D. Boison

D. Poulsen, T. Lusardi, J. Lan, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Adenosine-Based Cell Therapy Approaches for Pharmacoresistant Epilepsies

D. Boison, 2007, Neurodegenerative Diseases.

Possible Role of Adenosine in COVID-19 Pathogenesis and Therapeutic Opportunities

M. Murugan, J. Geiger, Nabab Khan, 2020, Frontiers in Pharmacology.

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

C. Limatola, B. Frenguelli, L. Maggi, 2014, Cerebral cortex.

Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?

Nikki K. Lytle, J. Lan, Tianfu Li, 2012, Glia.

Hyperexcitability and seizures in the THY-Tau22 mouse model of tauopathy

L. Buée, S. Parrot, D. Blum, 2020, Neurobiology of Aging.

Suppression of Kindled Seizures by Paracrine Adenosine Release from Stem Cell–Derived Brain Implants

O. Brüstle, W. Pralong, Peter Koch, 2005, Epilepsia.

Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

L. Covolan, E. Hargreaves, D. Boison, 2022, Brain Stimulation.

New insights into the mechanisms of the ketogenic diet

D. Boison, 2017, Current opinion in neurology.

The metabolic basis of epilepsy

J. Rho, D. Boison, 2022, Nature Reviews Neurology.

Homeostatic Control of Brain Function

S. Masino, D. Boison, 2015 .

Erratum: Acharya et al., New Concerns for Neurocognitive Function during Deep Space Exposures to Chronic, Low Dose-Rate, Neutron Radiation

J. Baulch, C. Limoli, T. Lusardi, 2019, eNeuro.

Adenosine A2A receptor blockade prevents cisplatin-induced impairments in neurogenesis and cognitive function

M. Rashid, J. Sung, M. Jang, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Survival and Injury Outcome After TBI: Influence of Pre- and Post-Exposure to Caffeine

T. Lusardi, D. Boison, 2012 .

Inhibition of Adenosine Kinase Attenuates Acute Lung Injury*

J. C. Morote-García, P. Rosenberger, D. Köhler, 2015, Critical care medicine.

When GABA Fails: Rundown on Chemokines

D. Boison, 2014, Epilepsy currents.

Epigenetics and epilepsy prevention: The therapeutic potential of adenosine and metabolic therapies

J. Rho, D. Boison, 2020, Neuropharmacology.

A Breather for SUDEP

D. Boison, 2012, Epilepsy currents.

Diaphragmatic pacing for the prevention of sudden unexpected death in epilepsy

M. Murugan, B. Purnell, D. Boison, 2022, Brain Communications.

Chopping Out CHOP Chops the Fate of Neurons

D. Boison, 2013, Epilepsy currents.

Astrocytes in the initiation and progression of epilepsy

E. Aronica, A. Vezzani, C. Steinhäuser, 2022, Nature Reviews Neurology.

Integrin-KCNB1 potassium channel complexes regulate neocortical neuronal development and are implicated in epilepsy

Elena Forzisi, F. Sesti, M. Rasin, 2022, Cell Death & Differentiation.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview

Arthur Christopoulos, Christopher Southan, Stephen PH Alexander, 2017, British journal of pharmacology.

Working memory and the homeostatic control of brain adenosine by adenosine kinase

B. Yee, S. McGarrity, D. Boison, 2012, Neuroscience.

Adenosine Kinase Expression in the Frontal Cortex in Schizophrenia.

A. Funk, R. Mccullumsmith, S. O’Donovan, 2019, Schizophrenia bulletin.

Transient use of a systemic adenosine kinase inhibitor attenuates epilepsy development in mice

D. Boison, Joseph L Friedman, U. Sandau, 2019, Epilepsia.

A novel mouse model for sudden unexpected death in epilepsy (SUDEP): Role of impaired adenosine clearance

Tianfu Li, D. Boison, H. Shen, 2010, Epilepsia.

The role of adenosine in alcohol-induced respiratory suppression

M. Murugan, B. Purnell, D. Boison, 2022, Neuropharmacology.

Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss

G. Housley, P. Thorne, D. Boison, 2017, Hearing Research.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Enzymes

Stephen P. H. Alexander, C. Southan, D. Fabbro, 2021, British journal of pharmacology.

Human mesenchymal stem cell grafts engineered to release adenosine reduce chronic seizures in a mouse model of CA3-selective epileptogenesis

D. Kaplan, Tianfu Li, D. Boison, 2009, Epilepsy Research.

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis.

Eleanor M. Pritchard, D. Kaplan, T. Lusardi, 2013, The Journal of clinical investigation.

Ketogenic diet, neuroprotection, and antiepileptogenesis

M. Murugan, D. Boison, Madhuvika Murugan, 2020, Epilepsy Research.

Commonalities in epileptogenic processes from different acute brain insults: Do they translate?

R. Dingledine, M. Walker, W. Löscher, 2018, Epilepsia.

Developmental role of adenosine kinase for the expression of sex-dependent neuropsychiatric behavior

A. T. Jones, Y. Huo, Y. Huo, 2018, Neuropharmacology.

Grafts of adenosine-releasing cells suppress seizures in kindling epilepsy

N. Déglon, P. Aebischer, D. Boison, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis

B. Yee, D. Boison, P. Singer, 2013 .

Adenosine hypothesis of schizophrenia – Opportunities for pharmacotherapy

J. Feldon, B. Yee, D. Boison, 2012, Neuropharmacology.

Transient Delivery of Adenosine as a Novel Therapy to Prevent Epileptogenesis

T. Lusardi, D. Boison, 2015 .

Adenosine Kinase: Exploitation for Therapeutic Gain

D. Boison, 2013, Pharmacological Reviews.

Regulation of Extracellular Adenosine

D. Boison, 2018 .

The role of adenosine in epilepsy

D. Boison, Jesica Reemmer, Landen Weltha, 2019, Brain Research Bulletin.

Opiate-induced changes in brain adenosine levels and narcotic drug responses

M. Zheng, G. Peltz, M. Wu, 2013, Neuroscience.

Glycine transporter 1 as a potential therapeutic target for schizophrenia-related symptoms: evidence from genetically modified mouse models and pharmacological inhibition.

J. Feldon, B. Yee, D. Boison, 2011, Biochemical pharmacology.

Regulation of cognition and symptoms of psychosis: Focus on GABAA receptors and glycine transporter 1`

J. Feldon, B. Yee, U. Rudolph, 2008, Pharmacology Biochemistry and Behavior.

Disruption of Glycine Transporter 1 Restricted to Forebrain Neurons Is Associated with a Procognitive and Antipsychotic Phenotypic Profile

J. Feldon, B. Yee, I. Knuesel, 2006, The Journal of Neuroscience.

DisruptionofGlycineTransporter1RestrictedtoForebrain NeuronsIsAssociatedwithaProcognitiveandAntipsychotic PhenotypicProfile

D. Boison, 2006 .

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning.

J. Feldon, B. Yee, D. Boison, 2010, Behavioral neuroscience.

TITLE : Transient Delivery of Adenosine as a Novel Therapy to Prevent Epileptogenesis PRINCIPAL INVESTIGATOR :

D. Boison, 2013 .

Adenosine Kinase: A Key Regulator of Purinergic Physiology.

M. Jarvis, D. Boison, 2020, Biochemical pharmacology.

entla, a Novel Epileptic and Ataxic Cacna2d2 Mutant of the Mouse*

N. Klugbauer, F. Hofmann, C. Becker, 2004, Journal of Biological Chemistry.

Disruption of the compacted myelin sheath of axons of the central nervous system in proteolipid protein-deficient mice.

W. Stoffel, D. Boison, Wilhelm Stoffel, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Engineered adenosine-releasing cells for epilepsy therapy: Human mesenchymal stem cells and human embryonic stem cells

D. Boison, 2009, Neurotherapeutics.

Adenosine augmentation therapies (AATs) for epilepsy: Prospect of cell and gene therapies

D. Boison, 2009, Epilepsy Research.

The adenosine kinase hypothesis of epileptogenesis

D. Boison, 2008, Progress in Neurobiology.

Adenosine kinase is a target for the prediction and prevention of epileptogenesis in mice.

Shigeyoshi Itohara, Takuji Iwasato, S. Itohara, 2008, The Journal of clinical investigation.

Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants.

R. Simon, T. Lusardi, O. Brüstle, 2007, Brain : a journal of neurology.

Neuroprotection in Ischemic Mouse Brain Induced by Stem Cell-Derived Brain Implants

R. Simon, G. Pignataro, D. Boison, 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Adenosine Metabolism: Emerging Concepts for Cancer Therapy.

G. Yegutkin, D. Boison, 2019, Cancer cell.

The impact of methodology on the reproducibility and rigor of DNA methylation data

S. Masino, J. Ohm, J. Hur, 2022, Scientific reports.

Developmental Role of Adenosine Kinase in the Cerebellum

E. Dicicco-Bloom, D. Boison, Hoda Gebril, 2021, eNeuro.

microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus

E. Jimenez-Mateos, C. Mooney, D. Henshall, 2015, Scientific Reports.

Methylxanthines, seizures, and excitotoxicity.

D. Boison, 2011, Handbook of experimental pharmacology.

Adenosine kinase expression determines DNA methylation in cancer cell lines

K. Jacobson, D. Boison, Kiran S Toti, 2021, ACS pharmacology & translational science.

Inhibitory RNA in epilepsy: Research tools and therapeutic perspectives

D. Boison, 2010, Epilepsia.

Mouse Oocytes Acquire Mechanisms That Permit Independent Cell Volume Regulation at the End of Oogenesis

J. Baltz, D. Boison, Alina P. Tartia, 2017, Journal of cellular physiology.

Comorbidities in Neurology: Is adenosine the common link?

E. Aronica, D. Boison, 2015, Neuropharmacology.

Glial adenosine kinase – A neuropathological marker of the epileptic brain

E. Aronica, A. Iyer, D. Boison, 2013, Neurochemistry International.

Overexpression of ADK in human astrocytic tumors and peritumoral tissue is related to tumor‐associated epilepsy

J. Reijneveld, J. Heimans, E. Aronica, 2012, Epilepsia.

Lentiviral RNAi-induced downregulation of adenosine kinase in human mesenchymal stem cell grafts: A novel perspective for seizure control

Jiang Lan, R. Simon, Tianfu Li, 2007, Experimental Neurology.

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia

S. Jalkanen, J. Laurila, G. Yegutkin, 2020, Journal of Cell Science.

Adenosinergic signaling in epilepsy

D. Boison, 2016, Neuropharmacology.

Homeostatic control of brain function – new approaches to understand epileptogenesis

S. Masino, D. Ruskin, D. Boison, 2013, Front. Cell. Neurosci..

The Purinome and the preBötzinger Complex – A Ménage of Unexplored Mechanisms That May Modulate/Shape the Hypoxic Ventilatory Response

C. Cass, G. Funk, S. Pagliardini, 2019, Front. Cell. Neurosci..

Adenosine kinase as a target for therapeutic antisense strategies in epilepsy

D. Poulsen, P. Theofilas, D. Boison, 2011, Epilepsia.

The Good, the Bad, and the Deadly: Adenosinergic Mechanisms Underlying Sudden Unexpected Death in Epilepsy

M. Murugan, B. Purnell, D. Boison, 2021, Frontiers in Neuroscience.

ATP and adenosine—Two players in the control of seizures and epilepsy development

T. Engel, D. Boison, Edward Beamer, 2021, Progress in Neurobiology.

Caffeine prevents acute mortality after TBI in rats without increased morbidity

T. Lusardi, C. Szybala, Nikki K. Lytle, 2012, Experimental Neurology.

TITLE: Survival and Injury Outcome After TBI: Influence of Pre- and Post-Exposure to Caffeine PRINCIPAL INVESTIGATOR:

D. Boison, 2012 .

Ketogenic Diet Improves Core Symptoms of Autism in BTBR Mice

S. Masino, J. Rho, D. Ruskin, 2013, PloS one.

Epilepsy and astrocyte energy metabolism

C. Steinhäuser, D. Boison, 2018, Glia.

4-Aminobutyrate Transaminase

D. Boison, 2008 .

Adenosine A2A Receptors in Striatal Glutamatergic Terminals and GABAergic Neurons Oppositely Modulate Psychostimulant Action and DARPP-32 Phosphorylation

R. Cunha, R. Moratalla, Patricia García-Sanz, 2013, PloS one.

Astrocyte-neuron circuits in epilepsy

B. Purnell, D. Boison, Mariana Alves, 2023, Neurobiology of Disease.

Specialty Grand Challenge for Brain Disease Mechanisms

D. Boison, 2021, Frontiers in Molecular Neuroscience.

Ketogenic Diet, Inflammation, and Epilepsy

D. Boison, 2021 .

Role of Adenosine in Epilepsy and Seizures.

Â. R. Tomé, R. Cunha, D. Rombo, 2020, Journal of caffeine and adenosine research.

Epilepsy Benchmarks Area II: Prevent Epilepsy and Its Progression

D. Binder, A. Poduri, V. Whittemore, 2020, Epilepsy currents.

Upregulation of adenosine kinase in astrocytes in experimental and human temporal lobe epilepsy

J. C. Baayen, E. Aronica, J. Gorter, 2011, Epilepsia.

Downregulation of Hippocampal Adenosine Kinase after Focal Ischemia as Potential Endogenous Neuroprotective Mechanism

R. Simon, G. Pignataro, S. Maysami, 2008, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Adenosine dysfunction in astrogliosis: cause for seizure generation?

B. Fredholm, R. Simon, Tianfu Li, 2007, Neuron glia biology.

Overexpression of Adenosine Kinase in Epileptic Hippocampus Contributes to Epileptogenesis

J. Fritschy, D. Boison, L. Scheurer, 2022 .

Seizure Suppression by Adenosine‐releasing Cells Is Independent of Seizure Frequency

N. Déglon, P. Aebischer, D. Boison, 2002, Epilepsia.

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Z. Dong, Xuejun Jiang, Qinkai Li, 2017, Nature Communications.

Functional analysis in vivo of the double mutant mouse deficient in both proteolipid protein (PLP) and myelin basic protein (MBP) in the central nervous system

W. Stoffel, H. Büssow, D. Boison, 1997, Cell and Tissue Research.

Adenosine signaling and function in glial cells

B. Fredholm, D. Boison, J. Chen, 2010, Cell Death and Differentiation.

Is Intrinsic Hyperexcitability in CA3 the Culprit for Seizures in Rett Syndrome?

D. Boison, 2012, Epilepsy currents.

Adhesive properties of proteolipid protein are responsible for the compaction of CNS myelin sheaths

W. Stoffel, D. D'urso, H. Büssow, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Adenosine kinase: An epigenetic modulator in development and disease

M. Murugan, D. Boison, Geetasravya Vegunta, 2021, Neurochemistry International.

Amino acid composition of brain cysts: levels of excitatory amino acids in cyst fluid fail to predict seizures

Y. Yonekawa, R. Bernays, N. Blau, 2003, Epilepsy Research.

Upregulation of adenosine A2A receptor and downregulation of GLT1 is associated with neuronal cell death in Rasmussen's encephalitis

Jing Wang, Jian Zhou, Y. Guan, 2020, Brain pathology.

Modulation of sensorimotor gating in prepulse inhibition by conditional brain glycine transporter 1 deletion in mice

J. Feldon, B. Yee, D. Boison, 2011, European Neuropsychopharmacology.

Deletion of striatal adenosine A2A receptor spares latent inhibition and prepulse inhibition but impairs active avoidance learning

B. Yee, Catherine J. Wei, D. Boison, 2013, Behavioural Brain Research.

Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery

Eleanor M. Pritchard, D. Kaplan, D. Boison, 2013 .

Selective inactivation of adenosine A(2A) receptors in striatal neurons enhances working memory and reversal learning.

J. Feldon, B. Yee, J. Coelho, 2011, Learning & memory.

Glycine transporter 1 is a target for the treatment of epilepsy

E. Aronica, J. Gorter, Nikki K. Lytle, 2015, Neuropharmacology.

Arousal Effect of Caffeine Depends on Adenosine A2A Receptors in the Shell of the Nucleus Accumbens

Raphaelle Winsky-Sommerer, Wei-Min Qu, Yoshihiro Urade, 2011, The Journal of Neuroscience.

Enhancement of the NMDA receptor function by reduction of glycine transporter-1 expression

K. Vogt, H. Bluethmann, H. Mohler, 2004, Neuroscience Letters.

Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice

Natalie E. Roese, J. Iliff, M. Grafe, 2022, Alzheimer's Research & Therapy.

Silk fibroin encapsulated powder reservoirs for sustained release of adenosine.

David L. Kaplan, Eleanor M. Pritchard, D. Kaplan, 2010, Journal of controlled release : official journal of the Controlled Release Society.

Myelin‐deficient rat: a point mutation in exon III (A‐‐‐‐C, Thr75‐‐‐‐Pro) of the myelin proteolipid protein causes dysmyelination and oligodendrocyte death.

W. Stoffel, D. Boison, 1989, The EMBO journal.

Adenosine dysfunction in epilepsy

D. Boison, 2012, Glia.

Adenosine and Epilepsy: From Therapeutic Rationale to New Therapeutic Strategies

D. Boison, 2005, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Steven A. Brown, A. Galione, S. Vasudevan, 2021, Nature Communications.

Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.

B. Yee, Nikki K. Lytle, J. Lan, 2012, The Journal of clinical investigation.

A randomized controlled trial to evaluate outcomes with Aggrenox in patients with SARS-CoV-2 infection

S. Libutti, A. Sonig, D. Finkle, 2023, PloS one.

Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation.

D. Boison, Kerry-Ann Stewart, 2009, Biochemical pharmacology.

Adenosine as a neuromodulator in neurological diseases.

Detlev Boison, D. Boison, 2008, Current opinion in pharmacology.

Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme

A. Marowsky, J. Fritschy, D. Boison, 2006, Neuroscience.

Astrogliosis in epilepsy leads to overexpression of adenosine kinase, resulting in seizure aggravation.

Thomas Rülicke, Laetitia Gabernet, T. Rülicke, 2005, Brain : a journal of neurology.

Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss

Ann Chi Yan Wong, Srdjan M. Vlajkovic, Cindy X. Guo, 2011, Experimental Gerontology.

Role of adenosine kinase in cochlear development and response to noise

Cindy X. Guo, G. Housley, P. Thorne, 2010, Journal of neuroscience research.

Adenosine dysfunction and adenosine kinase in epileptogenesis.

Detlev Boison, D. Boison, 2010, The open neuroscience journal.

A Critical Role of the Adenosine A2A Receptor in Extrastriatal Neurons in Modulating Psychomotor Activity as Revealed by Opposite Phenotypes of Striatum and Forebrain A2A Receptor Knock-Outs

J. Tsien, R. Cunha, Liqun Yu, 2008, The Journal of Neuroscience.

Enhanced recognition memory following glycine transporter 1 deletion in forebrain neurons.

J. Feldon, B. Yee, D. Boison, 2007, Behavioral neuroscience.

Ketogenic diet sensitizes glucose control of hippocampal excitability1

S. Masino, D. Ruskin, J. Geiger, 2014, Journal of Lipid Research.

Deletion of glycine transporter 1 (GlyT1) in forebrain neurons facilitates reversal learning: enhanced cognitive adaptability?

J. Feldon, B. Yee, D. Boison, 2009, Behavioral neuroscience.

Transgenic overexpression of adenosine kinase in brain leads to multiple learning impairments and altered sensitivity to psychomimetic drugs

J. Feldon, B. Yee, D. Boison, 2007, The European journal of neuroscience.

Genetic variation in the adenosine regulatory cycle is associated with posttraumatic epilepsy development

P. Kochanek, Y. Conley, A. Wagner, 2015, Epilepsia.

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007

Yonina C. Eldar, Karl J. Friston, Leslie G. Ungerleider, 2008, Neural plasticity.

Suppression of phrenic nerve activity as a potential predictor of imminent sudden unexpected death in epilepsy (SUDEP)

M. Murugan, T. Huynh, Omar Ashraf, 2020, Neuropharmacology.

Overexpression of adenosine kinase in cortical astrocytes and focal neocortical epilepsy in mice.

Ruikang K. Wang, Ruikang K Wang, Zhongwei Zhi, 2014, Journal of neurosurgery.

Sarcosine Suppresses Epileptogenesis in Rats With Effects on Hippocampal DNA Methylation

D. Boison, H. Shen, Jesica Reemmer, 2020, Frontiers in Molecular Neuroscience.

Purines and neuronal excitability: Links to the ketogenic diet

S. Masino, D. Ruskin, J. Geiger, 2012, Epilepsy Research.

Adenosine and Seizure Termination: Endogenous Mechanisms

Detlev Boison, D. Boison, 2013, Epilepsy currents.

Connexin 43-Mediated Astroglial Metabolic Networks Contribute to the Regulation of the Sleep-Wake Cycle

P. Haydon, E. Scemes, Zhongyan Wang, 2017, Neuron.

Seizure suppression by adenosine A2A receptor activation in a rat model of audiogenic brainstem epilepsy

D. Boison, A. Huber, M. Güttinger, 2002, Neuroscience Letters.

Adenosine Kinase Deficiency in the Brain Results in Maladaptive Synaptic Plasticity

Y. Huo, A. Jones, D. Boison, 2016, The Journal of Neuroscience.

Deletion of Adenosine A2A Receptors From Astrocytes Disrupts Glutamate Homeostasis Leading to Psychomotor and Cognitive Impairment: Relevance to Schizophrenia

Y. T. Wang, P. Agostinho, R. Cunha, 2015, Biological Psychiatry.

Adenosine turnover (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Boison, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Adenosine Kinase Deficiency Increases Susceptibility to a Carcinogen.

D. Boison, Rkia El-kharrag, R. Owen, 2019, Journal of caffeine and adenosine research.

Adenosine kinase is a new therapeutic target to prevent ischemic neuronal death.

D. Boison, H. Shen, 2010, The open drug discovery journal.

Adenosine Kinase Inhibition Protects against Cranial Radiation-Induced Cognitive Dysfunction

J. Baulch, C. Limoli, T. Lusardi, 2016, Front. Mol. Neurosci..

Adenosine kinase is critical for neointima formation after vascular injury by inducing aberrant DNA hypermethylation.

Yunchao Su, Xuejun Jiang, D. Fulton, 2020, Cardiovascular research.

Adenosine kinase, epilepsy and stroke: mechanisms and therapies.

D. Boison, 2006, Trends in pharmacological sciences.

Effects of Preinjury and Postinjury Exposure to Caffeine in a Rat Model of Traumatic Brain Injury.

T. Lusardi, Nikki K. Lytle, D. Boison, 2020, Journal of caffeine and adenosine research.

Seizure Suppression in Kindled Rats by Intraventricular Grafting of an Adenosine Releasing Synthetic Polymer

P. Aebischer, H. Mohler, D. Boison, 1999, Experimental Neurology.

Regulation of Fear Responses by Striatal and Extrastriatal Adenosine A2A Receptors in Forebrain

B. Yee, R. Cunha, Catherine J. Wei, 2014, Biological Psychiatry.

Genetic variations of adenosine kinase as predictable biomarkers of efficacy of vagus nerve stimulation in patients with pharmacoresistant epilepsy.

Jing Wang, Jian Zhou, Y. Guan, 2021, Journal of neurosurgery.

Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus

N. Dale, A. Irving, B. Frenguelli, 2009, Neuropharmacology.

Seizure suppression and lack of adenosine A1 receptor desensitization after focal long-term delivery of adenosine by encapsulated myoblasts

W. Pralong, Detlev Boison, Martin Güttinger, 2005, Experimental Neurology.

Seizure Suppression by Adenosine A1 Receptor Activation in a Mouse Model of Pharmacoresistant Epilepsy

J. Fritschy, Jean-Marc Fritschy, Detlev Boison, 2003, Epilepsia.

The Biochemistry and Epigenetics of Epilepsy: Focus on Adenosine and Glycine

D. Boison, 2016, Front. Mol. Neurosci..

Dysregulation of brain adenosine is detrimental to the expression of conditioned freezing but not general Pavlovian learning

B. Yee, D. Boison, P. Singer, 2013, Pharmacology Biochemistry and Behavior.

Manipulation of Adenosine Kinase Affects Sleep Regulation in Mice

Raphaelle Winsky-Sommerer, Irene Tobler, I. Tobler, 2010, The Journal of Neuroscience.

Aberrant adenosine signaling in patients with focal cortical dysplasia

Jing Wang, Jian Zhou, Y. Guan, 2023, Molecular Neurobiology.

Influence of Adenosine on Synaptic Excitability

R. Dias, D. Boison, A. Sebastião, 2017 .

Adenosine A1 receptors are crucial in keeping an epileptic focus localized

B. Fredholm, J. Lan, Tianfu Li, 2006, Experimental Neurology.

Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation

D. Boison, 2013 .

Transgenic Overexpression of Adenosine Kinase Aggravates Cell Death in Ischemia

R. Simon, G. Pignataro, D. Boison, 2007, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Adenosine turnover in GtoPdb v.2021.3

D. Boison, 2021, IUPHAR/BPS Guide to Pharmacology CITE.

Abstracts of the 16th Annual Meeting of The Israel Society for Neuroscience Eilat, Israel, November 25–27, 2007

Yonina C. Eldar, Karl J. Friston, Leslie G. Ungerleider, 2008, Neural plasticity.

Early perceptual loss in depression

Yonina C. Eldar, Karl J. Friston, Charles R. Seger, 2007 .

Adenosine Augmentation Therapy

D. Boison, 2012 .

Antiepileptic effects of silk-polymer based adenosine release in kindled rats

Eleanor M. Pritchard, D. Kaplan, T. Lusardi, 2009, Experimental Neurology.

Uncoupling of astrogliosis from epileptogenesis in adenosine kinase (ADK) transgenic mice.

J. Lan, Tianfu Li, D. Boison, 2008, Neuron glia biology.

Suppression of kindling epileptogenesis by adenosine-releasing stem cell-derived brain implants

R. Simon, T. Lusardi, O. Brüstle, 2007 .

Intact working memory in the absence of forebrain neuronal glycine transporter 1

J. Feldon, B. Yee, P. Gargiulo, 2012, Behavioural Brain Research.

From epidemiology to pathophysiology: what about caffeine in Alzheimer's disease?

L. Buée, D. Blum, M. Hamdane, 2014, Biochemical Society transactions.

Adenosine Receptors and Alzheimer’s Disease

F. Pasquier, L. Buée, D. Blum, 2013 .

The support of adenosine release from adenosine kinase deficient ES cells by silk substrates.

David L Kaplan, Lorenz Meinel, Hans P Merkle, 2006, Biomaterials.

Incorporation of proteinase inhibitors into silk-based delivery devices for enhanced control of degradation and drug release.

David L Kaplan, Eleanor M. Pritchard, D. Kaplan, 2011, Biomaterials.

Deep Brain Stimulation in the Dish: Focus on Mechanisms

D. Boison, 2014, Epilepsy currents.

Preclinical pharmacokinetics and tolerability of a novel meglumine‐based parenteral solution of topiramate and topiramate combinations for treatment of status epilepticus

H. Goodkin, R. D’Ambrosio, W. Löscher, 2023, Epilepsia.

Adenosine kinase inhibition promotes proliferation of neural stem cells after traumatic brain injury

E. Aronica, Y. Huo, D. Boison, 2020, Brain communications.

Meet Our Editorial Board Member

D. Boison, 2016, Current Neuropharmacology.

Dynamic Regulation of the Adenosine Kinase Gene during Early Postnatal Brain Development and Maturation

K. Kobow, D. Boison, K. Kiese, 2016, Front. Mol. Neurosci..

Role of adenosine in status epilepticus: A potential new target?

D. Boison, 2013, Epilepsia.

Silk polymer-based adenosine release: therapeutic potential for epilepsy.

David L Kaplan, Eleanor M. Pritchard, D. Kaplan, 2008, Biomaterials.

Glowing Feet Control the Blood of Seizures

D. Boison, 2013, Epilepsy currents.

Astrogliosis and adenosine kinase: a glial basis of epilepsy

D. Boison, 2008 .

Adenosine-Based Modulation of Brain Activity

D. Boison, 2009, Current Neuropharmacology.

A ketogenic diet suppresses seizures in mice through adenosine A₁ receptors.

B. Fredholm, S. Masino, E. Aronica, 2011, Journal of Clinical Investigation.

Homeostatic bioenergetic network regulation: a novel concept to avoid pharmacoresistance in epilepsy

S. Masino, J. Geiger, D. Boison, 2011, Expert opinion on drug discovery.

The Sound of Noninvasive Seizure Control

D. Boison, 2011, Epilepsy currents.

Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation

Z. Dong, Xuejun Jiang, Qinkai Li, 2017, Nature Communications.

Altered mnemonic functions and resistance to N-METHYL-d-Aspartate receptor antagonism by forebrain conditional knockout of glycine transporter 1

S. Itohara, B. Yee, T. Iwasato, 2009, Neuroscience.

Adenosine dysfunction in epilepsy

D. Boison, 2012, Glia.

Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase.

C. Limatola, B. Frenguelli, L. Maggi, 2014, Cerebral cortex.

Local disruption of glial adenosine homeostasis in mice associates with focal electrographic seizures: A first step in epileptogenesis?

Nikki K. Lytle, J. Lan, Tianfu Li, 2012, Glia.

Overexpression of Adenosine Kinase in Epileptic Hippocampus Contributes to Epileptogenesis

J. Fritschy, D. Boison, L. Scheurer, 2004, The Journal of Neuroscience.

Adenosine augmentation ameliorates psychotic and cognitive endophenotypes of schizophrenia.

B. Yee, Nikki K. Lytle, J. Lan, 2012, The Journal of clinical investigation.

Adenosine kinase determines the degree of brain injury after ischemic stroke in mice

D. Poulsen, T. Lusardi, J. Lan, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Ectopic expression of neuronal adenosine kinase, a biomarker in mesial temporal lobe epilepsy without hippocampal sclerosis

Jing Zhang, K. Yao, Jing Wang, 2023, Neuropathology and applied neurobiology.

Opiate-induced changes in brain adenosine levels and narcotic drug responses

Manhong Wu, M. Zheng, J. Clark, 2013, Neuroscience.

Trinity College Digital Repository Trinity College Digital Repository

B. Fredholm, S. Masino, E. Aronica, 2022 .

Impacts of forebrain neuronal glycine transporter 1 disruption in the senescent brain: evidence for age-dependent phenotypes in Pavlovian learning.

B. Yee, D. Boison, P. Singer, 2010, Behavioral neuroscience.

Examining the sex- and circadian dependency of a learning phenotype in mice with glycine transporter 1 deletion in two Pavlovian conditioning paradigms

B. Yee, D. Boison, H. Möhler, 2011, Neurobiology of Learning and Memory.

Deep brain stimulation of the anterior thalamus attenuates PTZ kindling with concomitant reduction of adenosine kinase expression in rats

L. Covolan, E. Hargreaves, D. Boison, 2022, Brain Stimulation.

Are glia targets for neuropathic orofacial pain therapy?

D. Boison, Manvitha Kuchukulla, 2020, Journal of the American Dental Association.