammary tumorigenesis.

Gregory P Tochtrop, J. von Lintig, N. Noy, 2013, Cancer research.

Metabolomics, Pathway Regulation, and Pathway Discovery*

Gregory P Tochtrop, Henri Brunengraber, Guo-Fang Zhang, 2011, The Journal of Biological Chemistry.

Molecular pharmacodynamics of emixustat in protection against retinal degeneration.

K. Palczewski, M. Golczak, Jianye Zhang, 2015, The Journal of clinical investigation.

Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain

Mingsheng Zhang, R. Deshaies, D. Fushman, 2004, Science.

New methodology toward α,β-unsaturated carboxylic acids from saturated acids.

Gregory P. Tochtrop, Qingjiang Li, 2014, Organic letters.

Metabolism of γ-hydroxybutyrate in perfused rat livers.

Guo-Fang Zhang, H. Brunengraber, V. Anderson, 2012, The Biochemical journal.

Thioredoxin Reductase is a major regulator of metabolism in leukemia cells

Y. Saunthararajah, N. Putluri, V. Putluri, 2021, Oncogene.

Targeted chemical libraries

R. Looper, Gregory P. Tochtrop, 2012 .

Determinants of cooperativity and site selectivity in human ileal bile acid binding protein.

D. Cistola, J. Monsey, Gregory P. Tochtrop, 2006, Biochemistry.

Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR

D. Cistola, D. Covey, Á. Bencsura, 2016, The FEBS journal.

Mapping the locations of estradiol and potent neuroprotective analogues in phospholipid bilayers by REDOR

L. Cegelski, J. Schaefer, D. Covey, 2005 .

Tuning the Metabolic Stability of Visual Cycle Modulators through Modification of an RPE65 Recognition Motif.

Jianye Zhang, P. Kiser, M. Bassetto, 2023, Journal of medicinal chemistry.

Rational Alteration of Pharmacokinetics of Chiral Fluorinated and Deuterated Derivatives of Emixustat for Retinal Therapy.

K. Palczewski, Jianye Zhang, P. Kiser, 2021, Journal of medicinal chemistry.

Synthesis and biological evaluation of analogues of a novel inhibitor of beta-amyloid secretion.

Jonathan D. Smith, L. Sayre, Subrata K. Ghosh, 2010, Journal of medicinal chemistry.

Using isotopic tools to dissect and quantitate parallel metabolic pathways.

Guo-Fang Zhang, H. Brunengraber, Gregory P. Tochtrop, 2010, Journal of the American Chemical Society.

Metabolism of Levulinate in Perfused Rat Livers and Live Rats

S. R. Harris, Guo-Fang Zhang, H. Brunengraber, 2010, The Journal of Biological Chemistry.

Direct access to 6/5/7/5- and 6/7/5/5-fused tetracyclic triterpenoids via divergent transannular aldol reaction of lanosterol-derived diketone.

Gregory P. Tochtrop, Y. Han, V. Ignatenko, 2013, The Journal of organic chemistry.

Modular Isotopomer Synthesis of γ-Hydroxybutyric Acid for a Quantitative Analysis of Metabolic Fates

Gregory P. Tochtrop, Sushabhan Sadhukhan, Guo-fang Zhang, 2014, ACS chemical biology.