K. Gohda

发表

An attempt to incorporate effect of direct interaction between a ligand and explicit water molecules into MM/3D‐RISM

K. Gohda, 2018, Chemical biology & drug design.

Discovery and optimization of benzimidazole derivatives as a novel chemotype of farnesoid X receptor (FXR) antagonists.

T. Nishimaki-Mogami, K. Gohda, N. Teno, 2017, Bioorganic & medicinal chemistry.

A quantitative structure-activity relationship study for structurally diverse HIV-1 protease inhibitors: contribution of conformational flexibility to inhibitory activity

K. Gohda, 2006, Journal of enzyme inhibition and medicinal chemistry.

Prediction of paclitaxel sensitivity by CDK1 and CDK2 activity in human breast cancer cells

G. Hortobagyi, T. Sakai, N. Ueno, 2009, Breast Cancer Research.

Synthetic Substrates Specific to Activated Plasmin Can Monitor the Enzymatic Functional Status in Situ in Breast Cancer Cells

Y. Tsuda, K. Fujimori, K. Gohda, 2014, Chemical biology & drug design.

Discovery of Orally Active and Nonsteroidal Farnesoid X Receptor (FXR) Antagonist with Propensity for Accumulation and Responsiveness in Ileum.

K. Fujimori, K. Oda, Arisa Masuda, 2021, ACS medicinal chemistry letters.

Detection and preliminary evaluation of circulating tumor cells in the peripheral blood of patients with eight types of cancer using a telomerase-specific adenovirus

Masaaki Ito, T. Okegawa, D. Nobuoka, 2014, Oncology reports.

Species differences between human and rat in the substrate specificity of cathepsin K.

Kenji. Suzuki, K. Gohda, N. Teno, 2008, Journal of biochemistry.

Combined markers of tumor cell proliferation and apoptosis are clinically prognostic in stage II colon cancer patients

R. Rosenberg, K. Janssen, C. V. D. Velde, 2014 .

Identification of potent farnesoid X receptor (FXR) antagonist showing favorable PK profile and distribution toward target tissues: Comprehensive understanding of structure-activity relationship of FXR antagonists.

K. Fujimori, T. Nishimaki-Mogami, K. Oda, 2019, Bioorganic & medicinal chemistry.

Synthesis of Novel Farnesoid X Receptor Agonists and Validation of Their Efficacy in Activating Differentiation of Mouse Bone Marrow-Derived Mesenchymal Stem Cells into Osteoblasts

K. Fujimori, K. Gohda, N. Teno, 2019, Molecules.

Nonacidic Chemotype Possessing N-Acylated Piperidine Moiety as Potent Farnesoid X Receptor (FXR) Antagonists.

K. Fujimori, T. Nishimaki-Mogami, K. Gohda, 2018, ACS medicinal chemistry letters.

Crystal structure of RNase T1 complexed with the product nucleotide 3'-GMP. Structural evidence for direct interaction of histidine 40 and glutamic acid 58 with the 2'-hydroxyl group of the ribose.

T. Hakoshima, K. Tomita, K. Oka, 1994, The Journal of biological chemistry.

Conformational Analysis of the Loop-to-Helix Transition of the α-Helix3 Plastic Region in the N-Terminal Domain of Human Hsp90α by a Computational Biochemistry Approach

K. Gohda, 2022, J. Chem. Inf. Model..

Computational conformational analysis of α-thrombin inhibitors possessing distinct scaffolds in aqueous solution and on Ala-sheet.

K. Gohda, 2019, Journal of molecular graphics & modelling.

Active site-directed plasmin inhibitors: Extension on the P2 residue.

Y. Tsuda, K. Gohda, N. Teno, 2016, Bioorganic & medicinal chemistry.

Identification of novel plasmin inhibitors possessing nitrile moiety as warhead.

Y. Tsuda, K. Gohda, N. Teno, 2011, Bioorganic & medicinal chemistry letters.

Synthesis and hybridization properties of l-oligodeoxynucleotide analogues fixed in a low anti glycosyl conformation.

H. Urata, M. Akagi, K. Gohda, 2004, Organic & biomolecular chemistry.

NMR Solution Structure of Lipocalin-type Prostaglandin D Synthase

Y. Urade, Yuji Kobayashi, K. Fujimori, 2007, Journal of Biological Chemistry.

Computational Modeling of a Binding Conformation of the Intermediate L-Histidinal to Histidinol Dehydrogenase

Peter Ertl, Keigo Gohda, Daisaku Ohta, 2001, J. Chem. Inf. Comput. Sci..

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer

H. Friess, T. Schuster, R. Rosenberg, 2012, British Journal of Cancer.

Specific activity of cyclin-dependent kinase I is a new potential predictor of tumour recurrence in stage II colon cancer

H. Friess, P. Kuppen, T. Schuster, 2011, British Journal of Cancer.

Validation study of the prognostic value of cyclin-dependent kinase (CDK)-based risk in Caucasian breast cancer patients

H. Putter, P. Kuppen, S. Noguchi, 2009, British Journal of Cancer.

Novel scaffold for cathepsin K inhibitors.

O. Ohmori, S. Cowan-Jacob, K. Masuya, 2007, Bioorganic & medicinal chemistry letters.

Novel Functional Assay for Spindle-Assembly Checkpoint by Cyclin-Dependent Kinase Activity to Predict Taxane Chemosensitivity in Breast Tumor Patient

G. Hortobagyi, L. Pusztai, W. Symmans, 2013, Journal of Cancer.

N1-Substituted benzimidazole scaffold for farnesoid X receptor (FXR) agonists accompanying prominent selectivity against vitamin D receptor (VDR).

K. Fujimori, K. Oda, Arisa Masuda, 2020, Bioorganic & medicinal chemistry.

Circulating tumor cells as a prognostic factor in patients with small cell lung cancer

A. Masago, K. Katono, N. Masuda, 2014, Oncology letters.

Prognostic impact of the number of viable circulating cells with high telomerase activity in gastric cancer patients: a prospective study.

H. Inoue, S. Kimura, Hiroaki Ito, 2014, International journal of oncology.

Prognostic impact of detecting viable circulating tumour cells in gastric cancer patients using a telomerase-specific viral agent: a prospective study

S. Kudo, H. Inoue, H. Satodate, 2012, BMC Cancer.

Multiple four-stranded conformations of human telomere sequence d(CCCTAA) in solution.

N. Shibayama, K. Kanaori, K. Makino, 2001, Nucleic acids research.

New chemotypes for cathepsin K inhibitors.

C. Betschart, K. Gohda, N. Teno, 2008, Bioorganic & medicinal chemistry letters.

Novel type of plasmin inhibitors: providing insight into P4 moiety and alternative scaffold to pyrrolopyrimidine.

Y. Tsuda, Arisa Masuda, T. Otsubo, 2015, Bioorganic & medicinal chemistry.

Pyrrolopyrimidine-inhibitors with hydantoin moiety as spacer can explore P4/S4 interaction on plasmin.

Y. Tsuda, T. Otsubo, K. Gohda, 2014, Bioorganic & medicinal chemistry.

Identification of endogenous surrogate ligands for human P2Y receptors through an in silico search.

Takeshi Hiramoto, Keigo Gohda, M. Omatsu-Kanbe, 2004, Journal of pharmacological sciences.

Long-term prognostic impact of circulating tumour cells in gastric cancer patients

H. Inoue, M. Onimaru, S. Kimura, 2016, World journal of gastroenterology.

High Thermal Stability Imparted by a Designed Tandem Arg–Trp Stretch in an α‐Helical Coiled Coil

H. Hiroaki, Toshiki Tanaka, K. Gohda, 2005 .

Design and identification of a new farnesoid X receptor (FXR) partial agonist by computational structure-activity analysis: Ligand-induced H8 helix fluctuation in the ligand-binding domain of FXR may lead to partial agonism.

K. Fujimori, Arisa Masuda, K. Gohda, 2021, Bioorganic & medicinal chemistry letters.

Identification of Novel Potent Inhibitors for ATP‐Phosphoribosyl Transferase Using Three‐Dimensional Structural Database Search Technique

D. Ohta, T. Kikuchi, K. Fujimori, 2001 .

Synthesis and evaluation of tripeptidic plasmin inhibitors with nitrile as warhead

K. Ikeda, Y. Tsuda, T. Otsubo, 2012, Journal of peptide science : an official publication of the European Peptide Society.

A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation

Toshio Hakoshima, Keigo Gohda, T. Hakoshima, 2008, J. Comput. Aided Mol. Des..

Discovery of FXR/PPARγ dual partial agonist.

K. Fujimori, K. Oda, Arisa Masuda, 2023, Bioorganic & medicinal chemistry.

Predicting subsite interactions of plasmin with substrates and inhibitors through computational docking analysis

Keigo Gohda, Yuko Tsuda, Y. Tsuda, 2012, Journal of enzyme inhibition and medicinal chemistry.