A. O’Brien

发表

Invasive Escherichia coli.

B. P. Doctor, P. Gemski, S. Formal, 1978, Journal of the American Veterinary Medical Association.

Immunochemical and cytotoxic activities of Shigella dysenteriae 1 (shiga) and shiga-like toxins

A. O’Brien, G. Laveck, 1982, Infection and immunity.

Characterization of monoclonal antibodies against Shiga-like toxin from Escherichia coli

R. Holmes, N. Strockbine, A. O’Brien, 1985, Infection and immunity.

Production of Shiga-like toxin by Escherichia coli.

J. Wells, I. Wachsmuth, A. O’Brien, 1986, The Journal of infectious diseases.

Effects of iron and temperature on Shiga-like toxin I production by Escherichia coli

R. Holmes, A. O’Brien, D. Weinstein, 1988, Infection and immunity.

Evaluation of the role of Shiga and Shiga-like toxins in mediating direct damage to human vascular endothelial cells.

J. Samuel, V. L. Tesh, J. Sharefkin, 1991, The Journal of infectious diseases.

New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli.

A. O’Brien, A. Melton-Celsa, 2014, Microbiology spectrum.

Mouse Models of Escherichia coli O157:H7 Infection and Shiga Toxin Injection

A. O’Brien, Krystle L. Mohawk, 2011, Journal of biomedicine & biotechnology.

Rapid Detection of Shiga Toxin-Producing Escherichia coli by Optical Immunoassay

J. Daly, Choong H. Park, L. Teel, 2007, Journal of Clinical Microbiology.

Escherichia coli strains isolated from pigs with edema disease produce a variant of Shiga-like toxin II

J. Peiris, S. Cryz, A. O’Brien, 1987 .

Acute renal tubular necrosis and death of mice orally infected with Escherichia coli strains that produce Shiga-like toxin type II

L. M. Sung, J. Samuel, A. O’Brien, 1990, Infection and immunity.

Mouse model for colonization and disease caused by enterohemorrhagic Escherichia coli O157:H7

A. O’Brien, E. A. Wadolkowski, J. A. Burris, 1990, Infection and immunity.

Virulence of enterohemorrhagic Escherichia coli O91:H21 clinical isolates in an orally infected mouse model

A. Melton, A. O’Brien, S. W. Lindgren, 1993, Infection and immunity.

Comparison of the relative toxicities of Shiga-like toxins type I and type II for mice

J. Samuel, V. M. Gordon, J. Owens, 1993, Infection and immunity.

Virulence of Shiga toxin-producing Escherichia coli (STEC) in orally-infected mice correlates with the type of toxin produced by the infecting strain.

A. O’Brien, C. K. Schmitt, A. Melton-Celsa, 1998, Japanese journal of medical science & biology.

Production ofa UniqueCytotoxin byCampylobacterjejuni

J. Barrett, R. Guerrant, A. O’Brien, 1987 .

Unique Cytotoxin by Campylobacterjejuni

R. Guerrant, A. O’Brien, Barrett, 2022 .

Role of a 60-megadalton plasmid and Shiga-like toxins in the pathogenesis of infection caused by enterohemorrhagic Escherichia coli O157:H7 in gnotobiotic piglets

S. Tzipori, M. Levine, H. Lior, 1987, Infection and immunity.

The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model.

M. McKee, S. Tzipori, J. Alroy, 1993, The Journal of clinical investigation.

Enterohemorrhagic Escherichia coli O157:H7 requires intimin to colonize the gnotobiotic pig intestine and to adhere to HEp-2 cells

M. McKee, R. Moxley, D. Francis, 1995, Infection and immunity.

Shiga toxin-producing Escherichia coli in Montana: bacterial genotypes and clinical profiles.

Gilbert S Chen, M. Ciol, T. Damrow, 2003, The Journal of infectious diseases.

Intimin Types α, β, and γ Bind to Nucleolin with Equivalent Affinity but Lower Avidity than to the Translocated Intimin Receptor*

A. O’Brien, J. Sinclair, 2004, Journal of Biological Chemistry.

Escherichia coli O157:H7 requires intimin for enteropathogenicity in calves.

B. Bosworth, H. Moon, A. O’Brien, 1998, Infection and immunity.

Salmonella typhimurium translocates flagellin across intestinal epithelia, inducing a proinflammatory response.

C. Hagedorn, L. Taylor, J. Madara, 2001, The Journal of clinical investigation.

Cytotoxic Necrotizing Factor Type 1 Production by Uropathogenic Escherichia coli Modulates Polymorphonuclear Leukocyte Function

A. O’Brien, S. Rasmussen, Jon M. Davis, 2005, Infection and Immunity.

Vaccination with genetically modified Shiga-like toxin IIe prevents edema disease in swine

J. Samuel, V. M. Gordon, B. Bosworth, 1996, Infection and immunity.

Comparative Pathogenicity of Escherichia coli O157 and Intimin-Negative Non-O157 Shiga Toxin-Producing E. coli Strains in Neonatal Pigs

H. Moon, A. O’Brien, A. Melton-Celsa, 2003, Infection and Immunity.

Truncated enterohemorrhagic Escherichia coli (EHEC) O157:H7 intimin (EaeA) fusion proteins promote adherence of EHEC strains to HEp-2 cells

M. McKee, A. O’Brien, M. Mckee, 1996, Infection and immunity.

The Established Intimin Receptor Tir and the Putative Eucaryotic Intimin Receptors Nucleolin and β1 Integrin Localize at or near the Site of Enterohemorrhagic Escherichia coli O157:H7 Adherence to Enterocytes In Vivo

A. O’Brien, E. Dean-Nystrom, J. Sinclair, 2006, Infection and Immunity.

Expression and contribution to virulence of each polysaccharide capsule of Bacillus cereus strain G9241

A. O’Brien, C. L. Ventura, J. M. Scarff, 2018, PloS one.

The roles of AtxA orthologs in virulence of anthrax‐like Bacillus cereus G9241

T. Koehler, A. O’Brien, C. L. Ventura, 2016, Molecular microbiology.

Enterohemorrhagic Escherichia coli O157:H7 requires intimin to colonize the gnotobiotic pig intestine and to adhere to HEp-2 cells

M. McKee, R. Moxley, D. Francis, 1995, Infection and immunity.

Overview and Historical Perspectives

J. Kaper, A. O’Brien, 2014, Microbiology spectrum.

Shiga Toxin-Producing Escherichia Coli

L. Teel, A. O’Brien, A. Melton-Celsa, 2011 .

The specific activities of Shiga-like toxin type II (SLT-II) and SLT-II-related toxins of enterohemorrhagic Escherichia coli differ when measured by Vero cell cytotoxicity but not by mouse lethality

J. Samuel, A. O’Brien, C. K. Schmitt, 1994, Infection and immunity.

Shiga-like toxin converting phage of enterohemorrhagic Escherichia coli strain 933.

C. Kerry, R. Holmes, A. O’Brien, 1989, Microbial pathogenesis.

Shiga and Shiga-Like Toxins: A Family of Related Cytotoxins

M. P. Jackson, R. Holmes, N. Strockbine, 1987 .

Growth of Escherichia coli in the presence of trimethoprim-sulfamethoxazole facilitates detection of Shiga-like toxin producing strains by colony blot assay

H. Karch, N. Strockbine, A. O’Brien, 1986 .

Shiga and Shiga-like toxins

A. O’Brien, R. K. Holmes, 1987 .

Virulence Potential of Activatable Shiga Toxin 2d-Producing Escherichia coli Isolates from Fresh Produce.

P. Feng, A. O’Brien, A. Melton-Celsa, 2015, Journal of food protection.

Cytotoxic Necrotizing Factor 1 and Hemolysin from Uropathogenic Escherichia coli Elicit Different Host Responses in the Murine Bladder

Mark A. Smith, D. Merrell, A. O’Brien, 2012, Infection and Immunity.

Shiga toxin, Shiga-like toxin II variant, and ricin are all single-site RNA N-glycosidases of 28 S RNA when microinjected into Xenopus oocytes.

S. Saxena, E. Ackerman, A. O’Brien, 1989, The Journal of biological chemistry.

Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C‐terminal two amino acids of the A2 peptide in the context of the appropriate B pentamer

A. O’Brien, A. Melton-Celsa, J. Kokai-Kun, 2002, Molecular microbiology.

Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91:H21 isolates in orally infected, streptomycin-treated mice

A. O’Brien, A. Melton-Celsa, S. Darnell, 1996, Infection and immunity.

An enzymatic mutant of Shiga-like toxin II variant is a vaccine candidate for edema disease of swine

J. Samuel, V. M. Gordon, H. Moon, 1992, Infection and immunity.

Identification of three amino acid residues in the B subunit of Shiga toxin and Shiga-like toxin type II that are essential for holotoxin activity

J. Samuel, R. Holmes, A. O’Brien, 1991, Journal of bacteriology.

Comparison of the glycolipid receptor specificities of Shiga-like toxin type II and Shiga-like toxin type II variants

J. Samuel, V. Ginsburg, A. O’Brien, 1990, Infection and immunity.

Cellular release of heat-labile enterotoxin of Escherichia coli by bacteriophage induction

P. Gemski, J. Wohlhieter, A. O’Brien, 1978, Infection and immunity.

Cloning of Shiga-like toxin structural genes from a toxin converting phage of Escherichia coli.

R. Holmes, N. Strockbine, A. O’Brien, 1985, Science.

A plasmid of enterohemorrhagic Escherichia coli O157:H7 is required for expression of a new fimbrial antigen and for adhesion to epithelial cells

M. Levine, H. Karch, C. Tacket, 1987, Infection and immunity.

Plant and Bacterial Toxins as RNA N-Glycosidases

A. O’Brien, A. Melton-Celsa, 2003 .

Shiga toxin 2a and Enteroaggregative Escherichia coli – a deadly combination

J. Nataro, N. Boisen, F. Scheutz, 2015, Gut microbes.

Flagella of Salmonella typhimurium are a virulence factor in infected C57BL/6J mice

H. Karch, M. Carsiotis, I. A. Holder, 1984, Infection and immunity.

Shiga Toxin–Producing Escherichia coli in Montana: Bacterial Genotypes and Clinical Proﬁles

M. Ciol, T. Damrow, P. Tarr, 2003 .

Decreased Adherence of EnterohemorrhagicEscherichia coli to HEp-2 Cells in the Presence of Antibodies That Recognize the C-Terminal Region of Intimin

L. Gansheroff, A. O’Brien, M. Wachtel, 1999, Infection and Immunity.

Escherichia coli O157:H7 Requires Intimin for Enteropathogenicity in Calves

B. Bosworth, H. Moon, A. O’Brien, 1998, Infection and Immunity.

Subinhibitory concentrations of antibiotics modulate amount of Shiga-like toxin produced by Escherichia coli

H. Karch, H. Kroll, A. O’Brien, 1985 .

Comparisons of Native Shiga Toxins (Stxs) Type 1 and 2 with Chimeric Toxins Indicate that the Source of the Binding Subunit Dictates Degree of Toxicity

M. J. Smith, A. O’Brien, A. Melton-Celsa, 2014, PloS one.

Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro.

R. Swanson, A. O’Brien, C. Lissner, 1983, Journal of immunology.

Control of early Salmonella typhimurium growth in innately Salmonella-resistant mice does not require functional T lymphocytes.

A. O’Brien, E. Metcalf, 1982, Journal of immunology.

Are the Lsh and Ity disease resistance genes at one locus on mouse chromosome 1?

J. Blackwell, D. Bradley, A. O’Brien, 1982, Nature.

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

Stefano Morabito, Lothar Beutin, Rosangela Tozzoli, 2012, Journal of Clinical Microbiology.

Reduced Toxicity of Shiga Toxin (Stx) Type 2c in Mice Compared to Stx2d Is Associated with Instability of Stx2c Holotoxin

E. Maynard, A. O’Brien, A. Melton-Celsa, 2015, Toxins.

Shiga Toxin Type 2dact Displays Increased Binding to Globotriaosylceramide in vitro and Increased Lethality in Mice after Activation by Elastase

A. O’Brien, A. Melton-Celsa, J. Bunger, 2013, Toxins.

pattern shared by intestinal E. coli. invasion potential reveals a new attachment coli O157:H7 adherence characteristics and Investigation of enterohemorrhagic Escherichia

M. McKee, A. O’Brien, 2013 .

Investigation of enterohemorrhagic Escherichia coli O157:H7 adherence characteristics and invasion potential reveals a new attachment pattern shared by intestinal E. coli

M. McKee, A. O’Brien, M. Mckee, 1995, Infection and immunity.

Adherence and colonization mechanisms of enteropathogenic and enterohemorrhagic Escherichia coli.

V. L. Tesh, A. O’Brien, 1992, Microbial pathogenesis.

Antibodies to intimin and Escherichia coli secreted proteins A and B in patients with enterohemorrhagic Escherichia coli infections

L. Gansheroff, K. Jarvis, J. Kaper, 2002, Pediatric Nephrology.

EnterohemorrhagicEscherichia coli O157:H7 Requires Intimin To Colonize the Gnotobiotic Pig Intestine and To Adhere to HEp-2 Cells

M. McKee, R. Moxley, D. Francis, 2019 .

Mutation of the Gene Encoding Cytotoxic Necrotizing Factor Type 1 (cnf1) Attenuates the Virulence of Uropathogenic Escherichia coli

R. Conran, H. Lockman, A. O’Brien, 2001, Infection and Immunity.

Vaccination of Pregnant Dams with IntiminO157 Protects Suckling Piglets from Escherichia coli O157:H7 Infection

L. Gansheroff, H. Moon, A. O’Brien, 2002, Infection and Immunity.

Escherichia coli O157:H7 Causes More-Severe Systemic Disease in Suckling Piglets than in Colostrum-Deprived Neonatal Piglets

H. Moon, A. O’Brien, J. Pohlenz, 2000, Infection and Immunity.

Genetic toxoids of Shiga toxin types 1 and 2 protect mice against homologous but not heterologous toxin challenge.

L. Teel, A. O’Brien, Sharon X Wen, 2006, Vaccine.

AnEnzymatic MutantofShiga-Like ToxinIIVariant Is aVaccine Candidate forEdemaDisease ofSwine

V. M. Gordon, H. Moon, A. O’Brien, 1992 .

Detection of Bacillus anthracis Spore Germination In Vivo by Bioluminescence Imaging

F. Alem, L. Teel, Farhang Alem, 2008, Infection and Immunity.

Novel Three-Dimensional Organoid Model for Evaluation of the Interaction of Uropathogenic Escherichia coli with Terminally Differentiated Human Urothelial Cells

Yarery C. Smith, Kerian K. Grande, Susan B. Rasmussen, 2006, Infection and Immunity.

The pathogenic mechanisms of Shiga toxin and the Shiga‐like toxins

V. L. Tesh, A. O’Brien, 1991, Molecular microbiology.

Two Domains of Cytotoxic Necrotizing Factor Type 1 Bind the Cellular Receptor, Laminin Receptor Precursor Protein

A. O’Brien, K. C. Meysick, S. Rasmussen, 2007, Infection and Immunity.

The Role of the AggR Regulon in the Virulence of the Shiga Toxin-Producing Enteroaggregative Escherichia coli Epidemic O104:H4 Strain in Mice

Mark A. Smith, J. Nataro, N. Boisen, 2019, Front. Microbiol..

ModelsOutbreak Isolate in Two Animal 2-Expressing Escherichia coli O104:H4 Virulence of the Shiga Toxin Type

Mark A. Smith, J. Nataro, A. O’Brien, 2014 .

Shigellosis and Escherichia coli diarrhea: relative importance of invasive and toxigenic mechanisms.

B. P. Doctor, P. Gemski, M. Thompson, 1979, The American journal of clinical nutrition.

Human Intestinal Tissue and Cultured Colonic Cells Contain Globotriaosylceramide Synthase mRNA and the Alternate Shiga Toxin Receptor Globotetraosylceramide

J. Rodriguez-Canales, J. Hanson, A. O’Brien, 2010, Infection and Immunity.

Cytotoxic Necrotizing Factor Type 1-Neutralizing Monoclonal Antibody NG8 Recognizes Three Amino Acids in a C-Terminal Region of the Toxin and Reduces Toxin Binding to HEp-2 Cells

A. O’Brien, K. C. Meysick, S. Rasmussen, 2008, Infection and Immunity.

Cytotoxic Necrotizing Factor Type 1-Positive Escherichia coli Causes Increased Inflammation and Tissue Damage to the Prostate in a Rat Prostatitis Model

H. Ceri, H. Lockman, M. Lang, 2001, Infection and Immunity.

Cytotoxic necrotizing factor type 2 produced by virulent Escherichia coli modifies the small GTP-binding proteins Rho involved in assembly of actin stress fibers.

C. Fiorentini, A. Labigne, É. Oswald, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of Shigella dysenteriae 1 (Shiga) toxin purified by anti-Shiga toxin affinity chromatography

D. Griffin, M. Thompson, A. O’Brien, 1980, Infection and immunity.

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody

M. Troxell, B. Magun, A. O’Brien, 2008, Infection and Immunity.

of Nebraska - Lincoln DigitalCommons@University of Nebraska - Lincoln Shiga and Shiga-Like Toxins Shiga and Shiga-Like Toxins

R. Holmes, A. O’Brien, 2019 .

Cytotoxic Necrotizing Factor Type 1 Delivered by Outer Membrane Vesicles of Uropathogenic Escherichia coli Attenuates Polymorphonuclear Leukocyte Antimicrobial Activity and Chemotaxis

A. O’Brien, S. Rasmussen, Humberto M. Carvalho, 2006, Infection and Immunity.

Escherichia coli O157:H7 infection in Dutch belted and New Zealand white rabbits.

J. Nataro, Daniel I Petkov, T. Coksaygan, 2010, Comparative medicine.

Animal models for STEC-mediated disease.

A. O’Brien, A. Melton-Celsa, 2003, Methods in molecular medicine.

Monoclonal Antibody 11E10, Which Neutralizes Shiga Toxin Type 2 (Stx2), Recognizes Three Regions on the Stx2 A Subunit, Blocks the Enzymatic Action of the Toxin In Vitro, and Alters the Overall Cellular Distribution of the Toxin

M. J. Smith, A. O’Brien, Cory M. Robinson, 2009, Infection and Immunity.

A genetic map of mouse chromosome 1 near the Lsh-Ity-Bcg disease resistance locus.

M. Potter, P. Gros, B. Mock, 1990, Genomics.

Influence of host genes on resistance of inbred mice to lethal infection with Salmonella typhimurium.

A. O’Brien, 1986, Current topics in microbiology and immunology.

A BALB/c congenic strain of mice that carries a genetic locus (Ityr) controlling resistance to intracellular parasites

P. Gros, M. Potter, E. Skamene, 1983, Infection and immunity.

Control of natural resistance to Salmonella typhimurium and Leishmania donovani in mice by closely linked but distinct genetic loci

B. Taylor, D. Rosenstreich, A. O’Brien, 1980, Nature.

Production of a Shiga-like cytotoxin by Campylobacter.

M. Blaser, G. Perez-Perez, A. O’Brien, 1988, Microbial pathogenesis.

Shiga-like toxin production from Escherichia coli associated with calf diarrhoea

A. O’Brien, D. Sherwood, D. Snodgrass, 1985, Veterinary Record.

Shiga Toxin-Producing Escherichia coli-Associated Kidney Failure in a 40-Year-Old Patient and Late Diagnosis by Novel Bacteriologic and Toxin Detection Methods

N. Aronson, L. Teel, A. O’Brien, 2003, Journal of Clinical Microbiology.

Biological properties of Shigella flexneri 2A toxin and its serological relationship to Shigella dysenteriae 1 toxin

B. P. Doctor, P. Gemski, M. Thompson, 1977, Infection and immunity.

The Salmonella typhimurium flgM gene, which encodes a negative regulator of flagella synthesis and is involved in virulence, is present and functional in other Salmonella species.

A. O’Brien, C. K. Schmitt, S. Darnell, 1996, FEMS microbiology letters.

Macrophage defect and inflammatory cell recruitment dysfunction in Salmonella susceptible C3H/HeJ mice.

R. Swanson, A. O’Brien, D. Weinstein, 1986, Cellular immunology.

Flagella help Salmonella typhimurium survive within murine macrophages

M. Carsiotis, A. O’Brien, D. Weinstein, 1984, Infection and immunity.

Mutations in hns reduce the adherence of Shiga toxin-producing E. coli 091:H21 strain B2F1 to human colonic epithelial cells and increase the production of hemolysin.

M. Scott, A. O’Brien, A. Melton-Celsa, 2003, Microbial pathogenesis.

Identification and Characterization of Shiga Toxin Type 2 Variants in Escherichia coli Isolates from Animals, Food, and Humans

Shaohua Zhao, J. Meng, Jie Zheng, 2008, Applied and Environmental Microbiology.

Intimin types alpha, beta, and gamma bind to nucleolin with equivalent affinity but lower avidity than to the translocated intimin receptor.

A. O’Brien, J. Sinclair, 2004, The Journal of biological chemistry.

Susceptibility of Mus musculus musculus (Czech I) mice to Salmonella typhimurium infection.

M. Potter, A. O’Brien, L. D'Hoostelaere, 1986, Current topics in microbiology and immunology.

Shiga-like toxin production and attaching effacing activity of Escherichia coli associated with calf diarrhea.

C. Duchesnes, H. Moon, J. Mainil, 1987, American journal of veterinary research.

Certhrax Is an Antivirulence Factor for the Anthrax-Like Organism Bacillus cereus Strain G9241

Stephanie L. Servetas, D. Merrell, Courtney D. Petro, 2018, Infection and Immunity.

Construction of a series of congenic mice with recombinant chromosome 1 regions surrounding the genetic loci for resistance to intracellular parasites (Ity, Lsh, and Bcg), DNA repair responses (Rep-1), and the cytoskeletal protein villin (Vil)

D. Cerretti, B. Mock, M. Potter, 1994, Infection and immunity.

Specific DNA probes to detect Escherichia coli strains producing cytotoxic necrotising factor type 1 or type 2.

É. Oswald, J. Mainil, A. O’Brien, 1994, Journal of medical microbiology.

Genetic control of the innate resistance of mice to Salmonella typhimurium: Ity gene is expressed in vivo by 24 hours after infection.

R. Swanson, A. O’Brien, 1983, Journal of immunology.

Effect of silica on the innate resistance of inbred mice to Salmonella typhimurium infection

S. Formal, A. O’Brien, I. Scher, 1979, Infection and immunity.

Characterization of monoclonal antibodies which recognize specific cell surface determinants on Salmonella typhimurium.

W. Biddison, M. Laveck, A. O’Brien, 1983, Advances in experimental medicine and biology.

Characterization of murine antibody response to Salmonella typhimurium by a class-specific solid-phase radioimmunoassay

A. O’Brien, E. Metcalf, 1981, Infection and immunity.

When a healthy diet turns deadly

A. O’Brien, A. Melton-Celsa, Steven D. Zumbrun, 2013, Gut microbes.

Shiga toxin type 2

M. James, M. Fujinaga, M. Fraser, 2004 .

Innate resistance of mice to Salmonella typhi infection

A. O’Brien, 1982, Infection and immunity.

Position on mouse chromosome 1 of a gene that controls resistance to Salmonella typhimurium.

B. Taylor, A. O’Brien, 1982, Infection and immunity.

Defect in macrophage effector function confers Salmonella typhimurium susceptibility on C3H/HeJ mice.

D. Rosenstreich, A. O’Brien, E. Metcalf, 1982, Cellular immunology.

Susceptibility of CBA/N mice to infection with Salmonella typhimurium: influence of the X-linked gene controlling B lymphocyte function.

R. Macdermott, G. Campbell, S. Formal, 1979, Journal of immunology.

Genetically conferred defect in anti-Salmonella antibody formation renders CBA/N mice innately susceptible to Salmonella typhimurium infection.

A. O’Brien, E. Metcalf, I. Scher, 1981, Journal of immunology.

Genetic control of natural resistance to Salmonella typhimurium in mice during the late phase of infection.

B. Taylor, D. Rosenstreich, A. O’Brien, 1984, Journal of immunology.

Genetic control of the susceptibility of C3HeB/FeJ mice to Salmonella typhimurium is regulated by a locus distinct from known salmonella response genes.

D. Rosenstreich, A. O’Brien, 1983, Journal of immunology.

Differential sensitivity of inbred mice to Salmonella typhimurium: a model for genetic regulation of innate resistance to bacterial infection.

D. Rosenstreich, A. O’Brien, E. Metcalf, 1980 .

Mouse chromosome 1 Ity locus regulates microbicidal activity of isolated peritoneal macrophages against a diverse group of intracellular and extracellular bacteria.

A. O’Brien, D. Weinstein, C. Lissner, 1985, Journal of immunology.

Genetic Control of Murine Resistance to Salmonella Typhimurium Infection

D. Rosenstreich, A. O’Brien, I. Scher, 1981 .

Ricin Crosses Polarized Human Intestinal Cells and Intestines of Ricin-Gavaged Mice without Evident Damage and Then Disseminates to Mouse Kidneys

Mark A. Smith, L. Teel, A. O’Brien, 2013, PloS one.

Shiga Toxins: Potent Poisons, Pathogenicity Determinants, and Pharmacological Agents

A. O’Brien, M. Smith, A. Melton-Celsa, 2005, EcoSal Plus.

Cell Surface-localized Nucleolin Is a Eukaryotic Receptor for the Adhesin Intimin-γ of Enterohemorrhagic Escherichia coliO157:H7*

A. O’Brien, J. Sinclair, 2002, The Journal of Biological Chemistry.

Mapping of genetic loci that modulate differential colonization by Escherichia coli O157:H7 TUV86-2 in advanced recombinant inbred BXD mice

M. Kotb, N. Abdeltawab, A. O’Brien, 2015, BMC Genomics.

Shiga and Shiga-like toxins.

R. Holmes, R K Holmes, A D O'Brien, 1987, Microbiological reviews.

Immunization of Mice with Formalin-Inactivated Spores from Avirulent Bacillus cereus Strains Provides Significant Protection from Challenge with Bacillus anthracis Ames

S. Welkos, J. Bozue, C. Cote, 2012, Clinical and Vaccine Immunology.

Silica enhancement of murine endotoxin sensitivity

S. N. Vogel, K. English, A. O’Brien, 1982, Infection and immunity.

PURIFICATION OF SHIGELLA DYSENTERIAE 1 (SHIGA)-LIKE TOXIN FROM ESCHERICHIA COLI 0157:H7 STRAIN ASSOCIATED WITH HAEMORRHAGIC COLITIS

S. Gorbach, T. Chang, A. O’Brien, 1983, The Lancet.

Detection of epithelial-cell injury, and quantification of infection, in the HCT-8 organoid model of cryptosporidiosis.

R. Guerrant, Richard L Guerrant, Alison D O'Brien, 2008, The Journal of infectious diseases.

Production of Shigella dysenteriae type 1-like cytotoxin by Escherichia coli.

M. Thompson, S. Formal, A. O’Brien, 1982, The Journal of infectious diseases.

Shiga toxin: biochemistry, genetics, mode of action, and role in pathogenesis.

M. P. Jackson, G. Keusch, K. Sandvig, 1992, Current topics in microbiology and immunology.

Morphologic evaluation of the effects of Shiga toxin and E coli Shiga-like toxin on the rabbit intestine.

H. Collins, S. Formal, A. O’Brien, 1986, The American journal of pathology.

Purified Shigella enterotoxin does not alter intestinal motility

J. Mathias, C. Sninsky, M. Clench, 1984, Infection and immunity.

A plant-based oral vaccine to protect against systemic intoxication by Shiga toxin type 2.

L. Teel, A. O’Brien, Sharon X Wen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Plant Cell-Based Intimin Vaccine Given Orally to Mice Primed with Intimin Reduces Time of Escherichia coli O157:H7 Shedding in Feces

H. Mason, A. O’Brien, Nicole A. Judge, 2004, Infection and Immunity.

A novel murine infection model for Shiga toxin-producing Escherichia coli.

V. Vanguri, J. Leong, J. Butterton, 2012, The Journal of clinical investigation.

Four Superoxide Dismutases Contribute to Bacillus anthracis Virulence and Provide Spores with Redundant Protection from Oxidative Stress

S. Stibitz, R. Bull, F. Alem, 2008, Infection and Immunity.

Shiga toxin of enterohemorrhagic Escherichia coli type O157:H7 promotes intestinal colonization.

M. J. Smith, A. O’Brien, Cory M. Robinson, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Hemolysin of Uropathogenic Escherichia coli Evokes Extensive Shedding of the Uroepithelium and Hemorrhage in Bladder Tissue within the First 24 Hours after Intraurethral Inoculation of Mice

R. Conran, Yarery C. Smith, A. O’Brien, 2008, Infection and Immunity.

The diarrheal response of humans to some classic serotypes of enteropathogenic Escherichia coli is dependent on a plasmid encoding an enteroadhesiveness factor.

M. Levine, H. Karch, R. Black, 1985, The Journal of infectious diseases.

Genetic control of susceptibility to Salmonella typhimurium in mice: role of the LPS gene.

R. Macdermott, D. Rosenstreich, G. Campbell, 1980, Journal of immunology.

The presence of the pAA plasmid in the German O104:H4 Shiga toxin type 2a (Stx2a)-producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer.

Anne-Marie Hansen, J. Nataro, J. Kaper, 2014, The Journal of infectious diseases.

Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models

J. Nataro, N. Boisen, A. O’Brien, 2013, Infection and Immunity.

Nucleotide sequence analysis and comparison of the structural genes for Shiga-like toxin I and Shiga-like toxin II encoded by bacteriophages from Escherichia coli 933

M. P. Jackson, R. Holmes, A. O’Brien, 1987 .

Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea.

R. Holmes, H. Smith, S. Formal, 1984, Science.

Two toxin-converting phages from Escherichia coli O157:H7 strain 933 encode antigenically distinct toxins with similar biologic activities

R. Holmes, N. Strockbine, H. Smith, 1986, Infection and immunity.

Bacterial toxins: friends or foes?

A. O’Brien, C. K. Schmitt, K. C. Meysick, 1999, Emerging infectious diseases.

Anthrax vaccination strategies.

A. O’Brien, R. Cybulski, P. Sanz, 2009, Molecular aspects of medicine.

Absence of All Components of the Flagellar Export and Synthesis Machinery Differentially Alters Virulence of Salmonella enterica Serovar Typhimurium in Models of Typhoid Fever, Survival in Macrophages, Tissue Culture Invasiveness, and Calf Enterocolitis

T. Wallis, J. S. Ikeda, A. O’Brien, 2001, Infection and Immunity.

Flagellar Phase Variation of Salmonella enterica Serovar Typhimurium Contributes to Virulence in the Murine Typhoid Infection Model but Does Not InfluenceSalmonella-Induced Enteropathogenesis

T. Wallis, C. O'Connor, J. S. Ikeda, 2001, Infection and Immunity.

Oral Intoxication of Mice with Shiga Toxin Type 2a (Stx2a) and Protection by Anti-Stx2a Monoclonal Antibody 11E10

M. Smith, Mark A. Smith, M. J. Smith, 2013, Infection and Immunity.

Purification and characterization of a Shigella dysenteriae 1-like toxin produced by Escherichia coli

A. O’Brien, G. Laveck, 1983, Infection and immunity.

Host cell cytotoxicity and cytoskeleton disruption by CerADPr, an ADP-ribosyltransferase of Bacillus cereus G9241.

J. Barbieri, Nathan C. Simon, A. O’Brien, 2013, Biochemistry.

Bacillus anthracis Exosporium Protein BclA Affects Spore Germination, Interaction with Extracellular Matrix Proteins, and Hydrophobicity

B. Janes, A. O’Brien, S. Rasmussen, 2007, Infection and Immunity.

Antimicrobial Effects of Interferon-Inducible CXC Chemokines against Bacillus anthracis Spores and Bacilli

M. Burdick, R. Strieter, Yinghua Zhu, 2009, Infection and Immunity.

Effect of Staphylococcus aureus delta toxin on Chinese hamster ovary cell morphology and Y-1 adrenal cell morphology and steroidogenesis

F. Kapral, A. O’Brien, 1977, Infection and immunity.

Recombinant Bacillus anthracis spore proteins enhance protection of mice primed with suboptimal amounts of protective antigen.

Dennis P. McDaniel, R. Bull, A. O’Brien, 2008, Vaccine.

In vivo formation of hybrid toxins comprising Shiga toxin and the Shiga-like toxins and role of the B subunit in localization and cytotoxic activity

M. P. Jackson, R. Holmes, A. O’Brien, 1989, Infection and immunity.

A three‐dimensional tissue culture model for the study of attach and efface lesion formation by enteropathogenic and enterohaemorrhagic Escherichia coli

L. Teel, G. Goping, Alison D O'Brien, 2005, Cellular microbiology.

Increased cyclic adenosine 3',5'-monophosphate content in guinea pig ileum after exposure to Staphylococcus aureus delta-toxin

F. Kapral, A. O’Brien, 1976, Infection and immunity.

Purification and some properties of a Vero toxin from a human strain of Escherichia coli that is immunologically related to Shiga-like toxin II (VT2).

T. Yutsudo, T. Hirayama, Y. Takeda, 1989, Microbial pathogenesis.

Functional analysis of the Shiga toxin and Shiga-like toxin type II variant binding subunits by using site-directed mutagenesis

M. P. Jackson, R. Holmes, A. O’Brien, 1990, Journal of bacteriology.

Cloning and sequencing of a Shiga-like toxin type II variant from Escherichia coli strain responsible for edema disease of swine

M. P. Jackson, J. Samuel, R. Holmes, 1988, Journal of bacteriology.

Bacillus cereus G9241 Makes Anthrax Toxin and Capsule like Highly Virulent B. anthracis Ames but Behaves like Attenuated Toxigenic Nonencapsulated B. anthracis Sterne in Rabbits and Mice

A. Keane-Myers, Melissa K. Wilson, F. Alem, 2011, Infection and Immunity.

Two copies of Shiga-like toxin II-related genes common in enterohemorrhagic Escherichia coli strains are responsible for the antigenic heterogeneity of the O157:H- strain E32511

M. McKee, A. O’Brien, C. K. Schmitt, 1991, Infection and immunity.

Characterization of a multi-component anthrax vaccine designed to target the initial stages of infection as well as toxaemia.

S. Welkos, J. Bozue, C. Cote, 2012, Journal of medical microbiology.

Escherichia coli 0157:H7 and other shiga toxin-producing E. coli strains

J. Kaper, James B. Kaper, Alison D. O'Brien, 1998 .

Enhanced Virulence of the Escherichia coli O157:H7 Spinach-Associated Outbreak Strain in Two Animal Models Is Associated with Higher Levels of Stx2 Production after Induction with Ciprofloxacin

M. Smith, Mark A. Smith, A. O’Brien, 2014, Infection and Immunity.

The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool

R. Lindsey, N. Strockbine, Courtney D. Petro, 2020, Frontiers in Cellular and Infection Microbiology.

Pathogenesis of Shiga-toxin producing escherichia coli.

L. Teel, A. O’Brien, A. Melton-Celsa, 2012, Current topics in microbiology and immunology.

Neutralizing antibodies to Shiga toxin type 2 (Stx2) reduce colonization of mice by Stx2-expressing Escherichia coli O157:H7.

A. O’Brien, Cory M. Robinson, A. Melton-Celsa, 2010, Vaccine.

Isolation and characterization of monoclonal antibodies to Shiga-like toxin II of enterohemorrhagic Escherichia coli and use of the monoclonal antibodies in a colony enzyme-linked immunosorbent assay

A. O’Brien, L. Marques, L. Perera, 1988, Journal of clinical microbiology.

Profile of Escherichia coli O157:H7 pathogen responsible for hamburger-borne outbreak of hemorrhagic colitis and hemolytic uremic syndrome in Washington

M. McKee, D. Griffin, A D O'Brien, 1993, Journal of clinical microbiology.

A single amino acid substitution in the enzymatic domain of cytotoxic necrotizing factor type 1 of Escherichia coli alters the tissue culture phenotype to that of the dermonecrotic toxin of Bordetella spp.

A. O’Brien, K. C. Meysick, S. Rasmussen, 2006, Molecular microbiology.

Nucleotide sequence analysis of the structural genes for Shiga-like toxin I encoded by bacteriophage 933J from Escherichia coli.

M. P. Jackson, R. Holmes, A. O’Brien, 1987, Microbial pathogenesis.

Cytotoxic Necrotizing Factor Type 1 of Uropathogenic Escherichia coli Kills Cultured Human Uroepithelial 5637 Cells by an Apoptotic Mechanism

A. O’Brien, K. C. Meysick, K. Meysick, 2000, Infection and Immunity.

Production of a unique cytotoxin by Campylobacter jejuni

R. Guerrant, R. Pennie, C. Wanke, 1987, Infection and immunity.

Transcription of the Shiga-like toxin type II and Shiga-like toxin type II variant operons of Escherichia coli

L. M. Sung, M. P. Jackson, R. Holmes, 1990, Journal of bacteriology.

Cloning and sequencing of the genes for Shiga toxin from Shigella dysenteriae type 1

L. M. Sung, M. P. Jackson, R. Holmes, 1988, Journal of bacteriology.

The attenuated phenotype of a Salmonella typhimurium flgM mutant is related to expression of FliC flagellin

A. O’Brien, C. K. Schmitt, S. Darnell, 1996, Journal of bacteriology.

Dietary choice affects Shiga toxin-producing Escherichia coli (STEC) O157:H7 colonization and disease

Mark A. Smith, D. Merrell, A. O’Brien, 2013, Proceedings of the National Academy of Sciences.

Mutation of flgM attenuates virulence of Salmonella typhimurium, and mutation of fliA represses the attenuated phenotype

B. Stocker, V. L. Tesh, A. O’Brien, 1994, Journal of bacteriology.

Structure of Shiga Toxin Type 2 (Stx2) from Escherichia coli O157:H7*

M. James, M. Fujinaga, M. Fraser, 2004, Journal of Biological Chemistry.

Ferrets as a model system for renal disease secondary to intestinal infection with Escherichia coli O157:H7 and other Shiga toxin-producing E. coli.

J. B. Woods, A. O’Brien, C. K. Schmitt, 2002, The Journal of infectious diseases.

Shiga Toxins of Shigella dysenteriae and Escherichia coli

A. O’Brien, A. Melton-Celsa, 2000 .

Shiga Toxin (Stx) Type 1a Reduces the Oral Toxicity of Stx Type 2a

A. O’Brien, A. Melton-Celsa, L. M. Russo, 2016, The Journal of infectious diseases.

Phase 1 Safety and Pharmacokinetic Study of Chimeric Murine-Human Monoclonal Antibody cαStx2 Administered Intravenously to Healthy Adult Volunteers

C. Tacket, R. Edelman, T. Dowling, 2005, Antimicrobial Agents and Chemotherapy.

Shiga Toxin Type 1a (Stx1a) Reduces the Toxicity of the More Potent Stx2a In Vivo and In Vitro

Mark A. Smith, Zhi-mei Liu, Courtney D. Petro, 2019, Infection and Immunity.

Antibodies against Hemolysin and Cytotoxic Necrotizing Factor Type 1 (CNF1) Reduce Bladder Inflammation in a Mouse Model of Urinary Tract Infection with Toxigenic Uropathogenic Escherichia coli

Mark A. Smith, R. Weingarten, Rebecca A. Weingarten, 2015, Infection and Immunity.

Epitope Mapping of Monoclonal Antibodies Capable of Neutralizing Cytotoxic Necrotizing Factor Type 1 of UropathogenicEscherichia coli

A. O’Brien, K. C. Meysick, K. Meysick, 2001, Infection and Immunity.

One of Two Copies of the Gene for the Activatable Shiga Toxin Type 2d in Escherichia coli O91:H21 Strain B2F1 Is Associated with an Inducible Bacteriophage

L. Teel, A. O’Brien, C. K. Schmitt, 2002, Infection and Immunity.

Mapping the minimal contiguous gene segment that encodes functionally active Shiga-like toxin II

J. Samuel, R. Holmes, A. O’Brien, 1991, Infection and immunity.

Development of a hybrid Shiga holotoxoid vaccine to elicit heterologous protection against Shiga toxins types 1 and 2.

L. Teel, M. J. Smith, A. O’Brien, 2006, Vaccine.

Shiga Toxins (Stxs): Multifaceted Pathogenicity Determinants

M. J. Smith, A. O’Brien, Cory M. Robinson, 2007 .

Additional evidence that the Lps gene locus regulates natural resistance to S. typhimurium in mice.

D. Rosenstreich, A. O’Brien, D. Weinstein, 1985, Journal of immunology.

Pathogenesis of Escherichia coli O157:H7 strain 86-24 following oral infection of BALB/c mice with an intact commensal flora.

A. O’Brien, E. Carroll, A. Melton-Celsa, 2010, Microbial pathogenesis.

Recombinant Exosporium Protein BclA of Bacillus anthracis Is Effective as a Booster for Mice Primed with Suboptimal Amounts of Protective Antigen

A. Cross, R. Bull, T. Kang, 2007, Infection and Immunity.

Shiga Toxin-Producing Escherichia Coli

L. Teel, A. O’Brien, A. Melton-Celsa, 2011 .

Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody

M. Troxell, B. Magun, A. O’Brien, 2008, Infection and Immunity.

The 13C4 Monoclonal Antibody That Neutralizes Shiga Toxin Type 1 (Stx1) Recognizes Three Regions on the Stx1 B Subunit and Prevents Stx1 from Binding to Its Eukaryotic Receptor Globotriaosylceramide

M. J. Smith, A. O’Brien, Humberto M. Carvalho, 2006, Infection and Immunity.

Bacterial toxins: friends or foes?

A. O’Brien, C. K. Schmitt, K. C. Meysick, 1999, Emerging infectious diseases.

Escherichia coli O157:H7 in beef cattle presented for slaughter in the U.S.: higher prevalence rates than previously estimated.

L. Gansheroff, A. O’Brien, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Multicenter Evaluation of a Sequence-Based Protocol for Subtyping Shiga Toxins and Standardizing Stx Nomenclature

L. Beutin, A. Caprioli, A. Mellmann, 2012, Journal of Clinical Microbiology.

Virulence of the Shiga Toxin Type 2-Expressing Escherichia coli O104:H4 German Outbreak Isolate in Two Animal Models

J. Nataro, N. Boisen, A. O’Brien, 2013, Infection and Immunity.

Protective Efficacy and Pharmacokinetics of Human/Mouse Chimeric Anti-Stx1 and Anti-Stx2 Antibodies in Mice

A. O’Brien, Humberto M. Carvalho, A. Melton-Celsa, 2015, Clinical and Vaccine Immunology.

New Therapeutic Developments against Shiga Toxin-Producing Escherichia coli

A. O’Brien, A. Melton-Celsa, 2014, Microbiology spectrum.

Protective efficacy and pharmacokinetics of human/mouse chimeric anti-Stx1 and anti- 1

A. O’Brien, Humberto M. Carvalho, A. Melton-Celsa, 2015 .

A plasmid of enterohemorrhagic Escherichia coli O157:H7 is required for expression of a new fimbrial antigen and for adhesion to epithelial cells

M. Levine, H. Karch, C. Tacket, 1987, Infection and immunity.

Antibody against the Carboxyl Terminus of Intimin α Reduces Enteropathogenic Escherichia coli Adherence to Tissue Culture Cells and Subsequent Induction of Actin Polymerization

L. Teel, A. O’Brien, Humberto M. Carvalho, 2005, Infection and Immunity.

Antimicrobial Effects of Interferon-Inducible CXC Chemokines against Bacillus anthracis Spores and Bacilli

M. Burdick, R. Strieter, Yinghua Zhu, 2009, Infection and Immunity.

Phase 1 Safety and Pharmacokinetic Study of Chimeric Murine-Human Monoclonal Antibody cαStx2 Administered Intravenously to Healthy Adult Volunteers

C. Tacket, R. Edelman, T. Dowling, 2005, Antimicrobial Agents and Chemotherapy.

Increased Tissue Conductance and Ion Transport in Guinea Pig Ileum After Exposure to Staphylococcus aureus Delta-Toxin In Vitro

H. J. Mcclung, F. Kapral, A. O’Brien, 1978, Infection and immunity.

Elastase in Intestinal Mucus Enhances the Cytotoxicity of Shiga Toxin Type 2d*

A. O’Brien, A. Melton-Celsa, J. Kokai-Kun, 2000, The Journal of Biological Chemistry.

Inhibition of water absorption in the intestine by Staphylococcus aureus delta-toxin

W. Drugan, F. Kapral, A. O’Brien, 1976, Infection and immunity.

Bacillus cereus G9241 Makes Anthrax Toxin and Capsule like Highly Virulent B. anthracis Ames but Behaves like Attenuated Toxigenic Nonencapsulated B. anthracis Sterne in Rabbits and Mice

A. Keane-Myers, Melissa K. Wilson, A. O’Brien, 2011, Infection and Immunity.

Shiga Toxin-Producing Escherichia Coli

L. Teel, A. O’Brien, A. Melton-Celsa, 2011 .

Immunization of Mice with Formalin-Inactivated Spores from Avirulent Bacillus cereus Strains Provides Significant Protection from Challenge with Bacillus anthracis Ames

S. Welkos, J. Bozue, C. Cote, 2012, Clinical and Vaccine Immunology.