S. Mente

发表

Azetidine and Piperidine Carbamates as Efficient, Covalent Inhibitors of Monoacylglycerol Lipase.

Timothy L. Foley, K. Fennell, J. Pandit, 2017, Journal of medicinal chemistry.

Strategies to minimize CNS toxicity: in vitro high-throughput assays and computational modeling

Patrick E. Trapa, Travis T Wager, J. Liras, 2012, Expert opinion on drug metabolism & toxicology.

Potent α-Synuclein Aggregation Inhibitors, Identified by High-Throughput Screening, Mainly Target the Monomeric State.

D. Otzen, F. Mulder, J. S. Pedersen, 2018, Cell chemical biology.

Getting the MAX out of Computational Models: The Prediction of Unbound-Brain and Unbound-Plasma Maximum Concentrations.

Travis T Wager, A. Doran, S. Mente, 2012, ACS medicinal chemistry letters.

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

M. Ehlers, P. Tierney, R. Kozak, 2018, Nature Communications.

Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer's disease.

J. Pandit, F. Menniti, M. Ahlijanian, 2009, Bioorganic & medicinal chemistry letters.

Ligand-protein interactions of selective casein kinase 1δ inhibitors.

K. Walton, M. Hayward, Travis T Wager, 2013, Journal of medicinal chemistry.

Exploring Aromatic Chemical Space with NEAT: Novel and Electronically Equivalent Aromatic Template

Brajesh K. Rai, Alan M. Mathiowetz, Meihua Tu, 2012, J. Chem. Inf. Model..

A novel series of [3.2.1] azabicyclic biaryl ethers as alpha3beta4 and alpha6/4beta4 nicotinic receptor agonists.

R. J. Mather, R. Hurst, J. Lowe, 2010, Bioorganic & medicinal chemistry letters.

Quantitative structure-activity relationship of phenoxyphenyl-methanamine compounds with 5HT2A, SERT, and hERG activities.

A. Fliri, S. Mente, A. Schmidt, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Trifluoromethyl Glycol Carbamates as Potent and Selective Covalent Monoacylglycerol Lipase (MAGL) Inhibitors for Treatment of Neuroinflammation.

Timothy L. Foley, J. Pandit, J. Cianfrogna, 2018, Journal of medicinal chemistry.

Discovery, SAR, and pharmacokinetics of a novel 3-hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors.

M. Mansour, S. Sakya, K. Borzilleri, 2009, Journal of medicinal chemistry.

Measurement of atropisomer racemization kinetics using segmented flow technology.

Scot Mente, Jennifer E Davoren, Mark W Bundesmann, 2012, ACS medicinal chemistry letters.

COMPUTER SIMULATIONS OF THE SOLVATOCHROMISM OF BETAINE-30

M. Maroncelli, S. Mente, 1999 .

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

David C. Wood, K. Fennell, R. Kurumbail, 2018, Journal of medicinal chemistry.

NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations

A. Drilon, S. Ou, D. Camidge, 2022, Cancer discovery.

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Laura McDowell, Scot Mente, Mihaly Hajos, 2017, Journal of medicinal chemistry.

Mapping the Binding Site of BMS-708163 on γ-Secretase with Cleavable Photoprobes.

K. Geoghegan, Christopher W. am Ende, Douglas S. Johnson, 2017, Cell chemical biology.

Solvation and the Excited-State Tautomerization of 7-Azaindole and 1-Azacarbazole: Computer Simulations in Water and Alcohol Solvents

M. Maroncelli, S. Mente, 1998 .

Dopamine D1 receptor-agonist interactions: A mutagenesis and homology modeling study.

Scot Mente, David L. Gray, S. Mente, 2015, Bioorganic & medicinal chemistry letters.

Discovery of two clinical histamine H(3) receptor antagonists: trans-N-ethyl-3-fluoro-3-[3-fluoro-4-(pyrrolidinylmethyl)phenyl]cyclobutanecarboxamide (PF-03654746) and trans-3-fluoro-3-[3-fluoro-4-(pyrrolidin-1-ylmethyl)phenyl]-N-(2-methylpropyl)cyclobutanecarboxamide (PF-03654764).

Jiri Aubrecht, Scot Mente, Jennifer B Munzner, 2011, Journal of medicinal chemistry.

Evaluation of classical potential functions for hydrogen bonding in 7-azaindole and 1-azacarbazole complexes

M. Maroncelli, S. Frankland, S. Mente, 1998 .

Central Modulation of Circadian Rhythm via CK1 Inhibition for Psychiatric Indications

Travis T Wager, J. Ohren, J. Offord, 2011 .

The use of the R language for medicinal chemistry applications.

Max Kuhn, Scot Mente, M. Kuhn, 2012, Current topics in medicinal chemistry.

Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor

M. Ehlers, P. Tierney, R. Kozak, 2018, Nature Communications.

A recursive-partitioning model for blood–brain barrier permeation

Franco Lombardo, Scot Mente, F. Lombardo, 2005, J. Comput. Aided Mol. Des..

Chapter 25. ADME by computer

Scot Mente, Matthew D. Wessel, S. Mente, 2001 .

Exploring Aromatic Chemical Space with NEAT: Novel and Electronically Equivalent Aromatic Template

A. Mathiowetz, S. Liras, M. Hayward, 2012, Journal of Chemical Information and Modeling.

A recursive-partitioning model for blood–brain barrier permeation

F. Lombardo, S. Mente, 2005, J. Comput. Aided Mol. Des..

Dynamic interaction of TCNQ- with .beta.-cyclodextrin: a two-dimensional NMR exchange study

N. L. Eastman, C. Hartzell, S. Mente, 1993 .

Design and Synthesis of Clinical Candidate PF-06852231 (CVL-231): A Brain Penetrant, Selective, Positive Allosteric Modulator of the M4 Muscarinic Acetylcholine Receptor.

Kevin Ogilvie, M. Brodney, S. Mente, 2024, Journal of medicinal chemistry.

Casein kinase 1δ/ε inhibitor PF-5006739 attenuates opioid drug-seeking behavior.

K. Walton, Travis T Wager, J. Ohren, 2014, ACS Chemical Neuroscience.