Timothy M. Pabst

发表

The Development and Application of a Monoclonal Antibody Purification Platform : A purification scheme to maximize the efficiency of the purification process and product purity while minimizing the development time for early-phase therapeutic antibodies

Paul Johnson, Judy Glynn, Timothy Hagerty, 2009 .

Protein separations with induced pH gradients using cation-exchange chromatographic columns containing weak acid groups.

Dorota Antos, Giorgio Carta, Alan K. Hunter, 2008, Journal of chromatography. A.

Protein Mass Transfer Kinetics in Ion Exchange Media: Measurements and Interpretations

Giorgio Carta, G. Carta, Timothy M Pabst, 2005 .

Process-scale purification and analytical characterization of highly gamma-carboxylated recombinant human prothrombin.

M. Wendeler, Xiangyang Wang, A. Hunter, 2014, Journal of chromatography. A.

Comparison of agarose and dextran-grafted agarose strong ion exchangers for the separation of protein aggregates.

Eric J. Suda, A. Hunter, Timothy M. Pabst, 2009, Journal of chromatography. A.

Separation of protein charge variants with induced pH gradients using anion exchange chromatographic columns

G. Carta, A. Hunter, Timothy M. Pabst, 2008, Biotechnology progress.

Formation of transient highly-charged mAb clusters strengthens interactions with host cell proteins and results in poor clearance of host cell proteins by protein A chromatography.

Chen Qian, Haibin Luo, William K. Wang, 2022, Journal of chromatography. A.

Liquid-liquid phase separation causes high turbidity and pressure during low pH elution process in Protein A chromatography.

Haibin Luo, Xiangyang Wang, William K. Wang, 2017, Journal of chromatography. A.

Binding and elution behavior of proteins on strong cation exchangers.

Eric J. Suda, A. Hunter, Timothy M. Pabst, 2009, Journal of chromatography. A.

Safety risk management for low molecular weight process‐related impurities in monoclonal antibody therapeutics: Categorization, risk assessment, testing strategy, and process development with leveraging clearance potential

Haibin Luo, Guoling Xi, William K. Wang, 2020, Biotechnology progress.

Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. I. Experimental observations and phenomenological model.

G. Carta, A. Hunter, Timothy M. Pabst, 2019, Journal of chromatography. A.

Comparison of strong anion-exchangers for the purification of a PEGylated protein.

A. Hunter, Timothy M. Pabst, J. Buckley, 2007, Journal of chromatography. A.

Camelid VHH affinity ligands enable separation of closely related biopharmaceuticals

M. Wendeler, Timothy M Pabst, Xiangyang Wang, 2016, Biotechnology journal.

Process optimization and protein engineering mitigated manufacturing challenges of a monoclonal antibody with liquid-liquid phase separation issue by disrupting inter-molecule electrostatic interactions

Haibin Luo, William K. Wang, A. Hunter, 2019, mAbs.

Chromatographic behavior of bivalent bispecific antibodies on cation exchange columns. II. Biomolecular perspectives.

G. Carta, A. Hunter, Timothy M. Pabst, 2019, Journal of chromatography. A.

Role of configurational flexibility on the adsorption kinetics of bivalent bispecific antibodies on porous cation exchange resins.

G. Carta, A. Hunter, Timothy M. Pabst, 2021, Journal of chromatography. A.

Cathepsin L Causes Proteolytic Cleavage of Chinese‐Hamster‐Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation

Haibin Luo, Timothy M Pabst, William K. Wang, 2018, Biotechnology progress.

Chromatographic and adsorptive behavior of a bivalent bispecific antibody and associated fragments.

G. Carta, A. Hunter, Ben Niu, 2021, Journal of chromatography. A.

Development and scale-up of a commercial fed batch refolding process for an anti-CD22 two chain immunotoxin

M. Wendeler, T. Linke, Matthew T. Aspelund, 2014, Biotechnology progress.

pH transitions in cation exchange chromatographic columns containing weak acid groups.

Giorgio Carta, G. Carta, Timothy M Pabst, 2007, Journal of chromatography. A.

Tuesday, November 6, 2007

S. Garde, A. Hunter, V. Upadhyayula, 2007 .

Evaluation of recent Protein A stationary phase innovations for capture of biotherapeutics.

Timothy M Pabst, A. Hunter, Timothy M. Pabst, 2018, Journal of chromatography. A.

Engineering of novel Staphylococcal Protein A ligands to enable milder elution pH and high dynamic binding capacity.

Annika Forss, Christopher Thompson, Timothy M Pabst, 2014, Journal of chromatography. A.

Systematic Interpolation Method Predicts Antibody Monomer-Dimer Separation by Gradient Elution Chromatography at High Protein Loads.

G. Carta, Timothy M Pabst, A. Hunter, 2018, Biotechnology journal.

Separation of antibody monomer-dimer mixtures by frontal analysis.

Giorgio Carta, G. Carta, Timothy M Pabst, 2017, Journal of chromatography. A.

Adsorption equilibrium and kinetics of monomer-dimer monoclonal antibody mixtures on a cation exchange resin.

Giorgio Carta, G. Carta, Timothy M Pabst, 2015, Journal of chromatography. A.