M. Rosenbach

发表

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.

A. Joshi, Tsing-bau Chen, R. DeVita, 2013, ACS medicinal chemistry letters.

Mice Deficient in Sphingosine Kinase 1 Are Rendered Lymphopenic by FTY720*

R. Proia, S. Spiegel, A. Olivera, 2004, Journal of Biological Chemistry.

Alteration of Lymphocyte Trafficking by Sphingosine-1-Phosphate Receptor Agonists

H. Rosen, C. L. Lynch, J. Hale, 2002, Science.

Immune Cell Regulation and Cardiovascular Effects of Sphingosine 1-Phosphate Receptor Agonists in Rodents Are Mediated via Distinct Receptor Subtypes

R. Proia, M. Forrest, C. Meyers, 2004, Journal of Pharmacology and Experimental Therapeutics.

Discovery of Novel Antifungal (1,3)-β-d-Glucan Synthase Inhibitors

R. Schwartz, F. Vicente, A. Cabello, 2000, Antimicrobial Agents and Chemotherapy.

Synthesis, stereochemical determination and biochemical characterization of the enantiomeric phosphate esters of the novel immunosuppressive agent FTY720.

G. Chrebet, J. Hale, S. Mandala, 2004, Bioorganic & medicinal chemistry.

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

G. Chrebet, M. Forrest, H. Rosen, 2004, Bioorganic & medicinal chemistry letters.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Inhibition of fungal sphingolipid biosynthesis by rustmicin, galbonolide B and their new 21-hydroxy analogs.

P. Salmon, O. Genilloud, D. Zink, 1998, The Journal of antibiotics.

Potent S1P receptor agonists replicate the pharmacologic actions of the novel immune modulator FTY720.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Discovery of 3-arylpropionic acids as potent agonists of sphingosine-1-phosphate receptor-1 (S1P1) with high selectivity against all other known S1P receptor subtypes.

G. Chrebet, J. Hale, S. Mills, 2006, Bioorganic & medicinal chemistry letters.

Antifungal spectrum, in vivo efficacy, and structure-activity relationship of ilicicolin h.

V. Hornak, C. Gill, Sheo B. Singh, 2012, ACS medicinal chemistry letters.

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain.

Shane W. Krska, R. DeVita, R. Nargund, 2014, ACS medicinal chemistry letters.

Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3.

S. A. Parent, G. Chrebet, M. Forrest, 2005, Journal of medicinal chemistry.

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, H. Rosen, C. L. Lynch, 2004, Bioorganic & medicinal chemistry letters.

Isolation of a thymidine kinase negative mutant of Nocardia lactamdurans.

G. Darland, M. Rosenbach, L. Kaplan, 1989, FEMS microbiology letters.

Elevated uridine nucleotide pools in fluorouracil/fluorouridine resistant mutants ofNocardia lactamdurans

G. Darland, M. Rosenbach, Joyce Greene, 1990, Journal of Industrial Microbiology.

Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver

M. Erion, D. Kemp, S. Souza, 2019, PloS one.

SAR studies of 3-arylpropionic acids as potent and selective agonists of sphingosine-1-phosphate receptor-1 (S1P1) with enhanced pharmacokinetic properties.

G. Chrebet, J. Hale, S. Mills, 2007, Bioorganic & medicinal chemistry letters.

Khafrefungin, a Novel Inhibitor of Sphingolipid Synthesis*

M. Garcia-Calvo, H. Bull, S. Mandala, 1997, The Journal of Biological Chemistry.

Selecting against S1P3 enhances the acute cardiovascular tolerability of 3-(N-benzyl)aminopropylphosphonic acid S1P receptor agonists.

G. Chrebet, M. Forrest, H. Rosen, 2004, Bioorganic & medicinal chemistry letters.

A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists.

M. Ferrer, B. Strulovici, S. A. Parent, 2004, Journal of medicinal chemistry.

Highly selective and potent agonists of sphingosine-1-phosphate 1 (S1P1) receptor.

G. Chrebet, P. Váchal, J. Hale, 2006, Bioorganic & Medicinal Chemistry Letters.

2-Aryl(pyrrolidin-4-yl)acetic acids are potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, C. L. Lynch, J. Hale, 2006, Bioorganic & medicinal chemistry letters.

The discovery of 3-(N-alkyl)aminopropylphosphonic acids as potent S1P receptor agonists.

G. Chrebet, H. Rosen, J. Hale, 2004, Bioorganic & medicinal chemistry letters.

Microbial hydroxylation of rustmicin (galbonolide A) and galbonolide B, two antifungal products produced by Micromonospora sp.

B. Heimbuch, D. Zink, G. Harris, 2001 .

Rustmicin, a Potent Antifungal Agent, Inhibits Sphingolipid Synthesis at Inositol Phosphoceramide Synthase*

M. Garcia-Calvo, H. Bull, C. Gill, 1998, The Journal of Biological Chemistry.

Antimicrobial activity of ergokonin A from Trichoderma longibrachiatum

A. Tsipouras, A. Cabello, K. Wilson, 2001, Journal of applied microbiology.

Discovery of Triazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, M. Struthers, Qingzhong Hu, 2015, ACS medicinal chemistry letters.

Discovery of Benzimidazole CYP11B2 Inhibitors with in Vivo Activity in Rhesus Monkeys.

Michael E. Lassman, Jeffrey T. Kuethe, M. Struthers, 2015, ACS medicinal chemistry letters.

2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists.

J. Hale, S. Mills, S. Mandala, 2006, Bioorganic & medicinal chemistry letters.

C-terminal Loop Mutations Determine Folding and SecretionProperties of PCSK9

D. Johns, T. Vogt, D. Wisniewski, 2016 .

Design and synthesis of conformationally constrained 3-(N-alkylamino)propylphosphonic acids as potent agonists of sphingosine-1-phosphate (S1P) receptors.

G. Chrebet, H. Rosen, C. L. Lynch, 2004, Bioorganic & medicinal chemistry letters.

Discovery of MK-3168: A PET Tracer for Imaging Brain Fatty Acid Amide Hydrolase.

A. Joshi, R. DeVita, R. Hargreaves, 2013, ACS medicinal chemistry letters.