H. Kashiwagi

发表

Protease-activated receptor-4 (PAR4) variant influences on platelet reactivity induced by PAR4-activating peptide through altered Ca2+ mobilization and ERK phosphorylation in healthy Japanese subjects.

S. Honda, Y. Kanakura, Y. Tomiyama, 2018, Thrombosis research.

Bleeding tendency and impaired platelet function in a patient carrying a heterozygous mutation in the thromboxane A2 receptor

S. Honda, Y. Kanakura, Y. Tomiyama, 2011, Journal of thrombosis and haemostasis : JTH.

Impaired platelet function in a patient with P2Y12 deficiency caused by a mutation in the translation initiation codon

S. Honda, Y. Kanakura, Y. Tomiyama, 2005, Journal of thrombosis and haemostasis : JTH.

Pathophysiology and management of primary immune thrombocytopenia

Y. Tomiyama, H. Kashiwagi, 2013, International Journal of Hematology.

Monoclonal anticardiolipin autoantibodies established from the (New Zealand white x BXSB)F1 mouse model of antiphospholipid syndrome cross-react with oxidized low-density lipoprotein.

Y. Matsuzawa, Y. Kanakura, Y. Tomiyama, 1995, Arthritis and rheumatism.

Apotential role for -actinin in inside-out IIb3 signaling

S. Honda, Y. Kanakura, Y. Tomiyama, 2016 .

A potential role for α-actinin in inside-out αIIbβ3 signaling.

S. Honda, Y. Kanakura, Y. Tomiyama, 2011, Blood.

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.

Y. Tomiyama, H. Saito, N. Takayama, 2011, Blood.

Not Just Another Pretty Face: Regulation of Platelet Function at the Cytoplasmic Face of Integrin αIIbβ3

S. Shattil, H. Kashiwagi, J. Gao, 1997, Thrombosis and Haemostasis.

Adiponectin Acts as an Endogenous Antithrombotic Factor

T. Funahashi, I. Shimomura, S. Honda, 2006, Arteriosclerosis, thrombosis, and vascular biology.

SHPS‐1 negatively regulates integrin αIIbβ3 function through CD47 without disturbing FAK phosphorylation

S. Honda, H. Yoshida, Y. Tomiyama, 2005 .

Reduced adhesion of monocyte-derived macrophages from CD36-deficient patients to type I collagen.

K. Matsumoto, S. Yamashita, Y. Matsuzawa, 2001, Biochemical and biophysical research communications.

Essential in Vivo Roles of the C-type Lectin Receptor CLEC-2

Y. Tomiyama, S. Nishimura, Y. Yatomi, 2010, The Journal of Biological Chemistry.

Positive and Negative Regulation of Integrin Function

Y. Tomiyama, H. Kashiwagi, M. Shiraga, 2008 .

Ligand binding to integrin a v b 3 requires tyrosine 178 in the a v subunit

S. Honda, Y. Tomiyama, S. Shattil, 2000 .

A Mutation in the Extracellular Cysteine-Rich Repeat Region of the β3 Subunit Activates Integrins IIbβ3 and Vβ3

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1999 .

Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency.

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1995, The Journal of clinical investigation.

Reduced uptake of oxidized low density lipoproteins in monocyte-derived macrophages from CD36-deficient subjects.

S. Yamashita, Y. Tomiyama, M. Ishigami, 1995, The Journal of clinical investigation.

A Novel Polymorphism in Glycoprotein IV (Replacement of Proline-90 by Serine) Predominates in Subjects with Platelet GPIV Deficiency

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1993, Thrombosis and Haemostasis.

A single nucleotide insertion in codon 317 of the CD36 gene leads to CD36 deficiency.

Y. Matsuzawa, S. Honda, Y. Kanakura, 1996, Arteriosclerosis, thrombosis, and vascular biology.

Abnormal Processing of the Glycoprotein IIb Transcript due to a Nonsense Mutation in Exon 17 Associated with Glanzmann’s Thrombasthenia

Y. Matsuzawa, Y. Tomiyama, Y. Kurata, 1995, Thrombosis and Haemostasis.

Mechanisms of corticosteroid action in immune thrombocytopenic purpura (ITP): experimental studies using ITP-prone mice, (NZW x BXSB) F1.

S. Honda, S. Ikehara, S. Tarui, 1992, Blood.

Expression levels of ABCG2 on cord red blood cells and study of fetal anemia associated with anti‐Jra

Y. Okamura, Y. Tomiyama, T. Miyoshi, 2016, Transfusion.

Fetal and neonatal anemia associated with anti‐Jra: A case report showing a poorly hemolytic mechanism

Y. Tomiyama, T. Tomimatsu, K. Nagamine, 2011, The journal of obstetrics and gynaecology research.

Affinity Modulation of Platelet Integrin αIIbβ3 by β3-Endonexin, a Selective Binding Partner of the β3 Integrin Cytoplasmic Tail

M. Schwartz, M. Ginsberg, S. Shattil, 1997, The Journal of cell biology.

Family Studies of Type II CD36 Deficient Subjects: Linkage of a CD36 Allele to a Platelet-Specific mRNA Expression Defect(s) Causing Type II CD36 Deficiency

Y. Matsuzawa, Y. Kanakura, Y. Tomiyama, 1995, Thrombosis and Haemostasis.

CD36 deficiency and insulin resistance

S. Yamashita, Y. Matsuzawa, K. Hirano, 2001, The Lancet.

Knock‐in mice bearing constitutively active αIIb(R990W) mutation develop macrothrombocytopenia with severe platelet dysfunction

T. Miyata, Y. Kanakura, Y. Tomiyama, 2019, Journal of thrombosis and haemostasis : JTH.

Anti-αvβ3 Antibodies in Chronic Immune Thrombocytopenic Purpura

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2001, Thrombosis and Haemostasis.

High-titer antinuclear antibodies, anti-SSA/Ro antibodies and anti-nuclear RNP antibodies in patients with idiopathic thrombocytopenic purpura.

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1994, Thrombosis and haemostasis.

Elevated platelet‐associated IgG in SLE patients due to anti‐platelet autoantibody: differentiation between autoantibodies and immune complexes by ether elution

Y. Tomiyama, Y. Kurata, S. Hayashi, 1993, British journal of haematology.

Platelet-Associated Anti-Glycoprotein (GP) IIb-IIIa Autoantibodies in Chronic Immune Thrombocytopenic Purpura Mainly Recognize Cation-Dependent Conformations: Comparison with the Epitopes of Serum Autoantibodies

Y. Matsuzawa, Y. Kanakura, Y. Tomiyama, 1996, Thrombosis and Haemostasis.

Cyclic thrombocytopenia associated with IgM anti‐GPIIb‐IIIa autoantibodies

Y. Tomiyama, H. Kashiwagi, M. Shiraga, 1994, British journal of haematology.

Diagnosis in General

Y. Tomiyama, H. Kashiwagi, 2017 .

Negative regulation of platelet function by semaphorin 3A

Y. Tomiyama, H. Kashiwagi, 2005 .

Development of an Automated Chemiluminescent Enzyme Immunoassay for Measuring Thrombopoietin in Human Plasma

Y. Tomiyama, M. Kuwana, H. Kashiwagi, 2022, Diagnostics.

Agonist stimulation, talin-1, and kindlin-3 are crucial for α(IIb)β(3) activation in a human megakaryoblastic cell line, CMK.

S. Honda, Y. Kanakura, Y. Tomiyama, 2013, Experimental hematology.

Expression of GPIV and Naka antigen on monocytes in Naka‐negative subjects whose platelets lack GPIV

Y. Matsuzawa, S. Honda, T. Nishiura, 1993, British journal of haematology.

Reference guide for management of adult immune thrombocytopenia in Japan: 2019 Revision

Y. Tomiyama, M. Murata, M. Kuwana, 2020, International Journal of Hematology.

Molecular Basis of CD36 Deficiency

H. Kashiwagi, 1996 .

A potential role for (cid:1) -actinin in inside-out (cid:1) IIb (cid:2) 3 signaling

S. Honda, Y. Kanakura, Y. Tomiyama, 2010 .

Critical role of ADP interaction with P2Y12 receptor in the maintenance of αIIbβ3 activation: association with Rap1B activation

Y. Kanakura, Y. Tomiyama, Y. Kurata, 2006, Journal of thrombosis and haemostasis : JTH.

Molecular analysis of a patient with type I Glanzmann thrombasthenia and clinical impact of the presence of anti-αIIbβ3 alloantibodies

Y. Doki, Y. Kanakura, Y. Tomiyama, 2011, International journal of hematology.

Successful treatment of acquired hemophilia A, complicated by chronic GVHD, with tocilizumab

M. Kawai, T. Hirano, K. Hagihara, 2011, Modern rheumatology.

Missense mutations in the (cid:1) 3 subunit have a different impact on the expression and function between (cid:2) IIb (cid:1) 3 and (cid:2) v (cid:1) 3

S. Honda, Y. Tomiyama, Y. Kurata, 2002 .

Demonstration of a marked reduction in the amount of GPIIb in most type II patients with Glanzmann's thrombasthenia

Y. Tomiyama, Y. Kurata, H. Kashiwagi, 1994, British journal of haematology.

A mutation in the extracellular cysteine-rich repeat region of the beta3 subunit activates integrins alphaIIbbeta3 and alphaVbeta3.

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1999, Blood.

B cells expressing CD5 antigen are markedly increased in peripheral blood and spleen lymphocytes from patients with immune thrombocytopenic purpura

S. Honda, S. Tarui, Y. Kurata, 1991, British journal of haematology.

Successful second allogeneic peripheral blood stem cell transplantation and donor lymphocyte infusion in patients with relapsed acute leukemia using the same donors as for the initial allogeneic bone marrow transplantation

Y. Matsuzawa, T. Nishiura, H. Yoshida, 2003, Bone Marrow Transplantation.

Platelet Adhesive Protein Defect Disorders

S. Kunishima, H. Kashiwagi, Shinji Kunishima, 2017 .

Integrin signaling: the platelet paradigm.

S. Shattil, H. Kashiwagi, N. Pampori, 1998, Blood.

Recognition of highly restricted regions in the β-propeller domain of αIIb by platelet-associated anti-αIIbβ3 autoantibodies in primary immune thrombocytopenia.

S. Honda, Y. Kanakura, Y. Tomiyama, 2012, Blood.

Reevaluation of platelet function in chronic immune thrombocytopenia: impacts of platelet size, platelet‐associated anti‐αIIbβ3 antibodies and thrombopoietin receptor agonists

Y. Kanakura, Y. Tomiyama, S. Hayashi, 2020, British journal of haematology.

Platelet function in chronic ITP

H. Kashiwagi, N. Nishiura, 2020 .

Diagnostic value of tests for reticulated platelets, plasma glycocalicin, and thrombopoietin levels for discriminating between hyperdestructive and hypoplastic thrombocytopenia.

S. Honda, Y. Tomiyama, Y. Kurata, 2001, American journal of clinical pathology.

ITP in Adults

Y. Tomiyama, H. Kashiwagi, 2017 .

site of glycoprotein (GP) IIb thrombocytopenic purpura recognizing epitopes close to the ligand-binding GPIIb-IIIa autoantibodies in chronic immune - Platelet-associated anti

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2013 .

Platelet-associated anti-GPIIb-IIIa autoantibodies in chronic immune thrombocytopenic purpura recognizing epitopes close to the ligand-binding site of glycoprotein (GP) IIb.

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2001, Blood.

Affinity Modulation of Platelet Integrin (cid:97) IIb by 3 -Endonexin, a Selective Binding Partner of the (cid:98) 3 Integrin Cytoplasmic Tail

M. Schwartz, M. Ginsberg, S. Shattil, 1997 .

RhoA and the Function of Platelet Integrin αIIbβ3

S. Shattil, H. Kashiwagi, X. Ren, 1998 .

RhoA and the Function of Platelet Integrin a IIb b

S. Shattil, H. Kashiwagi, X. Ren, 1998 .

Immature platelet fraction (IPF) as a predictive value for thrombopoietic recovery after allogeneic stem cell transplantation

Y. Kanakura, Y. Tomiyama, T. Maeda, 2018, International Journal of Hematology.

COMPARISON OF THE SENSITIVITY OF ABC-MACE, MACE, MAIPA AND FCM FOR THE DETECTION OF ANTI-PLATELET ALLOANTIBODIES

Y. Matsuzawa, Y. Tomiyama, Y. Kurata, 2010 .

Distinct effects of daratumumab on indirect and direct antiglobulin tests: a new method employing 0.01 mol/L dithiothreitol for negating the daratumumab interference with preserving K antigenicity (Osaka method)

Y. Tomiyama, H. Shibayama, T. Kiyokawa, 2018, Transfusion.

Additional validation of Osaka method (0.01 mol/L dithiothreitol) for negating the daratumumab interference

Y. Tomiyama, H. Shibayama, T. Kiyokawa, 2019, Transfusion.

Clinical significance of IPF% or RP% measurement in distinguishing primary immune thrombocytopenia from aplastic thrombocytopenic disorders

Y. Kanakura, Y. Tomiyama, T. Kiyokawa, 2015, International Journal of Hematology.

[Comparison of reticulated platelet count with plasma glycocalicin concentration as a marker of platelet turnover in patients with thrombocytopenic disorders].

S. Honda, Y. Tomiyama, Y. Kurata, 2000, [Rinsho ketsueki] The Japanese journal of clinical hematology.

[Comparison between two methods for the measurement reticulated platelet and their clinical significance--flow cytometry (FCM) method and IPF method Using automated hematology analyzer (XE-2000)].

Y. Tomiyama, Y. Kurata, S. Hayashi, 2009, Rinsho byori. The Japanese journal of clinical pathology.

[The sensitivity, specificity and predictive value of PAIgG, reticulated platelets, thrombopoietin levels, and platelet size for the differential diagnosis of thrombocytopenia].

S. Honda, Y. Tomiyama, Y. Kurata, 1999, [Rinsho ketsueki] The Japanese journal of clinical hematology.

A unique phenotype of acquired Glanzmann thrombasthenia due to non‐function‐blocking anti‐αIIbβ3 autoantibodies

S. Honda, Y. Kanakura, Y. Tomiyama, 2018, Journal of thrombosis and haemostasis : JTH.

FNAIT pathogenesis determined by serial analysis of three subsequent pregnancies of a woman with severe fetal and neonatal alloimmune thrombocytopenia (FNAIT) with anti-HPA-4b and anti-HPA-5b alloantibodies in the first sibling.

Y. Tomiyama, K. Mimura, M. Endo, 2023, International journal of hematology.

Autoimmune-mediated thrombocytopenia after allogeneic hematopoietic stem cell transplantation: significance of detecting reticulated platelets and glycoprotein-specific platelet autoantibodies

N. Hosen, Y. Tomiyama, T. Maeda, 2022, International Journal of Hematology.

Molecular Basis of CD 36 Deficiency Evidence That a 4780 CT Substitution ( Proline 90-+ Serine ) in CD 36 cDNA Accounts for CD 36 Deficiency

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2013 .

Human CalDAG-GEFI deficiency increases bleeding and delays αIIbβ3 activation.

S. Honda, Y. Nakazawa, Y. Kanakura, 2016, Blood.

Identification of molecular defects in a subject with type I CD36 deficiency.

Y. Matsuzawa, Y. Tomiyama, Robert Lipsky, 1994, Blood.

A naturally occurring Tyr143HisαIIb mutation abolishes αIIbβ3 function for soluble ligands but retains its ability for mediating cell adhesion and clot retraction: comparison with other mutations causing ligand-binding defects

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2003 .

Ligand binding to integrin alpha(v)beta(3) requires tyrosine 178 in the alpha(v) subunit.

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2001, Blood.

Effects of Splenectomy on Immune Thrombocytopenic Purpura in (NZW x BXSB) F1 Mice: Analyses of Platelet Kinetics and Anti-Platelet Antibody Production

S. Honda, S. Ikehara, S. Tarui, 1992, Thrombosis and Haemostasis.

Autoantibodies and Platelet Dysfunction

Y. Tomiyama, H. Kashiwagi, M. Akiyama, 2010 .

Presence of platelet‐associated anti‐glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency

Y. Kanakura, Y. Tomiyama, M. Moroi, 2009, Journal of thrombosis and haemostasis : JTH.

Negative regulation of platelet function by a secreted cell repulsive protein, semaphorin 3A.

Y. Kanakura, Y. Tomiyama, Y. Kurata, 2004, Blood.

Expression and subcellular localization of WAVE isoforms in the megakaryocyte/platelet lineage

S. Honda, Y. Kanakura, Y. Tomiyama, 2005, Journal of thrombosis and haemostasis : JTH.

Risk factors for skin, mucosal, and organ bleeding in adults with primary ITP: a nationwide study in Japan.

Y. Tomiyama, M. Murata, M. Kuwana, 2020, Blood advances.

Progress in pathophysiological understanding and treatment of thrombocytopenia

H. Kashiwagi, 2023, International Journal of Hematology.

chymotrypsin: a possible role for Na+/Ca2+ exchanger Affinity modulation of the platelet integrin alpha IIb beta 3 by alpha-

S. Honda, Y. Tomiyama, M. Handa, 2011 .

Affinity Modulation of the Platelet Integrin aIIbP 3 by a-Chymotrypsin : A Possible Role for Na + / Ca 2 + Exchanger

Y. Kanakura, M. Handa, Y. Kurata, 2002 .

RhoA and the function of platelet integrin alphaIIbbeta3.

S. Shattil, H. Kashiwagi, X. Ren, 1998, Blood.

Impaired Platelet Function in a P2Y12-Deficient Patient Caused by a Mutation in the Translation Initiation Codon.

S. Honda, Y. Kanakura, Y. Tomiyama, 2004 .

Missense mutations in the beta(3) subunit have a different impact on the expression and function between alpha(IIb)beta(3) and alpha(v)beta(3).

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2002, Blood.

Amino acid mutagenesis within ligand-binding loops in αv confers loss-of-function or gain-of-function phenotype on integrin αvβ3

S. Honda, Y. Tomiyama, Y. Kurata, 2004, Thrombosis and Haemostasis.

[Clinical significance of antinuclear antibody in patients with idiopathic thrombocytopenic purpura].

Y. Matsuzawa, S. Honda, Y. Tomiyama, 1992, [Rinsho ketsueki] The Japanese journal of clinical hematology.

Autoimmune bullous disease and Hashimoto's disease complicated by acquired hemophilia A.

Y. Kanakura, Y. Tomiyama, K. Oritani, 2017, [Rinsho ketsueki] The Japanese journal of clinical hematology.

Demonstration of novel gain-of-function mutations of αIIbβ3: association with macrothrombocytopenia and glanzmann thrombasthenia-like phenotype

H. Shimada, Y. Kanakura, Y. Tomiyama, 2013, Molecular genetics & genomic medicine.

Affinity modulation of the platelet integrin alpha IIb beta 3 by alpha-chymotrypsin: a possible role for Na+/Ca2+ exchanger.

Y. Matsuzawa, S. Honda, Y. Kanakura, 1996, Blood.

Secondary immune thrombocytopenic purpura with renal cell carcinoma

K. Nishimura, N. Nonomura, M. Uemura, 2019, IJU case reports.

[Effects of anticoagulants and storage temperature on immature platelet fraction % (IPF%) values in stored samples measured by the automated hematology analyzer, XE-5000--utility of CTAD-anticoagulation and room temperature storage].

Y. Tomiyama, Y. Kurata, S. Hayashi, 2011, Rinsho byori. The Japanese journal of clinical pathology.

Increased cleavage of von Willebrand factor by ADAMTS13 may contribute strongly to acquired von Willebrand syndrome development in patients with essential thrombocythemia

Y. Tomiyama, Haruyuki Tanaka, H. Kashiwagi, 2022, Journal of thrombosis and haemostasis : JTH.

Localized Relapse in Bone Marrow in a Posttransplantation Patient with t(6;9) Acute Myeloid Leukemia

Y. Matsuzawa, H. Yoshida, J. Ishikawa, 2003, International journal of hematology.

Integrin signaling: the platelet paradigm.

S. Shattil, H. Kashiwagi, N. Pampori, 1998, Blood.

Affinity Modulation of Platelet Integrin (cid:97) IIb by 3 -Endonexin, a Selective Binding Partner of the (cid:98) 3 Integrin Cytoplasmic Tail

M. Schwartz, M. Ginsberg, S. Shattil, 1997 .

Brief report Heterozygous ITGA2B R995W mutation inducing constitutive activation of the (cid:1) IIb (cid:2) 3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia

N. Takayama, M. Otsu, J. Suzumiya, 2011 .

Analyses of genetic abnormalities in type I CD36 deficiency in Japan: identification and cell biological characterization of two novel mutations that cause CD36 deficiency in man

Y. Matsuzawa, S. Honda, Y. Tomiyama, 2001, Human Genetics.

Activation of integrin αIIbβ3 in the glycoprotein Ib‐high population of a megakaryocytic cell line, CMK, by inside‐out signaling

S. Honda, Y. Tomiyama, Y. Kurata, 2004 .

Detection of Naka Antigen and GP lV (CD36) mRNA in Monocytes of Naka-Negative Subiects

S. Honda, Y. Tomiyama, Y. Kurata, 1992, Thrombosis and Haemostasis.

Gene analysis of platelet-Naka antigen expression on monocytes in platelet-Naka- subjects.

S. Honda, Y. Tomiyama, Y. Kurata, 1991 .

Reference guide for the diagnosis of adult primary immune thrombocytopenia, 2023 edition

H. Kashiwagi, T. Hato, Yoshiaki Tomiyama, 2023, International journal of hematology.

Integrin Cytoplasmic Region-binding Proteins

H. Kashiwagi, 1998 .