K. Hauser

发表

Molecular Basis for Interactions of HIV and Drugs of Abuse

A. Nath, V. Wojna, W. Cass, 2002, Journal of acquired immune deficiency syndromes.

HIV and opiates dysregulate K+- Cl− cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice

Aaron J Barbour, P. Knapp, K. Hauser, 2020, Neurobiology of Disease.

Ibudilast (AV411), and its AV1013 analog, reduce HIV-1 replication and neuronal death induced by HIV-1 and morphine

S. Snider, P. Knapp, Seth M. Dever, 2014, AIDS.

Interactions of HIV and drugs of abuse: the importance of glia, neural progenitors, and host genetic factors.

P. Knapp, K. Hauser, 2014, International review of neurobiology.

Synaptic Dysfunction in the Hippocampus Accompanies Learning and Memory Deficits in Human Immunodeficiency Virus Type-1 Tat Transgenic Mice

T. Krahe, W. Guido, L. Wise, 2013, Biological Psychiatry.

Characterization of cell-cell junction changes associated with the formation of a strong endothelial barrier

D. Conway, K. Hauser, MaryPeace McRae, 2018, Tissue barriers.

Ontogeny of proenkephalin mRNA and enkephalin peptide expression in the cerebellar cortex of the rat: spatial and temporal patterns of expression follow maturational gradients in the external granular layer and in Purkinje cells.

M. Kindy, B. Spruce, K. Hauser, 1993, Brain research. Developmental brain research.

Opioid and neuroHIV Comorbidity – Current and Future Perspectives

K. Hauser, S. Fitting, MaryPeace McRae, 2020, Journal of Neuroimmune Pharmacology.

Morphine alters astrocyte growth in primary cultures of mouse glial cells: evidence for a direct effect of opiates on neural maturation.

K. Hauser, A. Stiene-Martin, J. Gurwell, 1991, Brain research. Developmental brain research.

In utero nicotine exposure causes persistent, gender-dependant changes in locomotor activity and sensitivity to nicotine in C57Bl/6 mice

T. Pauly, J. R. Pauly, K. Hauser, 2004, International Journal of Developmental Neuroscience.

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

Alfred C. Chin, A. Dickens, Jiadi Xu, 2017, Scientific Reports.

Prodynorphin mutations cause the neurodegenerative disorder spinocerebellar ataxia type 23.

C. Wijmenga, R. Sinke, R. Zubarev, 2010, American journal of human genetics.

Caspase-3 activity is reduced after spinal cord injury in mice lacking dynorphin: Differential effects on glia and neurons

S. Scheff, G. Bakalkin, T. Yakovleva, 2007, Neuroscience.

Decoy peptides that bind dynorphin noncovalently prevent NMDA receptor-mediated neurotoxicity.

A. Basbaum, T. Shippenberg, G. Bakalkin, 2006, Journal of proteome research.

A novel soluble protein factor with non-opioid dynorphin A-binding activity.

T. Ekström, Z. Marinova, G. Bakalkin, 2004, Biochemical and biophysical research communications.

Alterations within the endogenous opioid system in mice with targeted deletion of the neutral endopeptidase (‘enkephalinase’) gene

K. Miczek, A. Saria, G. Zernig, 2000, Regulatory Peptides.

Neurodegeneration Within the Amygdala Is Differentially Induced by Opioid and HIV-1 Tat Exposure

P. Knapp, K. Hauser, S. R. Nass, 2022, Frontiers in Neuroscience.

Asymmetry of the endogenous opioid system in the human anterior cingulate: a putative molecular basis for lateralization of emotions and pain.

J. Kehr, O. Krishtal, D. H. Wedell, 2015, Cerebral cortex.

Differential Tolerance to FTY720-Induced Antinociception in Acute Thermal and Nerve Injury Mouse Pain Models: Role of Sphingosine-1-Phosphate Receptor Adaptation

D. Selley, A. Lichtman, J. Burston, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Cytotoxic effects of dynorphins through nonopioid intracellular mechanisms.

K. Reznikov, K. Tan-No, I. Gileva, 2001, Experimental cell research.

Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through AMPA/kainate receptor-mediated cytochrome c release and caspase-3 activation

Z. Marinova, G. Bakalkin, T. Yakovleva, 2016 .

Opioids Disrupt Ca2+Homeostasis and Induce Carbonyl Oxyradical Production in Mouse Astrocytesin Vitro:Transient Increases and Adaptation to Sustained Exposure

J. Carney, L. Opanashuk, J. Jackson, 1998, Experimental Neurology.

Morphine does not affect astrocyte survival in developing primary mixed-glial cultures.

K. Hauser, J. Gurwell, 1993, Brain research. Developmental brain research.

Effects of HIV‐1 Tat on oligodendrocyte viability are mediated by CaMKIIβ–GSK3β interactions

B. Fuss, P. Knapp, K. Hauser, 2019, Journal of neurochemistry.

Estrogen protects against the synergistic toxicity by HIV proteins, methamphetamine and cocaine

M. Mattson, Y. Liu, Jiayou Zhang, 2001, BMC Neuroscience.

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: Protection by diosgenin and l-deprenyl

M. Mattson, K. Chen, J. McArthur, 2006, Neurobiology of Disease.

Androgen action in fetal mouse spinal cord cultures: metabolic and morphologic aspects

N. MacLusky, K. Hauser, C. Toran-Allerand, 1987, Brain Research.

β‐Chemokine production by neural and glial progenitor cells is enhanced by HIV‐1 Tat: effects on microglial migration

M. Block, P. Knapp, K. Hauser, 2010, Journal of neurochemistry.

Toll-like Receptor Expression and Activation in Astroglia: Differential Regulation by HIV-1 Tat, gp120, and Morphine

N. El-Hage, K. Hauser, Elizabeth M. Podhaizer, 2011, Immunological investigations.

Glial growth is regulated by agonists selective for multiple opioid receptor types in vitro

K. Hauser, A. Stiene‐Martin, 1991, Journal of neuroscience research.

Opioid-dependent growth of glial cultures: suppression of astrocyte DNA synthesis by met-enkephalin.

K. Hauser, A. Stiene‐Martin, Kurt F. Hauser, 1990, Life sciences.

Bivalent Ligand Aiming Putative Mu Opioid Receptor and Chemokine Receptor CXCR4 Dimers in Opioid Enhanced HIV-1 Entry.

Bethany A. Reinecke, D. Selley, J. An, 2020, ACS medicinal chemistry letters.

A novel bivalent HIV-1 entry inhibitor reveals fundamental differences in CCR5-&mgr;-opioid receptor interactions between human astroglia and microglia

Seth M. Dever, N. El-Hage, K. Hauser, 2013, AIDS.

Independent actions by HIV-1 Tat and morphine to increase recruitment of monocyte-derived macrophages into the brain in a region-specific manner

P. Knapp, Woong-Ki Kim, K. Hauser, 2022, Neuroscience Letters.

CCR5 mediates HIV-1 Tat-induced neuroinflammation and influences morphine tolerance, dependence, and reward

P. Knapp, W. Dewey, H. Akbarali, 2017, Brain, Behavior, and Immunity.

Co-localization of proenkephalin mRNA using cRNA probes and a cell-type-specific immunocytochemical marker for intact astrocytes in vitro

K. Hauser, J. G. Osborne, A. Stiene‐Martin, 1991, Journal of Neuroscience Methods.

Glial-restricted precursors: Patterns of expression of opioid receptors and relationship to HIV-1 Tat and morphine susceptibility in vitro

P. Knapp, K. Hauser, S. Lutz, 2015 .

Glial-restricted precursors: Patterns of expression of opioid receptors and relationship to human immunodeficiency virus-1 Tat and morphine susceptibility in vitro

P. Knapp, N. El-Hage, K. Hauser, 2007, Neuroscience.

Cytokine-Induced YKL-40 Expression RelB/p50 Complexes Regulate

T. Kordula, S. Singh, B. Boyce, 2015 .

Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects.

P. Knapp, R. Masvekar, K. Hauser, 2015, Current HIV research.

Morphine efficacy is altered in conditional HIV-1 Tat transgenic mice.

P. Knapp, W. Dewey, Seth M. Dever, 2012, European journal of pharmacology.

Progressive Degeneration and Adaptive Excitability in Dopamine D1 and D2 Receptor-Expressing Striatal Neurons Exposed to HIV-1 Tat and Morphine

William D. Marks, P. Knapp, K. Hauser, 2022, Cellular and Molecular Neurobiology.

Androgen increases the number of cells in fetal mouse spinal cord cultures: implications for motoneuron survival

K. Hauser, C. Toran-Allerand, 1989, Brain Research.

Endogenous opioid systems and the growth of oligodendrocyte progenitors: Paradoxical increases in oligodendrogenesis as an indirect mechanism of opioid action

N. Bhat, K. Hauser, J. Gurwell, 1993, Glia.

Differential involvement of p38 and JNK MAP kinases in HIV-1 Tat and gp120-induced apoptosis and neurite degeneration in striatal neurons

A. Nath, P. Knapp, N. El-Hage, 2005, Neuroscience.

Morphine causes rapid increases in glial activation and neuronal injury in the striatum of inducible HIV‐1 tat transgenic mice

A. Nath, A. Bruce-Keller, A. Chauhan, 2008, Glia.

Abnormal Ca2+ regulation in oligodendrocytes from the dysmyelinating jimpy mouse

M. Ghandour, P. Knapp, K. Hauser, 1999, Brain Research.

Cell-type specific differences in antiretroviral penetration and the effects of HIV-1 Tat and morphine among primary human brain endothelial cells, astrocytes, pericytes, and microglia

J. McClay, K. Hauser, Omnia A Ismaiel, 2019, Neuroscience Letters.

Neutral endopeptidase knockout induces hyperalgesia in a model of visceral pain, an effect related to bradykinin and nitric oxide

L. Hersh, A. Saria, G. Zernig, 2002, Journal of Molecular Neuroscience.

Pregnane steroidogenesis is altered by HIV-1 Tat and morphine: Physiological allopregnanolone is protective against neurotoxic and psychomotor effects

M. Schumacher, P. Knapp, M. Salahuddin, 2020, Neurobiology of Stress.

A Bivalent Ligand Targeting the Putative Mu Opioid Receptor and Chemokine Receptor CCR5 Heterodimers: Binding Affinity versus Functional Activities.

D. Selley, Seth M. Dever, N. El-Hage, 2013, MedChemComm.

Neutral endopeptidase and alcohol consumption, experiments in neutral endopeptidase-deficient mice.

L. Hersh, A. Saria, G. Zernig, 2000, European journal of pharmacology.

Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein

J. Bigbee, P. Knapp, D. Bagdas, 2022, Experimental Neurology.

Opioid system diversity in developing neurons, astroglia, and oligodendroglia in the subventricular zone and striatum: Impact on gliogenesis in vivo

S. R. Thornton, P. Knapp, K. Hauser, 2001, Glia.

Lateralized response in dynorphin A peptide levels after traumatic brain injury

S. Scheff, G. Bakalkin, T. Yakovleva, 2012, Journal of the Neurological Sciences.

Secretoneurin promotes pertussis toxin‐sensitive neurite outgrowth in cerebellar granule cells

A. Saria, I. Berti, R. Fischer‐Colbrie, 2003, Journal of neurochemistry.

Selective vulnerability of cerebellar granule neuroblasts and their progeny to drugs with abuse liability

A. Nath, J. R. Pauly, A. Saria, 2003, The Cerebellum.

HIV‐1 neuropathogenesis: glial mechanisms revealed through substance abuse

A. Nath, D. Volsky, P. Knapp, 2007, Journal of neurochemistry.

Chronic nicotine exposure reduces N-methyl-d-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression

M. Prendergast, B. Harris, R. Holley, 2001, Neuroscience.

5α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat

P. Knapp, K. Hauser, S. Zou, 2016, Brain, Behavior, and Immunity.

Opiate Addiction Therapies and HIV-1 Tat: Interactive Effects on Glial [Ca2+]i, Oxyradical and Neuroinflammatory Chemokine Production and Correlative Neurotoxicity

P. Knapp, K. Hauser, S. Fitting, 2014, Current HIV research.

Interactive HIV-1 Tat and Morphine-Induced Synaptodendritic Injury Is Triggered through Focal Disruptions in Na+ Influx, Mitochondrial Instability, and Ca2+ Overload

William D. Marks, P. Knapp, M. Bowers, 2014, The Journal of Neuroscience.

Regional heterogeneity and diversity in cytokine and chemokine production by astroglia: differential responses to HIV-1 Tat, gp120, and morphine revealed by multiplex analysis.

P. Knapp, K. Hauser, S. Fitting, 2010, Journal of proteome research.

Synergistic increases in intracellular Ca2+, and the release of MCP‐1, RANTES, and IL‐6 by astrocytes treated with opiates and HIV‐1 Tat

A. Nath, P. Knapp, N. El-Hage, 2005, Glia.

μ-Opioid receptor-induced Ca 2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca 2+ -dependent mechanism

M. Mattson, R. Elde, K. Hauser, 1996, Brain Research.

Translocation of Dynorphin Neuropeptides across the Plasma Membrane

D. Hirschberg, T. Bergman, Z. Marinova, 2005, Journal of Biological Chemistry.

Cellular localization of proenkephalin mRNA and enkephalin peptide products in cultured astrocytes

K. Hauser, M. H. Melner, J. G. Osborne, 1990, Brain Research.

Endogenous opioids regulate dendritic growth and spine formation in developing rat brain

I. Zagon, P. McLaughlin, K. Hauser, 1987, Brain Research.

Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 activity in the forebrain

D. Selley, A. Lichtman, P. Knapp, 2016, Neurobiology of Disease.

Dynorphins in Central Nervous System Pathology

T. Yakovleva, G. Bakalkin, P. Knapp, 2012 .

Pathobiology of dynorphins in trauma and disease.

E. Hall, B. Vissel, S. Scheff, 2005, Frontiers in bioscience : a journal and virtual library.

Escalating morphine dosing in HIV-1 Tat transgenic mice with sustained Tat exposure reveals an allostatic shift in neuroinflammatory regulation accompanied by increased neuroprotective non-endocannabinoid lipid signaling molecules and amino acids

A. Lichtman, Zibo Li, P. Knapp, 2020, Journal of Neuroinflammation.

Opiate Drug Use and the Pathophysiology of NeuroAIDS

P. Knapp, Seth M. Dever, K. Hauser, 2012, Current HIV research.

Neurotoxicity of HIV-1 proteins gp120 and Tat in the rat striatum

A. Bansal, A. Nath, W. Maragos, 2000, Brain Research.

Simultaneous determination of intracellular concentrations of tenofovir, emtricitabine, and dolutegravir in human brain microvascular endothelial cells using liquid chromatography-tandem mass spectrometry (LC-MS/MS).

K. Hauser, Omnia A Ismaiel, MaryPeace McRae, 2019, Analytica chimica acta.

Molecular targets of opiate drug abuse in neuro AIDS

A. Nath, A. Bruce-Keller, P. Knapp, 2005, Neurotoxicity Research.

HIV‐1 Tat and opiate‐induced changes in astrocytes promote chemotaxis of microglia through the expression of MCP‐1 and alternative chemokines

J. Ambati, A. Bruce-Keller, P. Knapp, 2006, Glia.

Neurotoxicity and dysfunction of dopaminergic systems associated with AIDS dementia

Melina V Jones, J. Bell, A. Nath, 2000, Journal of psychopharmacology.

Structure-Based Design and Development of Chemical Probes Targeting Putative MOR-CCR5 Heterodimers to Inhibit Opioid Exacerbated HIV-1 Infectivity.

Boshi Huang, D. Selley, P. Knapp, 2021, Journal of medicinal chemistry.

Short interfering RNA‐induced gene silencing is transmitted between cells from the mammalian central nervous system

Guoying Wang, M. Ghandour, P. Knapp, 2006, Journal of neurochemistry.

Decreased number of interneurons and increased seizures in neuropilin 2 deficient mice: Implications for autism and epilepsy

E. Blalock, A. Bachstetter, R. Mervis, 2009, Epilepsia.

Apoptotic death of striatal neurons induced by human immunodeficiency virus-1 Tat and gp120: Differential involvement of caspase-3 and endonuclease G

A. Nath, P. Knapp, K. Hauser, 2011, Journal of NeuroVirology.

Dynorphin A (1–17) induces apoptosis in striatal neurons in vitro through α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor-mediated cytochrome C release and caspase-3 activation

D. Hirschberg, T. Bergman, Z. Marinova, 2003, Neuroscience.

Cocaine promotes both initiation and elongation phase of HIV-1 transcription by activating NF-κB and MSK1 and inducing selective epigenetic modifications at HIV-1 LTR.

J. Karn, F. Kashanchi, Geetaram Sahu, 2015, Virology.

Restoration of KCC2 Membrane Localization in Striatal Dopamine D2 Receptor-Expressing Medium Spiny Neurons Rescues Locomotor Deficits in HIV Tat-Transgenic Mice

Aaron J Barbour, P. Knapp, K. Hauser, 2021, ASN neuro.

HIV-1-Tat Protein Inhibits SC35-mediated Tau Exon 10 Inclusion through Up-regulation of DYRK1A Kinase*

A. Wilk, L. Del Valle, F. Peruzzi, 2015, The Journal of Biological Chemistry.

Opiate Drugs with Abuse Liability Hijack the Endogenous Opioid System to Disrupt Neuronal and Glial Maturation in the Central Nervous System

P. Knapp, K. Hauser, 2018, Front. Pediatr..

Transcriptional control of maladaptive and protective responses in alcoholics: A role of the NF-κB system

G. Bakalkin, T. Yakovleva, I. Bazov, 2011, Brain, Behavior, and Immunity.

CCL5/RANTES Gene Deletion Attenuates Opioid-Induced Increases in Glial CCL2/MCP-1 Immunoreactivity and Activation in HIV-1 Tat-Exposed Mice

A. Bruce-Keller, P. Knapp, Pamela E. Knapp, 2008, Journal of Neuroimmune Pharmacology.

Morphine and gp120 Toxic Interactions in Striatal Neurons are Dependent on HIV-1 Strain

P. Knapp, K. Hauser, S. Fitting, 2011, Journal of Neuroimmune Pharmacology.

Cross-talk between microglia and neurons regulates HIV latency

J. Karn, P. Knapp, Fengchun Ye, 2019, PLoS pathogens.

HIV-1 Tat causes cognitive deficits and selective loss of parvalbumin, somatostatin, and neuronal nitric oxide synthase expressing hippocampal CA1 interneuron subpopulations

William D. Marks, P. Knapp, K. Hauser, 2016, Journal of NeuroVirology.

Preferential vulnerability of astroglia and glial precursors to combined opioid and HIV‐1 Tat exposure in vitro

A. Nath, P. Knapp, N. El-Hage, 2004, The European journal of neuroscience.

Synergistic neurotoxicity of opioids and human immunodeficiency virus-1 Tat protein in striatal neurons in vitro

J. Zhang, Jiayou Zhang, A. Nath, 2001, Neuroscience.

Effects of chronic HIV-1 Tat exposure in the CNS: heightened vulnerability of males versus females to changes in cell numbers, synaptic integrity, and behavior

M. Miles, S. Farris, P. Knapp, 2013, Brain Structure and Function.

Morphine Inhibits Purkinje Cell Survival and Dendritic Differentiation in Organotypic Cultures of the Mouse Cerebellum

K. Hauser, J. Gurwell, C. Turbek, 1994, Experimental Neurology.

Stellate cell development in the frog cerebellum during spontaneous and thyroxin‐induced metamorphosis

A. Gona, K. Hauser, N. Uray, 1986, The Journal of comparative neurology.

Ultrastructural studies on the ventricular surface of the frog cerebellum

A. Gona, K. Hauser, 2004, Cell and Tissue Research.

Connexin‐purinergic signaling in enteric glia mediates the prolonged effect of morphine on constipation

W. Dewey, Aravind R. Gade, H. Akbarali, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Endogenous opioids and oligodendroglial function: Possible autocrine/paracrine effects on cell survival and development

G. Bakalkin, P. Knapp, B. Spruce, 2001, Glia.

Sensitization of enteric neurons to morphine by HIV‐1 Tat protein

P. Knapp, W. Dewey, H. Akbarali, 2015, Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society.

Effects of HIV-1 Tat on Enteric Neuropathogenesis

W. Dewey, N. El-Hage, H. Akbarali, 2014, The Journal of Neuroscience.

HIV-1 Tat exacerbates lipopolysaccharide-induced cytokine release via TLR4 signaling in the enteric nervous system

P. Brun, W. Dewey, H. Akbarali, 2016, Scientific Reports.

Cell‐specific actions of HIV‐Tat and morphine on opioid receptor expression in glia

A. Bruce-Keller, F. O. Dimayuga, J. Keller, 2008, Journal of neuroscience research.

Postnatal suppression of myomesin, muscle creatine kinase and the M-line in rat extraocular muscle

J. D. Porter, B. Gong, A. Merriam, 2003, Journal of Experimental Biology.

Autoradiographic studies of cerebellar histogenesis in the premetamorphic bullfrog tadpole: II. Formation of the interauricular granular band

A. Gona, K. Hauser, N. Uray, 1988, The Journal of comparative neurology.

Autoradiographic studies of cerebellar histogenesis in the premetamorphic bullfrog tadpole: I. Generation of the external granular layer

A. Gona, K. Hauser, N. Uray, 1987, The Journal of comparative neurology.

Purkinje cell maturation in the frog cerebellum during thyroxine-induced metamorphosis

A. Gona, K. Hauser, 1984, Neuroscience.

Effects of thyroidectomy and season on the external granular layer of the cerebellum in metamorphosing bullfrog tadpoles (Rana catesbeiana)

A. Gona, K. Hauser, 1983, Experimental Neurology.

Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice

P. Knapp, W. Dewey, K. Hauser, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Morphine and HIV‐Tat increase microglial‐free radical production and oxidative stress: possible role in cytokine regulation

A. Bruce-Keller, F. O. Dimayuga, J. Keller, 2009, Journal of neurochemistry.

Effects of HIV-1 Tat and Methamphetamine on Blood-Brain Barrier Integrity and Function In Vitro

J. McClay, P. Couraud, B. Weksler, 2017, Antimicrobial Agents and Chemotherapy.

Effects of HIV-1 Tat and Methamphetamine on Blood-1 Brain Barrier Integrity and Function In Vitro 2 3 4 Running Title : Tat and Methamphetamine effects on BBB 5 6

P. Couraud, B. Weksler, K. Hauser, 2017 .

Productive infection of human neural progenitor cells by R5 tropic HIV-1: opiate co-exposure heightens infectivity and functional vulnerability

P. Knapp, R. Masvekar, K. Hauser, 2017, AIDS.

HIV‐1 alters neural and glial progenitor cell dynamics in the central nervous system: Coordinated response to opiates during maturation

P. Knapp, K. Hauser, Elizabeth M. Podhaizer, 2012, Glia.

RelB/p50 Complexes Regulate Cytokine-Induced YKL-40 Expression

T. Kordula, S. Singh, B. Boyce, 2015, The Journal of Immunology.

Glial modulators as potential treatments of psychostimulant abuse.

K. Hauser, P. Beardsley, 2014, Advances in pharmacology.

Reduced intraepidermal nerve fibre density, glial activation, and sensory changes in HIV type-1 Tat-expressing female mice: involvement of Tat during early stages of HIV-associated painful sensory neuropathy

A. Rice, P. Knapp, D. Bagdas, 2018, Pain reports.

HIV-Tat elicits microglial glutamate release: Role of NAPDH oxidase and the cystine–glutamate antiporter

A. Bruce-Keller, J. Keller, P. Knapp, 2010, Neuroscience Letters.

Interactive comorbidity between opioid drug abuse and HIV-1 Tat: chronic exposure augments spine loss and sublethal dendritic pathology in striatal neurons.

A. Nath, P. Knapp, N. El-Hage, 2010, The American journal of pathology.

Exploration of bivalent ligands targeting putative mu opioid receptor and chemokine receptor CCR5 dimerization.

D. Selley, A. Nicola, P. Knapp, 2016, Bioorganic & medicinal chemistry.

Morphine potentiates neurodegenerative effects of HIV-1 Tat through actions at μ-opioid receptor-expressing glia.

P. Knapp, S. Welch, N. El-Hage, 2011, Brain : a journal of neurology.

Fractalkine/CX3CL1 protects striatal neurons from synergistic morphine and HIV-1 Tat-induced dendritic losses and death

D. Conrad, P. Knapp, N. El-Hage, 2011, Molecular Neurodegeneration.

Effects of chronic expression of the HIV-induced protein, transactivator of transcription, on circadian activity rhythms in mice, with or without morphine.

A. Nath, A. Bruce-Keller, P. Knapp, 2008, American journal of physiology. Regulatory, integrative and comparative physiology.

Impact of Opiate–HIV-1 Interactions on Neurotoxic Signaling

A. Nath, A. Bruce-Keller, P. Knapp, 2006, Journal of Neuroimmune Pharmacology.

Structure–Activity Analysis of Dynorphin A Toxicity in Spinal Cord Neurons: Intrinsic Neurotoxicity of Dynorphin A and Its Carboxyl-Terminal, Nonopioid Metabolites

P. Knapp, K. Hauser, C. Turbek, 2001, Experimental Neurology.

Dynorphin A (1–13) Neurotoxicity in Vitro: Opioid and Non-Opioid Mechanisms in Mouse Spinal Cord Neurons

K. Hauser, J. Foldes, C. Turbek, 1999, Experimental Neurology.

HIV‐1 Tat and morphine have interactive effects on oligodendrocyte survival and morphology

A. Nath, A. Bruce-Keller, P. Knapp, 2009, Glia.

Accelerated brain aging with opioid misuse and HIV: New insights on the role of glially derived pro-inflammation mediators and neuronal chloride homeostasis

P. Knapp, K. Hauser, Michael Ohene-Nyako, 2022, Current Opinion in Neurobiology.

Oligodendrocytes Are Targets of HIV-1 Tat: NMDA and AMPA Receptor-Mediated Effects on Survival and Development

B. Fuss, P. Knapp, K. Hauser, 2015, The Journal of Neuroscience.

HIV-1 Tat and morphine decrease murine inter-male social interactions and associated oxytocin levels in the prefrontal cortex, amygdala, and hypothalamic paraventricular nucleus

P. Knapp, T. Napier, K. Hauser, 2021, Hormones and Behavior.

Morphine Enhances HIV-1SF162-Mediated Neuron Death and Delays Recovery of Injured Neurites

P. Knapp, R. Masvekar, N. El-Hage, 2014, PloS one.

Endogenous opioid system in developing normal and jimpy oligodendrocytes: μ and κ opioid receptors mediate differential mitogenic and growth responses

P. Knapp, K. Hauser, K. Maderspach, 1998, Glia.

Morphine Exacerbates HIV-1 Tat-Induced Cytokine Production in Astrocytes through Convergent Effects on [Ca2+]i, NF-κB Trafficking and Transcription

A. Bruce-Keller, T. Yakovleva, G. Bakalkin, 2008, PloS one.

HIV-1 Tat and Morphine Differentially Disrupt Pyramidal Cell Structure and Function and Spatial Learning in Hippocampal Area CA1: Continuous versus Interrupted Morphine Exposure

William D. Marks, Aaron J Barbour, P. Knapp, 2021, eNeuro.

Cell-specific loss of κ-opioid receptors in oligodendrocytes of the dysmyelinating jimpy mouse

P. Knapp, K. Hauser, V. Adjan, 2009, Neuroscience Letters.

Opposing actions of the EGF family and opioids: heparin binding-epidermal growth factor (HB-EGF) protects mouse cerebellar neuroblasts against the antiproliferative effect of morphine

L. Opanashuk, K. Hauser, 1998, Brain Research.

Cell proliferation and protooncogene induction in oligodendroglial progenitors

N. Bhat, M. Kindy, K. Hauser, 1992, Journal of neuroscience research.

Depressive-like Behavior Is Accompanied by Prefrontal Cortical Innate Immune Fatigue and Dendritic Spine Losses after HIV-1 Tat and Morphine Exposure

P. Knapp, M. Damaj, K. Hauser, 2023, Viruses.

Selective Vulnerability of Striatal D2 versus D1 Dopamine Receptor-Expressing Medium Spiny Neurons in HIV-1 Tat Transgenic Male Mice

William D. Marks, Aaron J Barbour, P. Knapp, 2017, The Journal of Neuroscience.

NeuroAIDS, Drug Abuse, and Inflammation: Building Collaborative Research Activities

E. Masliah, Linda Chang, R. Gonzalez, 2006, Journal of Neuroimmune Pharmacology.

HIV-1 Tat disrupts blood-brain barrier integrity and increases phagocytic perivascular macrophages and microglia in the dorsal striatum of transgenic mice

M. Ghandour, P. Knapp, Woong-Ki Kim, 2017, Neuroscience Letters.

The effects of human immunodeficiency virus infection on the expression of the drug efflux proteins P‐glycoprotein and breast cancer resistance protein in a human intestine model

Tracey A. H. Taylor, K. Hauser, S. Fitting, 2012, The Journal of pharmacy and pharmacology.

Characterization of opioid-dependent glial development in dissociated and organotypic cultures of mouse central nervous system: critical periods and target specificity.

K. Hauser, A. Stiene‐Martin, 1991, Brain research. Developmental brain research.

Conditional expression of HIV-1 Tat in the mouse alters the onset and progression of tonic, inflammatory, and neuropathic hypersensitivity in a sex-dependent manner.

A. Rice, P. Knapp, D. Bagdas, 2020, European journal of pain.

Effect of nicotine on cerebellar granule neuron development

L. Opanashuk, J. R. Pauly, K. Hauser, 2001, The European journal of neuroscience.

Morphine regulates DNA synthesis in rat cerebellar neuroblasts in vitro.

K. Hauser, 1992, Brain research. Developmental brain research.

Myelin regulatory factor is a target of individual and interactive effects of HIV-1 Tat and morphine in the striatum and pre-frontal cortex

P. Knapp, Chloe A. Simons, K. Hauser, 2023, Journal of NeuroVirology.

Opioids, Astroglial Chemokines, Microglial Reactivity, and Neuronal Injury in HIV-1 Encephalitis

A. Bruce-Keller, P. Knapp, N. El-Hage, 2010 .

Ligand-Gated Purinergic Receptors Regulate HIV-1 Tat and Morphine Related Neurotoxicity in Primary Mouse Striatal Neuron-Glia Co-Cultures

K. Hauser, M. Sorrell, 2014, Journal of Neuroimmune Pharmacology.

HIV-1 Coinfection and Morphine Coexposure Severely Dysregulate Hepatitis C Virus-Induced Hepatic Proinflammatory Cytokine Release and Free Radical Production: Increased Pathogenesis Coincides with Uncoordinated Host Defenses

Seth M. Dever, N. El-Hage, K. Hauser, 2011, Journal of Virology.

Opioids modulate cell division in the germinal zone of the late embryonic neocortex

K. Reznikov, G. Bakalkin, K. Hauser, 1999, The European journal of neuroscience.

Morphine and HIV-1 Tat interact to cause region-specific hyperphosphorylation of tau in transgenic mice

P. Knapp, K. Hauser, S. R. Nass, 2020, Neuroscience Letters.

Endogenous opioid systems and the regulation of dendritic growth and spine formation

I. Zagon, P. McLaughlin, K. Hauser, 1989, The Journal of comparative neurology.

HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity

P. Knapp, A. Kashuba, M. Halquist, 2019, Journal of NeuroVirology.

Opiates selectively increase intracellular calcium in developing type-1 astrocytes: role of calcium in morphine-induced morphologic differentiation.

M. Mattson, K. Hauser, A. Stiene‐Martin, 1993, Brain research. Developmental brain research.

Regional, developmental, and cell cycle‐dependent differences in μ, δ, and κ‐opioid receptor expression among cultured mouse astrocytes

K. Hauser, R. Zhou, A. Stiene‐Martin, 1998 .

κ-Opioid receptor expression defines a phenotypically distinct subpopulation of astroglia: relationship to Ca2+ mobilization, development, and the antiproliferative effect of opioids

R. Elde, K. Hauser, J. Gurwell, 1996, Brain Research.

Casein Kinase 2 Mediates HIV- and Opioid-Induced Pathologic Phosphorylation of TAR DNA Binding Protein 43 in the Basal Ganglia

P. Knapp, R. Lukande, M. Nicol, 2023, ASN neuro.

Opioids intrinsically inhibit the genesis of mouse cerebellar granule neuron precursors in vitro: differential impact of μ and δ receptor activation on proliferation and neurite elongation

R. Elde, K. Hauser, A. Houdi, 2000, The European journal of neuroscience.

HIV-1 Tat reduces apical dendritic spine density throughout the trisynaptic pathway in the hippocampus of male transgenic mice

P. Knapp, K. Hauser, Virginia D. McLane, 2022, Neuroscience Letters.

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

P. Knapp, K. Hauser, Elizabeth M. Podhaizer, 2018, Journal of Neuroinflammation.

Plasma membrane poration by opioid neuropeptides: a possible mechanism of pathological signal transduction

C. Lindskog, G. Bakalkin, I. Bazov, 2015, Cell Death and Disease.

The FASEB Journal • FJ Express Full-Length Article Prodynorphin storage and processing in axon

T. Kaneko, V. Pickel, Y. Hurd, 2022 .

L. Hersh, A. Saria, C. Gerard, 1997, Neuroscience Letters.

Chronic HIV-1 Tat exposure alters anterior cingulate cortico-basal ganglia-thalamocortical synaptic circuitry, associated behavioral control, and immune regulation in male mice

P. Knapp, M. Damaj, K. Hauser, 2020, Brain, behavior, & immunity - health.

Morphine and gp120 Toxic Interactions in Striatal Neurons are Dependent on HIV-1 Strain

P. Knapp, N. El-Hage, K. Hauser, 2012, Journal of Neuroimmune Pharmacology.

GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity

P. Knapp, R. Masvekar, N. El-Hage, 2015, Molecular and Cellular Neuroscience.

Differential expression and HIV-1 regulation of μ-opioid receptor splice variants across human central nervous system cell types

P. Knapp, Seth M. Dever, K. Hauser, 2012, Journal of NeuroVirology.

PTEN gene silencing prevents HIV-1 gp120IIIB-induced degeneration of striatal neurons

P. Knapp, N. El-Hage, K. Hauser, 2011, Journal of NeuroVirology.

Diversity of the endogenous opioid system in development. Novel signal transduction translates multiple extracellular signals into neural cell growth and differentiation.

D. Mangoura, K. Hauser, 1998, Perspectives on developmental neurobiology.

Differential expression of the alternatively spliced OPRM1 isoform &mgr;-opioid receptor-1K in HIV-infected individuals

L. Diatchenko, P. Knapp, B. Costin, 2014, AIDS.

Regional, developmental, and cell cycle-dependent differences in mu, delta, and kappa-opioid receptor expression among cultured mouse astrocytes.

K. Hauser, R. Zhou, A. Stiene‐Martin, 1998, Glia.

CCR2 mediates increases in glial activation caused by exposure to HIV-1 Tat and opiates

J. Ambati, A. Bruce-Keller, P. Knapp, 2006, Journal of Neuroimmunology.

Genetic background regulates semaphorin gene expression and epileptogenesis in mouse brain after kainic acid status epilepticus

G. Smith, J. Yang, G. Barnes, 2005, Neuroscience.

Rat Nucleus Accumbens Core Astrocytes Modulate Reward and the Motivation to Self-Administer Ethanol after Abstinence

Ryan S. Poland, Cecilia Bull, Wahab A. Syed, 2014, Neuropsychopharmacology.

Chronic low-level expression of HIV-1 Tat promotes a neurodegenerative phenotype with aging

Alfred C. Chin, A. Dickens, Jiadi Xu, 2017, Scientific Reports.

μ-Opioid receptor activation enhances DNA synthesis in immature oligodendrocytes

P. Knapp, K. Hauser, 1996, Brain Research.

Dynorphin A toxicity in striatal neurons via an α-amino-3-hydroxy-5-methylisoxazole-4-propionate/kainate receptor mechanism

K. Hauser, R. Goody, S. M. Goebel, 2003, Neuroscience.

Spatial and temporal integration of neurotransmitter signals in the development of neural circuitry

M. Mattson, K. Hauser, 1991, Neurochemistry International.

Silencing the PTEN gene is protective against neuronal death induced by human immunodeficiency virus type 1 Tat

P. Knapp, Shi-Ping Zou, Pamela E. Knapp, 2007, Journal of NeuroVirology.

Survival of extraocular muscle in long-term organotypic culture: differential influence of appropriate and inappropriate motoneurons.

J. D. Porter, K. Hauser, 1993, Developmental biology.

Morphine suppresses DNA synthesis in cultured murine astrocytes from cortex, hippocampus and striatum

K. Hauser, A. Stiene‐Martin, 1993, Neuroscience Letters.

Target-derived matricryptins organize cerebellar synapse formation through α3β1 integrins.

Sylvie Ricard-Blum, S. Ricard-Blum, T. Pihlajaniemi, 2012, Cell reports.

Granule cell development in the frog cerebellum during spontaneous and thyroxine‐induced metamorphosis

A. Gona, K. Hauser, N. Uray, 1986, The Journal of comparative neurology.

Expression of proenkephalin mRNA in developing cerebellar cortex of the rat: expression levels coincide with maturational gradients in Purkinje cells.

M. Kindy, K. Hauser, J. G. Osborne, 1991, Brain research. Developmental brain research.

HIV‐1 alters neural and glial progenitor cell dynamics in the central nervous system: Coordinated response to opiates during maturation

P. Knapp, K. Hauser, Elizabeth M. Podhaizer, 2012, Glia.

Interactive HIV-1 Tat and Morphine-Induced Synaptodendritic Injury Is Triggered through Focal Disruptions in Na+ Influx, Mitochondrial Instability, and Ca2+ Overload

William D. Marks, P. Knapp, H. Akbarali, 2014, The Journal of Neuroscience.

Ligand-Gated Purinergic Receptors Regulate HIV-1 Tat and Morphine Related Neurotoxicity in Primary Mouse Striatal Neuron-Glia Co-Cultures

K. Hauser, M. Sorrell, 2013, Journal of Neuroimmune Pharmacology.

HIV-1 Tat and morphine interactions dynamically shift striatal monoamine levels and exploratory behaviors over time.

P. Knapp, K. Hauser, S. R. Nass, 2024, Journal of neurochemistry.

5α-reduced progestogens ameliorate mood-related behavioral pathology, neurotoxicity, and microgliosis associated with exposure to HIV-1 Tat

P. Knapp, K. Hauser, S. Zou, 2016, Brain, Behavior, and Immunity.

Fentanyl dysregulates neuroinflammation and disrupts blood-brain barrier integrity in HIV-1 Tat transgenic mice.

K. Hauser, MaryPeace McRae, Michael Ohene-Nyako, 2024, Journal of neurovirology.

mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism.

M. Mattson, R. Elde, K. Hauser, 1996, Brain research.

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates

P. Knapp, K. Hauser, Elizabeth M. Podhaizer, 2018, Journal of Neuroinflammation.

Morphine Tolerance and Physical Dependence Are Altered in Conditional HIV-1 Tat Transgenic Mice

P. Knapp, W. Dewey, K. Hauser, 2016, The Journal of Pharmacology and Experimental Therapeutics.